The effect of the quasar H1821+643 on the surrounding intracluster medium: revealing the underlying cooling flow

We present a detailed study of the thermodynamic properties of the intracluster medium of the only low redshift galaxy cluster to contain a highly luminous quasar, H1821+643. The cluster is a highly massive, strong cool core cluster. We find that the ICM entropy around the quasar is significantly lower than that of other similarly massive strong cool core clusters within the central 80 kpc, and that the entropy lies significantly below the extrapolated baseline entropy profile from hierarchical structure formation. By comparing the scaled temperature profile with those of other strong cool core clusters of similar total mass, we see that the entropy deficiency is due to the central temperature being significantly lower. This suggests that the presence of the quasar in the core of H1821+643 has had a dramatic cooling effect on the intracluster medium around it. We find that, if the quasar was brighter in the past, Compton cooling by radiation from the quasar may have caused the low entropy and temperature levels in the ICM around the quasar. Curiously, the gradients of the steep central temperature and entropy decline are in reasonable agreement with the profiles expected for a constant pressure cooling flow. It is possible that the system has been locked into a Compton cooled feedback cycle which prevents energy release from the black hole heating the gas sufficiently to switch it off, leading to the formation of a huge (~3x10^10 solar mass) supermassive black hole.Comment: 8 pages, 10 figures. Accepted for publication in MNRA

R3^3SGM: Real-time Raster-Respecting Semi-Global Matching for Power-Constrained Systems

Stereo depth estimation is used for many computer vision applications. Though many popular methods strive solely for depth quality, for real-time mobile applications (e.g. prosthetic glasses or micro-UAVs), speed and power efficiency are equally, if not more, important. Many real-world systems rely on Semi-Global Matching (SGM) to achieve a good accuracy vs. speed balance, but power efficiency is hard to achieve with conventional hardware, making the use of embedded devices such as FPGAs attractive for low-power applications. However, the full SGM algorithm is ill-suited to deployment on FPGAs, and so most FPGA variants of it are partial, at the expense of accuracy. In a non-FPGA context, the accuracy of SGM has been improved by More Global Matching (MGM), which also helps tackle the streaking artifacts that afflict SGM. In this paper, we propose a novel, resource-efficient method that is inspired by MGM's techniques for improving depth quality, but which can be implemented to run in real time on a low-power FPGA. Through evaluation on multiple datasets (KITTI and Middlebury), we show that in comparison to other real-time capable stereo approaches, we can achieve a state-of-the-art balance between accuracy, power efficiency and speed, making our approach highly desirable for use in real-time systems with limited power.Comment: Accepted in FPT 2018 as Oral presentation, 8 pages, 6 figures, 4 table

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons

A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve Growth Factor (NGF) for their growth and survival. To control [Ca2+]i, normal Ca2+ influx was eliminated by titration of extracellular Ca2+ with EGTA and reinstated through voltage-sensitive Ca2+ channels. The rate of neurite outgrowth and the number of neurites thus became dependent on the extent of depolarization by KCl, and withdrawal of KCl caused an immediate cessation of growth. Neurite outgrowth was completely blocked by the L type Ca2+ channel antagonists nifedipine, nitrendipine, D600, or diltiazem at sub- or micromolar concentrations. Measurement of [Ca2+]i in cell bodies using the fluorescent Ca2+ indicator fura-2 established that optimal growth, similar to that seen in normal medium, was obtained when [Ca2+]i was clamped at resting levels. These levels of [Ca2+]i were set by serum, which elevated [Ca2+]i by integral of 30 nM, whereas the addition of NGF had no effect on [Ca2+]i. The reduction of [Ca2+]o prevented neurite fasciculation but this had no effect on the rate of neurite elongation or on the number of extending neurites. These results show that neurite outgrowth from NGF-dependent neurons occurs over long periods in the complete absence of Ca2+ signals, suggesting that Ca2+ signals are not necessary for operating the basic machinery of neurite outgrowth

The Self and Individualism: An Analysis on the Current Regulations of Academic Writing

Individualism, the focus or emphasis on the self, is a highly discussed and debated topic in writing. This is mostly regarding how the self should be addressed and utilized in writing. Although it there is also debate about what the self truly is, and how one can represent it in their work, veering into more abstract thought and theorizing. The amount of individualism, or the “self” that one is able to, or should imprint onto one’s writing varies widely across numerous genres of academic writing, or even writing in general. For example, in much of scientific writing there’s a broad disapproval of the usage of the self: First-person pronouns are preferred to be left out, and writing in active tense is frowned upon. This is often argued to be for the sake of having an appearance of objectivity in work, which science should supposedly always be. Yet in other, more social sciences such as sociology or political science, there is an increased usage of this individualism. Usages of “I” and active tense can be observed. It can be argued that this is natural of these subjects as they are discussing both the self and culture, which is evidently much more difficult, if not impossible to separate from the one conducting the study. Regardless, this is but a small example of the variance of the usage of the self in writing. Throughout this paper I will analyze the concept of the self in writing, as well as the validity of the current regulations of individualism in academic writing. As well as the benefits of more varied regulations regarding the subject matter

Development and application of two novel monoclonal antibodies against overexpressed CD26 and integrin α3 in human pancreatic cancer.

Monoclonal antibody (mAb) technology is an excellent tool for the discovery of overexpressed cell surface tumour antigens and the development of targeting agents. Here, we report the development of two novel mAbs against CFPAC-1 human pancreatic cancer cells. Using ELISA, flow cytometry, immunoprecipitation, mass spectrometry, Western blot and immunohistochemistry, we found that the target antigens recognised by the two novel mAbs KU44.22B and KU44.13A, are integrin α3 and CD26 respectively, with high levels of expression in human pancreatic and other cancer cell lines and human pancreatic cancer tissue microarrays. Treatment with naked anti-CD26 mAb KU44.13A did not have any effect on the growth and migration of cancer cells nor did it induce receptor downregulation. In contrast, treatment with anti-integrin α3 mAb KU44.22B inhibited growth in vitro of Capan-2 cells, increased migration of BxPC-3 and CFPAC-1 cells and induced antibody internalisation. Both novel mAbs are capable of detecting their target antigens by immunohistochemistry but not by Western blot. These antibodies are excellent tools for studying the role of integrin α3 and CD26 in the complex biology of pancreatic cancer, their prognostic and predictive values and the therapeutic potential of their humanised and/or conjugated versions in patients whose tumours overexpress integrin α3 or CD26

Three water sites in upper mantle olivine and the role of titanium in the water weakening mechanism

Infrared spectroscopy on synthetic olivines has established that there are at least four different mechanisms by which hydrogen is incorporated into the crystal structure. Two mechanisms occur in the system MgO-SiO2-H2O associated with silicon and magnesium vacancies, respectively. A third mechanism is associated with trivalent cation substitution, commonly Fe3+ in natural olivine, while the fourth mechanism, which is the one most prevalent in natural olivines from the spinel-peridotite facies of the Earth’s upper mantle, is associated with Ti4+ [Berry et al., 2005]. Here first principles calculations based on density functional theory are used to derive the structure and relative energies of the two defects in the pure MgO-SiO2-H2O system, and possible hydrogen-bearing and hydrogen-free point defects in Ti4+-doped forsterite. Calculated structures are used to compare the predicted orientation of the O-H bonds with the experimentally determined polarization. The energies are used to discuss how different regimes of chemical environment, temperature (T), pressure (P), and both water content and water fugacity ( fH2O), impact on which of the different hydroxyl substitution mechanisms are thermodynamically stable. We find that given the presence of Ti impurities, the most stable mechanism involves the formation of silicon vacancies containing two protons charge balanced by a Ti4+ cation occupying an adjacent octahedral site. This mechanism leads to the water-mediated formation of silicon vacancies. As silicon is known to be the most slowly diffusing species in olivine, this provides a credible explanation of the observed water weakening effect in olivine