673 research outputs found
Stationary and Axisymmetric Solutions of Higher-Dimensional General Relativity
We study stationary and axisymmetric solutions of General Relativity, i.e.
pure gravity, in four or higher dimensions. D-dimensional stationary and
axisymmetric solutions are defined as having D-2 commuting Killing vector
fields. We derive a canonical form of the metric for such solutions that
effectively reduces the Einstein equations to a differential equation on an
axisymmetric D-2 by D-2 matrix field living in three-dimensional flat space
(apart from a subclass of solutions that instead reduce to a set of equations
on a D-2 by D-2 matrix field living in two-dimensional flat space). This
generalizes the Papapetrou form of the metric for stationary and axisymmetric
solutions in four dimensions, and furthermore generalizes the work on Weyl
solutions in four and higher dimensions. We analyze then the sources for the
solutions, which are in the form of thin rods along a line in the
three-dimensional flat space that the matrix field can be seen to live in. As
examples of stationary and axisymmetric solutions, we study the
five-dimensional rotating black hole and the rotating black ring, write the
metrics in the canonical form and analyze the structure of the rods for each
solution.Comment: 43 pages, v2: typos fixed, refs adde
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Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy.
Anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab have limited durability. While mechanisms of resistance remain undefined, it is likely that acquired resistance to anti-angiogenic therapy will involve alterations of the tumor microenvironment. We confirmed increased tumor-associated macrophages in bevacizumab-resistant glioblastoma patient specimens and two novel glioblastoma xenograft models of bevacizumab resistance. Microarray analysis suggested downregulated macrophage migration inhibitory factor (MIF) to be the most pertinent mediator of increased macrophages. Bevacizumab-resistant patient glioblastomas and both novel xenograft models of resistance had less MIF than bevacizumab-naive tumors, and harbored more M2/protumoral macrophages that specifically localized to the tumor edge. Xenografts expressing MIF-shRNA grew more rapidly with greater angiogenesis and had macrophages localizing to the tumor edge which were more prevalent and proliferative, and displayed M2 polarization, whereas bevacizumab-resistant xenografts transduced to upregulate MIF exhibited the opposite changes. Bone marrow-derived macrophage were polarized to an M2 phenotype in the presence of condition-media derived from bevacizumab-resistant xenograft-derived cells, while recombinant MIF drove M1 polarization. Media from macrophages exposed to bevacizumab-resistant tumor cell conditioned media increased glioma cell proliferation compared with media from macrophages exposed to bevacizumab-responsive tumor cell media, suggesting that macrophage polarization in bevacizumab-resistant xenografts is the source of their aggressive biology and results from a secreted factor. Two mechanisms of bevacizumab-induced MIF reduction were identified: (1) bevacizumab bound MIF and blocked MIF-induced M1 polarization of macrophages; and (2) VEGF increased glioma MIF production in a VEGFR2-dependent manner, suggesting that bevacizumab-induced VEGF depletion would downregulate MIF. Site-directed biopsies revealed enriched MIF and VEGF at the enhancing edge in bevacizumab-naive patients. This MIF enrichment was lost in bevacizumab-resistant glioblastomas, driving a tumor edge M1-to-M2 transition. Thus, bevacizumab resistance is driven by reduced MIF at the tumor edge causing proliferative expansion of M2 macrophages, which in turn promotes tumor growth
A Titanium Nitride Absorber for Controlling Optical Crosstalk in Horn-Coupled Aluminum LEKID Arrays for Millimeter Wavelengths
We discuss the design and measured performance of a titanium nitride (TiN)
mesh absorber we are developing for controlling optical crosstalk in
horn-coupled lumped-element kinetic inductance detector arrays for
millimeter-wavelengths. This absorber was added to the fused silica
anti-reflection coating attached to previously-characterized, 20-element
prototype arrays of LEKIDs fabricated from thin-film aluminum on silicon
substrates. To test the TiN crosstalk absorber, we compared the measured
response and noise properties of LEKID arrays with and without the TiN mesh.
For this test, the LEKIDs were illuminated with an adjustable, incoherent
electronic millimeter-wave source. Our measurements show that the optical
crosstalk in the LEKID array with the TiN absorber is reduced by 66\% on
average, so the approach is effective and a viable candidate for future
kilo-pixel arrays.Comment: 7 pages, 5 figures, accepted for publication in the Journal of Low
Temperature Physic
Horn-Coupled, Commercially-Fabricated Aluminum Lumped-Element Kinetic Inductance Detectors for Millimeter Wavelengths
We discuss the design, fabrication, and testing of prototype horn-coupled,
lumped-element kinetic inductance detectors (LEKIDs) designed for cosmic
microwave background (CMB) studies. The LEKIDs are made from a thin aluminum
film deposited on a silicon wafer and patterned using standard
photolithographic techniques at STAR Cryoelectronics, a commercial device
foundry. We fabricated twenty-element arrays, optimized for a spectral band
centered on 150 GHz, to test the sensitivity and yield of the devices as well
as the multiplexing scheme. We characterized the detectors in two
configurations. First, the detectors were tested in a dark environment with the
horn apertures covered, and second, the horn apertures were pointed towards a
beam-filling cryogenic blackbody load. These tests show that the multiplexing
scheme is robust and scalable, the yield across multiple LEKID arrays is 91%,
and the noise-equivalent temperatures (NET) for a 4 K optical load are in the
range 26\thinspace\pm6 \thinspace \mu \mbox{K} \sqrt{\mbox{s}}
The Detector System for the Stratospheric Kinetic Inductance Polarimeter (SKIP)
The Stratospheric Kinetic Inductance Polarimeter (SKIP) is a proposed
balloon-borne experiment designed to study the cosmic microwave background, the
cosmic infrared background and Galactic dust emission by observing 1133 square
degrees of sky in the Northern Hemisphere with launches from Kiruna, Sweden.
The instrument contains 2317 single-polarization, horn-coupled, aluminum
lumped-element kinetic inductance detectors (LEKID). The LEKIDs will be
maintained at 100 mK with an adiabatic demagnetization refrigerator. The
polarimeter operates in two configurations, one sensitive to a spectral band
centered on 150 GHz and the other sensitive to 260 and 350 GHz bands. The
detector readout system is based on the ROACH-1 board, and the detectors will
be biased below 300 MHz. The detector array is fed by an F/2.4 crossed-Dragone
telescope with a 500 mm aperture yielding a 15 arcmin FWHM beam at 150 GHz. To
minimize detector loading and maximize sensitivity, the entire optical system
will be cooled to 1 K. Linearly polarized sky signals will be modulated with a
metal-mesh half-wave plate that is mounted at the telescope aperture and
rotated by a superconducting magnetic bearing. The observation program consists
of at least two, five-day flights beginning with the 150 GHz observations.Comment: J Low Temp Phys DOI 10.1007/s10909-013-1014-3 The final publication
is available at link.springer.co
A LEKID-based CMB instrument design for large-scale observations in Greenland
We present the results of a feasibility study, which examined deployment of a
ground-based millimeter-wave polarimeter, tailored for observing the cosmic
microwave background (CMB), to Isi Station in Greenland. The instrument for
this study is based on lumped-element kinetic inductance detectors (LEKIDs) and
an F/2.4 catoptric, crossed-Dragone telescope with a 500 mm aperture. The
telescope is mounted inside the receiver and cooled to K by a
closed-cycle He refrigerator to reduce background loading on the detectors.
Linearly polarized signals from the sky are modulated with a metal-mesh
half-wave plate that is rotated at the aperture stop of the telescope with a
hollow-shaft motor based on a superconducting magnetic bearing. The modular
detector array design includes at least 2300 LEKIDs, and it can be configured
for spectral bands centered on 150~GHz or greater. Our study considered
configurations for observing in spectral bands centered on 150, 210 and
267~GHz. The entire polarimeter is mounted on a commercial precision rotary air
bearing, which allows fast azimuth scan speeds with negligible vibration and
mechanical wear over time. A slip ring provides power to the instrument,
enabling circular scans (360 degrees of continuous rotation). This mount, when
combined with sky rotation and the latitude of the observation site, produces a
hypotrochoid scan pattern, which yields excellent cross-linking and enables
34\% of the sky to be observed using a range of constant elevation scans. This
scan pattern and sky coverage combined with the beam size (15~arcmin at
150~GHz) makes the instrument sensitive to in the angular
power spectra
The Green Bank Northern Celestial Cap Pulsar Survey - I: Survey Description, Data Analysis, and Initial Results
We describe an ongoing search for pulsars and dispersed pulses of radio
emission, such as those from rotating radio transients (RRATs) and fast radio
bursts (FRBs), at 350 MHz using the Green Bank Telescope. With the Green Bank
Ultimate Pulsar Processing Instrument, we record 100 MHz of bandwidth divided
into 4,096 channels every 81.92 . This survey will cover the entire sky
visible to the Green Bank Telescope (, or 82% of the sky)
and outside of the Galactic Plane will be sensitive enough to detect slow
pulsars and low dispersion measure (30 ) millisecond
pulsars (MSPs) with a 0.08 duty cycle down to 1.1 mJy. For pulsars with a
spectral index of 1.6, we will be 2.5 times more sensitive than previous and
ongoing surveys over much of our survey region. Here we describe the survey,
the data analysis pipeline, initial discovery parameters for 62 pulsars, and
timing solutions for 5 new pulsars. PSR J02145222 is an MSP in a long-period
(512 days) orbit and has an optical counterpart identified in archival data.
PSR J06365129 is an MSP in a very short-period (96 minutes) orbit with a
very low mass companion (8 ). PSR J06455158 is an isolated MSP
with a timing residual RMS of 500 ns and has been added to pulsar timing array
experiments. PSR J14347257 is an isolated, intermediate-period pulsar that
has been partially recycled. PSR J18164510 is an eclipsing MSP in a
short-period orbit (8.7 hours) and may have recently completed its spin-up
phase.Comment: 18 pages, 10 figures, 5 tables, accepted by Ap
High quality factor manganese-doped aluminum lumped-element kinetic inductance detectors sensitive to frequencies below 100 GHz
Aluminum lumped-element kinetic inductance detectors (LEKIDs) sensitive to millimeter-wave photons have
been shown to exhibit high quality factors, making them highly sensitive and multiplexable. The superconducting
gap of aluminum limits aluminum LEKIDs to photon frequencies above 100 GHz. Manganese-doped
aluminum (Al-Mn) has a tunable critical temperature and could therefore be an attractive material for
LEKIDs sensitive to frequencies below 100 GHz if the internal quality factor remains sufficiently high when
manganese is added to the film. To investigate, we measured some of the key properties of Al-Mn LEKIDs.
A prototype eight-element LEKID array was fabricated using a 40 nm thick film of Al-Mn deposited on a
500 µm thick high-resistivity, float-zone silicon substrate. The manganese content was 900 ppm, the measured
Tc = 694 ± 1mK, and the resonance frequencies were near 150 MHz. Using measurements of the forward
scattering parameter S21 at various bath temperatures between 65 and 250 mK, we determined that the
Al-Mn LEKIDs we fabricated have internal quality factors greater than 2 × 105
, which is high enough for
millimeter-wave astrophysical observations. In the dark conditions under which these devices were measured,
the fractional frequency noise spectrum shows a shallow slope that depends on bath temperature and probe
tone amplitude, which could be two-level system noise. The anticipated white photon noise should dominate
this level of low-frequency noise when the detectors are illuminated with millimeter-waves in future measurements.
The LEKIDs responded to light pulses from a 1550 nm light-emitting diode, and we used these light
pulses to determine that the quasiparticle lifetime is 60 µs
The Green Bank North Celestial Cap Pulsar Survey. IV: Four New Timing Solutions
We present timing solutions for four pulsars discovered in the Green Bank
Northern Celestial Cap (GBNCC) survey. All four pulsars are isolated with spin
periods between 0.26s and 1.84s. PSR J00382501 has a 0.26s
period and a period derivative of ,
which is unusually low for isolated pulsars with similar periods. This low
period derivative may be simply an extreme value for an isolated pulsar or it
could indicate an unusual evolution path for PSR J00382501, such as a
disrupted recycled pulsar (DRP) from a binary system or an orphaned central
compact object (CCO). Correcting the observed spin-down rate for the Shklovskii
effect suggests that this pulsar may have an unusually low space velocity,
which is consistent with expectations for DRPs. There is no X-ray emission
detected from PSR J00382501 in an archival swift observation, which suggests
that it is not a young orphaned CCO. The high dispersion measure of PSR
J1949+3426 suggests a distance of 12.3kpc. This distance indicates that PSR
J1949+3426 is among the most distant 7% of Galactic field pulsars, and is one
of the most luminous pulsars.Comment: 7 pages, 5 figure
Ultra High Energy Cosmology with POLARBEAR
Observations of the temperature anisotropy of the Cosmic Microwave Background
(CMB) lend support to an inflationary origin of the universe, yet no direct
evidence verifying inflation exists. Many current experiments are focussing on
the CMB's polarization anisotropy, specifically its curl component (called
"B-mode" polarization), which remains undetected. The inflationary paradigm
predicts the existence of a primordial gravitational wave background that
imprints a unique B-mode signature on the CMB's polarization at large angular
scales. The CMB B-mode signal also encodes gravitational lensing information at
smaller angular scales, bearing the imprint of cosmological large scale
structures (LSS) which in turn may elucidate the properties of cosmological
neutrinos. The quest for detection of these signals; each of which is orders of
magnitude smaller than the CMB temperature anisotropy signal, has motivated the
development of background-limited detectors with precise control of systematic
effects. The POLARBEAR experiment is designed to perform a deep search for the
signature of gravitational waves from inflation and to characterize lensing of
the CMB by LSS. POLARBEAR is a 3.5 meter ground-based telescope with 3.8
arcminute angular resolution at 150 GHz. At the heart of the POLARBEAR receiver
is an array featuring 1274 antenna-coupled superconducting transition edge
sensor (TES) bolometers cooled to 0.25 Kelvin. POLARBEAR is designed to reach a
tensor-to-scalar ratio of 0.025 after two years of observation -- more than an
order of magnitude improvement over the current best results, which would test
physics at energies near the GUT scale. POLARBEAR had an engineering run in the
Inyo Mountains of Eastern California in 2010 and will begin observations in the
Atacama Desert in Chile in 2011.Comment: 8 pages, 6 figures, DPF 2011 conference proceeding
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