Evaluating Experimental Design of ERT for Soil Moisture Monitoring in Contour Hedgerow Intercropping Systems

Contour hedgerow intercropping systems have been proposed as an alternative to traditional agricultural practice with a single crop, as they are effective in reducing run-off and soil erosion. However, competition for water and nutrients between crops and associated hedgerows may reduce the overall performance of these systems. To get a more detailed understanding of the competition for water, spatially resolved monitoring of soil water contents in the soil-plant-atmosphere system is necessary. Electrical resistivity tomography (ERT) is potentially a valuable technique to monitor changes in soil moisture in space and time. In this study, the performance of different ERT electrode arrays to detect the soil moisture dynamics in a mono- and an intercropping system was tested. Their performance was analyzed based on a synthetic study using geophysical measures, such as data recovery and resolution, and using spatial statistics of retrieved water content, such as an adjusted coefficient of variation and semivariances. The synthetic ERT measurements detected differences between the cropping systems and retrieved spatial structure of the soil moisture distribution, but the variance and semivariance were underestimated. Sharp water content contrasts between horizons or in the neighborhood of a root water uptake bulb were smoothened. The addition of electrodes deeper in the soil improved the performance, but sometimes only marginally. ERT is therefore a valuable tool for soil moisture monitoring in the field under different cropping systems if an electrode array is used which can resolve the patterns expected to be present in the medium. The use of spatial statistics allowed to not only identify the overall model recovery, but also to quantify the recovery of spatial structures

Evaluating Experimental Design of ERT for Soil Moisture Monitoring in Contour Hedgerow Intercropping Systems

Contour hedgerow intercropping systems have been proposed as an alternative to traditional agricultural practice with a single crop, as they are effective in reducing run-off and soil erosion. However, competition for water and nutrients between crops and associated hedgerows may reduce the overall performance of these systems. To get a more detailed understanding of the competition for water, spatially resolved monitoring of soil water contents in the soil-plant-atmosphere system is necessary. Electrical resistivity tomography (ERT) is potentially a valuable technique to monitor changes in soil moisture in space and time. In this study, the performance of different ERT electrode arrays to detect the soil moisture dynamics in a mono- and an intercropping system was tested. Their performance was analyzed based on a synthetic study using geophysical measures, such as data recovery and resolution, and using spatial statistics of retrieved water content, such as an adjusted coefficient of variation and semivariances. The synthetic ERT measurements detected differences between the cropping systems and retrieved spatial structure of the soil moisture distribution, but the variance and semivariance were underestimated. Sharp water content contrasts between horizons or in the neighborhood of a root water uptake bulb were smoothened. The addition of electrodes deeper in the soil improved the performance, but sometimes only marginally. ERT is therefore a valuable tool for soil moisture monitoring in the field under different cropping systems if an electrode array is used which can resolve the patterns expected to be present in the medium. The use of spatial statistics allowed to not only identify the overall model recovery, but also to quantify the recovery of spatial structures

Evaluating Experimental Design of ERT for Soil Moisture Monitoring in Contour Hedgerow Intercropping Systems

Contour hedgerow intercropping systems have been proposed as an alternative to traditional agricultural practice with a single crop, as they are effective in reducing run-off and soil erosion. However, competition for water and nutrients between crops and associated hedgerows may reduce the overall performance of these systems. To get a more detailed understanding of the competition for water, spatially resolved monitoring of soil water contents in the soil-plant-atmosphere system is necessary. Electrical resistivity tomography (ERT) is potentially a valuable technique to monitor changes in soil moisture in space and time. In this study, the performance of different ERT electrode arrays to detect the soil moisture dynamics in a mono- and an intercropping system was tested. Their performance was analyzed based on a synthetic study using geophysical measures, such as data recovery and resolution, and using spatial statistics of retrieved water content, such as an adjusted coefficient of variation and semivariances. The synthetic ERT measurements detected differences between the cropping systems and retrieved spatial structure of the soil moisture distribution, but the variance and semivariance were underestimated. Sharp water content contrasts between horizons or in the neighborhood of a root water uptake bulb were smoothened. The addition of electrodes deeper in the soil improved the performance, but sometimes only marginally. ERT is therefore a valuable tool for soil moisture monitoring in the field under different cropping systems if an electrode array is used which can resolve the patterns expected to be present in the medium. The use of spatial statistics allowed to not only identify the overall model recovery, but also to quantify the recovery of spatial structures

In vitro comparison of antiviral drugs against feline herpesvirus 1

BACKGROUND: Feline herpesvirus 1 (FHV-1) is a common cause of respiratory and ocular disease in cats. Especially in young kittens that have not yet reached the age of vaccination, but already lost maternal immunity, severe disease may occur. Therefore, there is a need for an effective antiviral treatment. In the present study, the efficacy of six antiviral drugs, i.e. acyclovir, ganciclovir, cidofovir, foscarnet, adefovir and 9-(2-phosphonylmethoxyethyl)-2, 6-diaminopurine (PMEDAP), against FHV-1 was compared in Crandell-Rees feline kidney (CRFK) cells using reduction in plaque number and plaque size as parameters. RESULTS: The capacity to reduce the number of plaques was most pronounced for ganciclovir, PMEDAP and cidofovir. IC(50 (NUMBER) )values were 3.2 μg/ml (12.5 μM), 4.8 μg/ml (14.3 μM) and 6 μg/ml (21.5 μM), respectively. Adefovir and foscarnet were intermediately efficient with an IC(50 (NUMBER) )of 20 μg/ml (73.2 μM) and 27 μg/ml (140.6 μM), respectively. Acyclovir was least efficient (IC(50 (NUMBER) )of 56 μg/ml or 248.7 μM). All antiviral drugs were able to significantly reduce plaque size when compared with the untreated control. As observed for the reduction in plaque number, ganciclovir, PMEDAP and cidofovir were most potent in reducing plaque size. IC(50 (SIZE) )values were 0.4 μg/ml (1.7 μM), 0.9 μg/ml (2.7 μM) and 0.2 μg/ml (0.7 μM), respectively. Adefovir and foscarnet were intermediately potent, with an IC(50 (SIZE) )of 4 μg/ml (14.6 μM) and 7 μg/ml (36.4 μM), respectively. Acyclovir was least potent (IC(50 (SIZE) )of 15 μg/ml or 66.6 μM). The results demonstrate that the IC(50 (SIZE) )values were notably lower than the IC(50 (NUMBER) )values. The most remarkable effect was observed for cidofovir and ganciclovir. None of the products were toxic for CRFK cells at antiviral concentrations. CONCLUSION: In conclusion, measuring reduction in plaque number and plaque size are two valuable and complementary means of assessing the efficacy of an antiviral drug. By using these parameters for six selected antiviral drugs, we found that ganciclovir, PMEDAP, and cidofovir are the most potent inhibitors of FHV-1 replication in CRFK cells. Therefore, they may be valuable candidates for the treatment of FHV-1 infection in cats

Les unités médico-psychiatriques : les soins partagés en santé mentale

Cet article décrit le fonctionnement d’une unité hospitalière originale, couplant approche somatique et psychiatrique sous rubrique générique d’une Unité Médico-Psycho-Sociale (UMPS) implantée au sein du CHU d’Angers depuis 1996. Nous proposons d’examiner l’intérêt de cette mixité, tout en interrogeant ses limites et ses difficultés de fonctionnement. L’intérêt de la structure est de proposer une approche pluridisciplinaire, somatique et psychiatrique dans un même lieu de soins. Cette double compétence de la part des personnels médicaux et paramédicaux est nécessaire lorsque les avis ponctuels de la consultation-liaison ne suffisent plus et lors de situations complexes, dans lesquelles le double savoir-faire est sollicité, en lien avec les ressources d’une réanimation et des services de spécialités médicales et chirurgicales. Ce type d’unité, fondée sur un fonctionnement mixte et à binôme confirmé est peu représenté, tant en France qu’à l’étranger. La fréquence de la co-morbidité somatique et organique conduit pourtant à les considérer comme une réponse innovante aux difficultés rencontrées dans ces prises en charge. Nous décrivons deux cas cliniques afin d’argumenter notre propos

Étude exploratoire des caractéristiques professionnelles d'un échantillon de suicidants hospitalisés

Cette étude a pour objectif de décrire les caractéristiques professionnelles d’un échantillon de suicidants. Un enquêteur a interrogé les suicidants âgés de 18 à 65 ans, hospitalisés consécutivement dans une unité spécialisée du CHU d’Angers sur une durée de 6 mois et demi. Au total, 87 suicidants actifs avec un emploi ont été interrogés. Ils ont souvent été confrontés à des contraintes organisationnelles décrites dans la littérature comme responsables de souffrance mentale liée au travail. Cela concerne globalement autant les hommes que les femmes. En comparaison aux enquêtes de santé au travail (Sumer, Samotrace…), les suicidants sont plus nombreux à ressentir entre autres un stress intense au travail, une conscience professionnelle heurtée et à être en situation tendue selon le modèle de Karasek. Cela pourrait être en faveur d’un lien entre les tentatives de suicide et certains facteurs de pénibilité mentale au travail. Les résultats de cette étude sont à interpréter avec prudence du fait des phénomènes de circularité des données et de la faiblesse de l’échantillon

Impacts of soil management and climate on saturated and near-saturated hydraulic conductivity: analyses of the Open Tension-disk Infiltrometer Meta-database (OTIM)

Saturated and near-saturated soil hydraulic conductivities Kh (mm h−1) determine the partitioning of precipitation into surface runoff and infiltration and are fundamental to soils' susceptibility to preferential flow. Recent studies found indications that climate factors influence Kh, which is highly relevant in the face of climate change. In this study, we investigated relationships between pedoclimatic factors and Kh and also evaluated effects of land use and soil management. To this end, we collated the Open Tension-disk Infiltrometer Meta-database (OTIM), which contains 1297 individual data entries from 172 different publication sources. We analysed a spectrum of saturated and near-saturated hydraulic conductivities at matric potentials between 0 and 100 mm. We found that methodological details like the direction of the wetting sequence or the choice of method for calculating infiltration rates to hydraulic conductivities had a large impact on the results. We therefore restricted ourselves to a subset of 466 of the 1297 data entries with similar methodological approaches. Correlations between Ks and Kh at higher supply tensions decreased especially close to saturation, indicating a different flow mechanism at and very close to saturation than towards the dry end of the investigated tension range. Climate factors were better correlated with topsoil near-saturated hydraulic conductivities at supply tensions ≥ 30 mm than soil texture, bulk density and organic carbon content. We find it most likely that the climate variables are proxies for soil macropore networks created by the respective biological activity, pedogenesis and climate-specific land use and management choices. Due to incomplete documentation in the source publications of OTIM, we were able to investigate only a few land use types and agricultural management practices. Land use, tillage system and soil compaction significantly influenced Kh, with effect sizes appearing comparable to the ones of soil texture and soil organic carbon. The data in OTIM show that experimental bias is present, introduced by the choice of measurement time relative to soil tillage, experimental design or data evaluation procedures. The establishment of best-practice rules for tension-disk infiltrometer measurements would therefore be helpful. Future studies are needed to investigate how climate shapes soil macropore networks and how land use and management can be adapted to improve soil hydraulic properties. Both tasks require large numbers of new measurement data with improved documentation on soil biology and land use and management history.</p

Travail et tentatives de suicide

ObjectifL’irruption médiatique de suicides en lien avec le travail constitue un élément marquant de ces dernières années. Ce phénomène doit mobiliser tous les acteurs de l’entreprise, de l’agent au directeur. Pour envisager une prévention des suicides liés au travail, il est important de les définir en termes quantitatif et qualitatif. Afin de répondre en partie à cette problématique, cette étude vise à préciser les caractéristiques professionnelles d’un échantillon de suicidants dont une partie annonce un lien entre leur passage à l’acte suicidaire et leur travail. Méthodes Cette étude d’une durée de six mois a inclus les suicidants actifs ayant un emploi, âgés de 18 à 65ans, hospitalisés au CHU d’Angers. Au total, 87 suicidants consécutifs ont répondu aux questionnaires portant sur les caractéristiques du travail. Résultats Les suicidants appartenant au groupe « tentatives de suicide (TS) liées au travail » décrivent davantage la présence d’éléments d’organisations pathogènes du travail comprenant une surcharge de travail, des délais à respecter et des dérangements fréquents. De plus, ils rapportent également davantage de conflits dans l’entreprise. Cela concerne en majorité les cadres et les professions intermédiaires. La proportion des hommes est plus importante parmi les suicidants établissant un lien entre leur TS et leur travail, mais les femmes sont aussi concernées. Discussion Le lien entre le travail et les TS semble davantage provenir de l’organisation du travail, des rapports avec la hiérarchie et les collègues, ainsi que d’une mauvaise reconnaissance au travail, que de l’exposition aux contraintes physiques, aux horaires de travail et au type de contrat de travail. Conclusion La prévention du suicide lié au travail doit passer par une réflexion sur l’organisation du travail, les rapports sociaux au sein de l’entreprise et la promotion de la reconnaissance du travail réel

Medical-psychiatric units: shared care in mental health

This paper describes a highly unusual hospital unit that combines somatic and psychiatric approaches under the generic heading of a Medico-Psycho-Social Unit (MPSU) established at Angers University Hospital since 1996. The paper examines the value of a mixed approach while highlighting its limitations. The interest of the MPSU is that it provides a multidisciplinary, somatic and psychiatric approach on the same site. The joint expertise of medical and paramedical staff is required in cases where the assessment of the consultation-liaison services is not sufficient and in complex situations requiring the resources of an intensive care unit and specific medical and surgical specialties. Based on an established partnership and joint service provision, this type of unit is relatively uncommon both in France and abroad. However, the prevalence of somatic and organic comorbidity suggests that MPSUs are an innovative solution for the challenges of this type of care. Two clinical cases will be used as examples

Germline Mutations in FAN1 Cause Hereditary Colorectal Cancer by Impairing DNA Repair

Identification of genes associated with hereditary cancers facilitates management of patients with family histories of cancer. We performed exome sequencing of DNA from 3 individuals from a family with colorectal cancer who met the Amsterdam criteria for risk of hereditary nonpolyposis colorectal cancer. These individuals had mismatch repair-proficient tumors and each carried nonsense variant in the FANCD2/FANCI-associated nuclease 1 gene (FAN1), which encodes a nuclease involved in DNA inter-strand cross-link repair. We sequenced FAN1 in 176 additional families with histories of colorectal cancer and performed in vitro functional analyses of the mutant forms of FAN1 identified. We detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria and had mismatch repair-proficient cancers with no previously associated mutations. These findings link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway, supporting the connection between genome integrity and cancer risk