251 research outputs found
Genotypic variability in the functioning of photosystem II in leaves of covered and naked oats
Background. Comparing the characteristics of primary photosynthetic processes in photosystem II (PSII) in the leaves of two oat (Avena sativa L.) subspecies will help to understand their genetic differentiation. Comparisons between naked and covered oats to assess the efficiency of energy flows within PSII and its relation to useful agronomic traits have not been previously made but can have an effect on their cultivation practices.Materials and methods. Two-week-old plants of 16 covered and 17 naked oat genotypes were assessed for rapid chlorophyll Ξ± fluorescence using a Fluor Pen FP 110/S fluorometer. Data on the yield structure were obtained in 2021. The data were processed statistically using descriptive statistics, correlation (Excel 2013) and cluster (StatSoft Statistica 10; Ward's method) analyses.Results. The groups of oat genotypes differed significantly in the absolute magnitude of adsorbed (ABS/RC) and trapped (TRo/RC) light energy flows, which were higher in naked oats (by 7.8 and 7.4%, respectively). The efficiency of electron transfer from plastoquinone QB to PSI in naked oats exceeded that in covered oats by 8.2%. For the whole set of genotypes, a statistically significant correlation of grain yield with the PIABS performance index (r = 0.403), light energy adsorption (r = -0.477) and its utilization at the reaction centers of PSII (r = -0.452) was manifested. The performance indices (PIABS and PIABS_total) positively correlated with part of grain in total biomass (0.571 and 0.418, respectively) and were higher in covered oats (by 28.2 and 21.9%, respectively).Conclusion. The existence of significant differences was shown between covered and naked oats according to six of the nine evaluated structural and functional parameters of the PSII leaf functioning. The results of the cluster analysis demonstrated the tendency to the grouping of genotypes by the presence/absence of grain hullness
Search for potential gastric cancer markers using miRNA databases and gene expression analysis
Aim: The aim of this study was to identify genes that are differentially expressed in gastric tumors and to analyze the association of their expression level with tumor clinicopathologic features. Methods: In the present research, we used bioinformatic-driven search to identify miRNA that are down-regulated in gastric tumors and to find their potential targets. Then, the expression levels of some of the target mRNAs were investigated using reverse transcription polymerase chain reaction (RT-PCR) analysis. Results: As a result of the bioinformatics analysis, fifteen genes were found to be potentially differentially expressed between the tumors and normal gastric tissue. Five of them were chosen for the further analysis (WNT4, FGF12, EFEMP1, CTGF, and HSPG2) due to their important role in cell proliferation and differentiation. Expression levels of these genes were evaluated in our collection of frozen tissue samples of gastric tumor and paired normal stomach epithelia. Increased FGF12 expression was observed in diffuse type of gastric cancer while WNT4 mRNA was found to be down-regulated in intestinal type of gastric cancer. Besides, CTGF gene overexpression was revealed in diffuse type of stomach cancer in comparison with that in intestinal type. Up-regulation of CTGF was also associated with lymph node metastasis. Conclusions: The findings show its expedient to perform further investigations in order to clarify diagnostic and prognostic value of CTGF, FGF12, and WNT4βs in stomach cancer as well as the role of these genes in carcinogenesis
Structural and luminescent characteristics of YAG phosphors synthesized in the radiation field
YAG:Ce, YAGG:Ce ceramics were obtained by sintering the oxide powders in the radiation field. The results of investigations of the structure, composition and luminescence of ceramics are presented. The luminescence characteristics of powders exactly correspond to the phosphors luminescence used in practice obtained by solid-state synthesis methods. It has been established that in the used radiation exposure modes the main factor determining the efficiency of the synthesis is the ionization density
The Campanian Ignimbrite and Codola tephra layers: Two temporal/stratigraphic markers for the Early Upper Palaeolithic in southern Italy and eastern Europe
Tephra layers from archaeological sites in southern Italy and eastern Europe stratigraphically associated with
cultural levels containing Early Upper Palaeolithic industry were analysed. The results confirm the
occurrence of the Campanian Ignimbrite tephra (CI; ca. 40 cal ka BP) at Castelcivita Cave (southern Italy),
Temnata Cave (Bulgaria) and in the KostenkiβBorshchevo area of the Russian Plain. This tephra, originated
from the largest eruption of the Phlegrean Field caldera, represents the widest volcanic deposit and one of
the most important temporal/stratigraphic markers of western Eurasia. At Paglicci Cave and lesser sites in the
Apulia region we recognise a chemically and texturally different tephra, which lithologically, chronologically
and chemically matches the physical and chemical characteristics of the Plinian eruption of Codola; a poorly
known Late Pleistocene explosive event from the Neapolitan volcanoes, likely SommaβVesuvius. For this
latter, we propose a preliminary age estimate of ca. 33 cal ka BP and a correlation to the widespread C-10
marine tephra of the central Mediterranean. The stratigraphic position of both CI and Codola tephra layers at
Castelcivita and Paglicci help date the first and the last documented appearance of Early Upper Palaeolithic
industries of southern Italy to ca. 41β40 and 33 cal ka BP, respectively, or between two interstadial
oscillations of the Monticchio pollen record β to which the CI and Codola tephras are physically correlated β
corresponding to the Greenland interstadials 10β9 and 5. In eastern Europe, the stratigraphic and
chronometric data seem to indicate an earlier appearance of the Early Upper Palaeolithic industries, which
would predate of two millennia at least the overlying CI tephra. The tephrostratigraphic correlation indicates
that in both regions the innovations connected with the so-called Early Upper Palaeolithic β encompassing
subsistence strategy and stone tool technology β appeared and evolved during one of the most unstable
climatic phases of the Last Glacial period. On this basis, the marked environmental unpredictability
characterising this time-span is seen as a potential ecological factor involved in the cultural changes
observed
Electron Beam-Assisted Synthesis of YAG:Ce Ceramics
The work was carried out within the framework of the grant AP14870696 of the Ministry of Education and Science of the Republic of Kazakhstan. This research was funded by the Russian Science Foundation of the Russian Federation. (Grant No. 23-73-00108). A.I.P is also thankful for financial support from Latvian Project LZP-2018/1-0214. In addition, A.I.P. is thanking the Institute of Solid State Physics, University of Latvia (ISSP UL). ISSP UL as the Centre of Excellence has received funding from the European Unionβs Horizon 2020 Framework Programme H2020-WIDESPREAD01-2016-2017-Teaming Phase2 under grant agreement No. 739508, project CAMART2.In this work, we present the results of the structure and luminescence properties of YAG:Ce (Y3Al5O12 doped with Ce3+ ions) ceramic samples. Their synthesis was carried out by sintering samples from the initial oxide powders under the powerful action of a high-energy electron beam with an energy of 1.4 MeV and a power density of 22β25 kW/cm2. The measured diffraction patterns of the synthesized ceramics are in good agreement with the standard for YAG. Luminescence characteristics at stationary/time-resolved regimes were studied. It is shown that under the influence of a high-power electron beam on a mixture of powders, it is possible to synthesize YAG:Ce luminescent ceramics with characteristics close to the well-known YAG:Ce phosphor ceramics obtained by traditional methods of solid-state synthesis. Thus, it has been demonstrated that the technology of radiation synthesis of luminescent ceramics is very promising. Β© 2023 by the authors. --//-- Karipbayev Z.T., Lisitsyn V.M., Golkovski M.G., Zhilgildinov Z.S., Popov A.I., Zhunusbekov A.M., Polisadova E., Tulegenova A., Mussakhanov D.A., Alpyssova G., Piskunov S.; Electron Beam-Assisted Synthesis of YAG:Ce Ceramics; (2023) Materials, 16 (11), art. no. 4102; DOI: 10.3390/ma16114102; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85161490971&doi=10.3390%2fma16114102&partnerID=40&md5=e33da4c2d44c563881bdeffe410d734b published under the CC BY 4.0 licence.Grant AP14870696 of the Ministry of Education and Science of the Republic of Kazakhstan; Russian Science Foundation of the Russian Federation Grant No. 23-73-00108; the Latvian Council of Science LZP-2018/1-0214; ISSP UL as the Centre of Excellence has received funding from the European Unionβs Horizon 2020 Framework Programme H2020-WIDESPREAD01-2016-2017-Teaming Phase2 under grant agreement No. 739508, project CAMART2
THERMOLUMINESCENCE OF Ga2O3 IRRADIATED BY HIGH-DOSE PULSED ELECTRON BEAM
The TL curves of pure gallium oxide ceramics synthesized in a stream of fast electrons are studied. It is established that the TL curve is the sum of two peaks with activation energies of 0.84 and 0.95 eV. The nature of the dose characteristics of the TL of the studied material is analyzed
FEATURES OF THERMOLUMINESCENCE KINETICS OF ZrO2 CERAMICS SYNTHESIZED BY ELECTRON BEAM METHOD
Luminescent properties of ceramics of zirconium dioxide (ZrO2) synthesized by electron beam method are investigated. On the TL curves in the samples, a dominant TL peak was detected at 425-430 K, excited by a pulsed electron beam. The kinetic parameters of the TL peak were determined by two methods
Thermoluminescence of Magnesium Oxide Ceramics Obtained by the Method of Electron Beam Synthesis
The luminescent properties of MgO ceramics synthesized by the electron beam method were investigated. The luminescence centers were identified in the samples. The TL curves and dose characteristics of TL peaks excited by a pulsed electron beam (130 keV, 1.5β60 kGy) were analyzed
Study of the influence of the electron irradiation dose on the deformation of Mylar films taking into account the processes of destruction and crosslinking
Experimental studies of the dependence of the deformation [epsilon] on the dose of electron irradiation D taking into account the processes of destruction and crosslinking for films of the Mylar type have been carried out. It was obtained that the dependence of [epsilon] on D for the process of cross-linking is described by a linear and destruction by an exponential function
ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠΈΡΠΊΠ° ΠΈ Π°Π½Π°Π»ΠΈΠ·Π° Π³Π΅Π½Π½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ
Introduction. Searching for specific and sensitive molecular tumor markers is one of the important tasks of modern oncology. These markersΒ can be used for early tumor diagnosis and prognosis as well as for prediction of therapeutic response, estimation of tumor volume or to assessΒ disease recurrence through monitoring. Gene expression data base mining followed by experimental validation of results obtained is oneΒ of the promising approaches for searching of that kind.Objective: to identify several membrane proteins which can be used for serum diagnosis of intestinal type of gastric adenocarcinoma.Materials and methods. We used bioinformatic-driven search using Gene Ontology and The Cancer Genome Atlas (TCGA) data to identifyΒ mRNA up-regulated in gastric cancer (GC). Then, the expression levels of the mRNAs in 55 pare clinical specimens were investigated usingΒ reverse transcription polymerase chain reaction.Results. Comparative analysis of the mRNA levels in normal and tumor tissues using a new bioinformatics algorithm allowed to identifyΒ 3 high-copy transcripts (SULF1, PMEPA1 and SPARC), intracellular content of which markedly increased in GC. Expression analysisΒ of these genes in clinical specimens showed significantly higher mRNA levels of PMEPA1 and SPARC in tumor as compared to normal gastricΒ tissue. Interestingly more than twofold increase in expression level of these genes was observed in 75 % of intestinal-type GC. The sameΒ results were found only in 25 and 38 % of diffuse-type GC respectively.Conclusions. As a result of original bioinforamtic analysis using TCGA data base two genes (PMEPA1 and SPARC) were shown to be significantlyΒ upregulated in intestinal-type gastric adenocarcinoma. The findings show the importance of further investigation to clarify the clinicalΒ value of their expression level in stomach tumors as well as their role in carcinogenesis.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠ΄Π½Π° ΠΈΠ· Π²Π°ΠΆΠ½ΡΡ
Π·Π°Π΄Π°Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ β ΠΏΠΎΠΈΡΠΊ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ ΠΎΠΏΡΡ
ΠΎΠ»ΡΠΌΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅Β ΠΌΠΎΠ³ΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡΡΡ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠ°ΠΊΠ°, ΠΎΡΠ΅Π½ΠΊΠΈ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΡΡΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅Π³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ,Β Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΎΠ². ΠΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠ²Π½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΠ³ΠΎ ΠΏΠΎΠΈΡΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ Π°Π½Π°Π»ΠΈΠ· ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΎΠΌΠ½ΡΡ
Β Π±Π°Π· Π΄Π°Π½Π½ΡΡ
Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΊΠΈ Ρ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΉ Π²Π°Π»ΠΈΠ΄Π°ΡΠΈΠ΅ΠΉ ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π½Π° ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΠΎΠΈΡΠΊ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΡ
Π±Π΅Π»ΠΊΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Ρ Π΄Π»Ρ ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈΠ½ΡΠ΅ΡΡΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΡΠ°ΠΊΠ° ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° (Π Π) ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π±Π°Π· Π΄Π°Π½Π½ΡΡ
Β Gene Ontology ΠΈ the Cancer Genome Atlas (TCGA). ΠΠΎΡΠ»Π΅Π΄ΡΡΡΡΡ ΠΎΡΠ΅Π½ΠΊΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ² Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ Π½Π° ΠΏΠ°ΡΠ½ΡΡ
Β ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΆΠ΅Π»ΡΠ΄ΠΊΠ°, Π²Π·ΡΡΡΡ
ΠΎΡ 55 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ². ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ Π³Π΅Π½ΠΎΠ² ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ Ρ ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠ΅ΠΉ Π² ΡΠ΅ΠΆΠΈΠΌΠ΅ ΡΠ΅Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ ΠΏΠΎ ΠΌΠ΅ΡΠΎΠ΄Ρ ΞCq.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΡΠΎΠ²Π½Π΅ΠΉ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΌΠ°ΡΡΠΈΡΠ½ΡΡ
Π ΠΠ (ΠΌΠ ΠΠ) Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΡΠΊΠ°Π½Π΅ΠΉ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ Π½ΠΎΠ²ΠΎΠ³ΠΎ Π°Π»Π³ΠΎΡΠΈΡΠΌΠ° Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠΈΡΠΊΠ° ΠΏΡΠΈΠ²Π΅Π» ΠΊ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ 3 Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΎΠΊΠΎΠΏΠΈΠΉΠ½ΡΡ
ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΎΠ² (SULF1, PMEPA1Β ΠΈ SPARC), Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΡΡ
Π·Π°ΠΌΠ΅ΡΠ½ΠΎ ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ ΠΏΡΠΈ Π Π. ΠΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ ΡΡΠΎΠ²Π½Ρ ΠΌΠ ΠΠ Π΄Π°Π½Π½ΡΡ
Π³Π΅Π½ΠΎΠ² Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌΒ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΠ΅ΠΌ Π΄Π²ΡΠΊΡΠ°ΡΠ½ΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ PMEPA1 ΠΈ SPARC Π² 75 % ΠΎΠ±ΡΠ°Π·ΡΠΎΠ² Π Π ΠΈΠ½ΡΠ΅ΡΡΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎΒ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. Π ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
Π Π Π΄ΠΈΡΡΡΠ·Π½ΠΎΠ³ΠΎ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΡΡΠΎΡ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠΎΡΡΠ°Π²ΠΈΠ» 25 ΠΈ 38 % ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ.ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ Π±ΠΈΠΎΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π½Π° Π°Π½Π°Π»ΠΈΠ·Π΅ Π΄Π°Π½Π½ΡΡ
TCGA, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ Π²ΡΡΠ²ΠΈΡΡΒ 2 Π³Π΅Π½Π° (PMEPA1 ΠΈ SPARC), ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΡΡΠΈΡ
ΡΡ Π² ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
ΠΆΠ΅Π»ΡΠ΄ΠΊΠ° ΠΈΠ½ΡΠ΅ΡΡΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ°. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎΠ± Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΠΈ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠΎΠ»ΠΈ ΡΡΠΈΡ
Π³Π΅Π½ΠΎΠ² Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ Π Π ΠΈ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉΒ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ ΡΡΠΎΠ²Π½Ρ ΠΈΡ
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