158 research outputs found
Signatures of r-process elements in kilonova spectra
Binary neutron star (NS) mergers have been expected to synthesize r-process elements and emit radioactively powered radiation, called kilonova. Although r-process nucleosynthesis was confirmed by the observations of GW170817/AT2017gfo, no trace of individual elements has been identified except for strontium. In this paper, we perform systematic calculations of line strength for bound-bound transitions and radiative transfer simulations in NS merger ejecta toward element identification in kilonova spectra. We find that Sr II triplet lines appear in the spectrum of a lanthanide-poor model, which is consistent with the absorption feature observed in GW170817/AT2017gfo. The synthetic spectrum also shows the strong Ca II triplet lines. This is natural because Ca and Sr are co-produced in the material with relatively high electron fraction and their ions have similar atomic structures with only one s-electron in the outermost shell. The line strength, however, highly depends on the abundance distribution and temperature in the ejecta. For our lanthanide-rich model, the spectra show the features of doubly ionized heavy elements, such as Ce, Tb and Th. Our results suggest that the line forming region of GW170817/AT2017gfo was lanthanide-poor. We show that the Sr II and Ca II lines can be used as a probe of physical conditions in NS merger ejecta. Absence of the Ca II line features in GW170817/AT2017gfo implies that the Ca/Sr ratio is = 0.40 and entropy per nucleon (in units of Boltzmann constant) >= 25
Lanthanide Features in Near-infrared Spectra of Kilonovae
The observations of GW170817/AT2017gfo have provided us with evidence thatbinary neutron star mergers are sites of -process nucleosynthesis. However,the observed signatures in the spectra of GW170817/AT2017gfo have not beenfully decoded especially in the near-infrared (NIR) wavelengths. In this paper,we investigate the kilonova spectra over the entire wavelength range with theaim of elemental identification. We systematically calculate the strength ofbound-bound transitions by constructing a hybrid line list that is accurate forimportant strong transitions and complete for weak transitions. We find thatthe elements on the left side of the periodic table, such as Ca, Sr, Y, Zr, Ba,La, and Ce, tend to produce prominent absorption lines in the spectra. This isbecause such elements have a small number of valence electrons and low-lyingenergy levels, resulting in strong transitions. By performing self-consistentradiative transfer simulations for the entire ejecta, we find that La III andCe III appear in the NIR spectra, which can explain the absorption features at-14000 A in the spectra of GW170817/AT2017gfo. The massfractions of La and Ce are estimated to be and (1-100), respectively. An actinide element Th can also be asource of absorption as the atomic structure is analogous to that of Ce.However, we show that Th III features are less prominent in the spectra becauseof the denser energy levels of actinides compared to those of lanthanides.<br
Effects of spatial dispersion in near-field radiative heat transfer between two parallel metallic surfaces
We study the heat transfer between two parallel metallic semi-infinite media
with a gap in the nanometer-scale range. We show that the near-field radiative
heat flux saturates at distances smaller than the metal skin depth when using a
local dielectric constant and investigate the origin of this effect. The effect
of non-local corrections is analysed using the Lindhard-Mermin and
Boltzmann-Mermin models. We find that local and non-local models yield the same
heat fluxes for gaps larger than 2 nm. Finally, we explain the saturation
observed in a recent experiment as a manifestation of the skin depth and show
that heat is mainly dissipated by eddy currents in metallic bodies.Comment: Version without figures (8 figures in the complete version
Shape-dependence of near-field heat transfer between a spheroidal nanoparticle and a flat surface
We study the radiative heat transfer between a spheroidal metallic
nanoparticle and a planar metallic sample for near- and far-field distances. In
particular, we investigate the shape dependence of the heat transfer in the
near-field regime. In comparison with spherical particles, the heat transfer
typically varies by factors between 1/2 and 2 when the particle is deformed
such that its volume is kept constant. These estimates help to quantify the
deviation of the actual heat transfer recorded by a near-field scanning thermal
microscope from the value provided by a dipole model which assumes a perfectly
spherical sensor
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Lewy Body Dementia Association\u27s Research Centers of Excellence Program: Inaugural Meeting Proceedings.
The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator\u27s meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson\u27s disease dementia (PDD), and to create a clinical trials-ready network. Four working groups (WG) were created to pursue the LBDA RCOE aims: (1) increase access to high-quality clinical care, (2) increase access to support for people living with LBD and their caregivers, (3) increase knowledge of LBD among medical and allied (or other) professionals, and (4) create infrastructure for a clinical trials-ready network as well as resources to advance the study of new therapeutics
Somatostatin, substance P and calcitonin gene-related peptide-positive intramural nerve structures of the human large intestine affected by carcinoma.
Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings
Abstract
The first Lewy Body Dementia Association (LBDA) Research Centers of Excellence (RCOE) Investigator’s meeting was held on December 14, 2017, in New Orleans. The program was established to increase patient access to clinical experts on Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD), and to create a clinical trials-ready network. Four working groups (WG) were created to pursue the LBDA RCOE aims: (1) increase access to high-quality clinical care, (2) increase access to support for people living with LBD and their caregivers, (3) increase knowledge of LBD among medical and allied (or other) professionals, and (4) create infrastructure for a clinical trials-ready network as well as resources to advance the study of new therapeutics.https://deepblue.lib.umich.edu/bitstream/2027.42/148286/1/13195_2019_Article_476.pd
An ethnographic study of Latino preschool children's oral health in rural California: Intersections among family, community, provider and regulatory sectors
<p>Abstract</p> <p>Background</p> <p>Latino children experience a higher prevalence of caries than do children in any other racial/ethnic group in the US. This paper examines the intersections among four societal sectors or contexts of care which contribute to oral health disparities for low-income, preschool Latino<sup>1 </sup>children in rural California.</p> <p>Methods</p> <p>Findings are reported from an ethnographic investigation, conducted in 2005–2006, of family, community, professional/dental and policy/regulatory sectors or contexts of care that play central roles in creating or sustaining low income, rural children's poor oral health status. The study community of around 9,000 people, predominantly of Mexican-American origin, was located in California's agricultural Central Valley. Observations in homes, community facilities, and dental offices within the region were supplemented by in-depth interviews with 30 key informants (such as dental professionals, health educators, child welfare agents, clinic administrators and regulatory agents) and 47 primary caregivers (mothers) of children at least one of whom was under 6 years of age.</p> <p>Results</p> <p>Caregivers did not always recognize visible signs of caries among their children, nor respond quickly unless children also complained of pain. Fluctuating seasonal eligibility for public health insurance intersected with limited community infrastructure and civic amenities, including lack of public transportation, to create difficulties in access to care. The non-fluoridated municipal water supply is not widely consumed because of fears about pesticide pollution. If the dentist brought children into the clinic for multiple visits, this caused the accompanying parent hardship and occasionally resulted in the loss of his or her job. Few general dentists had received specific training in how to handle young patients. Children's dental fear and poor provider-parent communication were exacerbated by a scarcity of dentists willing to serve rural low-income populations. Stringent state fiscal reimbursement policies further complicated the situation.</p> <p>Conclusion</p> <p>Several societal sectors or contexts of care significantly intersected to produce or sustain poor oral health care for children. Parental beliefs and practices, leading for example to delay in seeking care, were compounded by lack of key community or economic resources, and the organization and delivery of professional dental services. In the context of state-mandated policies and procedures, these all worked to militate against children receiving timely care that would considerably reduce oral health disparities among this highly disadvantaged population.</p
Age at symptom onset and death and disease duration in genetic frontotemporal dementia : an international retrospective cohort study
Background: Frontotemporal dementia is a heterogenous neurodegenerative disorder, with about a third of cases being genetic. Most of this genetic component is accounted for by mutations in GRN, MAPT, and C9orf72. In this study, we aimed to complement previous phenotypic studies by doing an international study of age at symptom onset, age at death, and disease duration in individuals with mutations in GRN, MAPT, and C9orf72. Methods: In this international, retrospective cohort study, we collected data on age at symptom onset, age at death, and disease duration for patients with pathogenic mutations in the GRN and MAPT genes and pathological expansions in the C9orf72 gene through the Frontotemporal Dementia Prevention Initiative and from published papers. We used mixed effects models to explore differences in age at onset, age at death, and disease duration between genetic groups and individual mutations. We also assessed correlations between the age at onset and at death of each individual and the age at onset and at death of their parents and the mean age at onset and at death of their family members. Lastly, we used mixed effects models to investigate the extent to which variability in age at onset and at death could be accounted for by family membership and the specific mutation carried. Findings: Data were available from 3403 individuals from 1492 families: 1433 with C9orf72 expansions (755 families), 1179 with GRN mutations (483 families, 130 different mutations), and 791 with MAPT mutations (254 families, 67 different mutations). Mean age at symptom onset and at death was 49\ub75 years (SD 10\ub70; onset) and 58\ub75 years (11\ub73; death) in the MAPT group, 58\ub72 years (9\ub78; onset) and 65\ub73 years (10\ub79; death) in the C9orf72 group, and 61\ub73 years (8\ub78; onset) and 68\ub78 years (9\ub77; death) in the GRN group. Mean disease duration was 6\ub74 years (SD 4\ub79) in the C9orf72 group, 7\ub71 years (3\ub79) in the GRN group, and 9\ub73 years (6\ub74) in the MAPT group. Individual age at onset and at death was significantly correlated with both parental age at onset and at death and with mean family age at onset and at death in all three groups, with a stronger correlation observed in the MAPT group (r=0\ub745 between individual and parental age at onset, r=0\ub763 between individual and mean family age at onset, r=0\ub758 between individual and parental age at death, and r=0\ub769 between individual and mean family age at death) than in either the C9orf72 group (r=0\ub732 individual and parental age at onset, r=0\ub736 individual and mean family age at onset, r=0\ub738 individual and parental age at death, and r=0\ub740 individual and mean family age at death) or the GRN group (r=0\ub722 individual and parental age at onset, r=0\ub718 individual and mean family age at onset, r=0\ub722 individual and parental age at death, and r=0\ub732 individual and mean family age at death). Modelling showed that the variability in age at onset and at death in the MAPT group was explained partly by the specific mutation (48%, 95% CI 35\u201362, for age at onset; 61%, 47\u201373, for age at death), and even more by family membership (66%, 56\u201375, for age at onset; 74%, 65\u201382, for age at death). In the GRN group, only 2% (0\u201310) of the variability of age at onset and 9% (3\u201321) of that of age of death was explained by the specific mutation, whereas 14% (9\u201322) of the variability of age at onset and 20% (12\u201330) of that of age at death was explained by family membership. In the C9orf72 group, family membership explained 17% (11\u201326) of the variability of age at onset and 19% (12\u201329) of that of age at death. Interpretation: Our study showed that age at symptom onset and at death of people with genetic frontotemporal dementia is influenced by genetic group and, particularly for MAPT mutations, by the specific mutation carried and by family membership. Although estimation of age at onset will be an important factor in future pre-symptomatic therapeutic trials for all three genetic groups, our study suggests that data from other members of the family will be particularly helpful only for individuals with MAPT mutations. Further work in identifying both genetic and environmental factors that modify phenotype in all groups will be important to improve such estimates. Funding: UK Medical Research Council, National Institute for Health Research, and Alzheimer's Society
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