Measuring X-ray anisotropy in solar flares. Prospective stereoscopic capabilities of STIX and MiSolFA

During the next solar maximum, two upcoming space-borne X-ray missions, STIX on board Solar Orbiter and MiSolFA, will perform stereoscopic X-ray observations of solar flares at two different locations: STIX at 0.28 AU (at perihelion) and up to inclinations of $\sim25^{\circ}$, and MiSolFA in a low-Earth orbit. The combined observations from these cross-calibrated detectors will allow us to infer the electron anisotropy of individual flares confidently for the first time. We simulated both instrumental and physical effects for STIX and MiSolFA including thermal shielding, background and X-ray Compton backscattering (albedo effect) in the solar photosphere. We predict the expected number of observable flares available for stereoscopic measurements during the next solar maximum. We also discuss the range of useful spacecraft observation angles for the challenging case of close-to-isotropic flare anisotropy. The simulated results show that STIX and MiSolFA will be capable of detecting low levels of flare anisotropy, for M1-class or stronger flares, even with a relatively small spacecraft angular separation of 20-30{\deg}. Both instruments will directly measure the flare X-ray anisotropy of about 40 M- and X-class solar flares during the next solar maximum. Near-future stereoscopic observations with Solar Orbiter/STIX and MiSolFA will help distinguishing between competing flare-acceleration mechanisms, and provide essential constraints regarding collisional and non-collisional transport processes occurring in the flaring atmosphere for individual solar flares

Estimating the selection efficiency

The measurement of the efficiency of an event selection is always an important part of the analysis of experimental data. The statistical techniques which are needed to determine the efficiency and its uncertainty are reviewed. Frequentist and Bayesian approaches are illustrated, and the problem of choosing a meaningful prior is explicitly addressed. Several practical use cases are considered, from the problem of combining different samples to complex situations in which non-unit weights or non-independent selections have been used. The Bayesian approach allows to find analytical expressions which solve even the most complicate problems, which make use of the family of Beta distributions, the conjugate priors for the binomial sampling

Late postpancreatectomy hemorrhage after pancreaticoduodenectomy: is it possible to recognize risk factors?

CONTEXT: Post-pancreatectomy hemorrhage is one of the most common complications after pancreaticoduodenectomy. OBJECTIVE: To evaluate the late post-pancreatectomy hemorrhage rate according to the International Study Group of Pancreatic Surgery criteria and to recognize factors related to its onset. METHODS: A prospective study of 113 patients who underwent pancreaticoduodenectomy was conducted. Late post-pancreatectomy hemorrhage was defined according to the criteria of the International Study Group of Pancreatic Surgery. Demographic, clinical, surgical and pathological data were considered and related to late post-pancreatectomy hemorrhage. RESULTS: Thirty-one (27.4%) patients had a post-pancreatectomy hemorrhage. Twenty-five (22.1%) patients developed late post-pancreatectomy hemorrhage: 19 (16.8%) grade B, 6 (5.3%) grade C. Surgical re-operation was performed in 2 out of the 25 cases with late post-pancreatectomy hemorrhage (8.0%) grade C associated with postoperative pancreatic fistula. At univariate analysis, the only factor significantly related to late post-pancreatectomy hemorrhage was postoperative pancreatic fistula (P<0.001). Multivariate analysis underlined that the severity of postoperative pancreatic fistula (P<0.001) and pancreatic anastomosis (P=0.049) independently increased the risk of late hemorrhage. CONCLUSION: In patients undergoing pancreaticoduodenectomy, the criteria introduced by International Study Group of Pancreatic Surgery to define late postpancreatectomy hemorrhage are related to a higher incidence of hemorrhage than previously detected because they considered also mild hemorrhage

Space-Fluid Adaptive Sampling: A Field-Based, Self-organising Approach

A recurrent task in coordinated systems is managing (estimating, predicting, or controlling) signals that vary in space, such as distributed sensed data or computation outcomes. Especially in large-scale settings, the problem can be addressed through decentralised and situated computing systems: nodes can locally sense, process, and act upon signals, and coordinate with neighbours to implement collective strategies. Accordingly, in this work we devise distributed coordination strategies for the estimation of a spatial phenomenon through collaborative adaptive sampling. Our design is based on the idea of dynamically partitioning space into regions that compete and grow/shrink to provide accurate aggregate sampling. Such regions hence define a sort of virtualised space that is “fluid”, since its structure adapts in response to pressure forces exerted by the underlying phenomenon. We provide an adaptive sampling algorithm in the field-based coordination framework. Finally, we verify by simulation that the proposed algorithm effectively carries out a spatially adaptive sampling

Treatment of squamous cell carcinoma of the anal canal: A new strategies with anti-EGFR therapy and immunotherapy

The incidence of squamous cell carcinoma of the anal canal (SCAC) is increasing in both sexes but the standard treatment remains that of 20 years ago. However, interesting data have recently emerged on the use of anti-epidermal growth factor receptor (EGFR) agents and immunotherapy in advanced disease. Thus, new avenues of research are opening up that will hopefully lead to more effective therapeutic strategies. We provide an overview of the latest studies published on this tumor and discuss the possible future therapeutic options for combination therapy, anti-EGFR treatment and radiotherapy

Hydrological Uncertainty and Hydropower: New Methods to Optimize the Performance of the Plant☆

Abstract Hydrological uncertainty due to daily flow variability and to the effect of climate change on water resources is a critical topic in the feasibility evaluations of hydro-power projects, especially for run-of-river power plant. The effect produced by these factors on the annual energy output of such type of plant was investigated. Empirical methods to improve the performance of the plant are proposed, which enable the choice of the most suitable design flow (Q d ) according to the hydrological features of the river, to the frequency of dry and wet years in the basin and to the target energy production

Prognostic role of serum concentrations of high-sensitivity C-reactive protein in patients with metastatic colon rectal cancer: Results from the ITACa trial

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The prognostic role of hemoglobin levels in patients undergoing concurrent chemo-radiation for anal cancer

Background: Concurrent chemo-radiation (CT-RT) is a standard therapy for squamous cell carcinoma of anal canal. Different clinical and biological factors may potentially affect outcome. We investigated the prognostic role of baseline hemoglobin (Hb) in a cohort of anal cancer patients submitted to CT-RT with 5-fluorouracil and mitomycin C. Methods: Up to 161 patients with clinical stage T1-T4/N0-N3/M0 were treated. Response was assessed at 6 weeks and thereafter at 3, 6 and 12 months. Two different approaches were used:a)simultaneous integrated boost following RTOG 05-29 indications;b)first sequence of 45Gy/25 fractions to the pelvis followed by 9-14.4 Gy/5-8 fractions to the macroscopic disease. Primary endpoints were progression-free survival (PFS) and overall survival (OS). Results: On multivariate analysis, pre-treatment Hb level had a significant correlation to OS (HR:0.53;95% CI:0.33-0.87; p = 0.001), but not to PFS (HR:0.78;95% CI:0.53-1.15; p = 0.12) Patients with pre-treatment Hb ≥ 12 g/dl had 5-year PFS and OS of 82.2%, compared to 29.3% and 32.8% for those below the threshold. The likelihood to achieve a complete remission increased by 5.6% for every single-unit (g/dl) increase in baseline Hb level over 11 g/dl. On multivariate analysis, response to treatment had a significant correlation to PFS (incomplete vs complete response - HR:5.43;95% CI:2.75-10.7; p < 0.0001) and OS (HR: 6.96;95% CI:2.96-16.5; p < 0.0001). Conclusions: We showed that baseline Hb level is a strong indicator for poor response to RT-CT in anal cancer patients. A close clinical monitoring for incomplete response to treatment should be advised in patients with low pre-treatment Hb. The hypothesis that the preservation of adequate Hb level during treatment may lead to a better outcome needs prospective evaluation

Experimental study of masonry wall exposed to blast loading

The challenge of protecting the nation against the attack of terrorism has raised the importance to explore the understanding of building materials against the explosion. Unlike most of the building materials, brick masonry materials offer relatively small resistance against blast loading. In this research, a brick masonry wall was exposed to varying blast load at different scaled distances. Six tests with different amounts of explosives at various distances were carried out. Pressure time history, acceleration time history and strain at specific location were measured. The parameters measured from experimental pressure time history and acceleration time history is compared with those determined by ConWep to establish the correlations between experimental determined records and ConWep values. The experimental results were also compared with some researchers. These correlations may assist in understanding the behaviour of masonry structures subjected to explosive loading