The NUMEN project: NUclear Matrix Elements for Neutrinoless double beta decay

The article describes the main achievements of the NUMEN project togetherwith an updated and detailed overview of the related R&D activities andtheoretical developments. NUMEN proposes an innovative technique to access thenuclear matrix elements entering the expression of the lifetime of the doublebeta decay by cross section measurements of heavy-ion induced Double ChargeExchange (DCE) reactions. Despite the two processes, namely neutrinoless doublebeta decay and DCE reactions, are triggered by the weak and strong interactionrespectively, important analogies are suggested. The basic point is thecoincidence of the initial and final state many-body wave-functions in the twotypes of processes and the formal similarity of the transition operators. Firstexperimental results obtained at the INFN-LNS laboratory for the40Ca(18O,18Ne)40Ar reaction at 270 MeV, give encouraging indication on thecapability of the proposed technique to access relevant quantitativeinformation. The two major aspects for this project are the K800Superconducting Cyclotron and MAGNEX spectrometer. The former is used for theacceleration of the required high resolution and low emittance heavy ion beamsand the latter is the large acceptance magnetic spectrometer for the detectionof the ejectiles. The use of the high-order trajectory reconstructiontechnique, implemented in MAGNEX, allows to reach the experimental resolutionand sensitivity required for the accurate measurement of the DCE cross sectionsat forward angles. However, the tiny values of such cross sections and theresolution requirements demand beam intensities much larger than manageablewith the present facility. The on-going upgrade of the INFN-LNS facilities inthis perspective is part of the NUMEN project and will be discussed in thearticle

Incretins in patients with rheumatoid arthritis

Background: The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin effect are disrupted in patients with RA and if they are related to the IR found in these patients. Methods: We conducted a cross-sectional study that encompassed 361 subjects without diabetes, 151 patients with RA, and 210 sex-matched control subjects. Insulin, C-peptide, glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), dipeptidyl peptidase 4 (DPP-4) soluble form, and IR indexes by homeostatic model assessment (HOMA2) were assessed. A multivariable analysis adjusted for IR-related factors was performed. Additionally, ten patients and ten control subjects underwent a 566-kcal meal test so that we could further study the postprandial differences of these molecules between patients and control subjects. Results: Insulin, C-peptide, and HOMA2-IR indexes were higher in patients than in control subjects. This was also the case for GLP-1 (0.49 ± 1.28 vs. 0.71 ± 0.22 ng/ml, p = 0.000) and GIP (0.37 ± 0.40 vs. 1.78 ± 0.51 ng/ml, p = 0.000). These differences remained significant after multivariable adjustment including glucocorticoid intake. Disease Activity Score in 28 joints with erythrocyte sedimentation rate (? coefficient 46, 95% CI 6?87, p = 0.026) and Clinical Disease Activity Index (? coefficient 7.74, 95% CI 1.29?14.20, p = 0.019) were associated with DPP-4 serum levels. GLP-1 positively correlated with ?-cell function (HOMA2 of ?-cell production calculated with C-peptide) in patients but not in control subjects (interaction p = 0.003). The meal test in patients with RA revealed a higher total and late response AUC for glucose response, a later maximal response of C-peptide, and a flatter curve in GIP response. Conclusions: The incretin-insulin axis, both during fasting and postprandial, is impaired in patients with RA.This work was supported by grants from the Spanish Ministry of Health, Subdirección General de Evaluación y Fomento de la Investigación, Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–2016 Instituto de Salud Carlos III [ISCIII] PI14/00394) and by the Fondo Europeo de Desarrollo Regional (FEDER) (to IFA). The research of MAGG was supported by European Union FEDER funds and by the “Fondo de Investigación Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, and PI15/00525) of the Instituto de Salud Carlos III (ISCIII; Spanish Health Ministry). The research of MAGG was also partially supported by RETICS Programs RD12/0009 (RIER) and RD12/0009/0013 from the ISCIII (Spanish Health Ministry)

Italian consensus conference on guidelines for conservative treatment on lower limb muscle injuries in athlete.

Provide the state of the art concerning (1) biology and aetiology, (2) classification, (3) clinical assessment and (4) conservative treatment of lower limb muscle injuries (MI) in athletes. Seventy international experts with different medical backgrounds participated in the consensus conference. They discussed and approved a consensus composed of four sections which are presented in these documents. This paper represents a synthesis of the consensus conference, the following four sections are discussed: (i) The biology and aetiology of MIs. A definition of MI was formulated and some key points concerning physiology and pathogenesis of MIs were discussed. (ii) The MI classification. A classification of MIs was proposed. (iii) The MI clinical assessment, in which were discussed anamnesis, inspection and clinical examination and are provided the relative guidelines. (iv) The MI conservative treatment, in which are provided the guidelines for conservative treatment based on the severity of the lesion. Furthermore, instrumental therapy and pharmacological treatment were discussed. Knowledge of the aetiology and biology of MIs is an essential prerequisite in order to plan and conduct a rehabilitation plan. Another important aspect is the use of a rational MI classification on prognostic values. We propose a classification based on radiological investigations performed by ultrasonography and MRI strongly linked to prognostic factors. Furthermore, the consensus conference results will able to provide fundamental guidelines for diagnostic and rehabilitation practice, also considering instrumental therapy and pharmacological treatment of MI. Expert opinion, level IV

NUMEN project @ LNS: Status and perspectives

The aim of the NUMEN project is to access the Nuclear Matrix Elements (NME), involved in the half life of the neutrinoless double beta decay (0?ββ), by measuring the cross sections of Heavy Ions (HI) induced Double Charge Exchange (DCE) reactions with high accuracy. First evidence of the possibility to get quantitative information about NME from experiments is shown in the reaction 40Ca(18O,18Ne)40Ar at 270 MeV, performed with MAGNEX spectrometer using Superconducting Cyclotron (CS) beams at INFN - Laboratory Nazionali del Sud (LNS) in Catania. Preliminary tests on 116Sn and 116Cd target are already performed. High beam intensity is the new frontiers for these studies

NURE: An ERC project to study nuclear reactions for neutrinoless double beta decay

Neutrinoless double beta decay (0νββ) is considered the best potential resource to access the absolute neutrino mass scale. Moreover, if observed, it will signal that neutrinos are their own anti-particles (Majorana particles). Presently, this physics case is one of the most important research “beyond Standard Model” and might guide the way towards a Grand Unified Theory of fundamental interactions. Since the 0νββ decay process involves nuclei, its analysis necessarily implies nuclear structure issues. In the NURE project, supported by a Starting Grant of the European Research Council (ERC), nuclear reactions of double charge-exchange (DCE) are used as a tool to extract information on the 0νββ Nuclear Matrix Elements. In DCE reactions and ββ decay indeed the initial and final nuclear states are the same and the transition operators have similar structure. Thus the measurement of the DCE absolute cross-sections can give crucial information on ββ matrix elements. In a wider view, the NUMEN international collaboration plans a major upgrade of the INFN-LNS facilities in the next years in order to increase the experimental production of nuclei of at least two orders of magnitude, thus making feasible a systematic study of all the cases of interest as candidates for 0νββ