Environmental urbanization assessment using gis and multicriteria decision analysis: a case study for Denizli (Turkey) municipal area

In recent years, life quality of the urban areas is a growing interest of civil engineering. Environmental quality is essential to display the position of sustainable development and asserts the corresponding countermeasures to the protection of environment. Urban environmental quality involves multidisciplinary parameters and difficulties to be analyzed. The problem is not only complex but also involves many uncertainties, and decision-making on these issues is a challenging problem which contains many parameters and alternatives inherently. Multicriteria decision analysis (MCDA) is a very prepotent technique to solve that sort of problems, and it guides the users confidence by synthesizing that information. Environmental concerns frequently contain spatial information. Spatial multicriteria decision analysis (SMCDA) that includes Geographic Information System (GIS) is efficient to tackle that type of problems. This study has employed some geographic and urbanization parameters to assess the environmental urbanization quality used by those methods. The study area has been described in five categories: very favorable, favorable, moderate, unfavorable, and very unfavorable. The results are momentous to see the current situation, and they could help to mitigate the related concerns. The study proves that the SMCDA descriptions match the environmental quality perception in the city. © 2018 Erdal Akyol et al

Genel Olarak Pazarlama Kavramı ve Turizm Pazarlaması

İnsanlık tarihinin başlangıcından beri insanların ihtiyaçları, istekleri ve daha fazlasına sahip olma arzuları varolagelmiştir. Tarım toplumlarında bu ihtiyaçlarını değiş-tokuş yöntemiyle gidermeye çalışan insanlar özellikle makine ve kitle üretimine geçişin sağlandığı Sanayi Devrimi ile birlikte ihtiyaçlarından daha fazlasının üretildiği bir dönemi yaşamaya başlamışlardır. Bu dönemde işletmeler; müşterileri kendilerine çekebilmek adına farklı pazarlama stratejilerini izlemeye ve farklı pazarlama anlayışlarını benimsemeye başlamışlardır. Pazarlamanın düşüncesinin gelişimine bakıldığında üretimin aşamalarıyla aynı yönde bir gelişme gösterdiği görülmektedir. Günümüzde de işletmeler ihtiyaçları çerçevesinde her geçen gün yeni bir çağdaş pazarlama anlayışını uygulamaya koymaktadırlar. Turizm hem ekonomik hemde akademik önemi ve değeri geç keşfedilen sektörlerden birisidir. Turizm alanındaki çalışmalar diğer temel alanlardan çok sonra başlasa da günümüzde aynı seviyede ilerleme yolundadır. Endüstri sektörü ve işletmeleri üzerine yoğunlaşan endüstri pazarlamasından otuz yıl kadar sonra turizm pazarlamasına da değinilmeye başlanmıştır. Bu gecikmenin arka planında ise turizmin ekonomik, toplumsal ve işletmecilik değerinin geç farkedilmesinin rolü büyüktür

(1,0) superconformal theories in six dimensions and Killing spinor equations

We solve the Killing spinor equations of 6-dimensional (1,0) superconformal theories in all cases. In particular, we derive the conditions on the fields imposed by the Killing spinor equations and demonstrate that these depend on the isotropy group of the Killing spinors. We focus on the models proposed by Samtleben et al in \cite{ssw} and find that there are solutions preserving 1,2, 4 and 8 supersymmetries. We also explore the solutions which preserve 4 supersymmetries and find that many models admit string and 3-brane solitons as expected from the M-brane intersection rules. The string solitons are smooth regulated by the moduli of instanton configurations.Comment: 26 page

The effect of titanium (Ti) and titanium 500 (ti 500) implantation on the activation of rat macrophage subgroups

© 2019, Editorial Ciencias Medicas. All rights reserved. Introduction: Nowadays it is necessary to make new researches in order to solve the problems related to the prolongation of life and related health problems, especially fractures and spinal degeneration. The biocompatibility, mechanical compatibility, morphological compatibility and osseointegration properties of the implant material are very important. In order to prevent unwanted side effects in the use of biomaterials, new strategies need to be developed. Implants, where they will be implanted and their functions will vary according to the characteristics of the material used. The most commonly used metallic materials are 316L stainless steel, Co-Cr alloys and Ti alloys. Objective: To demostrate the effect of Titanium and Titanium 500 on activation of macropages Material and Methods: Our research was performed in the Laboratory of Cytokines and Receptors in the Department of Physiology of Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa. Our research has been approved by the Animal Experiments Local Ethics Committee of Bezmialem Vakif University (Approval Number:2017/218). In order to control the rejection of the patient with specific inflammation caused by titanium implantation, we analyzed the first triggered cells of the innate immun system, especially macrophages and sub-groups (M1, M2a, M2b, M2c), by implanting Titanium and Titanium 500 into the spinal region in Wistar albino male rats. According to the Power Analysis statistic program, 3 different groups of Wistar albino species male rats with a weight of 250 - 300 grams and 10-12 weeks of age were formed. Group I (n: 8, Sham group (Control)), Group II (n: 8, Titanium alloy), Group III (n: 8, Titanium 500). No implant was used in Group I (sham group). Only surgical stress was applied to the rats and they were closed again. In Group II and Group III, the rods were placed on the lamina. Peripheral blood samples were collected on the 1st, 3rd, 5th and 7th days following the implantation phase. M1 macrophages (CCL3, CCL4, CXCL9, IL-23), M2a macrophages (CD163, CD206), M2b macrophages (CCL1), M2c macrophage (SLAM) markers were examined by ELISA (Enzyme-Linked ImmunoSorbent Assay) method. Groups were compared with one-way analysis of variance (ANOVA). For the paired comparison of significant variables, a statistically significant difference (HSD) test was used for Tukey's homogeneous variance variables. Statistical significance was set at p < 0.05. Results and Conclusions: We believe that our analysis results will be helpful in the control, prevention, immunological and therapeutic methods of the reactions (inflammation, rejection, etc.) that may occur in patients who are implanted with Titanium (Ti) and Titanium 500 (Ti 500) implants (spinal, orthopedic, dental etc.)

Adaptive optics: principles and applications in ophthalmology

This is a comprehensive review of the principles and applications of adaptive optics (AO) in ophthalmology. It has been combined with flood illumination ophthalmoscopy, scanning laser ophthalmoscopy, as well as optical coherence tomography to image photoreceptors, retinal pigment epithelium (RPE), retinal ganglion cells, lamina cribrosa and the retinal vasculature. In this review, we highlight the clinical studies that have utilised AO to understand disease mechanisms. However, there are some limitations to using AO in a clinical setting including the cost of running an AO imaging service, the time needed to scan patients, the lack of normative databases and the very small size of area imaged. However, it is undoubtedly an exceptional research tool that enables visualisation of the retina at a cellular level

unreinforced masonry buildings

A recent earthquake of M=4.9 occurred on 29 October 2007 in C, ameli, Denizli, which is located in a seismically active region at southwest Anatolia, Turkey. It has caused extensive damages at unreinforced masonry buildings like many other cases observed in Turkey during other previous earthquakes. Most of the damaged structures were non-engineered, seismically deficient, unreinforced masonry buildings. This paper presents a site survey of these damaged buildings. In addition to typical masonry damages, some infrequent, event-specific damages were also observed. Reasons for the relatively wide spread damages considering the magnitude of the event are discussed in the paper

The prognostic relationship of 18F-FDG PET/CT metabolic and volumetric parameters in metastatic ALK plus NSCLC

ObjectiveThe aim of this study is to determine the role of metabolic and volumetric parameters obtained from 18Fluorine-Fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) imaging on progression-free survival (PFS) and overall survival (OS) in patients with advanced nonsquamous cell lung carcinoma (NSCLC) with anaplastic lymphoma kinase (ALK) rearrangement.MethodsPre and post-treatment PET/CT images of the ALK + NSCLC patients between January 2015 and July 2020 were evaluated. The highest standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were obtained from pre-tyrosine kinase inhibitor (TKI) basal PET/CT (PETpre) and post-TKI PET/CT (PETpost) images. Total MTV (tMTV) and total TLG (tTLG) values were calculated by summing MTV and TLG values in all tumor foci. The change (Delta) in pSUVmax, pMTV, pTLG, tMTV and tTLG before and after treatment was calculated.The relationship of these parameters with OS and PFS was analyzed.ResultstTLG(pre), tMTV(pre), pTLG(pre), pMTV(pre), increment SUVmax, increment tMTV and increment tTLG values were found to be associated with OS; increment tMTV, increment tTLG, tTLG(pre), tMTV(pre), pTLG(pre) and pMTV(pre) were associated with PFS. The cutoff values in both predicting OS and PFS were calculated as -31.6 and 391.1 for increment tMTV and tTLG(pre), respectively. In Cox regression analysis, increment tMTV and stage for OS and increment tMTV and tTLGpre for PFS were obtained as prognostic factors.ConclusionsMetabolic and volumetric parameters, especially TLG values in the whole body before treatment and change in whole body MTV value, obtained from PET/CT may be useful in predicting prognosis and determining treatment strategies for patients with advanced ALK + NSCLC

An anatomical variant: evaluation of accessory canals of the canalis sinuosus using cone beam computed tomography

Background: The anatomical variation of the anterior superior alveolar nerve described as canalis sinuosus (CS) is a less known structure of anterior maxilla. Due to the fact that it contains anterior superior alveolar nerve as well as veins and arteries, exact localisation of this structure will allow surgeons to avoid complications. Hence, the aim of this study was to verify the presence, reveal the frequency and characteristics of accessory canals of CS.Materials and methods: This study was based on retrospective evaluation of cone beam computed tomography (CBCT) scans. A total of 1460 CBCT images were analysed and collected data were noted. The following parameters were recorded: age, sex, presence or absence of CS, location in relation to the adjacentteeth and impaction of canine teeth.Results: A total of 6668 accessory canals were found in 1460 CBCT images. Of these, 672 (46.0%) were from female patients, and 788 (54.0%) were from male patients. 1034 (70.8%) of 1460 images had at least one accessory canal of CS. Maxillary intercentral region is the area where accessory canals were seen mostfrequently (n = 653, 44.72%).Conclusions: Canalis sinuosus is a bony canal which is incidentally found and less known structure of anterior portion of maxilla. Knowing the accessory canals deriving from this structure will allow surgeons to avoid complications and non-integration after dental implant procedures. Conventional imaging modalities have limited value in detecting this neurovascular structures. Therefore CBCT may have an important role for accurate diagnosis to reveal anatomical variations

Genotypic identification and technological characterization of lactic acid bacteria isolated from traditional Turkish Kargi tulum cheese

Kargi tulum cheese is an artisanal cheese produced through the spontaneous fermentation of raw milk ripened inside a goat-skin bag. The objective of this study was to characterize the dominant species of natural lactic acid bacteria (LAB) found in Kargi tulum cheese. Some technologically important properties of LAB isolates were also determined. Seven samples of cheese of different levels of ripeness were taken from local producers and 97 isolates were obtained from these samples. Non-spore forming, Gram-positive, catalase- and oxidase-negative isolates were assessed as LAB. Based on genotypic characterization, the dominant LAB were identified as Lactobacillus paracasei (43.3%), Lactobacillus plantarum (23.7%), Enterococcus durans (6.2%), Streptococcus thermophilus (6.2%), Lactobacillus brevis (5.2%), Enterococcus faecium (5.2%), Lactobacillus fermentum (4.1%) and Lactobacillus pentosus (1%). Homofermentative strains such as L. paracasei, L. plantarum, S. thermophilus; E. durans and E. faecium were selected as probable starter cultures. These strains were tolerant to 6.5% salt. They are also characterized by acidification ability (from pH = 6.6 to 4.7 to 6.0, in 6 to 8 h), low proteinase and high peptidase, esterase, esterase-lipase, β-galactosidase and β- glucosidase activities. They also produce diacetyl and H2O2.Key words: Lactic acid bacteria, genotypic characterization, technological characterization, tulum cheese