Pathogen burden and cortisol profiles over the day

Hypothalamic-pituitary-adrenocortical (HPA) regulation in adults is influenced by early psychosocial adversity, but the role of infectious disease history is poorly understood. We studied the association between cumulative pathogen burden and cortisol profile over the day in a sample of 317 healthy men and women aged 51-72 years. Cumulative pathogen burden was defined as positive serostatus for Chlamydia pneumoniae, cytomegalovirus (CMV) and herpes simplex virus 1 (HSV-1). Salivary cortisol was sampled repeatedly over the day. The cortisol slope was defined as the decrease across the day and evening. Age, gender, grade of employment, body mass index, smoking status, self-rated health, cardiovascular medication, depressed mood and time of waking were included as covariates. The pathogen burden averaged 1.76 (S.D. = 0.92). The cortisol slope was inversely associated with pathogen burden after controlling for covariates. When individual pathogens were studied, only CMV was associated with flatter cortisol rhythms in isolation. We conclude that pathogen burden is independently associated with flatter cortisol slopes over the day, and may contribute to disturbed neuroendocrine regulation

Yang-Mills Theory on a Cylinder Coupled to Point Particles

We study a model of quantum Yang-Mills theory with a finite number of gauge invariant degrees of freedom. The gauge field has only a finite number of degrees of freedom since we assume that space-time is a two dimensional cylinder. We couple the gauge field to matter, modeled by either one or two nonrelativistic point particles. These problems can be solved {\it without any gauge fixing}, by generalizing the canonical quantization methods of Ref.\[rajeev] to the case including matter. For this, we make use of the geometry of the space of connections, which has the structure of a Principal Fiber Bundle with an infinite dimensional fiber. We are able to reduce both problems to finite dimensional, exactly solvable, quantum mechanics problems. In the case of one particle, we find that the ground state energy will diverge in the limit of infinite radius of space, consistent with confinement. In the case of two particles, this does not happen if they can form a color singlet bound state (`meson').Comment: 37 pages, UR-1327 ER-40685-77

Open-mindedness can decrease persuasion amongst adolescents: The role of self-affirmation

Objectives Self-affirmation (e.g., by reflecting on important personal values) has been found to promote more open-minded appraisal of threatening health messages in at-risk adults. However, it is unclear how self-affirmation affects adolescents and whether it has differential effects on the impact of these messages amongst those at relatively lower and higher risk. The current study explored moderation by risk. Design Participants were randomly assigned to either a self-affirmation or a control condition before receiving a health message concerning physical activity. Methods Older adolescents (N = 125) completed a self-affirmation or control writing task before reading about the health consequences of not meeting recommendations to be physically active for at least 60 min daily. Most of the sample did not achieve these levels of activity (98%, N = 123). Consequently, the message informed these participants that – unless they changed their behaviour – they would be at higher risk of heart disease. Participants completed measures of responses to the message and behaviour-specific cognitions (e.g., self-efficacy) for meeting the recommendations. Results For relatively inactive participants, self-affirmation was associated with increased persuasion. However, for those who were moderately active (but not meeting recommendations), those in the self-affirmation condition were less persuaded by the message. Conclusions Whilst self-affirmation can increase message acceptance, there are circumstances when the open-mindedness it induces may decrease persuasion. The evidence provided in this study suggests that caution may be needed when recommendations are challenging and it could be considered reasonable to be sceptical about the need to change behaviour

Impact of a theoretically based sex education programme (SHARE) delivered by teachers on NHS registered conceptions and terminations: final results of cluster randomised trial

<b>Objective</b>: To assess the impact of a theoretically based sex education programme (SHARE) delivered by teachers compared with conventional education in terms of conceptions and terminations registered by the NHS. Design Follow-up of cluster randomised trial 4.5 years after intervention. <b>Setting</b>: NHS records of women who had attended 25 secondary schools in east Scotland. <b>Participants</b>: 4196 women (99.5% of those eligible). <b>Intervention</b>: SHARE programme (intervention group) v existing sex education (control group). <b>Main outcome measure</b>: NHS recorded conceptions and terminations for the achieved sample linked at age 20. <b>Results</b>: In an "intention to treat" analysis there were no significant differences between the groups in registered conceptions per 1000 pupils (300 SHARE v 274 control; difference 26, 95% confidence interval –33 to 86) and terminations per 1000 pupils (127 v 112; difference 15, –13 to 42) between ages 16 and 20. <b>Conclusions</b>: This specially designed sex education programme did not reduce conceptions or terminations by age 20 compared with conventional provision. The lack of effect was not due to quality of delivery. Enhancing teacher led school sex education beyond conventional provision in eastern Scotland is unlikely to reduce terminations in teenagers

High-Mobility Few-Layer Graphene Field Effect Transistors Fabricated on Epitaxial Ferroelectric Gate Oxides

The carrier mobility \mu of few-layer graphene (FLG) field-effect transistors increases ten-fold when the SiO_2 substrate is replaced by single-crystal epitaxial Pb(Zr_0.2Ti_0.8)O_3 (PZT). In the electron-only regime of the FLG, \mu reaches 7x10^4 cm^2/Vs at 300K for n = 2.4x10^12/cm^2, 70% of the intrinsic limit set by longitudinal acoustic (LA) phonons; it increases to 1.4x10^5 cm^2/Vs at low temperature. The temperature-dependent resistivity \rho(T) reveals a clear signature of LA phonon scattering, yielding a deformation potential D = 7.8+/-0.5 eV.Comment: 5 pages, 4 figure

Derivation of a Non-Local Interfacial Hamiltonian for Short-Ranged Wetting II: General Diagrammatic Structure

In our first paper, we showed how a non-local effective Hamiltionian for short-ranged wetting may be derived from an underlying Landau-Ginzburg-Wilson model. Here, we combine the Green's function method with standard perturbation theory to determine the general diagrammatic form of the binding potential functional beyond the double-parabola approximation for the Landau-Ginzburg-Wilson bulk potential. The main influence of cubic and quartic interactions is simply to alter the coefficients of the double parabola-like zig-zag diagrams and also to introduce curvature and tube-interaction corrections (also represented diagrammatically), which are of minor importance. Non-locality generates effective long-ranged many-body interfacial interactions due to the reflection of tube-like fluctuations from the wall. Alternative wall boundary conditions (with a surface field and enhancement) and the diagrammatic description of tricritical wetting are also discussed.Comment: (14 pages, 2 figures) Submitted J. Phys. Condens. Matte

Orthogonal measurements are {\it almost} sufficient for quantum discord of two qubits

The common use in literature of orthogonal measurements in obtaining quantum discord for two-qubit states is discussed and compared with more general measurements. We prove the optimality of orthogonal measurements for rank 2 states. While for rank 3 and 4 mixed states they are not optimal, we present strong numerical evidence showing that they give the correct quantum discord up to minimal corrections. Based on the connection, through purification with an ancilla, between discord and entanglement of formation (EoF), we give a tight upper bound for the EoF of a $2\otimes N$ mixed state of rank 2, given by an optimal decomposition of 2 elements. We also provide an alternative way to compute the quantum discord for two qubits based on the Bloch vectors of the state.Comment: EPL 96, 40005 (2011

Political affiliation dissimilarity: Exploring lone affiliate employees\u27 work attitudes and experiences

Political affiliation is an important demographic variable that has been relatively neglected in the organizational literature. At present, it is unclear how political dissimilarity between employees and their coworkers affects employees\u27 attitudes and experiences, and whether traditional theories are applicable to this unique form of diversity. Based on time-lagged data from a sample of working Americans (N = 360), we found that lone affiliates (employees who work with coworkers who do not share the same political affiliation) experienced lower levels of positive attitudes than majority affiliates (employees who work with coworkers who do share the same political affiliation). Specifically, in Republican majority organizations, Democrats had lower job satisfaction and affective commitment compared to Republicans. This difference was not found in Democrat majority organizations. Interestingly, these trends were not found for negative experiences, such as incivility from coworkers and depletion. Unaffiliated employees had a unique set of attitudes and experiences in that they suffered the most in organizations with no clear affiliation. Theoretical and practical implications, limitations, and future directions are also discussed

Synopsis of an engineering solution for a painful problem Phantom Limb Pain

This paper is synopsis of a recently proposed solution for treating patients who suffer from Phantom Limb Pain (PLP). The underpinning approach of this research and development project is based on an extension of “mirror box” therapy which has had some promising results in pain reduction. An outline of an immersive individually tailored environment giving the patient a virtually realised limb presence, as a means to pain reduction is provided. The virtual 3D holographic environment is meant to produce immersive, engaging and creative environments and tasks to encourage and maintain patients’ interest, an important aspect in two of the more challenging populations under consideration (over-60s and war veterans). The system is hoped to reduce PLP by more than 3 points on an 11 point Visual Analog Scale (VAS), when a score less than 3 could be attributed to distraction alone

Engineering entanglement for metrology with rotating matter waves

Entangled states of rotating, trapped ultracold bosons form a very promising scenario for quantum metrology. In order to employ such states for metrology, it is vital to understand their detailed form and the enhanced accuracy with which they could measure phase, in this case generated through rotation. In this work, we study the rotation of ultracold bosons in an asymmetric trapping potential beyond the lowest Landau level (LLL) approximation. We demonstrate that while the LLL can identify reasonably the critical frequency for a quantum phase transition and entangled state generation, it is vital to go beyond the LLL to identify the details of the state and quantify the quantum Fisher information (which bounds the accuracy of the phase measurement). We thus identify a new parameter regime for useful entangled state generation, amenable to experimental investigation