Special space curves characterized by det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0

By using the facts that the condition det(α⁽¹⁾,α⁽²⁾,α⁽³⁾)=0 characterizes a plane curve and the condition det(α⁽²⁾,α⁽³⁾,α⁽⁴⁾)=0 characterizes a curve of constant slope, we present special space curves characterized by the condition det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0, in different approaches. It is shown that the space curve is Salkowski if and only if det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0. The approach used in our investigation can be useful in understanding the role of the curves characterized by det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0 in differential geometry.За допомогою тих фактів, що умова det(α⁽¹⁾,α⁽²⁾,α⁽³⁾)=0 характеризує плоску криву, а умова det(α⁽²⁾,α⁽³⁾,α⁽⁴⁾)=0 — криву зі сталим нахилом, наведено спеціальні просторові криві, що характеризуються умовами det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0, в різних підходах. Показано, що просторова крива є кривою Салковського тоді i тільки тоді, коли det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0. Підхід, що використовується в роботі, є корисним для розуміння ролі кривих, що характеризуються умовою det(α⁽³⁾,α⁽⁴⁾,α⁽⁵⁾)=0 в диференціальній геометрії

Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV).

BACKGROUND Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease of the skin and mucous membranes. This disease typically affects the elderly and presents with itch and localized or, most frequently, generalized bullous lesions. A subset of patients only develops excoriations, prurigo-like lesions, and eczematous and/or urticarial erythematous lesions. The disease, which is significantly associated with neurological disorders, has high morbidity and severely impacts the quality of life. OBJECTIVES AND METHODOLOGY The Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology sought to update the guidelines for the management of BP based on new clinical information, and new evidence on diagnostic tools and interventions. The recommendations are either evidence-based or rely on expert opinion. The degree of consent among all task force members was included. RESULTS Treatment depends on the severity of BP and patients' comorbidities. High-potency topical corticosteroids are recommended as the mainstay of treatment whenever possible. Oral prednisone at a dose of 0.5 mg/kg/day is a recommended alternative. In case of contraindications or resistance to corticosteroids, immunosuppressive therapies, such as methotrexate, azathioprine, mycophenolate mofetil or mycophenolate acid, may be recommended. The use of doxycycline and dapsone is controversial. They may be recommended, in particular, in patients with contraindications to oral corticosteroids. B-cell-depleting therapy and intravenous immunoglobulins may be considered in treatment-resistant cases. Omalizumab and dupilumab have recently shown promising results. The final version of the guideline was consented to by several patient organizations. CONCLUSIONS The guidelines for the management of BP were updated. They summarize evidence- and expert-based recommendations useful in clinical practice

Antimicrobial activity and essential oil compositions of two Ranunculus species from Turkey: R. constantinopolitanus and R. arvensis

The isolated essential oils of Ranunculus constantinopolitanus and Ranunculus arvensis were tested for antimicrobial activity against the bacteria E. coli, K. pneumoniae, P. aeruginosa, E. faecalis, S. aureus, B. cereus and the fungus C. albicans. They showed moderate antimicrobial activity against P. aeruginosa, E. faecalis, S. aureus and C. albicans. The composition of essential oils obtained from the air-dried R. constantinopolitanus and R. arvensis were also analyzed by GC-MS. 45 and 36 Components were identified in the essential oils and the main component of these taxa was (Z)-phytol in the ratio 23.6 and 19.5 % from R. constantinopolitanus and R. arvensis, respectively

Chemical composition and antimicrobial activities of the essential oil from the flowers of Delphinium formosum

The essential oil from the flowers of Delphinium formosum Boiss. et Huet. (Ranunculaceae) was obtained by hydrodistillation in a Clevenger-type apparatus and analyzed by GC-MS. 68 Components were identified in the oil. The main components in the essential oil from the flowers of D. formosum were found to be tricosane (30.9 %), heneicosane (8.2 %), pentacosane (6.6 %), linalool (2.3 %) docosane (2.2 %) and phytol (2.1 %). The antimicrobial activity of the isolated essential oil from the flowers of the plant was also investigated and it showed moderate antibacterial activity against only E. faecalis and S. aureus. No antibacterial activity against other 5 bacteria and antifungal activity against 2 yeast-like fungi were observed

Chemical composition and antimicrobial activities of the essential oils of Viburnum opulus, Viburnum lantana and Viburnum orientala

The composition of the essential oils obtained from the air-dried Viburnum opulus and Viburnum lantana were analyzed by GC-MS. 40 and 53 Components were identified in the essential oils and the main component of these taxons were phytol and occidenol in the ratios 7.8 and 6.3 % from V. opulus and V. lantana, respectively. The isolated essential oils of V. opulus, V. lantana and V. orientala were also tested for antimicrobial activity against the bacteria E. coli, K. pneumoniae, P. aeruginosa, E. faecalis, S. aureus, B. cereus and the fungus C. tropicalis, at maximum essential oil concentrations in hexane of 250.500 and 1000 ?g/mL, respectively, though no activity was observed against all the test microorganisms for V. lantana and V. opulus. However, the essential oil of the V. orientale showed weak antibacterial activity against Gram-positive bacteria

Special Space Curves Characterized by det(α(3), α(4), α(5)) =0

By using the facts that the condition det(α(1), α(2), α(3)) =0 characterizes a plane curve and the condition det(α(2), α(3), α(4)) =0 characterizes a curve of constant slope, we present special space curves characterized by the condition det(α(3), α(4), α(5)) =0, in different approaches. It is shown that the space curve is Salkowski if and only if det(α(3), α(4), α(5)) =0. The approach used in our investigation can be useful in understanding the role of the curves characterized by det(α(3), α(4), α(5)) =0 in differential geometry. © 2014, Springer Science+Business Media New York

Edible packaging film derived from mechanically deboned chicken meat proteins: Effect of transglutaminase on physicochemical properties

In this study, effect of transglutaminase (TGase) addition on physical, water barrier, optical and mechanical properties of mechanically deboned chicken meat protein (MDCM-P) films was investigated. When TGase was added to the films, the thickness increased, but the solubility decreased. Films treated with TGase exhibited higher water vapor permeability than control film (p<0.05). When TGase concentration increased, the L? values of films decreased, but a? and b? values increased. All films showed very good barrier properties against UV light. The highest tensile strength was obtained in MDCM-P films containing 3% TGase (p<0.05). The elongation at break values increased with the TGase concentration increasing from 1 to 3%, but decreased at higher enzyme concentration (p<0.05). The addition of TGase altered molecular organization and intermolecular interaction in the film matrix. TGase treated films showed smoother and ordered surface structure and homogeneous and compact microstructure. The results indicated that TGase use can be an effective approach in improving the solubility and mechanical properties of MDCM-P films. Copyright © Korean Society for Food Science of Animal Resources

Tangent and trinormal spherical images of a time-like curve on the pseudohyperbolic space H0 3

In this work tangent and trinormal spherical images of a time-like curve lying on the pseudohyperbolic space H0 3 in Minkowski space-time are investigated. We observe that the mentioned spherical images are space-like curves. Besides, we determine relations between Frenet Serret invariants of spherical images and the base curve. Additionally, some characterizations of spherical images to be general helices if the base curve is a ccr-curve are presented