A case-based model for assessing the effectiveness of information systems outsourcing

Cataloged from PDF version of article.The objective of the research reported in this paper is to construct a model for assessing the effectiveness of Information Systems (IS) outsourcing. “Lack of in-house expertise” and “cost effectiveness” are widely accepted as major factors of motivation for IS outsourcing. In contrast with the decision models which are executed before an outsourcing engagement (a-priori), this effectiveness assessment model will be an a-posteriori guide which will enable clients to assess their outsourcing performance and re-evaluate their business and management strategies. Although various decision models and analytical frameworks have been proposed before, the literature is not abundant on a complete qualitative model. This paper examines the factors for outsourcing effectiveness through qualitative research conducted with multiple case studies for information systems developed for public organizations in the specific context of Turkey. A conceptual model consisting of various hypotheses is constructed and qualitatively evaluated

Tribological interaction between polytetrafluoroethylene and silicon oxide surfaces

Cataloged from PDF version of article.We investigated the tribological interaction between polytetrafluoroethylene (PTFE) and silicon oxide surfaces. A simple rig was designed to bring about a friction between the surfaces via sliding a piece of PTFE on a thermally oxidized silicon wafer specimen. A very mild inclination (similar to 0.5 degrees) along the sliding motion was also employed in order to monitor the tribological interaction in a gradual manner as a function of increasing contact force. Additionally, some patterns were sketched on the silicon oxide surface using the PTFE tip to investigate changes produced in the hydrophobicity of the surface, where the approximate water contact angle was 45 degrees before the transfer. The nature of the transferred materials was characterized by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). XPS results revealed that PTFE was faithfully transferred onto the silicon oxide surface upon even at the slightest contact and SEM images demonstrated that stable morphological changes could be imparted onto the surface. The minimum apparent contact pressure to realize the PTFE transfer is estimated as 5 kPa, much lower than reported previously. Stability of the patterns imparted towards many chemical washing processes lead us to postulate that the interaction is most likely to be chemical. Contact angle measurements, which were carried out to characterize and monitor the hydrophobicity of the silicon oxide surface, showed that upon PTFE transfer the hydrophobicity of the SiO2 surface could be significantly enhanced, which might also depend upon the pattern sketched onto the surface. Contact angle values above 100 degrees were obtained. (C) 2014 AIP Publishing LLC

Volume XCIII, Number 15, February 22, 1974

11th International Conference of Inborn Errors of Metabolism -- AUG 29-SEP 02, 2009 -- San Diego, CAWOS: 00026894260018

Combined XPS and contact angle studies of ethylene vinyl acetate and polyvinyl acetate blends

Cataloged from PDF version of article.In this study, we prepared thin films by blending ethylene vinyl acetate copolymers (EVA) containing 12-33 (wt.%) vinyl acetate (VA) with polyvinyl acetate (PVAc) and high density polyethylene homopolymers. Large area micropatterns having controlled protrusion sizes were obtained by phase-separation especially for the PVAc/EVA-33 blends using dip coating. These surfaces were characterized by XPS and contact angle measurements. A reasonably linear relation was found between the VA content on the surface (wt.%) obtained from XPS analysis and the VA content in bulk especially for PVAc/EVA-33 blend surfaces. PE segments were more enriched on the surface than that of the bulk for pure EVA copolymer surfaces similar to previous reports and VA enrichment was found on the EVA/HDPE blend surfaces due to high molecular weight of HDPE. Water theta(e) decreased with the increase in the VA content on the blend surface due to the polarity of VA. A good agreement was obtained between gamma(-)(s) and atomic oxygen surface concentration with the increase of VA content. The applicability of Cassie-Baxter equation was tested and found that it gave consistent results with the experimental water contact angles for the case where VA content was lower than 55 wt.% in the bulk composition. (C) 2011 Elsevier B. V. All rights reserved

A Datamining Based Decision Support System For Fruit Manufacturing

Agricultural activities provide one of the main sources of living in many regions of the world. Such products play significant roles for the survival of living organisms. Farmers all around the world work towards reaching their economic goals through agricultural activities. By doing this, they invest both their capital and time. In some occasions, such investments end up with serious losses and planted products either grow in low levels or do not grow at all. In this study, in order to avoid such situations and guide the investors intelligently, a decision support system based on decision tree is developed. Related parameters in accordance with the climatic and geographic characteristics of the region are determined within this proposed system. Then, appropriate types of fruits are proposed to the users as the outcome of the system based on these parameters. By doing this, producing more efficient and profitable products is aimed

Managing disruptions in the multi-depot vehicle scheduling problem

We consider two types of disruptions arising in the multi-depot vehicle scheduling; the delays and the extra trips. These disruptions may or may not occur during operations, and hence they need to be indirectly incorporated into the planned schedule by anticipating their likely occurence times. We present a unique recovery method to handle these potential disruptions. Our method is based on partially swapping two planned routes in such a way that the effect on the planned schedule is minimal, if these disruptions are actually realized. The mathematical programming model for the multi-depot vehicle scheduling problem, which incorporates these robustness considerations, possesses a special structure. This special structure causes the conventional column generation method fall short as the resulting problem grows also row-wise when columns are generated. We design an exact simultaneous column-and-row generation algorithm to find a valid lower-bound. The novel aspect of this algorithm is the pricing subproblem, which generates pairs of routes that form recovery solutions. Compromising on exactness, we modify this algorithm in order to enable it to solve practical-sized instances efficiently. This heuristic algorithm is shown to provide very tight bounds on the randomly generated instances in a short computation time

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity

miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a miR-132/212 double knockout mouse. These mice were viable and fertile with no overt adverse phenotype. Analysis of innate immune responses, including TLR-induced cytokine production and IFNβ induction in response to viral infection of primary fibroblasts did not reveal any phenotype in the knockouts. In contrast, the loss of miR-132 and miR-212, while not overtly affecting neuronal morphology, did affect synaptic function. In both hippocampal and neocortical slices miR-132/212 knockout reduced basal synaptic transmission, without affecting paired-pulse facilitation. Hippocampal long-term potentiation (LTP) induced by tetanic stimulation was not affected by miR-132/212 deletion, whilst theta burst LTP was enhanced. In contrast, neocortical theta burst-induced LTP was inhibited by loss of miR-132/212. Together these results indicate that miR-132 and/or miR-212 play a significant role in synaptic function, possibly by regulating the number of postsynaptic AMPA receptors under basal conditions and during activity-dependent synaptic plasticity

Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28.

Immune cell activation assays have been widely used for immune monitoring and for understanding disease mechanisms. However, these assays are typically limited in scope. A holistic study of circulating immune cell responses to different activators is lacking. Here we developed a cost-effective high-throughput multiplexed single-cell RNA-seq combined with epitope tagging (CITE-seq) to determine how classic activators of T cells (anti-CD3 coupled with anti-CD28) or monocytes (LPS) alter the cell composition and transcriptional profiles of peripheral blood mononuclear cells (PBMCs) from healthy human donors. Anti-CD3/CD28 treatment activated all classes of lymphocytes either directly (T cells) or indirectly (B and NK cells) but reduced monocyte numbers. Activated T and NK cells expressed senescence and effector molecules, whereas activated B cells transcriptionally resembled autoimmune disease- or age-associated B cells (e.g., CD11c, T-bet). In contrast, LPS specifically targeted monocytes and induced two main states: early activation characterized by the expression of chemoattractants and a later pro-inflammatory state characterized by expression of effector molecules. These data provide a foundation for future immune activation studies with single cell technologies (https://czi-pbmc-cite-seq.jax.org/)

Paget's disease of the breast in a male with lymphomatoid papulosis: a case report

<p>Abstract</p> <p>Introduction</p> <p>Paget's disease is an eczematous skin change of the nipple that is usually associated with an underlying breast malignancy. Male breast cancer represents only 1-3% of all breast malignancies and Paget's disease remains very rare.</p> <p>Case presentation</p> <p>We present the case of a 67-year-old Caucasian man with lymphomatoid papulosis who was diagnosed with Paget's disease of the nipple and who was treated successfully with surgery alone. We discuss the presentation, investigations, management and pathogenesis of Paget's disease of the nipple.</p> <p>Conclusion</p> <p>The case highlights the need to be vigilant when new skin lesions arise in the context of an underlying chronic skin disorder.</p