13 research outputs found
Higgs and SUSY searches at future colliders
In this talk, I discuss some aspects of Higgs searches at future colliders,
particularly comparing and contrasting the capabilities of LHC and Next Linear
Collider (NLC), including the aspects of Higgs searches in supersymmetric
theories. After this, I will discuss how the search and study of sparticles
other than the Higgs can give information about the parameters of the Minimal
Supersymmetric Standard Model (MSSM).Comment: 20 pages, 12 figures, laTeX, requires pramana.sty,ias.sty added. In
the Proceedings of XII DAE symposium, Chandigarh, December 199
Troglitazone suppresses telomerase activity independently of PPARÎł in estrogen-receptor negative breast cancer cells
<p>Abstract</p> <p>Background</p> <p>Breast cancer is one the highest causes of female cancer death worldwide. Many standard chemotherapeutic agents currently used to treat breast cancer are relatively non-specific and act on all rapidly dividing cells. In recent years, more specific targeted therapies have been introduced. It is known that telomerase is active in over 90% of breast cancer tumors but inactive in adjacent normal tissues. The prevalence of active telomerase in breast cancer patients makes telomerase an attractive therapeutic target. Recent evidence suggests that telomerase activity can be suppressed by peroxisome proliferator activated receptor gamma (PPARÎł). However, its effect on telomerase regulation in breast cancer has not been investigated.</p> <p>Methods</p> <p>In this study, we investigated the effect of the PPARÎł ligand, troglitazone, on telomerase activity in the MDA-MB-231 breast cancer cell line. Real time RT-PCR and telomerase activity assays were used to evaluate the effect of troglitazone. MDA-MB-231 cells had PPARÎł expression silenced using shRNA interference.</p> <p>Results</p> <p>We demonstrated that troglitazone reduced the mRNA expression of hTERT and telomerase activity in the MDA-MB-231 breast cancer cell line. Troglitazone reduced telomerase activity even in the absence of PPARÎł. In agreement with this result, we found no correlation between PPARÎł and hTERT mRNA transcript levels in breast cancer patients. Statistical significance was determined using Pearson correlation and the paired Student's <it>t </it>test.</p> <p>Conclusions</p> <p>To our knowledge, this is the first time that the effect of troglitazone on telomerase activity in breast cancer cells has been investigated. Our data suggest that troglitazone may be used as an anti-telomerase agent; however, the mechanism underlying this inhibitory effect remains to be determined.</p
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Risk Factors, Etiology, and Clinical Outcome of Ischemic Stroke in Young Adults Admitted in a Tertiary Care Hospital in India
Fluorinated benzylidene indanone exhibits antiproliferative activity through modulation of microtubule dynamics and antiangiogenic activity
Aquatic macroinvertebrate communities on wood in an Australian lowland river: experimental assessment of the interactions of habitat, substrate complexity and retained organic matter
Incidence and mortality rates of varicella among end stage renal disease (ESRD) patients in Singapore General Hospital, a 12-year review
A quantitative sampler for collecting invertebrates associated with deep submerged vegetation
Effects of light and temperature fluctuations on the growth of Myriophyllum spicatum in toxicity testsâa model-based analysis
Comparison of visible imaging, thermography and spectrometry methods to evaluate the effect of Heterodera schachtii inoculation on sugar beets
Abstract Background Phenotyping technologies are expected to provide predictive power for a range of applications in plant and crop sciences. Here, we use the disease pressure of Beet Cyst Nematodes (BCN) on sugar beet as an illustrative example to test the specific capabilities of different methods. Strong links between the above and belowground parts of sugar beet plants have made BCN suitable targets for use of non-destructive phenotyping methods. We compared the ability of visible light imaging, thermography and spectrometry to evaluate the effect of BCN on the growth of sugar beet plants. Results Two microplot experiments were sown with the nematode susceptible cultivar Aimanta and the nematode tolerant cultivar BlueFox under semi-field conditions. Visible imaging, thermal imaging and spectrometry were carried out on BCN infested and non-infested plants at different times during the plant development. Effects of a chemical nematicide were also evaluated using the three phenotyping methods. Leaf and beet biomass were measured at harvest. For both susceptible and tolerant cultivar, canopy area extracted from visible images was the earliest nematode stress indicator. Using such canopy area parameter, delay in leaf growth as well as benefit from a chemical nematicide could be detected already 15Â days after sowing. Spectrometry was suitable to identify the stress even when the canopy reached full coverage. Thermography could only detect stress on the susceptible cultivar. Spectral Vegetation Indices related to canopy cover (NDVI and MCARI2) and chlorophyll content (CHLG) were correlated with the final yield (RÂ =Â 0.69 on average for the susceptible cultivar) and the final nematode population in the soil (RÂ =Â 0.78 on average for the susceptible cultivar). Conclusion In this paper we compare the use of visible imaging, thermography and spectrometry over two cultivars and 2Â years under outdoor conditions. The three different techniques have their specific strengths in identifying BCN symptoms according to the type of cultivars and the growth stages of the sugar beet plants. Early detection of nematicide benefit and high yield predictability using visible imaging and spectrometry suggests promising applications for agricultural research and precision agriculture