Teachers’ perceptions of Inquiry-Based Science Education (IBSE) and the implications for gender equality in science education

This paper explores the perceived effectiveness of teacher training covering inquiry­based science learning for primary school children in England. Teachers who initially took part in teacher training between 2011 and 2013 as part of the FP7 project Pri­Sci­Net were interviewed during spring and summer term 2014; teachers were asked to reflect on their students’ reactions and engagement. Teachers’ responses were thematically analysed, and the implications are discussed within the context of longer­term implications of primary science education on girls’ attitudes and aspirations in science across their subsequent educatio

Understanding causality and uncertainty in volcanic observations: an example of forecasting eruptive activity on Soufrière Hills Volcano, Montserrat

Following a cessation in eruptive activity it is important to understand how a volcano will behave in the future and when it may next erupt. Such an assessment can be based on the volcano's long-term pattern of behaviour and insights into its current state via monitoring observations. We present a Bayesian network that integrates these two strands of evidence to forecast future eruptive scenarios using expert elicitation. The Bayesian approach provides a framework to quantify the magmatic causes in terms of volcanic effects (i.e., eruption and unrest). In October 2013, an expert elicitation was performed to populate a Bayesian network designed to help forecast future eruptive (in-)activity at Soufrière Hills Volcano. The Bayesian network was devised to assess the state of the shallow magmatic system, as a means to forecast the future eruptive activity in the context of the long-term behaviour at similar dome-building volcanoes. The findings highlight coherence amongst experts when interpreting the current behaviour of the volcano, but reveal considerable ambiguity when relating this to longer patterns of volcanism at dome-building volcanoes, as a class. By asking questions in terms of magmatic causes, the Bayesian approach highlights the importance of using short-term unrest indicators from monitoring data as evidence in long-term forecasts at volcanoes. Furthermore, it highlights potential biases in the judgements of volcanologists and identifies sources of uncertainty in terms of magmatic causes rather than scenario-based outcomes

From social contract to 'social contrick' : the depoliticisation of economic policy-making under Harold Wilson, 1974–75

The 1974-79 Labour Governments were elected on the basis of an agreement with the TUC promising a redistribution of income and wealth known as the Social Contract. However, the Government immediately began to marginalise these commitments in favour of preferences for incomes policy and public expenditure cuts, which has led the Social Contract to be described as the 'Social Contrick'. These changes were legitimised through a process of depoliticisation, and using an Open Marxist framework and evidence from the National Archives, the paper will show that the Treasury's exchange rate strategy and the need to secure external finance placed issues of confidence at the centre of political debate, allowing the Government to argue there was no alternative to the introduction of incomes policy and the reduction of public expenditure

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents

Antagonism of alphav beta6 is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an alphav beta3 antagonist lead and through simple variation in the nature and position of aryl substituent, the discovery of compounds with improved alphav beta6 activity is described. The compounds also have physicochemical properties commensurate with oral bioavailability and are high quality starting points for a drug discovery programme. Compounds 33S and 43E1 are pan alphav antagonists having ca 100 nM potency against alphav beta3, alphav beta5, alphav beta6 and alphav beta8 in cell adhesion assays. Detailed structure activity relationships with these integrins are described which also reveal substituents providing partial selectivity (defined as at least a 0.7 log difference in pIC50 values between the integrins in question) for alphav beta3 and alphav beta5

Strategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonists

YesThe integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer and associated conditions; thrombosis, angiogenesis and osteoporosis. The most reported strategy for drug development is synthesis of an agent that is highly selective for a single integrin receptor. However, the ability of cancer cells to change their integrin repertoire in response to drug treatment renders this approach vulnerable to the development of resistance and paradoxical promotion of tumor growth. Here, we review progress towards development of antagonists targeting two or more members of the RGD-binding integrins, notably αvβ3, αvβ5, αvβ6, αvβ8, α5β1, and αIIbβ3, as anticancer therapeutics

La incuestionabilidad del riesgo

Con anterioridad a la década de 1980, la literatura especializada en análisis y gestión del riesgo estaba dominada por la llamada visión tecnocrática o dominante. Esta visión establecía que los desastres naturales eran sucesos físicos extremos, producidos por una naturaleza caprichosa, externos a lo social y que requerían soluciones tecnológicas y de gestión por parte de expertos. Este artículo se centra en desarrollar una nueva explicación para entender la persistencia hegemónica de la visión tecnocrática basada en el concepto de incuestionabilidad del riesgo. Esta propuesta conceptual hace referencia a la incapacidad y desidia de los expertos, científicos y tomadores de decisiones en general (claimmakers) de identificar y actuar sobre las causas profundas de la producción del riesgo ya que ello conllevaría a cuestionar los imperativos normativos, las necesidades de las elites y los estilos de vida del actual sistema socioeconómico globalizado.Before de 1980s, the natural hazard analysis and management specialized literature was dominated by the so called "dominant" or "technocratic" view. Such perspective had established that natural disasters are extreme physical events caused by a whimsical nature and that these events are external to society. These events required technological and management solutions developed by experts. The current article aims at addressing a new explanatory component in the hegemonic persistence of the technocratic view. Such assumption was based on the "unquestionability of the risk" concept. It is stated that the "unquestionability of the risk" is the overall incapacity and neglect of experts, scientists and decision makers to identify and act over the deep causes of risk production, since it would make them question the normative imperatives and the demands from the elite as well as the life style in nowadays globalized socio-economic system

Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential. Weismann's prediction was derived by considering the role of natural selection in regulating the duration of an organism's life. For various reasons, Weismann's ideas on ageing fell into neglect following his death in 1914, and cytogerontology has only reappeared as a major research area following the demonstration by Hayflick and Moorhead in the early 1960s that diploid human fibroblasts are restricted to a finite number of divisions in vitro. In this review we give a detailed account of Weismann's theory, and we reveal that his ideas were both more extensive in their scope and more pertinent to current research than is generally recognised. We also appraise the progress which has been made over the past hundred years in investigating the causes of ageing, with particular emphasis being given to (i) the evolution of ageing, and (ii) ageing at the cellular level. We critically assess the current state of knowledge in these areas and recommend a series of points as primary targets for future research

Factors affecting growth and yield of short-duration pigeonpea and its potential for multiple harvests

Environmental and cultural factors that may limit the yield of short-duration pigeonpea were investigated over three seasons. Plants in the peninsular Indian environment at Patancheru grew less and produced less dry matter by first-flush maturity than at Hisar, a location in northern India where the environment is considered favourable for the growth of short-duration pigeonpea. However, with a similar sowing date in June, the mean seed yields of three genotypes, ICPL 4, ICPL 81 and ICPL 87, were very similar, at about 2·3 t/ha, in both environments. This was mainly due to the higher ratio of grain to above-ground dry matter at Patancheru. In addition to the first harvest, all genotypes showed a potential for two more harvests owing to the warm winters at Patancheru. The potential for multiple harvests was particularly high in ICPL 87, which yielded 5·2 t/ha from three harvests in 1982–3, 3·6 t/ha from two harvests in 1983–4, and 4·l t/ha from three harvests in 1984–5. The optimum plant population density at Patancheru was 25–35 plants/m2 for ICPL 87, but was higher for the other two genotypes. At Patancheru, the total dry-matter and seed yield of first and subsequent harvests were significantly reduced by delaying sowing beyond June. Generally, the second- and the third-harvest yields were lower on vertisol than on alfisol under both irrigated and unirrigated conditions. The total yield of ICPL 87 from two harvests was far higher than that of a well-adapted medium-duration genotype BDN 1, grown over a similar period. The yield advantage was greater on the alfisol because of the better multiple harvest potential of this soil. The results of this study demonstrate that properly managed short-duration genotypes of pigeonpea may have considerable potential for increased yield from multiple harvests in environments where winters are warm enough to permit continued growth

Effect of harvest methods on the second flush yield of short-duration pigeonpea (Cajanus cajan)

Short-duration pigeonpea can give up to three harvests in environments with mild winters (e.g. minimum temperature above 10 °C) such as those prevailing in peninsular India (Sharma, Saxena & Green. 1978; Chauhan, Venkataratnam & Sheldrake, 1984). This is mainly due to the short time (about 120 days) taken to produce the first flush, and the strong perennial character of pigeonpea. The seed yield of short-duration pigeonpea in this multiple-harvest system may reach 5·2 t/ha (Chauhan et al. 198