Data science of stroke imaging and enlightenment of the penumbra.

Imaging protocols of acute ischemic stroke continue to hold significant uncertainties regarding patient selection for reperfusion therapy with thrombolysis and mechanical thrombectomy. Given that patient inclusion criteria can easily introduce biases that may be unaccounted for, the reproducibility and reliability of the patient screening method is of utmost importance in clinical trial design. The optimal imaging screening protocol for selection in targeted populations remains uncertain. Acute neuroimaging provides a snapshot in time of the brain parenchyma and vasculature. By identifying the at-risk but still viable penumbral tissue, imaging can help estimate the potential benefit of a reperfusion therapy in these patients. This paper provides a perspective about the assessment of the penumbral tissue in the context of acute stroke and reviews several neuroimaging models that have recently been developed to assess the penumbra in a more reliable fashion. The complexity and variability of imaging features and techniques used in stroke will ultimately require advanced data driven software tools to provide quantitative measures of risk/benefit of recanalization therapy and help aid in making the most favorable clinical decisions

El Management como práctica: una aproximación a la naturaleza del trabajo directivo

En el presente trabajo se realiza una reflexión sobre la naturaleza del trabajo directivo –management–, a la luz de los tres modos posibles de conocimiento: la teoría, la práctica y la técnica. Puntualmente, se analiza el trabajo de tres autores: Henry Mintzberg, Ikujiro Nonaka y Alasdair MacIntyre, con el fin de mostrar cómo la evolución del estudio teórico de esta disciplina ha ido evidenciando su carácter eminentemente práctico. Mintzberg aporta una excelente introducción al fenómeno, ya que combina muy bien la observación práctica con la reflexión sobre lo que hacen los realmente directivos. Nonaka, por su parte, resalta el dinamismo de la empresa: su capacidad de innovar, de crear y compartir conocimiento. Finalmente, MacIntyre reivindica la perspectiva aristotélica en el estudio de la vida organizacional, con su revitalización de la noción de práctica. Se concluye resaltando que concebir el trabajo directivo como una práctica abre paso a una teoría normativa de la acción y su influencia en las organizaciones.This article reflects on the nature of managerial work, which historically has been approached as a theory, a practice, or a technique. The work of three authors, Henry Mintzberg, Ikujiro Nonaka and Alasdair MacIntyre, is analyzed in order to show how the evolution of this discipline’s theoretical study demonstrates its eminently practical nature. Mintzberg provides an excellent introduction to the phenomenon, perceptively combining practical observation with reflection on what managers actually do. Nonaka, on the other hand, highlights the dynamism of the business firm and its ability to innovate, create and share knowledge. Finally, MacIntyre revives the Aristotelian perspective in the study of organizational life, revitalizing the idea of practice. We conclude by emphasizing that conceiving of managerial work as a practice implies the acceptance of a normative theory of organizations

Bracatinga (Mimosa scabrella), eucalipto (Eucalyptus viminalis) e pinus (Pinus taeda) na recuperação de biodiversidade, a nível microbiológico de solos degradados.

Edição dos Anais do Congresso Florestal de Essências Nativas, 2., 1992, São Paulo. Edição especial

Initial Hubble Diagram Results from the Nearby Supernova Factory

The use of Type Ia supernovae as distance indicators led to the discovery of the accelerating expansion of the universe a decade ago. Now that large second generation surveys have significantly increased the size and quality of the high-redshift sample, the cosmological constraints are limited by the currently available sample of ~50 cosmologically useful nearby supernovae. The Nearby Supernova Factory addresses this problem by discovering nearby supernovae and observing their spectrophotometric time development. Our data sample includes over 2400 spectra from spectral timeseries of 185 supernovae. This talk presents results from a portion of this sample including a Hubble diagram (relative distance vs. redshift) and a description of some analyses using this rich dataset.Comment: Short version of proceedings for ICHEP08, Philadelphia PA, July 2008; see v1 for full-length versio

Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence.

BackgroundPatients with symptomatic intracranial atherosclerosis (ICAS) of ≥ 70% luminal stenosis are at high risk of stroke recurrence. We aimed to evaluate the relationships between hemodynamics of ICAS revealed by computational fluid dynamics (CFD) models and risk of stroke recurrence in this patient subset.MethodsPatients with a symptomatic ICAS lesion of 70-99% luminal stenosis were screened and enrolled in this study. CFD models were reconstructed based on baseline computed tomographic angiography (CTA) source images, to reveal hemodynamics of the qualifying symptomatic ICAS lesions. Change of pressures across a lesion was represented by the ratio of post- and pre-stenotic pressures. Change of shear strain rates (SSR) across a lesion was represented by the ratio of SSRs at the stenotic throat and proximal normal vessel segment, similar for the change of flow velocities. Patients were followed up for 1 year.ResultsOverall, 32 patients (median age 65; 59.4% males) were recruited. The median pressure, SSR and velocity ratios for the ICAS lesions were 0.40 (-2.46-0.79), 4.5 (2.2-20.6), and 7.4 (5.2-12.5), respectively. SSR ratio (hazard ratio [HR] 1.027; 95% confidence interval [CI], 1.004-1.051; P = 0.023) and velocity ratio (HR 1.029; 95% CI, 1.002-1.056; P = 0.035) were significantly related to recurrent territorial ischemic stroke within 1 year by univariate Cox regression, respectively with the c-statistics of 0.776 (95% CI, 0.594-0.903; P = 0.014) and 0.776 (95% CI, 0.594-0.903; P = 0.002) in receiver operating characteristic analysis.ConclusionsHemodynamics of ICAS on CFD models reconstructed from routinely obtained CTA images may predict subsequent stroke recurrence in patients with a symptomatic ICAS lesion of 70-99% luminal stenosis

SkyMapper Southern Survey: First Data Release (DR1)

We present the first data release (DR1) of the SkyMapper Southern Survey, a hemispheric survey carried out with the SkyMapper Telescope at Siding Spring Observatory in Australia. Here, we present the survey strategy, data processing, catalogue construction and database schema. The DR1 dataset includes over 66,000 images from the Shallow Survey component, covering an area of 17,200 deg$^2$ in all six SkyMapper passbands $uvgriz$, while the full area covered by any passband exceeds 20,000 deg$^2$. The catalogues contain over 285 million unique astrophysical objects, complete to roughly 18 mag in all bands. We compare our $griz$ point-source photometry with PanSTARRS1 DR1 and note an RMS scatter of 2%. The internal reproducibility of SkyMapper photometry is on the order of 1%. Astrometric precision is better than 0.2 arcsec based on comparison with Gaia DR1. We describe the end-user database, through which data are presented to the world community, and provide some illustrative science queries.Comment: 31 pages, 19 figures, 10 tables, PASA, accepte

PESSTO monitoring of SN 2012hn: further heterogeneity among faint type I supernovae

We present optical and infrared monitoring data of SN 2012hn collected by the Public ESO Spectroscopic Survey for Transient Objects (PESSTO). We show that SN 2012hn has a faint peak magnitude (MR ~ -15.7) and shows no hydrogen and no clear evidence for helium in its spectral evolution. Instead, we detect prominent Ca II lines at all epochs, which relates this transient to previously described 'Ca-rich' or 'gap' transients. However, the photospheric spectra (from -3 to +32 d with respect to peak) of SN 2012hn show a series of absorption lines which are unique, and a red continuum that is likely intrinsic rather than due to extinction. Lines of Ti II and Cr II are visible. This may be a temperature effect, which could also explain the red photospheric colour. A nebular spectrum at +150d shows prominent CaII, OI, CI and possibly MgI lines which appear similar in strength to those displayed by core-collapse SNe. To add to the puzzle, SN 2012hn is located at a projected distance of 6 kpc from an E/S0 host and is not close to any obvious starforming region. Overall SN 2012hn resembles a group of faint H-poor SNe that have been discovered recently and for which a convincing and consistent physical explanation is still missing. They all appear to explode preferentially in remote locations offset from a massive host galaxy with deep limits on any dwarf host galaxies, favouring old progenitor systems. SN 2012hn adds heterogeneity to this sample of objects. We discuss potential explosion channels including He-shell detonations and double detonations of white dwarfs as well as peculiar core-collapse SNe.Comment: 14 pages, 14 figures, accepted to MNRAS on 14/10/201

Very high-energy observations of the two high-frequency peaked BL Lac objects 1ES 1218+304 and H 1426+428

We present results of very-high-energy gamma-ray observations (E > 160 GeV) of two high-frequency-peaked BL Lac (HBL) objects, 1ES 1218+304 and H 1426+428, with the Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE). Both sources are very-high-energy gamma-ray emitters above 100 GeV, detected using ground-based Cherenkov telescopes. STACEE observations of 1ES 1218+304 and H 1426+428 did not produce detections; we present 99% CL flux upper limits for both sources, assuming spectral indices measured mostly at higher energies