Medium- and large-scale characterization of UMTS-allocated frequency division duplex channels

A dual-band sounder is used in both trolley and van measurements in the dense urban environment of Manchester city center to characterize the uplink (1920-1980 MHz) and downlink (2110-2170 MHz) frequency-division duplex (FDD) channels allocated to third-generation (3G) mobile radio systems. The data are analyzed with 60- and 5-MHz resolutions, as used for 3G wideband code-division multiple-access systems. Root-mean-square (rms) delay spread and 15-dB widths of mainly temporally averaged delay profile are presented either as cumulative distribution functions (cdfs) for each individual frequency band or as histograms of the difference between uplink and downlink on a local area basis. It was found that the histograms show larger differences between the two bands than the individual cdf and that the differences between the FDD channels are more pronounced on circumferential routes and shadowed locations. Correlations of rms delay spread with excess path loss and distance are on the order of 0.5 and 0.4, respectively

A new algorithm for high-quality ionogram generation and analysis

Standard digital ionograms that are generated by fast Fourier transform or autoregressive modeling suffer from high interference levels due to other users of the HF channel which produce artifacts and distortion, hence complicating automatic processing and information extraction. In this paper, a new method is proposed to obtain high-quality ionograms of the desired layer reflections and automatically extract important information such as critical frequencies. Following the standard procedures, two sets of periodograms are obtained by using rectangular and Blackman windows. These two periodograms are filtered and fused utilizing an automatic edge-detection-based time-frequency detector. The fused ionogram provides sharp description of the layer reflections with very low sidelobe structure (ringing). The performance of this new ionogram algorithm is tested using chirp sounder data collected from an oblique midlatitude path. It is observed that the presented algorithm is highly successful in obtaining robust and sharp ionograms free of artifacts. Furthermore, a new algorithm is proposed for automated computation of dispersion and critical frequencies of the magnetoionic components detected on the ionogram. Since efficient signal-processing algorithms are utilized, the proposed method can be implemented in real time

Optmized patch-like antennas for through the wall radar imaging and preliminary results with frequency modulated interrupted continuous wave

This paper presents optimized patch-like antennas for Through The Wall Imaging (TTWI) radar applications in the frequency range 0.5-2 GHz, and preliminary results using Frequency Modulated Interrupted Continuous Waveform (FMICW). Results of numerical simulations using basic models of the antenna are presented. The antenna optimization was aimed at making the radiation pattern more directional by focusing the energy in a single lobe to be directed towards the wall and the targets to be detected. The optimized antenna was manufactured and its measured parameters are compared with the simulated results which show good agreement. Some preliminary results from the FMICW radar system using this antenna are presented

Functional Interactions of Alcohol-sensitive Sites in the \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptor M3 and M4 Domains

The N-methyl-d-aspartate receptor is an important mediator of the behavioral effects of ethanol in the central nervous system. Previous studies have demonstrated sites in the third and fourth membrane-associated (M) domains of the N-methyl-d-aspartate receptor NR2A subunit that influence alcohol sensitivity and ion channel gating. We investigated whether two of these sites, Phe-637 in M3 and Met-823 in M4, interactively regulate the ethanol sensitivity of the receptor by testing dual substitution mutants at these positions. A majority of the mutations decreased steady-state glutamate EC50 values and maximal steady-state to peak current ratios (Iss/Ip), whereas only two mutations altered peak glutamate EC50 values. Steady-state glutamate EC50 values were correlated with maximal glutamate Iss/Ip values, suggesting that changes in glutamate potency were attributable to changes in desensitization. In addition, there was a significant interaction between the substituents at positions 637 and 823 with respect to glutamate potency and desensitization. IC50 values for ethanol among the mutants varied over the approximate range 100–325 mm. The sites in M3 and M4 significantly interacted in regulating ethanol sensitivity, although this was apparently dependent upon the presence of methionine in position 823. Molecular dynamics simulations of the NR2A subunit revealed possible binding sites for ethanol near both positions in the M domains. Consistent with this finding, the sum of the molecular volumes of the substituents at the two positions was not correlated with ethanol IC50 values. Thus, there is a functional interaction between Phe-637 and Met-823 with respect to glutamate potency, desensitization, and ethanol sensitivity, but the two positions do not appear to form a unitary site of alcohol action

Algorithm for high quality ionograms

A new ionogram algorithm, which is highly successful in generating robust and sharp digital ionograms free of artefacts and processing noise, is presented. An important feature of the algorithm is the distortionless zooming capability, which allows the user to concentrate only on the desired magnetoionic components of the ionogram

Radio propagation measurements and modeling for standardization of the site general path loss model in International Telecommunications Union recommendations for 5G wireless networks

The International Telecommunications Union Radiocommunication Sector (ITU‐R) Study Group 3 identified the need for a number of radio channel models in anticipation of the World Radiocommunications Conference in 2019 when the frequency allocation for 5G will be discussed. In response to the call for propagation path loss models, members of the study group carried out measurements in the frequency bands between 0.8 GHz up to 73 GHz in urban low rise and urban high rise as well as suburban environments. The data were subsequently merged to generate site general path loss models. The paper presents an overview of the radio channel measurements, the measured environments, the data analysis and the approach for the derivation of the path loss model adopted in Recommendation ITU‐R P.1411‐10

Synergistic Effect of Anemia and Red Blood Cells Transfusion on Inflammation and Lung Injury

Anemia and resultant red blood cell transfusion may be associated with adverse long-term clinical outcomes. To investigate the mechanism(s) responsible, we profiled inflammatory biomarkers and circulating levels of the bioactive lysophospholipid mediator sphingosine-1-phosphate (S1P) in control and anemic mice with or without LPS-induced systemic inflammation. Acute anemia or lipopolysaccharide (LPS) challenge alone triggered an increase of circulating levels of the inflammatory markers IL-6 and keratinocyte-derived chemokine (CXCL1/KC). Moreover, administration of LPS to anemic mice reduced circulating S1P levels and augmented lung injury and pulmonary vascular permeability. Transfusion of aged, but not fresh, red blood cells (RBCs) worsened pulmonary vascular leak. S1P levels decline markedly during storage of mouse RBCs. Loading stored murine RBCs with S1P prior to transfusion partially attenuated anemia-associated acute pulmonary vascular leak. Taken together, our results indicate that anemia and systemic inflammation can alter the S1P buffering capacity of RBCs, suggesting possible strategies for alleviating transfusion-related lung injury in clinical practice

Different Sites of Alcohol Action in the NMDA Receptor GluN2A and GluN2B Subunits

The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action. We and others have previously characterized four amino acid positions in the third and fourth membrane-associated (M) domains of the NMDA receptor GluN2A subunit that influence both ion channel gating and alcohol sensitivity. In this study, we found that substitution mutations at two of the four corresponding positions in the GluN2B subunit, F637 and G826, influence ethanol sensitivity and ion channel gating. Because position 826 contains a glycine residue in the native protein, we focused our attention on GluN2B(F637). Substitution mutations at GluN2B(F637) significantly altered ethanol IC50 values, glutamate EC50 values for peak (Ip) and steady-state (Iss) current, and steady-state to peak current ratios (Iss:Ip). Changes in apparent glutamate affinity were not due to agonist trapping in desensitized states, as glutamate Iss EC50 values were not correlated with Iss:Ip values. Ethanol sensitivity was correlated with values of both Ip and Iss glutamate EC50, but not with Iss:Ip. Values of ethanol IC50, glutamate EC50, and Iss:Ip for mutants at GluN2B(F637) were highly correlated with the corresponding values for mutants at GluN2A(F636), consistent with similar functional roles of this position in both subunits. These results demonstrate that GluN2B(Phe637) regulates ethanol action and ion channel function of NMDA receptors. However, despite highly conserved M domain sequences, ethanol\u27s actions on GluN2A and GluN2B subunits differ