596 research outputs found
Low-Background gamma counting at the Kimballton Underground Research Facility
The next generation of low-background physics experiments will require the
use of materials with unprecedented radio-purity. A gamma-counting facility at
the Kimballton Underground Research Facility (KURF) has been commissioned to
perform initial screening of materials for radioactivity primarily from
nuclides in the 238U and 232Th decay chains, 40K and cosmic-ray induced
isotopes. The facility consists of two commercial low-background high purity
germanium (HPGe) detectors. A continuum background reduction better than a
factor of 10 was achieved by going underground. This paper describes the
facility, detector systems, analysis techniques and selected assay results.Comment: 7 pages, 7 figures. Submitted to NIM
Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC). The automated quantitative ARCHITECT (R) ProGRP assay was developed to aid in the differential diagnosis and in the management of SCLC. The purpose of this study was to evaluate the analytical performance of this chemiluminescent microparticle immunoassay at multiple sites. Methods: ARCHITECT ProGRP measures ProGRP using a two-step sandwich using monoclonal anti-ProGRP antibodies coated on paramagnetic microparticles and labeled with acridinium. Analytical performance of the assay was evaluated at four sites: Abbott Japan, Denka Seiken, the Johns Hopkins University, and the University of Munich. Results: Total precision (%CV) for nine analyte concentrations was between 2.2 and 5.7. The analytical sensitivity of the assay was between 0.20 pg/mL and 0.88 pg/mL. The functional sensitivity at 20% CV was between 0.66 pg/mL and 1.73 pg/mL. The assay was linear up to 50,000 pg/mL using a 1:10 autodilution protocol. The calibration curve was stable for 30 days. Comparison with the Fujirebio microtiter plate enzyme-linked immunosorbent assay (EIA) ProGRP assay gave a slope of 0.93 and a correlation coefficient (r) of 0.99. Conclusions: These results demonstrate that the ARCHITECT ProGRP assay has excellent sensitivity, precision, and correlation to a reference method. This assay provides a convenient automated method for ProGRP measurement in serum and plasma in hospitals and clinical laboratories. Clin Chem Lab Med 2009;47:1557-63
Responsive glyco-poly(2-oxazoline)s: synthesis, cloud point tuning, and lectin binding
A new sugar-substituted 2-oxazoline monomer was prepared using the copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. Its copolymerization with 2-ethyl-2-oxazoline as well as 2-(dec-9-enyl)-2-oxazoline, yielding well-defined copolymers with the possibility to tune the properties by thiol-ene "click" reactions, is described. Extensive solubility studies on the corresponding glycocopolymers demonstrated that the lower critical solution temperature behavior and pH-responsiveness of these copolymers can be adjusted in water and phosphate-buffered saline (PBS) depending on the choice of the thiol. By conjugation of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose and subsequent deprotection of the sugar moieties, the hydrophilicity of the copolymer could be increased significantly, allowing a cloud-point tuning in the physiological range. Furthermore, the binding capability of the glycosylated copoly(2-oxazoline) to concanavalin A was investigated
Temperature Evolution of Sodium Nitrite Structure in a Restricted Geometry
The NaNO nanocomposite ferroelectric material in porous glass was
studied by neutron diffraction. For the first time the details of the crystal
structure including positions and anisotropic thermal parameters were
determined for the solid material, embedded in a porous matrix, in ferro- and
paraelectric phases. It is demonstrated that in the ferroelectric phase the
structure is consistent with bulk data but above transition temperature the
giant growth of amplitudes of thermal vibrations is observed, resulting in the
formation of a "premelted state". Such a conclusion is in a good agreement with
the results of dielectric measurements published earlier.Comment: 4 pages, 4 figure
New anti-perovskite-type Superconductor ZnNyNi3
We have synthesized a new superconductor ZnNyNi3 with Tc ~3 K. The crystal
structure has the same anti-perovskite-type such as MgCNi3 and CdCNi3. As far
as we know, this is the third superconducting material in Ni-based
anti-perovskite series. For this material, superconducting parameters,
lower-critical field Hc1(0), upper-critical field Hc2(0), coherence length
x(0), penetration depth l(0), and Gintzburg -Landau parameter k(0) have been
experimentally determined.Comment: 13 pages, 3 figures, 1 tabl
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Does the source migration pathway of HBCDs to household dust influence their bioaccessibility?
A study was conducted to assess the human bioaccessibility of dust contaminated with hexabromocyclododecane (HBCD) via two migration pathways a) volatilisation with subsequent partitioning to dust particles, and b) abrasion of treated textile fibres directly to the dust. This was achieved using previously developed experimental chamber designs to generate dust samples contaminated with HBCDs emit-ted from a HBCD treated textile curtain. The generated dust samples were exposed to an in vitro colon extended physiologically based extraction test (CE-PBET). The bioaccessibility of the HBCDs which were incorporated within dust as a result of volatilisation from the curtain material with subsequent partitioning to dust was higher than in dusts contaminated with HBCDs via abrasion of the curtain (35% and 15% respectively). We propose this occurs due to a stronger binding of HBCDs to treated fabric fibres than that experienced following volatilisation and sorption of HBCDs to dust particles
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