Health technology in education: Challenges to the effectiveness of the application

The development of healthy and harmonious personality – is the first importance of any modern school. The topical issue of health declining of pupils makes a question about reconsideration of educational system and goal’s correction towards the health technology as a formula to success of developing new generationРазвитие здоровой и гармоничной личности является приоритетом любой школы. Актуальная проблема ухудшения здоровья школьников ставит вопрос о пересмотре системы образования и смещении ориентиров на здоровьесберегающие технологии как залог успеха формирования подрастающего поколени

Sparks and waves in a stochastic fire-diffuse-fire model of Ca2+

Calcium ions are an important second messenger in living cells. Indeed calcium signals in the form of waves have been the subject of much recent experimental interest. It is now well established that these waves are composed of elementary stochastic release events (calcium puffs) from spatially localized calcium stores. Here we develop a computationally inexpensive model of calcium release based upon a stochastic generalization of the Fire-Diffuse-Fire (FDF) threshold model. Our model retains the discrete nature of calcium stores, but also incorporates a notion of release probability via the introduction of threshold noise. Numerical simulations of the model illustrate that stochastic calcium release leads to the spontaneous production of calcium sparks that may merge to form saltatory waves. In the parameter regime where deterministic waves exist it is possible to identify a critical level of noise defining a non-equilibrium phase-transition between propagating and abortive structures. A statistical analysis shows that this transition is the same as for models in the directed percolation universality class. Moreover, in the regime where no initial structure can survive deterministically, threshold noise is shown to generate a form of array enhanced coherence resonance whereby all calcium stores release periodically and simultaneously

A Technique for Decreasing Reactivity of Coal Material to Suppress the Oxygen Absorption Process

The paper describes the mechanisms of self-ignition formation in coal liable to spontaneous combustion, on the basis of experimental works performed to analyze heat and mass transfer in the coal-air system. A new approach was developed to the coal self-heating suppression and thermodynamic control of the oxidation process. The influence of coal moisture content and thermal behaviour of air in the cooling process was studied during moisture evaporation

Environmental Hazard Identification Technique Developing of Territorial Administrations Strategy as Exemplified in Siberian Federal District

This work, on the example of the Siberian Federal District of the Russian Federation, presents a method for determining mass airbursts of combustion gaseous eco-toxicants, as a technique for assessing the contributory environmental load on the atmosphere. Potential environmental hazards are analyzed by mass of contaminated airbursts. A comparison of specific gross toxicants' emissions in territorial entities of the Russian Federation is made

Wave bifurcation and propagation failure in a model of Ca2+ release

The De Young Keizer model for intracellular calcium oscillations is based around a detailed description of the dynamics for inositol trisphosphate (IP3) receptors. Systematic reductions of the kinetic schemes for IP3 dynamics have proved especially fruitful in understanding the transition from excitable to oscillatory behaviour. With the inclusion of diffusive transport of calcium ions the model also supports wave propagation. The analysis of waves, even in reduced models, is typically only possible with the use of numerical bifurcation techniques. In this paper we review the travelling wave properties of the biophysical De Young Keizer model and show that much of its behaviour can be reproduced by a much simpler Fire-Diffuse-Fire (FDF) type model. The FDF model includes both a refractory process and an IP3 dependent threshold. Parameters of the FDF model are constrained using a comprehensive numerical bifurcation analysis of solitary pulses and periodic waves in the De Young Keizer model. The linear stability of numerically constructed solution branches is calculated using pseudospectral techniques. The combination of numerical bifurcation and stability analysis also allows us to highlight the mechanisms that give rise to propagation failure. Moreover, a kinematic theory of wave propagation, based around numerically computed dispersion curves is used to predict waves which connect periodic orbits. Direct numerical simulations of the De Young Keizer model confirm this prediction. Corresponding travelling wave solutions of the FDF model are obtained analytically and are shown to be in good qualitative agreement with those of the De Young Keizer model. Moreover, the FDF model may be naturally extended to include the discrete nature of calcium stores within a cell, without the loss of analytical tractability. By considering calcium stores as idealised point sources we are able to explicitly construct solutions of the FDF model that correspond to saltatory periodic travelling waves

Technology of Water Purification With Chlorinated Derivatives and Assessment of Risk Associated With Human Exposure to These Substances

In the given paper the authors consider the technology of water purification with consideration to the recommendations of the World Health Organization (WHO), European Union (EU) and standards of developed countries. Carcinogenic Unit Risk (UR) magnitude for people constantly exposed to the analyzed carcinogens in the course of a lifetime is estimated. The authors calculate and evaluate unique carcinogenic risk as a complementary probability of cancer development during the whole life of CR when introducing EU standards into water purification technology

Dialogue of cultures : concept in Russian humanities

The urgency of the problem under study is caused by the lack of a common opinion in the scientific social and humanitarian community about the content of "culture dialogue" concept and the interdisciplinary status of cultural research. The article is aimed at the revealing of the variety of used terms identical to "culture dialogue" and the presentation of a possible classification of values that are laid down in this term depending on the research problem. The leading approach to the study of this problem is the poly-paradigmatic approach, in which the main research method is the comparative analysis method, aimed at the comparison of existing definitions, the determination of their common and specific base components. The main results of the article represent the approaches to the definition of "culture dialogue" existing in the Russian humanitarian field. The materials of the article can be useful to develop the lecture materials for the students studying a wide range of social humanitarian educational programs, during the selection of a methodological approach in anthropological, historical, cultural, artistic, scientific and philosophical studies.peer-reviewe

The release of inhibition model reproduces kinetics and plasticity of neurotransmitter release in central synapses

Calcium-evoked release of neurotransmitters from synaptic vesicles (SVs) is catalysed by SNARE proteins. The predominant view is that, at rest, complete assembly of SNARE complexes is inhibited ('clamped') by synaptotagmin and complexin molecules. Calcium binding by synaptotagmins releases this fusion clamp and triggers fast SV exocytosis. However, this model has not been quantitatively tested over physiological timescales. Here we describe an experimentally constrained computational modelling framework to quantitatively assess how the molecular architecture of the fusion clamp affects SV exocytosis. Our results argue that the 'release-of-inhibition' model can indeed account for fast calcium-activated SV fusion, and that dual binding of synaptotagmin-1 and synaptotagmin-7 to the same SNARE complex enables synergistic regulation of the kinetics and plasticity of neurotransmitter release. The developed framework provides a powerful and adaptable tool to link the molecular biochemistry of presynaptic proteins to physiological data and efficiently test the plausibility of calcium-activated neurotransmitter release models

Quantitative prediction of selectivity in iridium-catalysed hydrogen isotope exchange reactions

A pallette of commonly used directing groups, including various pharmaceutically relevant nitrogen-containing heterocycles, are quantitatively ranked based on the results of intermolecular hydrogen isotope exchange competition reactions using two iridium complexes: [Ir(COD)(IMes)(PPh3)][BArF24] and [IrCl(COD)(IMes)]. The directing group power scales that have been constructred from these data reveal a wide range of reactivity covering four orders of magnitude. Intramolecular competition experiments have demonstrated that the obtained reactivity scale provides accurate predictions of regioselectivity within molecules with multiple competing directing groups. This work contributes to our understanding and control of regioselectivity in metal-catalysed C-H activation reactions