Anaesthetic management of a patient with thoracopagus

We report the case of a 10-day-old male child weighing 3.5 kg, with mass over the sternal region, a set of four limbs and an omphalocoele that had undergone surgical separation. An exoparasitic twin had fully developed hind limbs, well-developed genitalia, one fully developed upper limb and another, underdeveloped upper limb. Echocardiography and a computed tomographic scan revealed no gross cardiac anomaly and the sharing of any other major organ was absent. The limbs of the parasite were lying in front of the neck and interfered with holding the mask in position. One anaesthetist held these limbs apart. We avoided the use of muscle relaxant out of fear that the large mass could hamper ventilation. The neonate was intubated successfully under deep inhalation anaesthesia. He had an uneventful recovery.Keywords: thoracopagus; anaesthetic managemen

A robust control scheme for flexible arms with friction in the joints

A general control scheme to control flexible arms with friction in the joints is proposed in this paper. This scheme presents the advantage of being robust in the sense that it minimizes the effects of the Coulomb friction existing in the motor and the effects of changes in the dynamic friction coefficient. A justification of the robustness properties of the scheme is given in terms of the sensitivity analysis

Basal internal anal sphincter tone, inhibitory neurotransmission, and other factors contributing to the maintenance of high pressures in the anal canal

Maintenance of the basal tone in the internal anal sphincter (IAS) is critical for rectoanal continence. Effective evacuation requires a fully functional rectoanal inhibitory reflex (RAIR)-mediated relaxation of the IAS via inhibitory neurotransmission (INT). Systematic studies examining the nature of the INT in different species have identified nitric oxide (NO) as the major inhibitory neurotransmitter. However, other mediators such as vasoactive intestinal polypeptide (VIP), ATP, and carbon monoxide (CO) may also play species-specific role under certain experimental conditions. Measurements of the intraluminal pressures in the IAS along with the force of the isolated IAS tissues are the mainstay in the basic studies for the molecular mechanisms underlying the basal tone and in the nature of the INT. The identification of NO as the inhibitory neurotransmitter has led to major advances in the diagnosis and treatment of a number of rectoanal motility disorders associated with the IAS dysfunction. Besides the IAS, the high pressures in the anal canal are affected by the external anal sphincter (EAS) function, and its malfunction may also lead to rectoanal incontinence. Different approaches including biofeedback have been attempted to improve the EAS function, with variable outcomes. There is a dire need for the innovative ways to improve the week high pressures zone in the anal canal. This viewpoint focuses on two studies that extend the above concept of multiplicity of inhibitory neurotransmitters (Neurogastroenterol Motil 2011 23 e11–25), and that high pressures in the anal canal can be improved by the EAS plication (Neurogastroenterol Motil 2011 23 70–5)

What happens after prejudice is confronted in the workplace? How mindsets affect minorities' and women's outlook on future social relations

Organizations are increasingly concerned with fostering successful diversity. Toward this end, diversity research has focused on trying to reduce prejudice and biased behavior. But what happens when prejudice in the workplace inevitably occurs? Research also needs to focus on whether recovery and repair of social relations after incidents of prejudice are possible. To begin investigating this question, we develop a new framework for understanding reactions to prejudice in the workplace. We hypothesized that when women and minorities choose to confront a prejudiced comment in a workplace interaction (vs. remain silent) and hold a growth (vs. fixed) mindset — the belief that others can change — they remain more positive in their subsequent outlook in the workplace. Studies 1a, 1b, and 2 used hypothetical workplace scenarios to expose participants to someone who expressed bias; Study 3 ensured real-world relevance by eliciting retrospective accounts of workplace bias from African American employees. Across studies, women and minorities who confronted the perpetrator of prejudice exhibited more positive subsequent expectations of that co-worker when they held a growth mindset. Importantly, these more positive expectations were associated with reports of greater workplace belonging (Study 2), ratings of improved relations with co-workers who had displayed bias (Study 3), and greater workplace satisfaction (Studies 2-3). Thus, a growth mindset contributes to successful workplace diversity by protecting women’s and minorities’ outlook when they opt to confront expressions of bias

Is education a fundamental right? People's lay theories about intellectual potential drive their positions on education

Does every child have a fundamental right to receive a high quality education? We propose that people’s beliefs about whether “nearly everyone” or “only some people” have high intellectual potential drive their positions on education. Three studies found that the more people believed that nearly everyone has high potential, the more they viewed education as a fundamental human right. Further, people who viewed education as a fundamental right, in turn, (1) were more likely to support the institution of free public education; (2) were more concerned upon learning that students in the country were not performing well academically compared to students in peer nations; and (3) were more likely to support redistributing educational funds more equitably across wealthier and poorer school districts. The studies show that people’s beliefs about intellectual potential can influence their positions on education, which can affect the future quality of life for countless students

Facing challenges in an ageing world

Editorial.The sponsorship of the following contributors made possible the meeting: Universidad Pablo de Olavide, Centro Andaluz de Biología del Desarrollo, Springer Publishers, International Coenzyme Q10 Association, Sociedad Española de Biología Celular, Universidad Internacional de Andalucía, Junta de Andalucía, Cien por Cien Natural, Pharma Nord Denmark, C. Viral, ThermoFisher Scientific and Cultek.Peer Reviewe

Non-linear complex principal component analysis of nearshore bathymetry

International audienceComplex principal component analysis (CPCA) is a useful linear method for dimensionality reduction of data sets characterized by propagating patterns, where the CPCA modes are linear functions of the complex principal component (CPC), consisting of an amplitude and a phase. The use of non-linear methods, such as the neural-network based circular non-linear principal component analysis (NLPCA.cir) and the recently developed non-linear complex principal component analysis (NLCPCA), may provide a more accurate description of data in case the lower-dimensional structure is non-linear. NLPCA.cir extracts non-linear phase information without amplitude variability, while NLCPCA is capable of extracting both. NLCPCA can thus be viewed as a non-linear generalization of CPCA. In this article, NLCPCA is applied to bathymetry data from the sandy barred beaches at Egmond aan Zee (Netherlands), the Hasaki coast (Japan) and Duck (North Carolina, USA) to examine how effective this new method is in comparison to CPCA and NLPCA.cir in representing propagating phenomena. At Duck, the underlying low-dimensional data structure is found to have linear phase and amplitude variability only and, accordingly, CPCA performs as well as NLCPCA. At Egmond, the reduced data structure contains non-linear spatial patterns (asymmetric bar/trough shapes) without much temporal amplitude variability and, consequently, is about equally well modelled by NLCPCA and NLPCA.cir. Finally, at Hasaki, the data structure displays not only non-linear spatial variability but also considerably temporal amplitude variability, and NLCPCA outperforms both CPCA and NLPCA.cir. Because it is difficult to know the structure of data in advance as to which one of the three models should be used, the generalized NLCPCA model can be used in each situation

Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone.

The present study focused on the role of microRNA-139-5p (miRNA-139-5p) in the regulation of basal tone in internal anal sphincter (IAS). Applying genome-wide miRNA microarrays on the phenotypically distinct smooth muscle cells (SMCs) within the rat anorectrum, we identified miRNA-139-5p as differentially expressed RNA repressor with highest expression in the purely phasic smooth muscle of anococcygeus (ASM) vs. the truly tonic smooth muscle of IAS. This pattern of miRNA-139-5p expression, previously shown to target ROCK2, was validated by target prediction using ingenuity pathway (IPA) and by qPCR analyses. Immunoblotting, immunocytochemistry (ICC), and functional assays using IAS tissues and cells subjected to overexpression/knockdown of miRNA-139-5p confirmed the inverse relationship between miRNA-139-5p and ROCK2 expressions/IAS tone. Overexpression of miRNA-139-5p caused a decrease, while knockdown by anti-miRNA-139-5p caused an increase in the IAS tone; these tissue contractile responses were confirmed by single-cell contraction using magnetic twisting cytometry (MTC). These findings suggest miRNA-139-5p is capable of significantly influencing the phenotypic tonicity in smooth muscle via ROCK2: a lack of tone in ASM may be associated with the suppression of ROCK2 by high expression of miRNA-139-5p, whereas basal IAS tone may be associated with the persistence of ROCK2 due to low expression of miRNA-139-5p