58 research outputs found
Cerclajes y enclavado intramedular en fracturas subtrocantéreas: ¿vascularización femoral o reducción anatómica?
Nuestro objetivo es valorar el beneficio y los resultados clínico-radiológicos del uso de los cerclajes
y el enclavado intramedular en las fracturas subtrocantéreas tipo IIIA de Seinsheimer y compararlo con un
grupo control. Se utilizaron dos grupos de 19 pacientes (grupo con cerclaje y grupo sin cerclaje) y se obtuvieron
los siguientes resultados; tasas de reducción anatómica 89.5% y 84.2%; tasas de consolidación 100% y 94,7%;
tiempo medio de consolidación 20 y 23.9 semanas. Los resultados utilizando la escala de Harris fueron de 62,7
y 68,3; y una tasa de complicaciones del 5.2% y del 21%. Estos resultados sugieren que el uso de cerclajes en
las fracturas subtrocantéreas, no influencia de forma negativa nuestra tasa de consolidación, infección o complicaciones;
sin embargo promovemos el uso de cerclajes después de intentar la reducción de manera cerrada, y
siempre con un buen manejo de partes blandas.Our goal is to assess the benefit and the clinical and radiological outcomes of using cerclage and
intramedullary nail in subtrochanteric fractures type IIIA of Seinsheimer and comparing with a control group.
Two groups of 19 patients (cerclage group and non-cerclage group) were used and the following results were
obtained; anatomic reduction rates 89.5% and 84.2; consolidation rates 100% and 94.7%; mean healing time 20
and 23.9 weeks. Our mean Harris Hip Score were 62.7 and 68.3; and a complication rate of 5.2% and 21%. The
results suggest that the use of cerclage in subtrochanteric fractures does not negatively influence in the rate of
consolidation, infection or complications as opposed to a subotpimal reduction. Nevertheless we emphasize open
reduction and cerclage wiring after the attempt of closed reduction, and always taking care of soft tissues
Phoretic Motion of Spheroidal Particles Due To Self-Generated Solute Gradients
We study theoretically the phoretic motion of a spheroidal particle, which
generates solute gradients in the surrounding unbounded solvent via chemical
reactions active on its surface in a cap-like region centered at one of the
poles of the particle. We derive, within the constraints of the mapping to
classical diffusio-phoresis, an analytical expression for the phoretic velocity
of such an object. This allows us to analyze in detail the dependence of the
velocity on the aspect ratio of the polar and the equatorial diameters of the
particle and on the fraction of the particle surface contributing to the
chemical reaction. The particular cases of a sphere and of an approximation for
a needle-like particle, which are the most common shapes employed in
experimental realizations of such self-propelled objects, are obtained from the
general solution in the limits that the aspect ratio approaches one or becomes
very large, respectively.Comment: 18 pages, 5 figures, to appear in European Physical Journal
Gramene 2018: unifying comparative genomics and pathway resources for plant research
Gramene (http://www.gramene.org) is a knowledgebase for comparative functional analysis in major crops and model plant species. The current release, #54, includes over 1.7 million genes from 44 reference genomes, most of which were organized into 62,367 gene families through orthologous and paralogous gene classification, whole-genome alignments, and synteny. Additional gene annotations include ontology-based protein structure and function; genetic, epigenetic, and phenotypic diversity; and pathway associations. Gramene's Plant Reactome provides a knowledgebase of cellular-level plant pathway networks. Specifically, it uses curated rice reference pathways to derive pathway projections for an additional 66 species based on gene orthology, and facilitates display of gene expression, gene-gene interactions, and user-defined omics data in the context of these pathways. As a community portal, Gramene integrates best-of-class software and infrastructure components including the Ensembl genome browser, Reactome pathway browser, and Expression Atlas widgets, and undergoes periodic data and software upgrades. Via powerful, intuitive search interfaces, users can easily query across various portals and interactively analyze search results by clicking on diverse features such as genomic context, highly augmented gene trees, gene expression anatomograms, associated pathways, and external informatics resources. All data in Gramene are accessible through both visual and programmatic interfaces
Prdm9, a Major Determinant of Meiotic Recombination Hotspots, Is Not Functional in Dogs and Their Wild Relatives, Wolves and Coyotes
Meiotic recombination is a fundamental process needed for the correct segregation of chromosomes during meiosis in sexually reproducing organisms. In humans, 80% of crossovers are estimated to occur at specific areas of the genome called recombination hotspots. Recently, a protein called PRDM9 was identified as a major player in determining the location of genome-wide meiotic recombination hotspots in humans and mice. The origin of this protein seems to be ancient in evolutionary time, as reflected by its fairly conserved structure in lineages that diverged over 700 million years ago. Despite its important role, there are many animal groups in which Prdm9 is absent (e.g. birds, reptiles, amphibians, diptera) and it has been suggested to have disruptive mutations and thus to be a pseudogene in dogs. Because of the dog's history through domestication and artificial selection, we wanted to confirm the presence of a disrupted Prdm9 gene in dogs and determine whether this was exclusive of this species or whether it also occurred in its wild ancestor, the wolf, and in a close relative, the coyote. We sequenced the region in the dog genome that aligned to the last exon of the human Prdm9, containing the entire zinc finger domain, in 4 dogs, 17 wolves and 2 coyotes. Our results show that the three canid species possess mutations that likely make this gene non functional. Because these mutations are shared across the three species, they must have appeared prior to the split of the wolf and the coyote, millions of years ago, and are not related to domestication. In addition, our results suggest that in these three canid species recombination does not occur at hotspots or hotspot location is controlled through a mechanism yet to be determined
Plant Reactome: a knowledgebase and resource for comparative pathway analysis
Plant Reactome (https://plantreactome.gramene.org) is an open-source, comparative plant pathway knowledgebase of the Gramene project. It uses Oryza sativa (rice) as a reference species for manual curation of pathways and extends pathway knowledge to another 82 plant species via gene-orthology projection using the Reactome data model and framework. It currently hosts 298 reference pathways, including metabolic and transport pathways, transcriptional networks, hormone signaling pathways, and plant developmental processes. In addition to browsing plant pathways, users can upload and analyze their omics data, such as the gene-expression data, and overlay curated or experimental gene-gene interaction data to extend pathway knowledge. The curation team actively engages researchers and students on gene and pathway curation by offering workshops and online tutorials. The Plant Reactome supports, implements and collaborates with the wider community to make data and tools related to genes, genomes, and pathways Findable, Accessible, Interoperable and Re-usable (FAIR)
Water-soluble aluminium phthalocyanine–polymer conjugates for PDT: photodynamic activities and pharmacokinetics in tumour-bearing mice
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