Radiographic findings in hereditary multiple exostoses and a new theory of the pathogenesis of exostoses.

Analysis of 330 exostoses in 18 patients affected by hereditary multiple exostoses disease suggested a new classification of exostoses as eccentric or full-thickness. Radiographically arrest of metaphyseal remodeling with failure of coning and persistence of the primary metaphyseal trabeculae was evident in full-thickness exostoses. Similar bone lesions can be obtained experimentally with inhibitors of bone turn-over. A localized, peripheral defect in remodeling over a limited time can give a satisfactory explanation also for the origin of eccentric exostoses. The thesis that this is the basic mechanism of exostosis formation is presented

Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication.

6openopenPazzaglia, U; Apostoli, P; Congiu, T; Catalani, S; Marchese, M; Zarattini, G.Pazzaglia, Ugo; Apostoli, Pietro; Congiu, T; Catalani, S; Marchese, M; Zarattini, Guid

Plasma endothelin-1 concentrations in patients with retinal vein occlusions

Aims-To investigate whether plasma levels of endothelin-1 (ET-1), a potent vasoconstricting peptide that is crucial in regulating retinal blood flow, were elevated in patients with retinal vein occlusion (RVO). Methods-ET-1 plasma concentrations were determined by radioimmunoassays in a double blind fashion in a group of 18 selected patients with RVO, in 20 healthy age matched non-smoking, normoglycaemic, normotensive control subjects, and in 15 patients with uncomplicated essential hypertension in the same age range. Results-Patients with RVO had significantly increased ET-1 plasma levels (14.22 (SD 4.6) pg/ml) compared with both normal subjects (7.90 (1.6) pg/ml; p < 0.05) and hypertensive patients (8.50 (2.9) pg/ml; p < 0.05), The highest concentrations of circulating ET-1 were found in patients with RVO of the ischaemic type (16.97 (3.5) pg/ml; p < 0.01; n = 7). Systemic hypertension alone did not account for the observed increase in plasma ET-I concentrations. Conclusions-These findings raise the possibility that the increased circulating ET-1 levels in patients with RVO may be a marker of the occlusive event, thereby suggesting that ET-1 homeostasis may be relevant to RVO pathogenesis and retinal ischaemic manifestations

Detection of Synergistic Hemolysis Between Vibrio Cholerae Non-o1 and Staphylococcal Beta-lysin with Modified Camp Test

Suatu hemolisis sinergistik pada lempeng agar darah domba diperlihatkan oleh Vibrio cholerae non-O1 dengan beta-lisin dari stafilokok. Sebanyak 167 galur (strains) non-Ol yang diuji dengan metode modifikasi CAMP menunjukkan suatu gambaran hemolisis berupa bulan sabit yang tipis; sedangkan V. cholerae biotipe El Tor dan biotipe klasik yang digunakan sebagai galur kontrol memperlihatkan reaksi CAMP berupa gambaran seperti sosis untuk biotipe El Tor dan negatif untuk biotipe klasik

Does Warming Enhance the Effects of Eutrophication in the Seagrass Posidonia oceanica?

Seagrass meadows are disappearing at rates comparable to those reported for mangroves, coral reefs, and tropical rainforests. One of the main causes of their decline is the so-called cultural eutrophication, i.e., the input of abnormal amounts of nutrients derived from human activities. Besides the impact of eutrophication at a local scale, the occurrence of additional stress factors such as global sea warming may create synergisms in detriment of seagrass meadows’ health. In the present study, we aimed to evaluate if plants undergoing chronic cultural eutrophication and plants growing in relatively pristine waters are more (or less) sensitive to heat stress, nutrient load and the combination of both stressors. To address this question, a mesocosm experiment was conducted using Posidonia oceanica collected from two environments with different nutrients load history. Plants were exposed in controlled conditions to high nutrient concentrations, increased temperature and their combination for 5 weeks, to assess the effect of the single stressors and their interaction. Our results revealed that plants experiencing chronic cultural eutrophication (EU) are more sensitive to further exposure to multiple stressors than plants growing in oligotrophic habitats (OL). OL and EU plants showed different morphological traits and physiological performances, which corroborates the role of local pressures in activating different strategies in response to global environmental changes. EU-plants appeared to be weaker during the treatments, showing the greatest percentage of mortality, particularly under increased temperature. Temperature and nutrient treatments showed opposite effects when tested individually and an offset response when combined. The activation of physiological strategies with high energetic expenses to cope with excess of nutrients and other stressors, could affect plants present and future persistence, particularly under eutrophic conditions. Our results represent a step forward in understanding the complex interactions that occur in natural environments. Moreover, unraveling intraspecific strategies and the role of local acclimation/adaptation in response to multiple stressors could be crucial for seagrass conservation strategies under a climate change scenario

ASSERT4SOA: Toward Security Certification of Service-Oriented Applications

ASSERT4SOA project proposes machine readable certificates to be used to allow Web service requesters to automatically assess the security properties of Web services (and their providers) as certified by a trusted third party. This vision promises to open up an entire new market for certification services

A three-day forest-bathing retreat enhances positive affect, vitality, optimism, and gratitude: An option for green-care tourism in Italy?

Forest-bathing experiences can be seen as guided recreational activities led by non-clinical trained practitioners in the context of green, slow, and mindful tourism. Notwithstanding its growing practice, there is a lack of research on the psychological benefits which can help support nature-based tourism destination managers in unlocking the potential of this emerging tourism demand. This study will fill in this gap by testing the hypothesis that a three-day forest-bathing retreat, which fits with the most common type of holidays in Europe, will enhance positive affect, vitality, optimism, and gratitude as indicators of hedonic and eudaimonic well-being. Forty-four adults were involved in the residential program and filled-in self-report questionnaires before and after the experience to assess the well-being dimensions considered. Results showed a significant increase for all the assessed variables. We conclude that forest bathing as a mindful tourism practice carried out in natural settings dominated by forests can favor hedonic and eudaimonic well-being, thus becoming a potential source of attractiveness for nature-based touristic destinations, but more transdisciplinary efforts are needed to exploit this potential. In particular, research gaps still exist in Europe on cause-effect relations between forest features and psychological benefits, how forests could be managed to guarantee these benefits to the advantage of a tourism destination, and how tourism and forest management sectors could collaborate in this direction