Application of the SAFT-γ Mie group contribution equation of state to fluids of relevance to the oil and gas industry

Calculated data for all the figures presented in publication

Historical legacies and African development

As Africa’s role on the global stage is rising, so does the need to understand the shadow of history on the continent’s economy and polity. We discuss recent works that shed light on Africa’s colonial and precolonial legacies. The emerging corpus is remarkably interdisciplinary. Archives, ethnographic materials, georeferenced censuses, surveys, and satellite imagery are some of the sources often combined to test influential conjectures put forward in African historiography. Exploiting within-country variation and employing credible, albeit mostly local, identification techniques, this recent literature has uncovered strong evidence of historical continuity as well as instances of rupture in the evolution of the African economy. The exposition proceeds in reverse chronological order. Starting from the colonial period, which has been linked to almost all of Africa’s postindependence maladies, we first review works that uncover the lasting legacies of colonial investments in infrastructure and human capital and quantify the role of various extractive institutions, such as indirect rule and oppression associated with concessionary agreements. Second, we discuss the long-lasting impact of the "Scramble for Africa," which led to ethnic partitioning and the creation of artificial modern states. Third, we cover studies on the multifaceted legacy of the slave trades. Fourth, we analyze the contemporary role of various precolonial, ethnic-specific, institutional and social traits, such as political centralization. We conclude by offering some thoughts on what we view as open questions

Determination of bulk discharge current in the dielectric film of MEMS capacitive switches

The present work presents a new method to calculate the discharge current in the bulk of dielectric films of MEMS capacitive switches. This method takes into account the real MEMS switch with non uniform trapped charge and air gap distributions. Assessment of switches with silicon nitride dielectric film shows that the discharge current transient seems to obey the stretched exponential law. The decay characteristics depend on the polarization field’s polarity, a fact comes along with experimental results obtained from thermally stimulated depolarization currents (TSDC) method used in MIM capacitors

AgeDB: the first manually collected, in-the-wild age database

Over the last few years, increased interest has arisen with respect to age-related tasks in the Computer Vision community. As a result, several "in-the-wild" databases annotated with respect to the age attribute became available in the literature. Nevertheless, one major drawback of these databases is that they are semi-automatically collected and annotated and thus they contain noisy labels. Therefore, the algorithms that are evaluated in such databases are prone to noisy estimates. In order to overcome such drawbacks, we present in this paper the first, to the best of knowledge, manually collected "in-the-wild" age database, dubbed AgeDB, containing images annotated with accurate to the year, noise-free labels. As demonstrated by a series of experiments utilizing state-of-the-art algorithms, this unique property renders AgeDB suitable when performing experiments on age-invariant face verification, age estimation and face age progression "in-the-wild"

Genome sequences of two pseudorabies virus strains isolated in Greece

Pseudorabies virus (species Suid herpesvirus 1) belongs to the genus Varicellovirus, subfamily Alphaherpesvirinae, family Herpesviridae, and is the causative agent of an acute and frequently fatal disease that affects mainly pigs. Here, we report the genome sequences of two strains of this virus isolated in Greece in 2010

Clinical applications of gene therapy for rare diseases: A review

Rare diseases collectively exact a high toll on society due to their sheer number and overall prevalence. Their heterogeneity, diversity, and nature pose daunting clinical challenges for both management and treatment. In this review, we discuss recent advances in clinical applications of gene therapy for rare diseases, focusing on a variety of viral and non-viral strategies. The use of adeno-associated virus (AAV) vectors is discussed in the context of Luxturna, licenced for the treatment of RPE65 deficiency in the retinal epithelium. Imlygic, a herpes virus vector licenced for the treatment of refractory metastatic melanoma, will be an example of oncolytic vectors developed against rare cancers. Yescarta and Kymriah will showcase the use of retrovirus and lentivirus vectors in the autologous ex vivo production of chimeric antigen receptor T cells (CAR-T), licenced for the treatment of refractory leukaemias and lymphomas. Similar retroviral and lentiviral technology can be applied to autologous haematopoietic stem cells, exemplified by Strimvelis and Zynteglo, licenced treatments for adenosine deaminase-severe combined immunodeficiency (ADA-SCID) and β-thalassaemia respectively. Antisense oligonucleotide technologies will be highlighted through Onpattro and Tegsedi, RNA interference drugs licenced for familial transthyretin (TTR) amyloidosis, and Spinraza, a splice-switching treatment for spinal muscular atrophy (SMA). An initial comparison of the effectiveness of AAV and oligonucleotide therapies in SMA is possible with Zolgensma, an AAV serotype 9 vector, and Spinraza. Through these examples of marketed gene therapies and gene cell therapies, we will discuss the expanding applications of such novel technologies to previously intractable rare diseases