An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents

There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive traits, how many would meet diagnostic criteria for autism spectrum disorder, and whether these traits are shared by parents

An Analytical Study of Coupled Two-State Stochastic Resonators

The two-state model of stochastic resonance is extended to a chain of coupled two-state elements governed by the dynamics of Glauber's stochastic Ising model. Appropriate assumptions on the model parameters turn the chain into a prototype system of coupled stochastic resonators. In a weak-signal limit analytical expressions are derived for the spectral power amplification and the signal-to-noise ratio of a two-state element embedded into the chain. The effect of the coupling between the elements on both quantities is analysed and array-enhanced stochastic resonance is established for pure as well as noisy periodic signals. The coupling-induced improvement of the SNR compared to an uncoupled element is shown to be limited by a factor four which is only reached for vanishing input noise.Comment: 29 pages, 5 figure

An examination of the clinical outcomes of adolescents and young adults with broad autism spectrum traits and autism spectrum disorder and anorexia nervosa: A multi centre study

Objectives: To compare the clinical outcomes of adolescents and young adults with anorexia nervosa (AN) comorbid with broad autism spectrum disorder (ASD) or ASD traits. Method: The developmental and well‐being assessment and social aptitude scale were used to categorize adolescents and young adults with AN (N = 149) into those with ASD traits (N = 23), and those who also fulfilled diagnostic criteria for a possible/probable ASD (N = 6). We compared both eating disorders specific measures and broader outcome measures at intake and 12 months follow‐up. Results: Those with ASD traits had significantly more inpatient/day‐patient service use (p = .015), as well as medication use (p < .001) at baseline. Both groups had high social difficulties and poorer global functioning (strengths and difficulties questionnaire) at baseline, which improved over time but remained higher at 12 months in the ASD traits group (p = .002). However, the improvement in eating disorder symptoms at 12 months was similar between groups with or without ASD traits. Treatment completion rates between AN only and ASD traits were similar (80.1 vs. 86.5%). Discussion: Adolescents with AN and ASD traits show similar reductions in their eating disorder symptoms. Nevertheless, their social difficulties remain high suggesting that these are life‐long difficulties rather than starvation effects

μ-CS: An extension of the TM4 platform to manage Affymetrix binary data

<p>Abstract</p> <p>Background</p> <p>A main goal in understanding cell mechanisms is to explain the relationship among genes and related molecular processes through the combined use of technological platforms and bioinformatics analysis. High throughput platforms, such as microarrays, enable the investigation of the whole genome in a single experiment. There exist different kind of microarray platforms, that produce different types of binary data (images and raw data). Moreover, also considering a single vendor, different chips are available. The analysis of microarray data requires an initial preprocessing phase (i.e. normalization and summarization) of raw data that makes them suitable for use on existing platforms, such as the TIGR M4 Suite. Nevertheless, the annotations of data with additional information such as gene function, is needed to perform more powerful analysis. Raw data preprocessing and annotation is often performed in a manual and error prone way. Moreover, many available preprocessing tools do not support annotation. Thus novel, platform independent, and possibly open source tools enabling the semi-automatic preprocessing and annotation of microarray data are needed.</p> <p>Results</p> <p>The paper presents <it>μ</it>-CS (Microarray Cel file Summarizer), a cross-platform tool for the automatic normalization, summarization and annotation of Affymetrix binary data. <it>μ</it>-CS is based on a client-server architecture. The <it>μ</it>-CS client is provided both as a plug-in of the TIGR M4 platform and as a Java standalone tool and enables users to read, preprocess and analyse binary microarray data, avoiding the manual invocation of external tools (e.g. the Affymetrix Power Tools), the manual loading of preprocessing libraries, and the management of intermediate files. The <it>μ</it>-CS server automatically updates the references to the summarization and annotation libraries that are provided to the <it>μ</it>-CS client before the preprocessing. The <it>μ</it>-CS server is based on the web services technology and can be easily extended to support more microarray vendors (e.g. Illumina).</p> <p>Conclusions</p> <p>Thus <it>μ</it>-CS users can directly manage binary data without worrying about locating and invoking the proper preprocessing tools and chip-specific libraries. Moreover, users of the <it>μ</it>-CS plugin for TM4 can manage Affymetrix binary files without using external tools, such as APT (Affymetrix Power Tools) and related libraries. Consequently, <it>μ</it>-CS offers four main advantages: (i) it avoids to waste time for searching the correct libraries, (ii) it reduces possible errors in the preprocessing and further analysis phases, e.g. due to the incorrect choice of parameters or the use of old libraries, (iii) it implements the annotation of preprocessed data, and finally, (iv) it may enhance the quality of further analysis since it provides the most updated annotation libraries. The <it>μ</it>-CS client is freely available as a plugin of the TM4 platform as well as a standalone application at the project web site (<url>http://bioingegneria.unicz.it/M-CS</url>).</p

Cliophysics: Socio-political Reliability Theory, Polity Duration and African Political (In)stabilities

Quantification of historical sociological processes have recently gained attention among theoreticians in the effort of providing a solid theoretical understanding of the behaviors and regularities present in sociopolitical dynamics. Here we present a reliability theory of polity processes with emphases on individual political dynamics of African countries. We found that the structural properties of polity failure rates successfully capture the risk of political vulnerability and instabilities in which 87.50%, 75%, 71.43%, and 0% of the countries with monotonically increasing, unimodal, U-shaped and monotonically decreasing polity failure rates, respectively, have high level of state fragility indices. The quasi-U-shape relationship between average polity duration and regime types corroborates historical precedents and explains the stability of the autocracies and democracies.Comment: 4 pages, 3 figures, 1 tabl

Neutral beam injector oxygen impurity measurements and concentration reduction via gettering processes. Revision 1

We have measured the reduction of oxygen impurity levels by means of gettering within the arc chambers of the TMX-U neutral-beam injectors using the TMX-U neutral-beam test stand. Our analysis incorporated silicon surface-probe measurements and optical Doppler-shift measurements of the hydrogen alpha spectra of deuterium atoms with energies appropriate for D/sub 2/O parentage. Without gettering, the Auger electron spectroscopy analysis of an exposed silicon sample showed a large oxygen peak below the surface peak with a concentration equivalence of approximately 2% for an accelerated beam. After gettering, with either titanium or chromium getters, optical monochromator data indicated a reduction in the oxygen concentration of at least a factor of 10 whereas Auger spectroscopy data showed at least a factor-of-eight reduction. Other metallic impurities remained below the level of detection even after gettering. Additional effects observed during this study include a change in the accelerated deuterium species concentrations, loss of gettering activity, loss of arc operation, and a change in arc performance due to arc chamber gas absorption during operation

Neutral beam injector oxygen impurity measurements and concentration reduction via gettering processes

The reduction of oxygen impurity levels by means of gettering within the arc chambers of the TMX-U neutral beam injectors has been measured. The TMX-U Neutral Beam Test Stand was used for this experiment. Analysis incorporated silicon surface probes and optical Doppler-shift measurements of the Lyman alpha spectra of deuterium atoms with energies appropriate for D/sub 2/O parentage. Without gettering, the Auger electron spectroscopy analysis of an exposed silicon sample showed a large oxygen peak below the surface peak with a concentration equivalent of approximately 2% for an accelerated beam. After gettering, with either titanium or chromium getters, the oxygen concentration was reduced by at least a factor of 10 according to optical monochromator data, and at least a factor of 8 from Auger spectroscopy data. Simultaneously, other metallic impurities were not increased substantially as a result of gettering. Additional effects observed during this study include a change in the accelerated deuterium species concentrations, loss of gettering activity and arc operation, and a change in arc performance from arc chamber gas absorption during operation

Thermal Resonance in Signal Transmission

We use temperature tuning to control signal propagation in simple one-dimensional arrays of masses connected by hard anharmonic springs and with no local potentials. In our numerical model a sustained signal is applied at one site of a chain immersed in a thermal environment and the signal-to-noise ratio is measured at each oscillator. We show that raising the temperature can lead to enhanced signal propagation along the chain, resulting in thermal resonance effects akin to the resonance observed in arrays of bistable systems.Comment: To appear in Phys. Rev.

Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.

Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic approaches. Matrix metalloproteinases (MMPs) are emerging as key effectors of tissue destruction in TB but have not been comprehensively studied in plasma, nor have gender differences been investigated. We measured the plasma concentrations of MMPs in a carefully characterised, prospectively recruited clinical cohort of 380 individuals. The collagenases, MMP-1 and MMP-8, were elevated in plasma of patients with pulmonary TB relative to healthy controls, and MMP-7 (matrilysin) and MMP-9 (gelatinase B) were also increased. MMP-8 was TB-specific (p<0.001), not being elevated in symptomatic controls (symptoms suspicious of TB but active disease excluded). Plasma MMP-8 concentrations inversely correlated with body mass index. Plasma MMP-8 concentration was 1.51-fold higher in males than females with TB (p<0.05) and this difference was not due to greater disease severity in men. Gender-specific analysis of MMPs demonstrated consistent increase in MMP-1 and -8 in TB, but MMP-8 was a better discriminator for TB in men. Plasma collagenases are elevated in pulmonary TB and differ between men and women. Gender must be considered in investigation of TB immunopathology and development of novel diagnostic markers