Chapter One – An Overview of Architecture-Level Power- and Energy-Efficient Design Techniques

Power dissipation and energy consumption became the primary design constraint for almost all computer systems in the last 15 years. Both computer architects and circuit designers intent to reduce power and energy (without a performance degradation) at all design levels, as it is currently the main obstacle to continue with further scaling according to Moore's law. The aim of this survey is to provide a comprehensive overview of power- and energy-efficient “state-of-the-art” techniques. We classify techniques by component where they apply to, which is the most natural way from a designer point of view. We further divide the techniques by the component of power/energy they optimize (static or dynamic), covering in that way complete low-power design flow at the architectural level. At the end, we conclude that only a holistic approach that assumes optimizations at all design levels can lead to significant savings.Peer ReviewedPostprint (published version

Psychometric properties and validation of the Spanish versions of the overall anxiety and depression severity and impairment scales

Background: Anxiety and depressive disorders are the most frequent disorders for which patients seek care in public health settings in Spain. This study aimed at validating the Overall Anxiety Severity and Impairment Scale (OASIS) and the Overall Depression Severity and Impairment Scale (ODSIS), which are brief screening scales for anxiety and depression consisting of only five items each. Methods: The study was conducted in a Spanish clinical sample receiving outpatient mental health treatment (N = 339). A subsample of participants (n = 219) was assessed before and after receiving a course of cognitive-behavioral treatment. Results: The results revealed excellent internal consistency estimates (Cronbach's alpha for the OASIS and the ODSIS was 0.87 and 0.94, respectively), along with promising convergent and discriminant validity and test-criterion relationships (i.e., moderate correlation with other measures of depression and anxiety, as well as with neuroticism, quality of life, adjustment, and negative affect). A one-dimensional structure was obtained for the OASIS and the ODSIS. The ROC analyses indicated an area under the curve of 0.83 for the OASIS and the ODSIS when predicting moderate-to-severe anxiety and depression, respectively. Good sensitivity to therapeutic change was also evidence and the analysis of the sensitivity as a function of 1-specificity area suggested a cutoff value of 10 for both scales. Limitations: Inter-rater reliability of diagnoses with the ADIS-IV interview could not be investigated and the results obtained may not be generalizable to other samples and health settings. Conclusions: The availability of these two short and psychometrically sound measures should make screening of anxiety and depressive symptoms in routine care more feasible

Opipramol inhibits lipolysis in human adipocytes without altering glucose uptake and differently from antipsychotic and antidepressant drugs with adverse effects on body weight control

Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to hyperphagia and direct peripheral impairment of fat cell lipolysis. Several investigations have reproduced in vitro direct actions of antipsychotics on rodent adipocytes, cultured preadipocytes, or human adipose tissue-derived stem cells. However, to our knowledge, no such direct action has been described in human mature adipocytes. The aim of the present study was to compare in human adipocytes the putative direct alterations of lipolysis by antipsychotics (haloperidol, olanzapine, ziprazidone, risperidone), antidepressants (pargyline, phenelzine), or anxiolytics (opipramol). Lipolytic responses to the tested drugs, and to recognized lipolytic (e.g., isoprenaline) or antilipolytic agents (e.g., insulin) were determined, together with glucose transport and amine oxidase activities in abdominal subcutaneous adipocytes from individuals undergoing plastic surgery. None of the tested drugs were lipolytic. Surprisingly, only opipramol exhibited substantial antilipolytic properties in the micromolar to millimolar range. An opipramol antilipolytic effect was evident against isoprenaline-, forskolin-, or atrial natriuretic peptide-stimulated lipolysis. Opipramol did not impair insulin activation of glucose transport but inhibited monoamine oxidase (MAO) activity to the same extent as antidepressants recognized as MAO inhibitors (pargyline, harmine, or phenelzine), whereas antipsychotics were inefficient. Considering its unique properties, opipramol, which is not associated with weight gain in treated patients, is a good candidate for drug repurposing because it limits exaggerated lipolysis, prevents hydrogen peroxide release by amine oxidases in adipocytes, and is thereby of potential use to limit lipotoxicity and oxidative stress, two deleterious complications of diabetes and obesity

Psychometric properties and validation of the Spanish versions of the overall anxiety and depression severity and impairment scales

Background Anxiety and depressive disorders are the most frequent disorders for which patients seek care in public health settings in Spain. This study aimed at validating the Overall Anxiety Severity and Impairment Scale (OASIS) and the Overall Depression Severity and Impairment Scale (ODSIS), which are brief screening scales for anxiety and depression consisting of only five items each. Methods The study was conducted in a Spanish clinical sample receiving outpatient mental health treatment (N = 339). A subsample of participants (n = 219) was assessed before and after receiving a course of cognitive-behavioral treatment. Results The results revealed excellent internal consistency estimates (Cronbach's alpha for the OASIS and the ODSIS was 0.87 and 0.94, respectively), along with promising convergent and discriminant validity and test-criterion relationships (i.e., moderate correlation with other measures of depression and anxiety, as well as with neuroticism, quality of life, adjustment, and negative affect). A one-dimensional structure was obtained for the OASIS and the ODSIS. The ROC analyses indicated an area under the curve of 0.83 for the OASIS and the ODSIS when predicting moderate-to-severe anxiety and depression, respectively. Good sensitivity to therapeutic change was also evidence and the analysis of the sensitivity as a function of 1-specificity area suggested a cutoff value of 10 for both scales. Limitations Inter-rater reliability of diagnoses with the ADIS-IV interview could not be investigated and the results obtained may not be generalizable to other samples and health settings. Conclusions The availability of these two short and psychometrically sound measures should make screening of anxiety and depressive symptoms in routine care more feasible

Self-energy of image states on copper surfaces

We report extensive calculations of the imaginary part of the electron self-energy in the vicinity of the (100) and (111) surfaces of Cu. The quasiparticle self-energy is computed by going beyond a free-electron description of the metal surface, either within the GW approximation of many-body theory or with inclusion, within the GW$\Gamma$ approximation, of short-range exchange-correlation effects. Calculations of the decay rate of the first three image states on Cu(100) and the first image state on Cu(111) are also reported, and the impact of both band structure and many-body effects on the electron relaxation process is discussed.Comment: 8 pages, 5 figures, to appear in Phys. Rev.

An Assessment of Students’ Satisfaction in Higher Education

Student’s Satisfaction (SS) with a particular subject may impact the learning process, being the figure of attentiveness of the utmost importance over time, and also a very difficult undertaking to accomplish. To go forward with such exercise, a workable methodology for problem solving had to be built and tested. It is based on a thermodynamic approach to Knowledge Representation and Reasoning, which is the ultimate goal of SS assessment when working on a particular topic

Permanencia y graduación, reto de la educación superior frente a la calidad académica

En el contexto del sistema de aseguramiento de la calidad en la educaciónsuperior en Colombia, se hace referencia a las acciones que las institucionesrealizan en relación al tiempo de permanencia y graduación de los estudiantes.En este aspecto el Ministerio de Educación Nacional (2006) resalta que lasInstituciones de Educación Superior (IES) deben esforzarse por llevar acciones no sólo para el ingreso de los nuevos estudiantes sino también para que éstos culminen exitosamente sus estudios. Este artículo presenta un análisis de los resultados producto de la investigación que como acción UNISANGIL plantea para identificar los factores que están asociados al incumplimiento de la duración prevista para el proceso de la formación de sus programas y el desarrollo de estrategias que permitan disminuir la alta permanencia de los estudiantes en la institución sin culminar sus estudios de pregrado. La investigación se lleva a cabo con el programa de Tecnología en Gestión de Empresas de Economía Solidaria a Distancia de la sede San Gil. La metodología aplicada parte de identificación de variables dependientes e independientes en relación con el tiempo de duración del programa y aquellas que influyen en ese tiempo de permanencia; para el análisis y la aplicación de la información y de correlación de las variables se aplicó el software Statgraphics Plus; se obtuvo como resultado que las variables que tienen mayor incidencia para que los estudiantes de la Tecnología en Gestión de Empresas de Economía Solidaria de UNISANGIL se gradúen en el tiempo previsto son apoyo financiero, modalidad de práctica empresarial y promedio de asignaturas cursadas por semestre

Perinatal depression in the Spanish context: consensus report from the general council of psychology of Spain

Background: Perinatal depression is a major public health problem, with an estimated prevalence of approximately 15% during the first postpartum year. Despite the high prevalence of postpartum depression, there is no consensus regarding assessment and treatment in the Spanish context. The General Council of Psychology of Spain convened a working group of experts in the field, including both academics and healthcare professionals, to review and propose recommendations based on evidence and best practices that could be applied in the Spanish context. Method: A literature search was completed in various databases (e.g., Medline, PsychInfo) including a combination of terms related to peripartum depression (PPD) assessment and diagnosis, prevention, treatment, and cost-effectiveness. A narrative synthesis of the literature has been conducted together with a critical overview of PPD with a special focus on the Spanish context. Results: In this consensus report, developing questions including prevalence and assessment tools, comparative effectiveness of preventive and treatment interventions, and cost-effectiveness of PPD management have been analyzed. Conclusions: The General Council of Psychology of Spain network advocates the establishment of compulsory screening protocols in all the autonomous regions. Also, it is necessary to promote the inclusion in maternal education of programs for the promotion of mental well-being and selective/indicated prevention carried out by a psychology professional with specialized training in the area. This consensus document also promotes the presence of a psychology professional with specialized training in the area. Antecedentes. La depresión perinatal es un importante problema de salud pública, con una prevalencia estimada de aproximadamente el 15% durante el primer año posparto. A pesar de la gran prevalencia de depresión posparto (DPP), no existe consenso sobre la evaluación y el tratamiento en el contexto español. El Consejo General de Psicología de España convocó a un grupo de trabajo de expertos en la materia, tanto académicos como profesionales sanitarios, para revisar y proponer recomendaciones basadas en evidencias y mejores prácticas que puedan aplicarse en el contexto español. Método. Se realizó una búsqueda bibliográfica en varias bases de datos (p. ej., Medline, PsychInfo) que incluía una combinación de términos relacionados con la evaluación y el diagnóstico de la DPP, prevención, tratamiento y coste-eficacia. Se ha realizado una síntesis narrativa de la literatura junto con una visión crítica de la DPP con un enfoque especial en el contexto español. Resultados. Las preguntas de desarrollo que incluyen prevalencia y herramientas de evaluación, la eficacia comparativa de las intervenciones preventivas y de tratamiento y la relación coste-efectividad de la gestión de la PPD se han analizado en este informe de consenso. Conclusiones. La red del Consejo General de Psicología de España aboga por el establecimiento de protocolos obligatorios de cribado en todas las Comunidades Autónomas. Asimismo, es necesario promover la inclusión en la educación materna de programas de promoción del bienestar mental y la prevención selectiva indicada llevadas a cabo por un profesional de la psicología con formación especializada en el área

The effects of sample position and gas flow pattern on the sintering of a 7xxx aluminum alloy

The effects of sample position and gas flow pattern on the sintering of a 7xxx aluminum alloy Al-7Zn-2.5Mg-1Cu in flowing nitrogen have been investigated both experimentally and numerically. The near-surface pore distribution and sintered density of the samples show a strong dependency on the sample separation distance over the range from 2 mm to 40 mm. The open porosity in each sample increases with increasing separation distance while the closed porosity remains essentially unchanged. A two-dimensional computational fluid dynamics (CFD) model has been developed to analyze the gas flow behavior near the sample surfaces during isothermal sintering. The streamlines, velocity profile, and volume flow rate in the cavity between each two samples are presented as a function of the sample separation distance at a fixed nitrogen flow rate of 6 L/min. The CFD modeling results provide essential details for understanding the near-surface pore distribution and density of the sintered samples. It is proposed that the different gas flow patterns near the sample surfaces result in variations of the oxygen content from the incoming nitrogen flow in the local sintering atmosphere, which affects the self-gettering process of the aluminum compacts during sintering. This leads to the development of different near-surface pore distributions and sintered densities