Coherent Pion Radiation From Nucleon Antinucleon Annihilation

A unified picture of nucleon antinucleon annihilation into pions emerges from a classical description of the pion wave produced in annihilation and the subsequent quantization of that wave as a coherent state. When the constraints of energy-momentum and iso-spin conservation are imposed on the coherent state, the pion number distribution and charge ratios are found to be in excellent agreement with experiment.Comment: LaTex, 8 text pages, 1 PostScript figure, PSI-PR-93-2

NUDT2 initiates viral RNA degradation by removal of 5′-phosphates.

While viral replication processes are largely understood, comparably little is known on cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5 '-triphosphate (PPP-) group that impairs degradation by the canonical 5 '-3 ' degradation pathway. Here we show that the Nudix hydrolase 2 (NUDT2) trims viral PPP-RNA into monophosphorylated (P)-RNA, which serves as a substrate for the 5 '-3 ' exonuclease XRN1. NUDT2 removes 5 '-phosphates from PPP-RNA in an RNA sequence- and overhang-independent manner and its ablation in cells increases growth of PPP-RNA viruses, suggesting an involvement in antiviral immunity. NUDT2 is highly homologous to bacterial RNA pyrophosphatase H (RppH), a protein involved in the metabolism of bacterial mRNA, which is 5 '-tri- or diphosphorylated. Our results show a conserved function between bacterial RppH and mammalian NUDT2, indicating that the function may have adapted from a protein responsible for RNA turnover in bacteria into a protein involved in the immune defense in mammals. RNA of some viruses is protected from degradation by a 5 ' triphosphate group. Here the authors identify nudix hydrolase 2 (NUDT2) as novel antiviral defense protein that dephosphorylates viral RNA and thereby enables its degradation.We thank the core facility of the MPI of biochemistry for support

Spin density matrix of the ω in the reaction p¯p→ωπ0

The spin density matrix of the ω has been determined for the reaction p¯p→ωπ0 with unpolarized in-flight data measured by the Crystal Barrel LEAR experiment at CERN. The two main decay modes of the ω into π0γ and π+π-π0 have been separately analyzed for various p¯ momenta between 600 and 1940 MeV/c. The results obtained with the usual method by extracting the matrix elements via the ω decay angular distributions and with the more sophisticated method via a full partial wave analysis are in good agreement. A strong spin alignment of the ω is clearly visible in this energy regime and all individual spin density matrix elements exhibit an oscillatory dependence on the production angle. In addition, the largest contributing orbital angular momentum of the p¯p system has been identified for the different beam momenta. It increases from Lp¯pmax = 2 at 600 MeV/c to Lp¯pmax = 5 at 1940 MeV/c

Astrocytic Ca2+ Waves Guide CNS Growth Cones to Remote Regions of Neuronal Activity

Activity plays a critical role in network formation during developmental, experience-dependent, and injury related remodeling. Here we report a mechanism by which axon trajectory can be altered in response to remote neuronal activity. Using photoconductive stimulation to trigger high frequency action potentials in rat hippocampal neurons in vitro, we find that activity functions as an attractive cue for growth cones in the local environment. The underlying guidance mechanism involves astrocyte Ca2+ waves, as the connexin-43 antagonist carbenoxolone abolishes the attraction when activity is initiated at a distance greater than 120 µm. The asymmetric growth cone filopodia extension that precedes turning can be blocked with CNQX (10 µM), but not with the ATP and adenosine receptor antagonists suramin (100 µM) and alloxazine (4 µM), suggesting non-NMDA glutamate receptors on the growth cone mediate the interaction with astrocytes. These results define a potential long-range signalling pathway for activity-dependent axon guidance in which growth cones turn towards directional, temporally coordinated astrocyte Ca2+ waves that are triggered by neuronal activity. To assess the viability of the guidance effect in an injury paradigm, we performed the assay in the presence of conditioned media from lipopolysaccharide (LPS) activated purified microglial cultures, as well as directly activating the glia present in our co-cultures. Growth cone attraction was not inhibited under these conditions, suggesting this mechanism could be used to guide regeneration following axonal injury

Personalized Feedback on Staff Dose in Fluoroscopy-Guided Interventions: A New Era in Radiation Dose Monitoring

Radiation safety and protection are a key component of fluoroscopy-guided interventions. We hypothesize that providing weekly personal dose feedback will increase radiation awareness and ultimately will lead to optimized behavior. Therefore, we designed and implemented a personalized feedback of procedure and personal doses for medical staff involved in fluoroscopy-guided interventions. Medical staff (physicians and technicians, n = 27) involved in fluoroscopy-guided interventions were equipped with electronic personal dose meters (PDMs). Procedure dose data including the dose area product and effective doses from PDMs were prospectively monitored for each consecutive procedure over an 8-month period (n = 1082). A personalized feedback form was designed displaying for each staff individually the personal dose per procedure, as well as relative and cumulative doses. This study consisted of two phases: (1) 1-5th months: Staff did not receive feedback (n = 701) and (2) 6-8th months: Staff received weekly individual dose feedback (n = 381). An anonymous evaluation was performed on the feedback and occupational dose. Personalized feedback was scored valuable by 76% of the staff and increased radiation dose awareness for 71%. 57 and 52% reported an increased feeling of occupational safety and changing their behavior because of personalized feedback, respectively. For technicians, the normalized dose was significantly lower in the feedback phase compared to the prefeedback phase: [median (IQR) normalized dose (phase 1) 0.12 (0.04-0.50) A mu Sv/Gy cm(2) versus (phase 2) 0.08 (0.02-0.24) A mu Sv/Gy cm(2), p = 0.002]. Personalized dose feedback increases radiation awareness and safety and can be provided to staff involved in fluoroscopy-guided interventions

Flavor Production in Pb(160AGeV) on Pb Collisions: Effect of Color Ropes and Hadronic Rescattering

Collective interactions in the preequilibrium quark matter and hadronic resonance gas stage of ultrarelativistic nucleus-nucleus collisions are studied in the framework of the the transport theoretical approach RQMD. The paper reviews string fusion into color ropes and hadronic rescattering which serve as models for these interactions. Hadron production in central Pb(160AGeV) on Pb collisions has been calculated. The changes of the final flavor composition are more pronounced than in previous RQMD studies of light ion induced reactions at 200AGeV. The ratio of created quark pairs $s\bar{s}$/($u\bar{u}$+$d\bar{d}$) is enhanced by a factor of 2.4 in comparison to $pp$ results. Color rope formation increases the initially produced antibaryons to 3 times the value in the `NN mode', but only one quarter of the produced antibaryons survives because of subsequent strong absorption. The differences in the final particle composition for Pb on Pb collisions compared to S induced reactions are attributed to the hadronic resonance gas stage which is baryon-richer and lasts longer.Comment: 60 pages + 11 postscript figures (uuencoded and included

Untersuchungen zur Nukleon-Antinukleon-Wechselwirkung

Available from TIB Hannover: DW 3017 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Un outil peu connu mais efficient au service du principe ALARA : ISOE (Information System on Occupational Exposure)

An efficient but little known tool for the application of the ALARA principle: ISOE (Information System on Occupational Exposure). The Information System on Occupational Exposure to ionizing radiation (ISOE) is a program launched by the Nuclear Energy Agency (NEA) in 1992. It was developed to address the needs of nuclear power plants and safety authorities as a comparison and information tool on practices in terms of optimization (ALARA principle), in NEA member countries. To date, more than 90% of the operating nuclear power plants in the world are participating in this program, which is organized in a decentralized form, with a steering group and four technical centers (Europe, Asia, north America and IAEA). The ISOE program includes an occupational exposure database and an information exchange and communication network. The databases permit the preparation of studies and comparisons of practices, either in a factual or analytical way. Thus, the ISOE program favors exchanges to the benefit of all participants and helps to bring operational radiation protection ever closer towards the "achievable" of ALARA