High Performance Work Systems: A Necessity for Startups

New businesses are an important part of any economy, yet the key elements to achieve startup success are often unclear or up for debate. Attracting, selecting, and training employees are often critical activities for most startups. Research suggests that high performance work systems (i.e., a bundle of human resource practices) enhance organizational performance. However, we posit that most startups lack these systems at the onset, yet with minimal effort can establish a system to improve their likelihood of meeting their goals, enhancing capabilities, and ensuring long-term survival.

Rocket Testing and Integrated System Health Management

Integrated System Health Management (ISHM) describes a set of system capabilities that in aggregate perform: determination of condition for each system element, detection of anomalies, diagnosis of causes for anomalies, and prognostics for future anomalies and system behavior. The ISHM should also provide operators with situational awareness of the system by integrating contextual and timely data, information, and knowledge (DIaK) as needed. ISHM capabilities can be implemented using a variety of technologies and tools. This chapter provides an overview of ISHM contributing technologies and describes in further detail a novel implementation architecture along with associated taxonomy, ontology, and standards. The operational ISHM testbed is based on a subsystem of a rocket engine test stand. Such test stands contain many elements that are common to manufacturing systems, and thereby serve to illustrate the potential benefits and methodologies of the ISHM approach for intelligent manufacturing

Evaluation of a Conversation Management Toolkit for Multi Agent Programming

The Agent Conversation Reasoning Engine (ACRE) is intended to aid agent developers to improve the management and reliability of agent communication. To evaluate its effectiveness, a problem scenario was created that could be used to compare code written with and without the use of ACRE by groups of test subjects. This paper describes the requirements that the evaluation scenario was intended to meet and how these motivated the design of the problem. Two experiments were conducted with two separate sets of students and their solutions were analysed using a combination of simple objective metrics and subjective analysis. The analysis suggested that ACRE by default prevents some common problems arising that would limit the reliability and extensibility of conversation-handling code. As ACRE has to date been integrated only with the Agent Factory multi agent framework, it was necessary to verify that the problems identified are not unique to that platform. Thus a comparison was made with best practice communication code written for the Jason platform, in order to demonstrate the wider applicability of a system such as ACRE.Comment: appears as Programming Multi-Agent Systems - 10th International Workshop, ProMAS 2012, Valencia, Spain, June 5, 2012, Revised Selected Paper

Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building.

A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and model fitness evaluation to a single-objective, hybrid genetic algorithm for global optimization of the model structure. In this study, the generalizability of this approach for pharmacokinetic model building is evaluated by comparing (1) correct and spurious covariate relationships in a simulated dataset resulting from automated stepwise covariate modeling, Lasso methods, and single-objective hybrid genetic algorithm approaches to covariate identification and (2) information criteria values, model structures, convergence, and model parameter values resulting from manual stepwise versus single-objective, hybrid genetic algorithm approaches to model building for seven compounds. Both manual stepwise and single-objective, hybrid genetic algorithm approaches to model building were applied, blinded to the results of the other approach, for selection of the compartment structure as well as inclusion and model form of inter-individual and inter-occasion variability, residual error, and covariates from a common set of model options. For the simulated dataset, stepwise covariate modeling identified three of four true covariates and two spurious covariates; Lasso identified two of four true and 0 spurious covariates; and the single-objective, hybrid genetic algorithm identified three of four true covariates and one spurious covariate. For the clinical datasets, the Akaike information criterion was a median of 22.3 points lower (range of 470.5 point decrease to 0.1 point decrease) for the best single-objective hybrid genetic-algorithm candidate model versus the final manual stepwise model: the Akaike information criterion was lower by greater than 10 points for four compounds and differed by less than 10 points for three compounds. The root mean squared error and absolute mean prediction error of the best single-objective hybrid genetic algorithm candidates were a median of 0.2 points higher (range of 38.9 point decrease to 27.3 point increase) and 0.02 points lower (range of 0.98 point decrease to 0.74 point increase), respectively, than that of the final stepwise models. In addition, the best single-objective, hybrid genetic algorithm candidate models had successful convergence and covariance steps for each compound, used the same compartment structure as the manual stepwise approach for 6 of 7 (86 %) compounds, and identified 54 % (7 of 13) of covariates included by the manual stepwise approach and 16 covariate relationships not included by manual stepwise models. The model parameter values between the final manual stepwise and best single-objective, hybrid genetic algorithm models differed by a median of 26.7 % (q₁ = 4.9 % and q₃ = 57.1 %). Finally, the single-objective, hybrid genetic algorithm approach was able to identify models capable of estimating absorption rate parameters for four compounds that the manual stepwise approach did not identify. The single-objective, hybrid genetic algorithm represents a general pharmacokinetic model building methodology whose ability to rapidly search the feasible solution space leads to nearly equivalent or superior model fits to pharmacokinetic data

A quasi-diagonal approach to the estimation of Lyapunov spectra for spatio-temporal systems from multivariate time series

We describe methods of estimating the entire Lyapunov spectrum of a spatially extended system from multivariate time-series observations. Provided that the coupling in the system is short range, the Jacobian has a banded structure and can be estimated using spatially localised reconstructions in low embedding dimensions. This circumvents the ``curse of dimensionality'' that prevents the accurate reconstruction of high-dimensional dynamics from observed time series. The technique is illustrated using coupled map lattices as prototype models for spatio-temporal chaos and is found to work even when the coupling is not strictly local but only exponentially decaying.Comment: 13 pages, LaTeX (RevTeX), 13 Postscript figs, to be submitted to Phys.Rev.

Platforming Equality: Policy Challenges for the Digital Economy

This is the final version. Available from Autonomy via the link in this recordWelcome to Autonomy’s ‘Platforming Equality’ document: a collection of papers on the challenges that the digital economy poses to policymakers, activists and researchers. We’ve invited a range of contributors to probe deeper into under-examined topics in the digital economy and to shed light on how they operate. Another aim of the collection is to explore policy options for alleviating a range of new challenges that have emerged within the digital economy. Contributors move beyond theoretical discussion of the problems themselves and turn towards an analysis of responses that are open to activists, municipal authorities and government policy makers. Articles suggest a range of policy recommendations and discuss the strengths and weaknesses of different approaches. Each contributor examines a specific issue based on their own research and an analysis of the existing literature. They then provide their own perspective on the policies and approaches that would be most suitable to tackling the issue