Force Eruption of Mandibular Second Incisor in an 11- Year Old Boy: A Technical Report

There is a great challenge in the treatment of deeply fractured and un-restorable teeth among dentists. Orthodontic force eruption is a method of treatment for these teeth to preserve natural root system and periodontal structures. This technical report is a new modification of this procedure presented in an 11- year old boy with deeply fractured left second mandibular incisor. The fractured teeth were treated with root canal therapy and a file #80 was modified to become a hook cemented into the fractured tooth. Anterior teeth were splinted and used as anchorage to help the root extrusion. 1-year follow up of the tooth showed the convenience of the treatment. This simple and low-cost method can be an acceptable alternative to the current high cost techniques, achieving the same results

5-Meth­oxy-1-(3,4,5-trimethoxy­phen­yl)-1H-indole

The title compound, C18H19NO4, was prepared as an indole derivative with possible anti­mitotic properties. The planes of the indole and trimethoxy­phenyl rings make a dihedral angle of 45.35 (5)° with one another. In the crystal, mol­ecules related by a twofold screw axis exhibit arene C—H⋯arene-π inter­actions which are 3.035 (1) Å in length

Methyl 5,6-dimeth­oxy-1H-indole-2-carboxyl­ate

The title compound, C12H13NO4, was prepared as a precursor to an indole derivative with possible anti­mitotic properties. The mol­ecule is very nearly planar; the maximum deviation of any non-H atom from the mean plane of the indole ring is 0.120 (3) Å for each of two meth­oxy C atoms. The pairs of mol­ecules related by the inversion centre at (0,0,) are connected by two symmetry-equivalent N—H⋯O hydrogen bonds, while the pairs of mol­ecules related by the inversion centre at (0,0,0) exhibit a π-stacking inter­action of the indole rings, with an inter­planar separation of 3.39 (3) Å

Outcomes of Adult Patients with Small Body Size Supported with a Continuous-Flow Left Ventricular Assist Device

There is insufficient data on patients with small body size to determine if this should be considered a risk factor for continuous-flow left ventricular assist device (CF-LVAD) support. We sought to evaluate survival outcomes, adverse events, and functional status of CF-LVAD patients with body surface area (BSA) <1.5 m2 in a large national registry. Adults with BSA < 1.5 m2 (n = 128) implanted with a HeartMate II (HMII)-LVAD from the Interagency Registry for Mechanically Assisted Circulatory Support registry from April 2008 to December 2012 formed this cohort. Outcomes were compared with HMII bridge to transplant (BTT) and destination therapy (DT) post approval studies. The majority of patients were female (n = 106, 83%). A total of 64% (n = 82) were implanted for BTT and 36% (n = 46) for DT. The median BSA (range) was 1.44 (1.19–1.49) and 1.45 (1.25–1.49) m2 for BTT and DT, respectively. Overall survival 1 year post implant was 81% ± 5% for BTT and 84% ± 6% for DT. The most common adverse events for BTT and DT patients were bleeding (0.91, 0.88 events/patient year) and driveline infection (16%, 0.28 events/patient year). Six months post implantation, 87% of BTT and 77% of DT patients were New York Heart Association functional class I or II. Post implant survival, functional status improvement, and adverse event profile for adult BTT and DT HMII patients with BSA < 1.5 m2 are favorable and comparable with outcomes published in the overall patient population

Preliminary Mean-line Design and Optimization of a Radial Turbo-Expander for Waste Heat Recovery Using Organic Rankine Cycle

AbstractThis study presents an optimized modelling approach for ORC based on radial turbo-expander, where the constant expander efficiency is replaced by dynamic efficiency and is unique for each set of cycle operating conditions and working fluid properties. The model was used to identify the key variables that have significant effects on the turbine overall size. These parameters are then included in the optimization process using genetic algorithm to minimize the turbine overall size for six organic fluids. Results showed that, dynamic efficiency approach predicted considerable differences in the turbine efficiencies of various working fluids at different operating conditions with the maximum difference of 7.3% predicted between the turbine efficiencies of n-pentane and R245fa. Also, the optimization results predicted that minimum turbine overall size was achieved by R236fa with the value of 0.0576m. Such results highlight the potential of the optimized modeling technique to further improve the performance estimation of ORC and minimize the size

Improving Aviation Safety through Modeling Accident Risk Assessment of Runway

The exponential increase in aviation activity and air traffic in recent decades has raised several public health issues. One of the critical public health concerns is runway safety and the increasing demand for airports without accidents. In addition to threatening human lives, runway accidents are often associated with severe environmental and pollution consequences. In this study, a three-step approach is used for runway risk assessment considering probability, location, and consequences of accidents through advanced statistical methods. This study proposes novel models for the implementation of these three steps in Iran. Data on runway excursion accidents were collected from several countries with similar air accident rates. The proposed models empower engineers to advance an accurate assessment of the accident probability and safety assessment of airports. For in-service airports, it is possible to assess existing runways to remove obstacles close to runways if necessary. Also, the proposed models can be used for preliminary evaluations of developing existing airports and the construction of new runways. Document type: Articl

Feasibility and efficacy of bypassing the right ventricle and pulmonary circulation to treat right ventricular failure: an experimental study

<p>Abstract</p> <p>Background</p> <p>Right ventricular failure (RVF) and -support is associated with poor results. We aimed for a new approach of right - sided assistance bypassing the right ventricle and pulmonary circulation in order to better decompress the right ventricle and optimize left ventricular filling.</p> <p>Methods</p> <p>From a microaxial pump (Abiomed), a low resistance oxygenator (Maquet and Novalung) and two cannulas (28 and 27 Fr) a system was set up and evaluated in an ovine model (n = 7). Connection with the heart was the right and left atrium. One hour the system was operated without RVF and turned of again. Then a RVF was induced and the course with the system running was evaluated. Complete hemodynamic monitoring was performed as well as echocardiography, flow measurement and blood gas analysis.</p> <p>Results</p> <p>The overall performance of the system was reliable. Without RVF no relevant changes of hemodynamics occurred; blood gases were supra normal. In RVF a cardiogenic shock developed (MAP 35 ± 13 mmHg, CO 1,1 ± 0,7 l/min). Immediately after starting the system the circulation normalized (significant increase of MAP to 85 ± 13 mmHg, of CO to 4,5 ± 1,9). Echocardiography also revealed right ventricular recovery. After stopping the system, RVF returned.</p> <p>Conclusions</p> <p>Bypassing the right ventricle and pulmonary circulation with an oxygenating assist device, which may offer the advantages of enhanced right ventricular decompression and augmented left atrial filling, is feasible and effective in the treatment of acute RVF. Long time experiments are needed.</p

The Distressed Brain: A Group Blind Source Separation Analysis on Tinnitus

Background: Tinnitus, the perception of a sound without an external sound source, can lead to variable amounts of distress. Methodology: In a group of tinnitus patients with variable amounts of tinnitus related distress, as measured by the Tinnitus Questionnaire (TQ), an electroencephalography (EEG) is performed, evaluating the patients ’ resting state electrical brain activity. This resting state electrical activity is compared with a control group and between patients with low (N = 30) and high distress (N = 25). The groups are homogeneous for tinnitus type, tinnitus duration or tinnitus laterality. A group blind source separation (BSS) analysis is performed using a large normative sample (N = 84), generating seven normative components to which high and low tinnitus patients are compared. A correlation analysis of the obtained normative components ’ relative power and distress is performed. Furthermore, the functional connectivity as reflected by lagged phase synchronization is analyzed between the brain areas defined by the components. Finally, a group BSS analysis on the Tinnitus group as a whole is performed. Conclusions: Tinnitus can be characterized by at least four BSS components, two of which are posterior cingulate based, one based on the subgenual anterior cingulate and one based on the parahippocampus. Only the subgenual component correlates with distress. When performed on a normative sample, group BSS reveals that distress is characterized by two anterior cingulate based components. Spectral analysis of these components demonstrates that distress in tinnitus is relate