Slow Slip Events and Time-Dependent Variations in Locking Beneath Lower Cook Inlet of the Alaska-Aleutian Subduction Zone

We identify a series of abrupt changes in GPS site velocities in Lower Cook Inlet, Alaska, in late 2004, early 2010, and late 2011. The site motions during each time period are nearly linear. The surface deformations inferred from GPS for pre-2004 and 2010–2011 are similar to each other, as are 2004–2010 and post-2011. We estimate the slip distribution on the Alaska-Aleutian subduction plate interface accounting for upper plate block rotations and interpret this toggling between two deformation patterns as caused by transient slip. We find that by allowing negative slip deficit rates (i.e., creep rates in excess of relative plate motion), the data in Lower Cook Inlet are fit significantly better during pre-2004 and 2010–2011, suggesting the occurrence of slow slip events (SSEs) there during those time periods. The earlier SSE lasted at least 9 years (observations in that area began in 1995) with Mw ~7.8. The latter SSE had almost the same area as the earlier one and a duration of ~2 years with Mw ~7.2. During 2004–2010 and post-2011, the inversions result in only positive slip deficit rates (i.e., locking) in Lower Cook Inlet. Slip rates are nearly constant during the Lower Cook Inlet SSEs, and the events start and stop abruptly. Both of these properties contrast with observations of SSEs in Upper Cook Inlet and elsewhere. The Lower Cook Inlet SSEs are consistent with previously proposed duration-magnitude scaling laws and demonstrate that slow slip events can last as long as a decade

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells.

Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB inhibitors have been suggested as potential therapeutic drugs for inflammatory diseases. We show here that DTCs inhibited both interleukin 2 (IL-2) synthesis and membrane expression of antigens which are induced during T-cell activation. This inhibition, which occurred with a parallel activation of c-Jun transactivating functions and expression, was reflected by transfection experiments at the IL-2 promoter level, and involved not only the inhibition of NF-kappaB-driven reporter activation but also that of nuclear factor of activated T cells (NFAT). Accordingly, electrophoretic mobility shift assays (EMSAs) indicated that pyrrolidine DTC (PDTC) prevented NF-kappaB, and NFAT DNA-binding activity in T cells stimulated with either phorbol myristate acetate plus ionophore or antibodies against the CD3-T-cell receptor complex and simultaneously activated the binding of AP-1. Furthermore, PDTC differentially targeted both NFATp and NFATc family members, inhibiting the transactivation functions of NFATp and mRNA induction of NFATc. Strikingly, Western blotting and immunocytochemical experiments indicated that PDTC promoted a transient and rapid shuttling of NFATp and NFATc, leading to their accelerated export from the nucleus of activated T cells. We propose that the activation of an NFAT kinase by PDTC could be responsible for the rapid shuttling of the NFAT, therefore transiently converting the sustained transactivation of this transcription factor that occurs during lymphocyte activation, and show that c-Jun NH2-terminal kinase (JNK) can act by directly phosphorylating NFATp. In addition, the combined inhibitory effects on NFAT and NF-KB support a potential use of DTCs as immunosuppressants

Multi-criteria evaluation method for freight logistics innovations

The objective of this study is to build up a common approach for the assessment of logistics innovations. Innovations are referred to here as best practices and are considered as existing approaches or solutions providing an answer to a relevant problem or challenge in freight transport. The impact evaluation of logistics innovations takes into account strategic targets, topics covered, transferability and novelty of the best practices. A freight specific multi-criteria analysis approach was designed for the evaluation process

The Means of an End: A Study of the Serial Endings in BLEAK HOUSE

Perhaps more so than any other writer of his era, Charles Dickens knew how to tell a story that would draw readers in and keep them wanting more. This was especially important in a novel like Bleak House, which was originally published in nineteen monthly installments between March 1852 and September 1853. This essay examines the endings of the serial numbers in Bleak House and evaluates the extent to which Dickens used these endings to propel story, heighten physical or emotional drama, and keep readers engaged. By conducting a distant reading of the text and building on existing research, I will show that when the number endings are not suspenseful, they function in other ways—most notably to promote sympathy