Effect of β-cyclodextrin on trans fats, CLA, PUFA, and phospholipids of milk fat: Method update

Peer Reviewe

Bioorthogonal catalytic activation of Platinum and Ruthenium anticancer complexes by FAD and flavoproteins

Recent advances in bioorthogonal catalysis promise to deliver new chemical tools for performing chemoselective transformations in complex biological environments. Herein, we report how FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), and four flavoproteins act as unconventional photocatalysts capable of converting PtIV and RuII complexes into potentially toxic PtII or RuII-OH2 species. In the presence of electron donors and low doses of visible light, the flavoproteins mini singlet oxygen generator (miniSOG) and NADH oxidase (NOX) catalytically activate PtIV prodrugs with bioorthogonal selectivity. In the presence of NADH, NOX catalyzes PtIV activation in the dark as well, indicating for the first time that flavoenzymes may contribute to initiating the activity of PtIV chemotherapeutic agents

Rapid probe of the nicotine spectra by high-resolution rotational spectroscopy

Nicotine has been investigated in the gas phase and two conformational forms were characterized through their rotational spectra. Two spectroscopic techniques have been used to obtain the spectra: a new design of broadband Fourier transform microwave (FTMW) spectroscopy with an in-phase/quadrature- phase-modulation passage-acquired-coherence technique (IMPACT) and narrowband FTMW spectroscopy with coaxially oriented beam-resonator arrangement (COBRA). The rotational, centrifugal distortion and hyperfine quadrupole coupling constants of two conformers of nicotine have been determined and found to be in N-methyl trans configurations with the pyridine and pyrrolidine rings perpendicular to one another. The quadrupole hyperfine structure originated by two 14N nuclei has been completely resolved for both conformers and used for their unambiguous identification. © 2011 the Owner Societies

Interaction of molecular and atomic hydrogen with (5,5) and (6,6) single-wall carbon nanotubes

Density functional theory has been used to study the interaction of molecular and atomic hydrogen with (5,5) and (6,6) single-wall carbon nanotubes. Static calculations allowing for different degrees of structural relaxation are performed, in addition to dynamical simulations. Molecular physisorption inside and outside the nanotube walls is predicted to be the most stable state of those systems. The binding energies for physisorption of the H2 molecule outside the nanotube are in the range 0.04–0.07 eV. This means that uptake and release of molecular hydrogen from nanotubes is a relatively easy process, as many experiments have proved. A chemisorption state, with the molecule dissociated and the two hydrogen atoms bonded to neighbor carbon atoms, has also been found. However, reaching this dissociative chemisorption state for an incoming molecule, or starting from the physisorbed molecule, is difficult because of the existence of a substantial activation barrier. The dissociative chemisorption deforms the tube and weakens the C-C bond. This effect can catalyze the shattering and scission of the tube by incoming hydrogen molecules with sufficient kinetic energy.This work was supported by DGESIC (Grant No. PB98-0345) and European Community (RTN-COMELCAN). We acknowledge the computational facilities provided by CESCA and CEPBA.Peer reviewe

Analytical microsystem for the spectrophotometric determination of titratable acidity in wines

info:eu-repo/semantics/publishedVersio

Coherent artifact and time-dependent polarization in amplified ultrafast erbium-doped fibre lasers

Mode-locked erbium-doped fibre lasers are ultrashort pulsed sources widely studied due to their versatility and multiple applications in the near infrared range. Here we present the experimental study of the emission of a passive mode-locked erbium-doped fibre laser with an amplification stage outside the cavity by means of Frequency Resolved Optical Gating (FROG) and spectral interferometry. Due to shot-to-shot instabilities, the FROG traces can be understood as the combination of two different traces, corresponding to the coherent artifact and the average pulse characteristics. We have modified a Principal Components Generalized Projections Algorithm, in order to make it able to retrieve efficiently both the coherent artifact and the average pulse. In addition, we study the temporal dependence of the polarization, showing that the pulses present time-dependent polarization with a stable spectral relative phase between the horizontal and vertical projections. Up to our knowledge, this is the first experimental study that shows the FROG measurements of unstable pulse trains associated with the coherent artifact and analyses the time-dependent polarization in ultrafast fibre lasers

Vulnerability and resilience of high-mountain pine forests of the Gredos range (Ávila, Spanish Central System): two thousand years of socio-ecological dynamics

RESUMEN: En este trabajo se presenta el análisis palinológico de la turbera de Pozo de la Nieve, localizada en el Parque Natural del Valle de Iruelas (Ávila), un área de alto valor sociocultural dentro de la Sierra de Gredos (Sistema Central). Con el objetivo de relacionar los cambios en el paisaje con la explotación de los recursos naturales y eventos climáticos, en primer lugar se han realizado 7 dataciones radiocarbónicas que sitúan el inicio del registro sedimentario ca. 240 cal BC. Los datos polínicos indican la existencia de un denso pinar altimontano dominado por Pinus sylvestris/nigra desde la Segunda Edad de Hierro hasta el periodo islámico. A partir del periodo cristiano las actividades antrópicas se intensifican, especialmente la ganadería en la Edad Contemporánea, lo cual conlleva la progresiva desaparición del pinar de alta montaña y el desarrollo de pastizales mediante el manejo del fuego, situación que culmina con el desarrollo del paisaje actual dominado por piornales pirófilos.ABSTRACT: We present the palynological study of Pozo de la Nieve peat bog, located in a very valuable socio-cultural placement within the Iruelas Valley Natural Park (Gredos range, Iberian Central System). We have focused in relating landscape changes to natural resources management and climatic events. Firstly, we carried out seven radiocarbon dates suggesting the origin of this record ca. 240 cal BC. The palynological data show the existence of dense high-mountain pine woodlands dominated by Pinus sylvestris/nigra from the Late Iron Age to the Muslim period. Later, from the Christian period, anthropogenic activities have intensified, especially livestock grazing in the Contemporary Age. Its consequences are the progressive disappearance of highmountain pine forests and the extension of grasslands by means of fire, which has shaped current landscape dominated by broom communities.Este trabajo ha sido financiado por el proyecto Desirè-HAR2013-43701-P (Plan Nacional I+D+I, Ministerio de Economía y Competitividad de España). Sebastián Pérez Díaz está financiado por el Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i en la modalidad Juan de la Cierva-Incorporación. Mónica Ruiz Alonso está financiada por el Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i en la modalidad Juan de la Cierva-Formación

Elogios honorificos y sublimes priuilegios de la cabeza del Serafico doctor de la Iglesia S. Buenauentura : propuestos al ... Concurso de Religiones Sagradas, Doctores, y Maestros de la Vniuersidad de Alcalà, que asistieron a la celebridad de su Translacion en el Conuento de S. Diego

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 2008Sign.: ¶\p6\s, A-B\p4\s, C\p2\sPort. con orla tip