737 research outputs found

    Unfriend?: An analysis of friendship comparing subjects’ perceptions of face-to-face versus Internet-mediated relationships

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    The purpose of this study was to find out how similar or different peoples’ perceptions are of friendships which are primarily face-to-face and those which are primarily internet mediated. It was hypothesized that, based on qualities which are shared by each respective medium, individuals would not find perceptions of face-to-face and Internet-mediated friendships to be significantly different. One hundred fifty-one undergraduate students at The University of Akron were given a survey developed from a literature review to test how important certain general friendship qualities were to their concept of each type of friendship. It was found that, while all of the qualities were found to be of some degree of importance for each type of friendship, every quality was found to be more important in face-to-face friendships. From the results of this study, it was theorized that individuals have a lower expectation of the degree to which each of the considered qualities would be fulfilled in a primarily Internet-mediated friendship than one which is primarily engaged face-to-face

    Feasibility study of inlet shock stability system of YF-12

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    The feasibility of self actuating bleed valves as a shock stabilization system in the inlet of the YF-12 is considered for vortex valves, slide valves, and poppet valves. Analytical estimation of valve performance indicates that only the slide and poppet valves located in the inlet cowl can meet the desired steady state stabilizing flows, and of the two the poppet valve is substantially faster in response to dynamic disturbances. The poppet valve is, therefore, selected as the best shock stability system for the YF-12 inlet

    On the interpretation of ionospheric resonances stimulated by Alouette I

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    Interpretation of ionospheric resonances stimulated by Alouette I - electrostatic plasma wave theory, observation of group delay, and application to ionospher

    Appointment of Counsel for Indigent Defendants

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    In-flight calibration of the Apollo 14 500 mm Hasselblad camera

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    In-flight calibration of 500-mm Hasselblad camera flown on Apollo 1

    Respiration Rates of Two Midge Species at Different Temperatures

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    Respiration values for Chironomus n. sp. ranged from 0.11 mm³ O₂ /mg/hr at 5C to 0.44 mm³ O₂. /gm/hr at 25C. The range for Chaoborus punctipennis was from 0.15 mm³ O₂ /mg/hr at 5C to 0.56 mm³ O₂ /mg/hr at 25C. These low respiratory rates allow the two species to withstand low oxygen tensions for extended periods of time. Reflecting this ability, both species attained their greatest numerical and biomass values in the profundal regions of three strip-mine lakes whose lower waters become oxygen depleted during thermal stratification

    Final Review Report to U.S. Office of Naval Research from California Institute of Technology

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    This report covers briefly the research performed under Contract Nonr 220(50) between September 1, 1963 and September 1, 1969. This con- tract was a continuation of a previous contract, Nonr 220(13), and in some cases carried through without interruption projects begun under the former contract. Equipment used under the former contract was continued under Nonr 220(50). The research was both theoretical and experimental and generally covered the following areas: Plasma wave resonances in spatially non-uniform plasmas Cyclotron and upper hybrid echo phenomena in plasmas Plasma wave echoes Cyclotron harmonic waves in plasmas Resonance cones in anisotropic plasmas Recombination radiation from forward biased p-n junctions Electro-optic effect Infrared absorption in gallium arsenide Modes in optical resonators with gain The results of the research were circulated in the form of O.N.R. Technical Reports and published articles in technical journals, lists of which appear in Sections III and IV of this report

    B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis

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    <div><p>Recent success with B cell depletion therapies has revitalized efforts to understand the pathogenic role of B cells in Multiple Sclerosis (MS). Using the adoptive transfer system of experimental autoimmune encephalomyelitis (EAE), a murine model of MS, we have previously shown that mice in which B cells are the only MHCII-expressing antigen presenting cell (APC) are susceptible to EAE. However, a reproducible delay in the day of onset of disease driven by exclusive B cell antigen presentation suggests that B cells require optimal conditions to function as APCs in EAE. In this study, we utilize an <i>in vivo</i> genetic system to conditionally and temporally regulate expression of MHCII to test the hypothesis that B cell APCs mediate attenuated and delayed neuroinflammatory T cell responses during EAE. Remarkably, induction of MHCII on B cells following the transfer of encephalitogenic CD4 T cells induced a rapid and robust form of EAE, while no change in the time to disease onset occurred for recipient mice in which MHCII is induced on a normal complement of APC subsets. Changes in CD4 T cell activation over time did not account for more rapid onset of EAE symptoms in this new B cell-mediated EAE model. Our system represents a novel model to study how the timing of pathogenic cognate interactions between lymphocytes facilitates the development of autoimmune attacks within the CNS.</p></div
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