High resolution study of associated C IV absorption systems in NGC 5548

We present the results of a careful analysis of associated absorption systems toward NGC 5548. Most of the well resolved narrow components in the associated system, defined by the Lyman alpha, C IV and N V profiles, show velocity separation similar (to within 10~\kms) to the C IV doublet splitting. We estimate the chance probability of occurrence of such pairs with velocity separation equal to C IV doublet splitting to be $6\times10^{-3}$. Thus it is more likely that most of the narrow components are line-locked with C IV doublet splitting. This will mean that the radiative acceleration plays an important role in the kinematics of the absorbing clouds. We build grids of photoionization models and estimate the radiative acceleration due to all possible bound-bound transitions. We show that the clouds producing absorption have densities less than $10^9 cm^{-3}$, and are in the outer regions of the broad emission line region (BLR). We note that the clouds which are line-locked cannot produce appreciable optical depths of O VII and O VIII, and hence cannot be responsible for the observed ionized edges, in the soft X-ray. We discuss the implications of the presence of optically thin clouds in the outer regions of the BLR to the models of broad emission lines.Comment: 21 pages, latex (aasms4 style), incluedes 4 ps figures. To appear in Astrophysical Journa

The burden of cardiovascular disease in sub-Saharan Africa

Correspondence: The burden of cardiovascular disease in sub-Saharan Africa by Anthony Mbewu

Genetic studies of Type 2 (non-insulin-dependent) diabetes mellitus: lack of association with seven genetic markers

Type 2 (non-insulin-dependent) diabetes mellitus, a disease of complex aetiology, has been reported to be nonrandomly associated with several polymorphic markers in human populations. These data, plus evidence of a high prevalence of Type 2 diabetes mellitus in American Indians and mixed populations, such as Mexican-Americans, which is only partially attributable to the prevalence of obesity in these populations, makes it imperative that the nature of such associations be clarified in relation to genetic susceptibility to Type 2 diabetes mellitus. The present paper reports the results of tests of association between Type 2 diabetes mellitus and seven polymorphic markers: the blood groups - ABO, Rhesus, Duffy and Kell (K and KP) - haptoglobin and group specific component; among Anglo and Hispanic populations in the San Luis Valley of Colorado, USA. The sample population consisted of 788 individuals of which 398 were Anglo subjects (97 Type 2 diabetes mellitus patients and 301 normal individuals) and 390 Hispanic subjects (191 Type 2 diabetes mellitus patients and 199 normal individuals). Association between Type 2 diabetes mellitus and genetic markers in patients was tested using the G2 statistic within each ethnic class using normal frequencies as a comparison. Results of the tests indicated that only the Kell blood group was significantly associated with Type 2 diabetes mellitus at a 5% level among the Anglo subjects (G2=5.16, 1df). This significant value can be explained by chance alone, if multiple comparisons are taken into account. Our tests have not shown the previously reported haptoglobin or Rhesus blood group associations seen in Mexican-Americans in San Antonio, Texas

Orbital changes, variation in solar activity and increased anthropogenic activities: controls on the Holocene flood frequency in the Lake Ledro area, Northern Italy

International audienceTwo lacustrine sediment cores from Lake Ledro in northern Italy were studied to produce chronologies of floodevents for the past 10 000 yr. For this purpose, we have developed an automatic method that objectively identifies the sedimentary imprint of river floods in the downstream lake basin. The method was based on colour data extracted from processed core photographs, and the count data were analysed to capture the flood signal. Flood frequency and reconstructed sedimentary dynamics were compared with lake-level changes and pollen inferred vegetation dynamics. The results suggest a record marked by low flood frequency during the early and middle Holocene (10 000–4500 cal BP). Only modest increases during short intervals are recorded at ca. 8000, 7500, and 7100 cal BP. After 4500–4000 cal BP, the record shows a shift toward increased flood frequency. With the exception of two short intervals around 2900–2500 and 1800–1400 cal BP, which show a slightly reduced number of floods, the trend of increasing flood frequency prevailed until the 20th century, reaching a maximum between the 16th and the 19th centuries. Brief-flood frequency increases recorded during the early and middle Holocene can be attributed to climatic oscillations. On a centennial time scale, major changes in flood frequency, such as those observed after ca. 4500/4000 and 500 cal BP, can be attributed to large-scale climatic changes such as the Neo-glacial and Little Ice Age, which are under orbital and possibly solar control. However, in the Bronze Age and during the Middle Ages and modern times, forest clearing and land use probably partially control the flood activity

A Structure for Quasars

This paper proposes a simple, empirically derived, unifying structure for the inner regions of quasars. This structure is constructed to explain the broad absorption line (BAL) regions, the narrow `associated' ultraviolet and X-ray warm absorbers (NALs); and is also found to explain the broad emission line regions (BELR), and several scattering features, including a substantial fraction of the broad X-ray Iron-K emission line, and the bi-conical extended narrow emission line region (ENLR) structures seen on large kiloparsec scales in Seyfert images. Small extensions of the model to allow luminosity dependent changes in the structure may explain the UV and X-ray Baldwin effects and the greater prevalence of obscuration in low luminosity AGN.Comment: 35 pages, including 8 color figures (figures 4abc are big). Astrophysical Journal, in press. Expanded version of conference paper astro-ph/000516

Dipolar ordering in Fe8?

We show that the low-temperature physics of molecular nanomagnets, contrary to the prevailing one-molecule picture, must be determined by the long-range magnetic ordering due to many-body dipolar interactions. The calculations here performed, using Ewald's summation, suggest a ferromagnetic ground state with a Curie temperature of about 130 mK. The energy of this state is quite close to those of an antiferromagnetic state and to a glass of frozen spin chains. The latter may be realized at finite temperature due to its high entropy.Comment: 7 pages, no figures, submitted to EP

Ab-initio density-functional lattice-dynamics studies of ice

We present the results of first-principles computational studies of the dynamical properties of hexagonal ice using both the ab-initio pseudopotential method and the full-potential augmented plane-wave method. Properties obtained using both the generalized gradient approximation (GGA) and the meta-GGA in density-functional theory are compared. The lattice-dynamical properties of the structures are obtained using a finite-difference evaluation of the dynamical matrix and force-constant matrix from atomic forces. Phonon dispersion is evaluated by the direct determination of the force-constant matrix in supercells derived from the primitive molecule unit cells with the assumption that force constants are zero beyond the second molecular nearest neighbors. The k-dependent phonon frequencies are then obtained from the force-constant matrix and dispersion relations, and the Brillouin-zone integrated density of states is evaluated. The importance of phonon dispersion in the various regions of the phonon spectra is then assessed and compared to existing neutron-scattering data. Frozen-phonon calculations are used to compare phonon frequencies evaluated in both the GGA and meta-GGA

Single star progenitors of long gamma-ray bursts I: Model grids and redshift dependent GRB rate

We present grids of massive star evolution models at four different metallicities (Z=0.004, 0.002, 0.001, 0.00001). The effects of rotation on the stellar structure and the transport of angular momentum and chemical elements through the Spruit-Tayler dynamo and rotationally induced instabilities are considered. After discussing uncertainties involved with the adopted physics, we elaborate the final fate of massive stars as a function of initial mass and spin rate, at each considered metallicity. In particular, we investigate for which initial conditions long gamma-ray bursts (GRBs) are expected to be produced in the frame of the collapsar model. Then, using an empirical spin distribution of young massive metal-poor stars and a specified metallicity-dependent history of star-formation, we compute the expected GRB rate as function of metallicity and redshift based on our stellar evolution models. The GRB production in our models is limited to metallicities of Z \lsim 0.004, with the consequence that about 50 % of all GRBs are predicted to be found at redshifts above z = 4, with most supernovae occurring at redshifts below z\simeq 2.2. The average GRB/SN ratio predicted by our model is about 1/200 globally, and 1/1250 at low redshift. Future strategies for testing the considered GRB progenitor scenario are briefly discussed.Comment: 17 pages, 10 figures, 6 tables, accpeted by A&A, corrected, reference adde

Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS)

Aim Approximately half of the participants in the Diabetes Prevention Outcomes Study (DPPOS) had diabetes after 15 years of follow-up, whereas nearly all the others remained with pre-diabetes. We examined whether formerly unexplored factors in the DPPOS coexisted with known risk factors that posed additional risk for, or protection from, diabetes as well as microvascular disease. Methods Cox proportional hazard models were used to examine predictors of diabetes. Sequential modelling procedures considered known and formerly unexplored factors. We also constructed models to determine whether the same unexplored factors that associated with progression to diabetes also predicted the prevalence of microvascular disease. Hazard ratios (HR) are per standard deviation change in the variable. Results In models adjusted for demographics and known diabetes risk factors, two formerly unknown factors were associated with risk for both diabetes and microvascular disease: number of medications taken (HR = 1.07, 95% confidence intervals (95% CI) 1.03 to 1.12 for diabetes; odds ratio (OR) = 1.10, 95% CI 1.04 to 1.16 for microvascular disease) and variability in HbA1c (HR = 1.02, 95% CI 1.01 to 1.03 for diabetes; OR = 1.06, 95% CI 1.04 to 1.09 for microvascular disease per sd). Total comorbidities increased risk for diabetes (HR = 1.10, 95% CI 1.04 to 1.16), whereas higher systolic (OR = 1.22, 95% CI 1.13 to 1.31) and diastolic (OR = 1.14, 95% CI 1.05 to 1.22) blood pressure, as well as the use of anti-hypertensives (OR = 1.41, 95% CI 1.23 to 1.62), increased risk of microvascular disease. Conclusions Several formerly unexplored factors in the DPPOS predicted additional risk for diabetes and/or microvascular disease – particularly hypertension and the use of anti-hypertensive medications – helping to explain some of the residual disease risk in participants of the DPPOS

Uptake and transport of novel amphiphilic polyelectrolyte-insulin nanocomplexes by caco-2 cells - towards oral insulin

“The original publication is available at www.springerlink.com”. Copyright SpringerPurpose: The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated. Method: Polyallylamine (PAA) (15 kDa) was grafted with palmitoyl chains (Pa) and subsequently modified with quaternary ammonium moieties (QPa). These two amphiphilic polyelectrolytes (APs) were tagged with rhodamine and their uptake by Caco-2 cells or their polyelectrolyte complexes (PECs) with fluorescein isothiocyanate-insulin (FITC-insulin) uptake were investigated using fluorescence microscopy. The integrity of the monolayer was determined by measurement of transepithelial electrical resistance (TEER). Insulin transport through Caco-2 monolayers was determined during TEER experiments. Result: Pa and insulin were co-localised in the cell membranes while QPa complexes were found within the cytoplasm. QPa complex uptake was not affected by calcium, cytochalasin D or nocodazole. Uptake was reduced by co-incubation with sodium azide, an active transport inhibitor. Both polymers opened tight junctions reversibly where the TEER values fell by up to 35 % within 30 minutes incubation with Caco-2 cells. Insulin transport through monolayers increased when QPa was used (0.27 ngmL-1 of insulin in basal compartment) compared to Pa (0.14 ngmL-1 of insulin in basal compartment) after 2 hours. Conclusion: These APs have been shown to be taken up by Caco-2 cells and reversibly open tight cell junctions. Further work is required to optimise these formulations with a view to maximising their potential to facilitate oral delivery of insulin.Peer reviewe