AC transmission system planning choosing lines from a discrete set

Transmission system planning (TSP) is a difficult nonlinear optimization problem involving non-convex quadratic terms, as well as discrete variables. We extend prior results for linear relaxations, drawing on a preliminary notional model of the power grid for the State of Florida. Realistic line choices necessitate a binary formulation, which is at the same time substantially more expensive than the mixed-integer counterpart and more accurate. In many cases, our relaxation directly generates a feasible solution; where it does not, we apply a practical load-deflation heuristic to recover strong solutions.United States. Office of Naval Research (Grant N00014-02-1-0623

The differential diagnosis of multiple personality disorder from borderline personality disorder

p. 041-046Considerable controversy surrounds the relationship between multiple personality disorder (MPD) and borderline personality disorder (BPD). Some authors argue that MPD is a variant of BPD, and most agree that the differential diagnosis of the two is often very difficult. In this article data are presented from a study comparing historical, demographic and psychological testing variables between the two groups. No statistically significant differences were found between the two groups on these variables. However, certain trends emerged which may serve as a catalyst for further research. The relationship between the disorders may be complex; clinicians may need to use more sophisticated research techniques and develop more sensitive diagnostic criteria before it is understood

Sharp Phase Change in Shape Memory Alloy Thermal Actuators for Subsea Flow Control

Gas-lifted oil wells are susceptible to failure through malfunction of gas lift valves (GLV). One failure mode occurs when the GLV check valve fails and product passes into the well annulus, potentially reaching the wellhead. This is a growing concern as offshore wells are drilled thousands of meters below the ocean floor in extreme temperature and pressure conditions and repair and monitoring become difficult. The authors have previously developed a thermally-actuated safety valve to prevent product backflow into the annulus in the event of check valve failure. The safety valve uses shape memory alloy (SMA) wires to translate a temperature change into a displacement and, based on commercially available SMA wire material properties, requires a 6°C temperature change to fully actuate. In some wells, however, check valve failure may result in less than 6°C temperature change. In this paper a new concept is developed to sharpen the austenitic phase change in SMA actuators. The concept has broad practical implications because it will allow thermally-activated devices, such as fluid control valves, to become much more precise, i.e., translating a small temperature change into a large displacement. The new concept uses the fact that SMA transition temperatures are stress dependent. By specifically controlling stress in the wire, the temperature difference required for austenitic transition can be decreased. This is achieved with a negative-differential spring — a spring that exerts a decreasing amount of force as it is displaced. The concept is tested experimentally by conductively and electrically heating SMA wires connected to a negative-differential spring. Results show a 2.9°C-5°C reductions, respectively, in the temperature difference required for austenitic transition.Chevron Corporation (MIT-Chevron University Partnership Program

Design of a Thermally-Actuated Gas Lift Safety Valve

Gas-lifted oil wells are susceptible to failure through malfunction of gas lift valve assemblies (GLV). One failure mode occurs when the GLV check valve fails and product passes into the well annulus, potentially reaching the wellhead. This is a growing concern as offshore wells are drilled thousands of meters below the ocean floor in extreme temperature and pressure conditions, and repair and monitoring become difficult. Currently no safeguard exists in the GLV to prevent product passage in the event of check valve failure. In this paper a design and operational procedures are proposed for a thermally-actuated positive-locking safety valve to seal the GLV in the event of check valve failure. A thermal model of the well and GLV system is developed and compared to well data to verify feasibility of a thermally-actuated safety valve. A 3× scale prototype safety valve is built and tested under simulated failure scenarios and well start-up scenarios. Realistic well temperatures in the range of 20C to 70C are used. Results demonstrate valve closure in response to simulated check valve failure and valve opening during simulated well start-up

Failure Mode and Sensitivity Analysis of Gas Lift Valves

Gas-lifted oil wells are susceptible to failure through malfunction of gas lift valves. This is a growing concern as offshore wells are drilled thousands of meters below the ocean floor in extreme temperature and pressure conditions and repair and monitoring become more difficult. Gas lift valves and oil well systems have been modeled but system failure modes are not well understood. In this paper a quasi-steady-state fluid-mechanical model is constructed to study failure modes and sensitivities of a gas-lifted well system including the reservoir, two-phase flow within the tubing, and gas lift valve geometry. A set of three differential algebraic equations of the system is solved to determine the system state. Gas lift valve, two-phase flow, and reservoir models are validated with well and experimental data. Sensitivity analysis is performed on the model and sensitive parameters are identified. Failure modes of the system and parameter values that lead to failure modes are identified using Monte Carlo simulation. In particular, we find that the failure mode of backflow through the gas lift valve with a leaky check valve is sensitive to small variations in several design parameters.Chevron Corporation (MIT-Chevron University Partnership Program

The relationship between Hippocampal asymmetry and working memory processing in combat-related PTSD: a monozygotic twin study

BACKGROUND: PTSD is associated with reduction in hippocampal volume and abnormalities in hippocampal function. Hippocampal asymmetry has received less attention, but potentially could indicate lateralised differences in vulnerability to trauma. The P300 event-related potential component reflects the immediate processing of significant environmental stimuli and has generators in several brain regions including the hippocampus. P300 amplitude is generally reduced in people with PTSD. METHODS: Our study examined hippocampal volume asymmetry and the relationship between hippocampal asymmetry and P300 amplitude in male monozygotic twins discordant for Vietnam combat exposure. Lateralised hippocampal volume and P300 data were obtained from 70 male participants, of whom 12 had PTSD. We were able to compare (1) combat veterans with current PTSD; (2) their non-combat-exposed co-twins; (3) combat veterans without current PTSD and (4) their non-combat-exposed co-twins. RESULTS: There were no significant differences between groups in hippocampal asymmetry. There were no group differences in performance of an auditory oddball target detection task or in P300 amplitude. There was a significant positive correlation between P300 amplitude and the magnitude of hippocampal asymmetry in participants with PTSD. CONCLUSIONS: These findings suggest that greater hippocampal asymmetry in PTSD is associated with a need to allocate more attentional resources when processing significant environmental stimuli.Timothy Hall, Cherrie Galletly, C.R. Clark, Melinda Veltmeyer, Linda J. Metzger, Mark W. Gilbertson, Scott P. Orr, Roger K. Pitman and Alexander McFarlan

Experiments in dynamic control of autonomous marine vehicles using acoustic modems

Marine robots are an increasingly attractive means for observing and monitoring in the ocean, but underwater acoustic communication (“acomms”) remains a major challenge, especially for real-time control. Packet loss occurs widely, bit rates are low, and there are significant delays. We consider here strategies for feedback control with acomms links in either the sensor-controller channel, or the controller-actuator channel. On the controller-actuator side we implement sparse packetized predictive control (S-PPC), which simultaneously addresses packet-loss and the data rate limit. For the sensor-controller channel we study a modified information filter (MIF) in a Linear Quadratic Gaussian (LQG) control scheme. Field experiments were carried out with both approaches, regulating crosstrack error in a robotic kayak using acomms. Outcomes with both the S-PPC and MIF LQG confirm that good performance is achievable.United States. Office of Naval Research (Grant N00014-09-1-0700)National Science Foundation (U.S.) (Contract CNS-1212597)Finmeccanic

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae

A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast) due to an inability to sense or repair DNA damage by topoisomerase 2 (yTop2). We describe the characterization of LS1, identified in a high throughput screen for small molecules that shorten the replicative lifespan of yeast. LS1 accelerates aging without affecting proliferative growth or viability. Genetic and biochemical criteria reveal LS1 to be a weak Top2 poison. Top2 poisons induce the accumulation of covalent Top2-linked DNA double strand breaks that, if left unrepaired, lead to genome instability and death. LS1 is toxic to cells deficient in homologous recombination, suggesting that the damage it induces is normally mitigated by genome maintenance systems. The essential roles of yTop2 in proliferating cells may come with a fitness trade-off in older cells that are less able to sense or repair yTop2-mediated DNA damage. Consistent with this idea, cells live longer when yTop2 expression levels are reduced. These results identify intrinsic yTop2-mediated DNA damage as a potentially manageable cause of aging

The choroid plexus and cerebrospinal fluid: Emerging roles in development, disease, and therapy

Although universally recognized as the source of cerebrospinal fluid (CSF), the choroid plexus (ChP) has been one of the most understudied tissues in neuroscience. The reasons for this are multiple and varied, including historical perceptions about passive and permissive roles for the ChP, experimental issues, and lack of clinical salience. However, recent work on the ChP and instructive signals in the CSF have sparked new hypotheses about how the ChP and CSF provide unexpected means for regulating nervous system structure and function in health and disease, as well as new ChP-based therapeutic approaches using pluripotent stem cell technology. This minisymposium combines new and established investigators to capture some of the newfound excitement surrounding the ChP-CSF system

Relationships Between Chemoreflex Responses, Sleep Quality, and Hematocrit in Andean Men and Women.

Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) and blunted ventilation compared to other high-altitude populations. While many Andeans develop Chronic Mountain Sickness (CMS) and excessive erythrocytosis, Hct varies markedly within Andean men and women and may be driven by individual differences in ventilatory control and/or sleep events which exacerbate hypoxemia. To test this hypothesis, we quantified relationships between resting ventilation and ventilatory chemoreflexes, sleep desaturation, breathing disturbance, and Hct in Andean men and women. Ventilatory measures were made in 109 individuals (n = 63 men; n = 46 women), and sleep measures in 45 of these participants (n = 22 men; n = 23 women). In both men and women, high Hct was associated with low daytime SpO2 (p < 0.001 and p < 0.002, respectively) and decreased sleep SpO2 (mean, nadir, and time <80%; all p < 0.02). In men, high Hct was also associated with increased end-tidal PCO2 (p < 0.009). While ventilatory responses to hypoxia and hypercapnia did not predict Hct, decreased hypoxic ventilatory responses were associated with lower daytime SpO2 in men (p < 0.01) and women (p < 0.009) and with lower nadir sleep SpO2 in women (p < 0.02). Decreased ventilatory responses to CO2 were associated with more time below 80% SpO2 during sleep in men (p < 0.05). The obstructive apnea index and apnea-hypopnea index also predicted Hct and CMS scores in men after accounting for age, BMI, and SpO2 during sleep. Finally, heart rate response to hypoxia was lower in men with higher Hct (p < 0.0001). These data support the idea that hypoventilation and decreased ventilatory sensitivity to hypoxia are associated with decreased day time and nighttime SpO2 levels that may exacerbate the stimulus for erythropoiesis in Andean men and women. However, interventional and longitudinal studies are required to establish the causal relationships between these associations