Non-linear propagation of kink waves to the solar chromosphere

Small-scale magnetic field concentrations (magnetic elements) in the quiet Sun are believed to contribute to the energy budget of the upper layers of the Sun's atmosphere, as they are observed to support a large number of MHD modes. In recent years, kink waves in magnetic elements were observed at different heights in the solar atmosphere, from the photosphere to the corona. However, the propagation of these waves has not been fully evaluated. Our aim is to investigate the propagation of kink waves in small magnetic elements in the solar atmosphere. We analysed spectropolarimetric data of high-quality and long duration of a photospheric quiet Sun region observed near the disk center with the spectropolarimeter CRISP at the Swedish Solar Telescope (SST), and complemented by simultaneous and co-spatial broad-band chromospheric observations of the same region. Our findings reveal a clear upward propagation of kink waves with frequency above $~2.6$ mHz. Moreover, the signature of a non-linear propagation process is also observed. By comparing photospheric to chromospheric power spectra, no signature of an energy dissipation is found at least at the atmospheric heights at which the data analysed originate. This implies that most of the energy carried by the kink waves (within the frequency range under study $< 17$ mHz) flows to upper layers in the Sun's atmosphere.Comment: A&A accepte

The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence

Purpose: Interleukin (IL)-8 is a proinflammatory C-X-C chemokine involved in inflammation underling cardiac diseases, primary or in comorbid condition, such diabetic cardiomyopathy (DCM). The phosphodiesterase type 5 inhibitor sildenafil can ameliorate cardiac conditions by counteracting inflammation. The study aim is to evaluate the effect of sildenafil on serum IL-8 in DCM subjects vs. placebo, and on IL-8 release in human endothelial cells (Hfaec) and peripheral blood mononuclear cells (PBMC) under inflammatory stimuli. Methods: IL-8 was quantified: in sera of (30) DCM subjects before (baseline) and after sildenafil (100&nbsp;mg/day, 3-months) vs. (16) placebo and (15) healthy subjects, by multiplatform array; in supernatants from inflammation-challenged cells after sildenafil (1&nbsp;µM), by ELISA. Results: Baseline IL-8 was higher in DCM vs. healthy subjects (149.14 ± 46.89 vs. 16.17 ± 5.38&nbsp;pg/ml, p &lt; 0.01). Sildenafil, not placebo, significantly reduced serum IL-8 (23.7 ± 5.9&nbsp;pg/ml, p &lt; 0.05 vs. baseline). Receiver operating characteristic (ROC) curve for IL-8 was 0.945 (95% confidence interval&nbsp;of 0.772 to 1.0, p &lt; 0.01), showing good capacity of discriminating the response in terms of drug-induced IL-8 decrease (sensitivity of 0.93, specificity of 0.90). Sildenafil significantly decreased IL-8 protein release by inflammation-induced Hfaec and PBMC and downregulated IL-8 mRNA in PBMC, without affecting cell number or PDE5 expression. Conclusion: Sildenafil might be suggested as potential novel pharmacological tool to control DCM progression through IL-8 targeting at systemic and cellular level

Interdisciplinary study for knowledge and dating of the San Francesco convent in Stampace, Cagliari – Italy (XIII-XXI century)

The Franciscan monastery, situated in the historic center of Cagliari (Sardinia), was founded in the thirteenth century, and transformed during the later centuries, up to the present day. The complexity of the case and the lack of objective data about its history has led us to carry out an interdisciplinary inquiry, in order to achieve a better knowledge of the building, preliminary for the drafting of a restoration project that respects all the signs that the time left. Starting from a deep examination of the indirect sources, turned out to be incomplete, the investigation continued with the execution of a survey with laser scanner and with the characterization of materials and related diseases of degradation. For the laser scanner survey we used a Faro Focus 3D, versatile and lightweight instrument that allows to perform scans with high speed point acquisition and high accuracy. For data elaboration we used the JRC 3D Reconstructor Software by the Gexcel srl. The characterization of the materials was performed on a reasoned sampling of natural and artificial materials, referring to masonry, interstitial mortars and plasters, carried out at strategic points, representative of the various phases of the construction. The samples were studied through mineralogical-petrographic methods with instrumental techniques for the analysis of component materials (OM, X-Ray diffraction). The data obtained, crossed with the results of the reconstruction of historical maps, of the examination of masonry techniques and of the analysis of pattern elements (arches, vaults, decorative elements), have facilitated stratigraphic analysis and helped to advance chronological reasoned hypothesis referring to the building. Besides, an interdisciplinary approach for the study of cultural heritage is very important to define a proper restoration and conservation intervention

Polarised kink waves in magnetic elements: evidence for chromospheric helical waves

In recent years, new high spatial resolution observations of the Sun's atmosphere have revealed the presence of a plethora of small-scale magnetic elements down to the resolution limit of the current cohort of solar telescopes (~100–120 km on the solar photosphere). These small magnetic field concentrations, due to the granular buffeting, can support and guide several magnetohydrodynamic wave modes that would eventually contribute to the energy budget of the upper layers of the atmosphere. In this work, exploiting the high spatial and temporal resolution chromospheric data acquired with the Swedish 1 m Solar Telescope, and applying the empirical mode decomposition technique to the tracking of the solar magnetic features, we analyze the perturbations of the horizontal velocity vector of a set of chromospheric magnetic elements. We find observational evidence that suggests a phase relation between the two components of the velocity vector itself, resulting in its helical motion

Far UV responsivity of commercial silicon photodetectors

Abstract Responsivity measurements have been performed on commercial silicon photodetectors in the UV range 200–400 nm. The microstrip and pixel detectors have been reverse biased in fully depleted condition (more than 25 V reverse bias) and in partially depleted condition (5 V reverse bias). We have also performed measurements in back illumination geometry, of particular interest in most industrial applications. Promising results obtained with commercial photodetectors in the UV range in terms of photocurrent stability and sensitivity open a variety of applications

Human exonuclease 1 role in response to UV irradiation

DNA damage checkpoints are surveillance mechanisms that monitor the integrity of the genome. Nucleotide excision repair (NER) is a DNA repair mechanism that cells use to remove UV-induced DNA lesions. Previous publication from our laboratory demonstrated that recognition and processing of UV-induced damage by NER is required for proper activation of checkpoint through interactions between NER proteins and checkpoint factors in yeast and human primary fibroblasts. From a two hybrid screening in yeast exonuclease 1 (Exo1) was identified as a 9-1-1 complex interactor. Exo1 is a 5\u2019-3\u2019 exonuclease and 5'-flap-endonuclease with many different roles in DNA metabolism such as meiotic and mitotic recombination, mismatch repair and telomere processing. Characterization of an exo1 yeast deleted strain has shown that this protein is involved in the early steps of UV-induced DNA damage checkpoint. In human cells EXO1 is present as two isoforms named hEXO1a and hEXO1b genetarated by alternative splicing. We are analyzing the role of EXO1 in checkpoint activation in response to UV-C damage in human cells: using siRNA against both a and b isoform of hEXO1 in G1 cells we were able to observe a defect in Chk1 and p53 phosphorylation induced by UV-C irradiation

Gallium arsenide photodetectors for imaging in the far ultraviolet region

The aim of the present work is to systematically investigate the response and stability of commercial GaAs devices in the 200–400 nm UV range with a view to establishing their potentiality in imaging devices. The irradiation results of GaAs detectors with various geometries are presented and discussed. The detectors were reverse biased in fully depleted condition and in partially depleted condition (5 V reverse bias) in order to investigate the possibilities of integration with the standard bias values of read-out-integrated circuits. The results show that fabrication technology for nondedicated devices is still immature

Impaired radial artery compliance in normotensive subjects with familial hypercholesterolemia

Hypercholesterolemia impairs arteriolar dilatation, but whether the vascular abnormalities accompanying this condition include large artery function is unknown. We addressed this issue in 13 normotensive subjects with familial hypercholesterolemia (serum cholesterol 401.6 \ub1 16.9 mg/dl, mean \ub1 S.E., FHC) and no evidence of atherosclerotic lesions, in whom radial artery (RA) diameter and blood pressure (BP) were measured beat to beat by an echotracking and a Finapres device, respectively. RA compliance (RAG) was derived from the diameter/BP relationship and expressed over the systo-diastolic BP range, both at baseline and after a 12-min brachial artery occlusion. RAC was expressed also as the area under the RAC/BP curve divided for pulse BP. Measurements included maximal forearm blood flow (plethysmography) and minimal forearm vascular resistance (FVR) which were obtained from the values following the 12-min brachial arterial occlusion. Data were collected before and after 6- and 24-month lipid lowering treatment (simvastatin 40 mg/day). Ten age-matched normotensive normocholesterolemic healthy subjects (N) served as controls. Compared to N, baseline RAC was strikingly reduced in FHC (-53.5%, P &lt; 0.01). After ischemia RAC increased significantly and markedly in N (+38.7, P &lt; 0.01), while only a modest and non-significant increase was observed in FHC. Minimal FVR was markedly higher in FHC than in N (3.5 \ub1 0.9 vs 1.6 \ub1 0.1 units, P &lt; 0.01). In FHC (7 subjects) RAC remained unchanged after 6 months of lipid lowering treatment, but increased markedly (+55.2%, P &lt; 0.05) when treatment was prolonged to 24 months. Lipid lowering treatment also reduced minimal FVR, the effect being significant bath after 6 and after 24 months. No changes in RAC and minimal FVR were seen after 6 months in controls. Thus, in subjects with a marked increase in serum cholesterol due to FHC, not only arteriolar dilatation, but also RAC and distensibility are markedly impaired. This impairment can be favourably affected by an effective lipid lowering treatment of long duration

Assessment of interatomic potentials for atomistic analysis of static and dynamic properties of screw dislocations in W

Screw dislocations in bcc metals display non-planar cores at zero temperature which result in high lattice friction and thermally activated strain rate behavior. In bcc W, electronic structure molecular statics calculations reveal a compact, non-degenerate core with an associated Peierls stress between 1.7 and 2.8 GPa. However, a full picture of the dynamic behavior of dislocations can only be gained by using more efficient atomistic simulations based on semiempirical interatomic potentials. In this paper we assess the suitability of five different potentials in terms of static properties relevant to screw dislocations in pure W. As well, we perform molecular dynamics simulations of stress-assisted glide using all five potentials to study the dynamic behavior of screw dislocations under shear stress. Dislocations are seen to display thermally-activated motion in most of the applied stress range, with a gradual transition to a viscous damping regime at high stresses. We find that one potential predicts a core transformation from compact to dissociated at finite temperature that affects the energetics of kink-pair production and impacts the mechanism of motion. We conclude that a modified embedded-atom potential achieves the best compromise in terms of static and dynamic screw dislocation properties, although at an expense of about ten-fold compared to central potentials