Breathing Spots in a Reaction-Diffusion System

A quasi-2-dimensional stationary spot in a disk-shaped chemical reactor is observed to bifurcate to an oscillating spot when a control parameter is increased beyond a critical value. Further increase of the control parameter leads to the collapse and disappearance of the spot. Analysis of a bistable activator-inhibitor model indicates that the observed behavior is a consequence of interaction of the front with the boundary near a parity breaking front bifurcation.Comment: 4 pages RevTeX, see also http://chaos.ph.utexas.edu/ and http://t7.lanl.gov/People/Aric

The first CCD photometric study of the open cluster NGC 2126

We present the first CCD photometric observations of the northern open cluster NGC 2126. Data were taken on eight nights in February and December 2002 with a total time span of ~57 hours. Almost 1000 individual V-band frames were examined to find short-period variable stars. We discovered six new variable stars, of which one is a promising candidate for an eclipsing binary with a pulsating component. Two stars were classified as delta Scuti stars and one as Algol-type eclipsing binary. Two stars are slow variables with ambiguous classification. From absolute VRI photometry we have estimated the main characteristics of the cluster: m-M=11.0+/-0.5, E(V-I)=0.4+/-0.1, E(V-R)=0.08+/-0.06 (E(B-V)=0.2+/-0.15) and d=1.3+/-0.6 kpc. Cluster membership is suggested for three variable stars from their positions on the colour-magnitude diagram.Comment: 7 pages, 10 figures, accepted for publication in A&

Age and nutritional state influence the effects of cholecystokinin on energy balance

AbstractCholecystokinin (CCK) is anorexic, irrespective whether it is applied intraperitoneally (IP) or intracerebroventricularly (ICV) in male Wistar rats. The metabolic effects depend on the route of administration: by the IP route it elicits hypothermia (presumably by type-1 receptors, CCK1R-s), while ICV administration is followed by fever-like hypermetabolism and hyperthermia via activation of CCK2R-s, which latter response seems to be most important in the postprandial (compensatory) hypermetabolism. The efficacy of the IP injected CCK varies with age: it causes strong anorexia in young adult 4 and 6-months old and again in old rats (aged 18–24months), but the middle-aged (12-month old) ones seem to be resistant to this effect. Such pattern of effects may contribute to the explanation of age-related obesity observed in middle-aged animals as well as to the aging anorexia and loss of body weight in old ones. Diet-induced obesity accelerates the appearance of CCK-resistance as well as the return of high sensitivity to CCK in further aging, while chronic calorie-restriction prevents the development of resistance, as if the speed of the age-related regulatory changes was altered by the nutritional state. The effects of ICV applied CCK also change with age: the characteristic anorexic and hypermetabolic/hyperthermic effects can be observed in young adult rats, but the effects gradually and monotonically decline with age and disappear by the old age of 24months. These disparate age-related patterns of CCK efficacy upon peripheral or central administration routes may indicate that although both peripheral and central CCKR-s exert anorexic effects, they may have dissimilar roles in the regulation of overall energy balance

Common mechanisms of placental dysfunction in preeclampsia, gestational diabetes, and COVID-19 in pregnant women

COVID-19 infection, preeclampsia and gestational diabetes mellitus in pregnancy cause similar changes in the placenta and influence development of the fetus between conception and birth in gestation. Proper uterine and placental vascularization is essential for normal fetal development. The transplacental exchange is regulated and maintained by the placental endothelium. During placental implantation, the trophoblast differentiates into two distinct layers, the inner cytotrophoblast and outer syncytiotrophoblast, which are key elements of the human placental barrier. Proinflammatory cytokines exacerbate ischemic events and create an upward spiral of an inflammatory reaction in the placenta. Placental pathology in gestational COVID-19 shows desquamation and damage of trophoblast and chronic histiocytic intervillositis. Similar lesions also occur in gestational diabetes mellitus and preeclampsia. The systemic inflammatory response of the mother, the increased inflammation in the placenta and cytokine production by placental trophoblasts should be monitored throughout pregnancy. Placental angiogenesis can be evaluated by serum vascular endothelial growth factor, Annexin A2, placental growth factor or sclerostin. Tissue damage can be assessed by measuring levels of serum lactate dehydrogenase and myeloperoxidase. Blood flow can be monitored with three-dimensional Doppler and pathological changes can be documented with paraffin-embedded tissue sections stained with hematoxylin and eosin, and electron microscope images as well as immunohistochemistry tests for vascular endothelial growth factor, placental growth factor, sclerostin and Annexin A2. The damage of maternal and fetal vascular perfusion (villitis and fibrin deposition) is a common mechanism of gestational diseases. The placenta lesions liberate anti-endothelial factors that lead to anti-angiogenic conditions and are the common mechanism of maternal placental vascular malperfusion in gestational diseases. Keywords: dysfunction, inflammation, pathology, placenta, pregnancy, vascularizatio

Forming the first planetary systems: debris around Galactic thick disc stars

The thick disc contains stars formed within the first Gyr of Galactic history, and little is known about their planetary systems. The Spitzer MIPS instrument was used to search 11 of the closest of these old low-metal stars for circumstellar debris, as a signpost that bodies at least as large as planetesimals were formed. A total of 22 thick disc stars has now been observed, after including archival data, but dust is not found in any of the systems. The data rule out a high incidence of debris among star systems from early in the Galaxy's formation. However, some stars of this very old population do host giant planets, at possibly more than the general incidence among low-metal Sun-like stars. As the Solar System contains gas giants but little cometary dust, the thick disc could host analogue systems that formed many Gyr before the Sun.Comment: accepted by MNRAS Letters; 5 pages, 4 figure

E-BOSS: an Extensive stellar BOw Shock Survey. I: Methods and First Catalogue

Context: Bow shocks are produced by many astrophysical objects where shock waves are present. Stellar bow shocks, generated by runaway stars, have been previously detected in small numbers and well-studied. Along with progress in model development and improvements in observing instruments, our knowledge of the emission produced by these objects and its origin can now be more clearly understood. Aims: We produce a stellar bow-shock catalogue by applying uniform search criteria and a systematic search process. This catalogue is a starting point for statistical studies, to help us address fundamental questions such as, for instance, the conditions under wich a stellar bow shock is detectable. Methods: By using the newest infrared data releases, we carried out a search for bow shocks produced by early-type runaway stars. We first explored whether a set of known IRAS bow shock candidates are visible in the most recently available IR data, which has much higher resolution and sensitivity. We then carried out a selection of runaway stars from the latest, large runaway catalogue available. In this first release, we focused on OB stars and searched for bow-shaped features in the vicinity of these stars. Results: We provide a bow-shock candidate survey that gathers a total of 28 members which we call the Extensive stellar BOw Shock Survey (E-BOSS). We derive the main bow-shock parameters, and present some preliminary statistical results on the detected objects. Conclusions: Our analysis of the initial sample and the newly detected objects yields a bow-shock detectability around OB stars of $\sim$ 10 per cent. The detections do not seem to depend particularly on either stellar mass, age or position. The extension of the E-BOSS sample, with upcoming IR data, and by considering, for example, other spectral types as well, will allow us to perform a more detailed study of the findings.Comment: A&A accepted (25-NOV-2011), 15 pages, 4 tables, 11 figure