Molecular Tracers of Embedded Star Formation in Ophiuchus

In this paper we analyze nine SCUBA cores in Ophiuchus using the second-lowest rotational transitions of four molecular species (12CO, 13CO, C18O, and C17O) to search for clues to the evolutionary state and star-formation activity within each core. Specifically, we look for evidence of outflows, infall, and CO depletion. The line wings in the CO spectra are used to detect outflows, spectral asymmetries in 13CO are used to determine infall characteristics, and a comparison of the dust emission (from SCUBA observations) and gas emission (from C18O) is used to determine the fractional CO freeze-out. Through comparison with Spitzer observations of protostellar sources in Ophiuchus, we discuss the usefulness of CO and its isotopologues as the sole indicators of the evolutionary state of each core. This study is an important pilot project for the JCMT Legacy Survey of the Gould Belt (GBS) and the Galactic Plane (JPS), which intend to complement the SCUBA-2 dust continuum observations with HARP observations of 12CO, 13CO, C18O, and C17O J = 3 - 2 in order to determine whether or not the cold dust clumps detected by SCUBA-2 are protostellar or starless objects. Our classification of the evolutionary state of the cores (based on molecular line maps and SCUBA observations) is in agreement with the Spitzer designation for six or seven of the nine SCUBA cores. However, several important caveats exist in the interpretation of these results, many of which large mapping surveys like the GBS may be able to overcome to provide a clearer picture of activity in crowded fields.Comment: 43 pages including 19 postscript figures. Accepted for publication in the PAS

Presynaptic Depression in Phasic Motor Nerve Terminals and Influence of 5-HT on Vesicle Dynamics

Synaptic depression that is induced by electrical stimulation of the glutamatergic neuromuscular junction (NMJ) of the crayfish can be offset by recruitment of vesicles from a presynaptic reserve pool. This recruitment occurs following treatment of the NMJ with serotonin (5-HT), which results in a delay in the onset of synaptic depression induced by high frequency stimulation. The results of this study demonstrate that the releasable vesicles are insufficiently replenished during high frequency stimulation and that the readily releasable pool of vesicles (RRP) can be enhanced by the reserve pool (RP) in the presence of 5-HT. Anatomical visualization of vesicular pools by transmission electron microscopy after depression or during 5-HT treatment showed no differences in the number of docked and RRP vesicles. We propose that the RRP vesicles can recycle empty and that a role for 5-HT might be to induce a rapid enhancement of synaptic transmission during synaptic fatigue

The effect of a strong external radiation field on protostellar envelopes in Orion

We discuss the effects of an enhanced interstellar radiation field (ISRF) on the observables of protostellar cores in the Orion cloud region. Dust radiative transfer is used to constrain the envelope physical structure by reproducing SCUBA 850 micron emission. Previously reported 13CO, C17O and H2CO line observations are reproduced through detailed Monte Carlo line radiative transfer models. It is found that the 13CO line emission is marginally optically thick and sensitive to the physical conditions in the outer envelope. An increased temperature in this region is needed in order to reproduce the 13CO line strengths and it is suggested to be caused by a strong heating from the exterior, corresponding to an ISRF in Orion 10^3 times stronger than the "standard" ISRF. The typical temperatures in the outer envelope are higher than the desorption temperature for CO. The C17O emission is less sensitive to this increased temperature but rather traces the bulk envelope material. The data are only fit by a model where CO is depleted, except in the inner and outermost regions where the temperature increases above 30-40 K. The fact that the temperatures do not drop below approximately 25 K in any of the envelopes whereas a significant fraction of CO is frozen-out suggest that the interstellar radiation field has changed through the evolution of the cores. The H2CO lines are successfully reproduced in the model of an increased ISRF with constant abundances of 3-5x10^{-10}.Comment: 11 pages, 10 figures. Accepted for publication in A&

EXPRESS: Differences in outcomes following an intensive upper-limb rehabilitation programme for patients with common CNS-acting drug prescriptions

Difficulty using the upper-limb is a major barrier to independence for many patients post-stroke or brain injury. High dose rehabilitation can result in clinically significant improvements in function even years after the incident, however there is still high variability in patient responsiveness to such interventions that cannot be explained by age, sex or time since stroke. This retrospective study investigated whether patients prescribed certain classes of CNS-acting drugs - GABA agonists, antiepileptics and antidepressants-differed in their outcomes on the 3 week intensive Queen Square Upper-Limb (QSUL) programme. For 277 stroke or brain injury patients (167 male, median age 52 years (IQR 21), median time since incident 20 months (IQR 26)) upper-limb impairment and activity was assessed at admission to the programme and at 6 months post-discharge, using the upper limb component of the Fugl-Meyer (FM), Action Research Arm Test (ARAT), and Chedoke Arm and Hand Activity Inventory (CAHAI). Drug prescriptions were obtained from primary care physicians at referral. Specification curve analysis (SCA) was used to protect against selective reporting results and add robustness to the conclusions of this retrospective study. Patients with GABA agonist prescriptions had significantly worse upper-limb scores at admission but no evidence for a significant difference in programme-induced improvements was found. Additionally, no evidence of significant differences in patients with or without antiepileptic drug prescriptions on either admission to, or improvement on, the programme was found in this study. Whereas, though no evidence was found for differences in admission scores, patients with antidepressant prescriptions experienced reduced improvement in upper-limb function, even when accounting for anxiety and depression scores.These results demonstrate that, when prescribed typically, there was no evidence that patients prescribed GABA agonists performed worse on this high-intensity rehabilitation programme. Patients prescribed antidepressants, however, performed poorer than expected on the QSUL rehabilitation programme. While the reasons for these differences are unclear, identifying these patients prior to admission may allow for better accommodation of differences in their rehabilitation needs

Probation, credibility and justice

This paper explores the difficulties that arise for probation agencies or those that deliver community sanctions in developing and maintaining their credibility in prevailing ‘late-modern’ social conditions. It begins by questioning the limits of the pursuit and promise of ‘public protection’ as a source of credibility, and then proceeds to examine the emergence of an alternative strategy – based principally on reparation and ‘payback’ – in Scotland, arguing that these Scottish developments have much to say to the emerging debates in England and Wales (and elsewhere) about the ‘rehabilitation revolution’ and the proper use of imprisonment. The paper provides a critical account of the development and meaning of the Scottish version of ‘payback’, linking it to some important philosophical and empirical studies that may help to steer the development of payback away from a ‘merely punitive’ drift. In the conclusion, I argue that probation agencies and services need to engage much more deeply and urgently with their roles as justice services, rather than as ‘mere’ crime reduction agencies

Topos theory and `neo-realist' quantum theory

Topos theory, a branch of category theory, has been proposed as mathematical basis for the formulation of physical theories. In this article, we give a brief introduction to this approach, emphasising the logical aspects. Each topos serves as a `mathematical universe' with an internal logic, which is used to assign truth-values to all propositions about a physical system. We show in detail how this works for (algebraic) quantum theory.Comment: 22 pages, no figures; contribution for Proceedings of workshop "Recent Developments in Quantum Field Theory", MPI MIS Leipzig, July 200

Waves of disruption in clean energy transitions: sociotechnical dimensions of system disruption in Germany and the United Kingdom

Academic and policy literatures are seeing a growing discussion about ‘clean energy disruption’. However, the term disruption often lacks definitional clarity. Departing from the concept of disruptive innovation and based on a review of firm-based management and socio-technical transitions literatures, we derive four dimensions of system disruption: technology, markets and business models, ownership and actors, and regulation. We apply these dimensions to analyse the status of disruption in two exemplary countries pursuing ambitious low-carbon energy transitions: Germany and the United Kingdom (UK). The views of a diverse range of actors are investigated regarding how disruption is unfolding and what is seen as disruptive in the energy sector. Our analysis draws on 28 expert interviews, supplemented with a review of empirical studies. We find that despite comparable shares of renewables in the two countries' electricity systems, the scale of disruption in Germany significantly exceeds that in the UK, covering all four rather than just two dimensions. We also find a greater awareness of and resistance to expected further waves of disruption in Germany, as compared to the UK. Finally, we discuss the implications of the notion of disruption for understanding and governing socio-technical transitions

Radiative Transfer in Prestellar Cores: A Monte Carlo Approach

We use our Monte Carlo radiative transfer code to study non-embedded prestellar cores and cores that are embedded at the centre of a molecular cloud. Our study indicates that the temperature inside embedded cores is lower than in isolated non-embedded cores, and generally less than 12 K, even when the cores are surrounded by an ambient cloud of small visual extinction (Av~5). Our study shows that the best wavelength region to observe embedded cores is between 400 and 500 microns, where the core is quite distinct from the background. We also predict that very sensitive observations (~1-3 MJy/sr) at 170-200 microns can be used to estimate how deeply a core is embedded in its parent molecular cloud. Finally, we present preliminary results of asymmetric models of non-embedded cores.Comment: 8 pages, 15 figures, to appear in the conference proceedings of "Open Issues in Local Star Formation and Early Stellar Evolution", held in Ouro Preto (Brazil), April 5-10, 200