Quality characteristics and phenolic compounds of European pear cultivars

Background: Pear fruits are an important source of plant secondary metabolites and one of the major sources of dietary phenolic compounds.Materials and Methods: The aim of this study was to determine the individual phenolic compounds and some quality characteristics of the flesh and peel of the fruit in four pear cultivars. The phenolic  composition of these pear cultivars was determined by high performance liquid chromatography with diode array detection (HPLC-DAD).Results: The fruit flesh firmness ranged from 35.2 to 85.8 N in the pear cultivars. The soluble solids content was higher in the flesh, while titrate-able acidity, vitamin C, individual phenolic compounds and total phenolics were generally higher in the peel. Arbutin, chlorogenic acid and epicatechin were detected as major phenolic compounds in the peel and flesh of pear fruits. Arbutin, chlorogenic acid and epicatechin of the flesh and peel ranged from 834.8 to 937.9 mg kg-1; from 332.1 to 460.7 mg kg-1; and from 77.2 to 104.0 mg kg-1 for ‘Seckel’ pear fruits, respectively. The highest total phenolics were found to be in the peel and flesh of the ‘Flemish Beauty’ pear fruits.Conclusion: Because of the higher level of antioxidant components in the peel of pear fruits (all phenolic compounds and vitamin C) consumption of unpeeled pears, after proper washing, is recommended to maximize the dietary benefit.Key words: Arbutin, Chlorogenic acid, Flesh and Peel, HPLC, Pear cultivars, Vitamin

THE MENSTRUAL CYCLE PHASE AND EFFECT OF AROMATHERAPY ON ORTHODONTIC DEBONDING PAIN

Objectives: The aim of this prospective clinical study was to evaluate the effects of the menstrual cycle phases and aromatherapy on women's perception of orthodontic debonding pain. Materials and Methods: The materials of our study were consisted of randomly selected 48 female patients (mean age:19.00±3.40). Four different study groups were performed. LA+; the patients in the luteal phase and received aromatherapy(n=12), LA-; the patients in the luteal phase and did not receive aromatherapy(n=13), FA+; the patients in the follicular phase and received aromatherapy(n=11), FA-; the patients in the follicular phase and did not receive aromatherapy(n=12). Debonding was performed and the pain experience for each tooth was scored by the patient on a visual analogue scale (VAS). Also, participants' general responses to pain were assessed with the Pain Catastrophizing Scale (PCS). The aromatherapy protocol was to inhale lavender oil from approximately 30 cm for 3 minutes, 3 minutes before debonding. Results: It was found that the mean VAS scores were higher in the luteal phase than in the follicular phase, however this difference was not statistically significant. There was no statistically significant difference between the groups with and without aromatherapy in terms of VAS scores(P>0.05). The correlation between total PCS scores and total VAS scores was statistically significant (r=0.310, P<0.05). Conclusions: Debonding in female patients is recommended for the comfort of patients on days when the patient's menstrual phase is in the follicular phase. It should be considered that patients with a lower pain threshold will experience more pain during the orthodontic debonding procedure

Perspectives on care and communication involving incurably ill Turkish and Moroccan patients, relatives and professionals: a systematic literature review

<p>Abstract</p> <p>Background</p> <p>Our aim was to obtain a clearer picture of the relevant care experiences and care perceptions of incurably ill Turkish and Moroccan patients, their relatives and professional care providers, as well as of communication and decision-making patterns at the end of life. The ultimate objective is to improve palliative care for Turkish and Moroccan immigrants in the Netherlands, by taking account of socio-cultural factors in the guidelines for palliative care.</p> <p>Methods</p> <p>A systematic literature review was undertaken. The data sources were seventeen national and international literature databases, four Dutch journals dedicated to palliative care and 37 websites of relevant national and international organizations. All the references found were checked to see whether they met the structured inclusion criteria. Inclusion was limited to publications dealing with primary empirical research on the relationship between socio-cultural factors and the health or care situation of Turkish or Moroccan patients with an oncological or incurable disease. The selection was made by first reading the titles and abstracts and subsequently the full texts. The process of deciding which studies to include was carried out by two reviewers independently. A generic appraisal instrument was applied to assess the methodological quality.</p> <p>Results</p> <p>Fifty-seven studies were found that reported findings for the countries of origin (mainly Turkey) and the immigrant host countries (mainly the Netherlands). The central themes were experiences and perceptions of family care, professional care, end-of-life care and communication. Family care is considered a duty, even when such care becomes a severe burden for the main female family caregiver in particular. Professional hospital care is preferred by many of the patients and relatives because they are looking for a cure and security. End-of-life care is strongly influenced by the continuing hope for recovery. Relatives are often quite influential in end-of-life decisions, such as the decision to withdraw or withhold treatments. The diagnosis, prognosis and end-of-life decisions are seldom discussed with the patient, and communication about pain and mental problems is often limited. Language barriers and the dominance of the family may exacerbate communication problems.</p> <p>Conclusions</p> <p>This review confirms the view that family members of patients with a Turkish or Moroccan background have a central role in care, communication and decision making at the end of life. This, in combination with their continuing hope for the patient’s recovery may inhibit open communication between patients, relatives and professionals as partners in palliative care. This implies that organizations and professionals involved in palliative care should take patients’ socio-cultural characteristics into account and incorporate cultural sensitivity into care standards and care practices<it>.</it></p

Constitutional Microsatellite Instability, Genotype, and Phenotype Correlations in Constitutional Mismatch Repair Deficiency

Background &amp; aims: Constitutional mismatch repair deficiency (CMMRD) is a rare recessive childhood cancer predisposition syndrome caused by germline mismatch repair variants. Constitutional microsatellite instability (cMSI) is a CMMRD diagnostic hallmark and may associate with cancer risk. We quantified cMSI in a large CMMRD patient cohort to explore genotype-phenotype correlations using novel MSI markers selected for instability in blood.Methods: Three CMMRD, 1 Lynch syndrome, and 2 control blood samples were genome sequenced to &gt;120 7 depth. A pilot cohort of 8 CMMRD and 38 control blood samples and a blinded cohort of 56 CMMRD, 8 suspected CMMRD, 40 Lynch syndrome, and 43 control blood samples were amplicon sequenced to 5000 7 depth. Sample cMSI score was calculated using a published method comparing microsatellite reference allele frequencies with 80 controls.Results: Thirty-two mononucleotide repeats were selected from blood genome and pilot amplicon sequencing data. cMSI scoring using these MSI markers achieved 100% sensitivity (95% CI, 93.6%-100.0%) and specificity (95% CI 97.9%-100.0%), was reproducible, and was superior to an established tumor MSI marker panel. Lower cMSI scores were found in patients with CMMRD with MSH6 deficiency and patients with at least 1 mismatch repair missense variant, and patients with biallelic truncating/copy number variants had higher scores. cMSI score did not correlate with age at first tumor.Conclusions: We present an inexpensive and scalable cMSI assay that enhances CMMRD detection relative to existing methods. cMSI score is associated with mismatch repair genotype but not phenotype, suggesting it is not a useful predictor of cancer risk

Strawberry culture in Turkey

3rd Balkan Symposium on Fruit Growing -- SEP 16-18, 2015 -- Belgrade, SERBIAWOS: 000385238300082Turkey strawberry production consistently increased since the beginning of strawberry culture in 1965. In the last 10 years, strawberry production has shown a dramatic increase from 150,000 (2003) to 376,070 t (2014), making Turkey the fourth largest strawberry producer in the world after China, USA and Mexico. Main strawberry producing regions in Turkey are Mediterranean (52.1%), Aegean (24.7%), and Marmara (14.6%). In the Mediterranean region, Mersin city has achieved 35% of total production followed by Aydin, Antalya, Bursa and Konya cities. Strawberry export of Turkey also increased year by year. Strawberry export of Turkey was 24,774 t in 2013 and 11,870 t was exported to the Russian Federation. Protected strawberry culture has also an increasing trend. High tunnels account for 1/3 of the current production, followed by mini tunnels. Annual hill plastic culture system is a common practice in Turkey's strawberry growing. The strawberry nurseries are generally located in Central Anatolia region, mostly around Cappadocia. Frigo plants are still dominating in production. There are several strawberry cultivars bred and registered in Turkey although they have not been utilized on a large commercial scale in production. In recent years, 'Camarosa' and 'Sweet Charlie' cultivars have been replaced by cultivars such as 'Rubygem', 'Festival', 'Albion', 'Florida Fortuna', and 'Camino Real'. Soilless culture in strawberry growing is also developing in Turkey. In this article, the current status of strawberry production, developments in strawberry growing techniques and nursery plant sector, as well as future projection of strawberry industry are evaluated.Int Soc Horticultural Sc

Faster & strong: string dictionary compression using sampling and fast vectorized decompression

String dictionaries constitute a large portion of the memory footprint of database applications. While strong string dictionary compression algorithms exist, these come with impractical access and compression times. Therefore, lightweight algorithms such as front coding (PFC) are favored in practice. This paper endeavors to make strong string dictionary compression practical. We focus on Re-Pair Front Coding (RPFC), a grammar-based compression algorithm, since it consistently offers better compression ratios than other algorithms in the literature. To accelerate compression times, we propose block-based RPFC (BRPFC) which consists in independently compressing small blocks of the dictionary. For further accelerated compression times especially on large string dictionaries, we also propose an alternative version of BRPFC that uses sampling to speed up compression. Moreover, to accelerate access times, we devise a vectorized access method, using Intel® Advanced Vector Extensions 512 (Intel® AVX-512). Our experimental evaluation shows that sampled BRPFC offers compression times up to 190 × faster than RPFC, and random string lookups 2.3 × faster than RPFC on average. These results move our modified RPFC into a practical range for use in database systems because the overhead of Re-Pair-based compression for access times can be reduced by 2 ×