Surface roughness effect on ultracold neutron interaction with a wall and implications for computer simulations

We review the diffuse scattering and the loss coefficient in ultracold neutron reflection from slightly rough surfaces, report a surprising reduction in loss coefficient due to roughness, and discuss the possibility of transition from quantum treatment to ray optics. The results are used in a computer simulation of neutron storage in a recent neutron lifetime experiment that re-ported a large discrepancy of neutron lifetime with the current particle data value. Our partial re-analysis suggests the possibility of systematic effects that were not included in this publication.Comment: 39 pages, 9 figures; additional calculations include

High-resolution periodic mode shapes identification for wind turbines

The stability analysis of in-operation wind turbines is a very important topic, that has received considerable attention in the last years. Many identification algorithms have been developed to estimate frequencies and damping ratios, but very few papers have been dedicated to the mode shapes. The knowledge of high-resolution mode shapes could be exploited for several applications including model validation, accurate description of the vibratory content of a machine and spatially-accurate damage detection. In this work, we will present a procedure to compute the high-resolution periodic mode shapes of a wind turbine, and apply it to a high-fidelity wind turbine model. The results show that this methodology is able to identify the first low-damped modes of the system with good accuracy

How Many Templates for GW Chirp Detection? The Minimal-Match Issue Revisited

In a recent paper dealing with maximum likelihood detection of gravitational wave chirps from coalescing binaries with unknown parameters we introduced an accurate representation of the no-signal cumulative distribution of the supremum of the whole correlator bank. This result can be used to derive a refined estimate of the number of templates yielding the best tradeoff between detector's performance (in terms of lost signals among those potentially detectable) and computational burden.Comment: submitted to Class. Quantum Grav. Typing error in eq. (4.8) fixed; figure replaced in version

Rotating Electromagnetic Waves in Toroid-Shaped Regions

Electromagnetic waves, solving the full set of Maxwell equations in vacuum, are numerically computed. These waves occupy a fixed bounded region of the three dimensional space, topologically equivalent to a toroid. Thus, their fluid dynamics analogs are vortex rings. An analysis of the shape of the sections of the rings, depending on the angular speed of rotation and the major diameter, is carried out. Successively, spherical electromagnetic vortex rings of Hill's type are taken into consideration. For some interesting peculiar configurations, explicit numerical solutions are exhibited.Comment: 27 pages, 40 figure

The expression pattern of MUC1 (EMA) is related to tumour characteristics and clinical outcome of invasive ductal breast carcinoma

Aims: To clarify MUC1 patterns in invasive ductal breast carcinoma and to relate them to clinicopathological parameters, coexpression of other biological markers and prognosis. Methods and results: Samples from 243 consecutive patients with primary ductal carcinoma were incorporated into tissue microarrays (TMAs). Slides were stained for MUC1, oestrogen receptor (ER), progesterone receptor (PR), Her2/neu, p53 and cyclin D1. Apical membrane MUC1 expression was associated with smaller tumours (P = 0.001), lower tumour grades (P < 0.001), PR positivity (P = 0.003) and increased overall survival (OS; P = 0.030). Diffuse cytoplasmic MUC1 expression was associated with cyclin D1 positivity (P = 0.009) and increased relapse-free survival (RFS; P = 0.034). Negativity for MUC1 was associated with ER negativity (P = 0.004), PR negativity (P = 0.001) and cyclin D1 negativity (P = 0.009). In stepwise multivariate analysis MUC1 negativity was an independent predictor of both RFS [hazard ratio (HR) 3.5, 95% confidence interval (CI) 1.5, 8.5; P = 0.005] and OS (HR 14.7, 9 5% Cl 4.9, 44. 1; P < 0.001). Conclusions: The expression pattern of MUC1 in invasive ductal breast carcinoma is related to tumour characteristics and clinical outcome. In addition, negative MUC1 expression is an independent risk factor for poor RFS and OS, besides 'classical' prognostic indicators

Microwave apparatus for gravitational waves observation

In this report the theoretical and experimental activities for the development of superconducting microwave cavities for the detection of gravitational waves are presented.Comment: 42 pages, 28 figure

Latest results from the EU project AVATAR: aerodynamic modelling of 10 MW wind turbines

This paper presents the most recent results from the EU project AVATAR in which aerodynamic models are improved and validated for wind turbines on a scale of 10 MW and more. Measurements on a DU 00-W-212 airfoil are presented which have been taken in the pressurized DNW-HDG wind tunnel up to a Reynolds number of 15 Million. These measurements are compared with measurements in the LM wind tunnel for Reynolds numbers of 3 and 6 Million and with calculational results. In the analysis of results special attention is paid to high Reynolds numbers effects. CFD calculations on airfoil performance showed an unexpected large scatter which eventually was reduced by paying even more attention to grid independency and domain size in relation to grid topology. Moreover calculations are presented on flow devices (leading and trailing edge flaps and vortex generators). Finally results are shown between results from 3D rotor models where a comparison is made between results from vortex wake methods and BEM methods at yawed conditions

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis.

Barretts esophagus (BE) involves a metaplastic replacement of native esophageal squamous epithelium (Sq) by columnar-intestinalized mucosa, and it is the main risk factor for Barrett-related adenocarcinoma (BAc). Ultra-conserved regions (UCRs) are a class non-coding sequences that are conserved in humans, mice and rats. More than 90% of UCRs are transcribed (T-UCRs) in normal tissues, and are altered at transcriptional level in tumorigenesis. To identify the T-UCR profiles that are dysregulated in Barretts mucosa transformation, microarray analysis was performed on a discovery set of 51 macro-dissected samples obtained from 14 long-segment BE patients. Results were validated in an independent series of esophageal biopsy/surgery specimens and in two murine models of Barretts esophagus (i.e. esophagogastric-duodenal anastomosis). Progression from normal to BE to adenocarcinoma was each associated with specific and mutually exclusive T-UCR signatures that included up-regulation of uc.58-, uc.202-, uc.207-, and uc.223- and down-regulation of uc.214+. A 9 T-UCR signature characterized BE versus Sq (with the down-regulation of uc.161-, uc.165-, and uc.327-, and the up-regulation of uc.153-, uc.158-, uc.206-, uc.274-, uc.472-, and uc.473-). Analogous BE-specific T-UCR profiles were shared by human and murine lesions. This study is the first demonstration of a role for T-UCRs in the transformation of Barretts mucosa