The Healthy Native Youth Implementation toolbox: Using Implementation Mapping to adapt an Online Decision Support System to Promote Culturally-Relevant Sexual Health Education For american indian and alaska Native Youth

BACKGROUND: American Indian and Alaska Native (AI/AN) youth experience serious disparities in sexual and reproductive health, including the highest teen birth rate among racial/ethnic groups, and disproportionate rates of sexually transmitted infections (STI), including HIV. A growing number of evidence-based programs (EBPs) that integrate the strengths and cultural teachings of Native communities exist. Yet, multiple factors, including lack of trained personnel, limited resources, and geographic isolation, may hinder their adoption and implementation. Innovative implementation strategies that facilitate the adoption and implementation of sexual health EBPs in Native communities may help reduce these disparities. METHODS: We applied Implementation Mapping, a systematic planning framework that utilizes theory, empirical evidence, and community input, to adapt a theory-based, online decision support system, iCHAMPSS (CHoosing And Maintaining Effective Programs for Sex Education in Schools), to support underlying dissemination and implementation processes unique to Native communities. We used an iterative design process, incorporating input from Native practitioners and academicians, to ensure that the adapted decision support system reflects cultural identification, community values, and experiences. RESULTS: Grounded in diffusion of innovations, organizational stage theory, and social cognitive theory, the CONCLUSION: There is a continued need to design, test, and evaluate D&I strategies that are relevant to Native communities. Th

Diazoxide Promotes Oligodendrocyte Precursor Cell Proliferation and Myelination

Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants. It has been suggested that white matter injury in this condition is due to altered oligodendrocyte (OL) development or death, resulting in OL loss and hypomyelination. At present drugs are not available that stimulate OL proliferation and promote myelination. Evidence suggests that depolarizing stimuli reduces OL proliferation and differentiation, whereas agents that hyperpolarize OLs stimulate OL proliferation and differentiation. Considering that the drug diazoxide activates K(ATP) channels to hyperpolarize cells, we tested if this compound could influence OL proliferation and myelination.Studies were performed using rat oligodendrocyte precursor cell (OPC) cultures, cerebellar slice cultures, and an in vivo model of PWMI in which newborn mice were exposed to chronic sublethal hypoxia (10% O(2)). We found that K(ATP) channel components Kir 6.1 and 6.2 and SUR2 were expressed in oligodendrocytes. Additionally, diazoxide potently stimulated OPC proliferation, as did other K(ATP) activators. Diazoxide also stimulated myelination in cerebellar slice cultures. We also found that diazoxide prevented hypomyelination and ventriculomegaly following chronic sublethal hypoxia.These results identify KATP channel components in OLs and show that diazoxide can stimulate OL proliferation in vitro. Importantly we find that diazoxide can promote myelination in vivo and prevent hypoxia-induced PWMI

HPP761872_Supplemental_Table_B – Supplemental material for <i>Texting 4 Sexual Health:</i> Improving Attitudes, Intention, and Behavior Among American Indian and Alaska Native Youth

<p>Supplemental material, HPP761872_Supplemental_Table_B for <i>Texting 4 Sexual Health:</i> Improving Attitudes, Intention, and Behavior Among American Indian and Alaska Native Youth by Patricia Yao, Rongwei Fu, Stephanie Craig Rushing, David Stephens, Joan S. Ash and Karen B. Eden in Health Promotion Practice</p

HPP761872_Supplemental_Table_A – Supplemental material for <i>Texting 4 Sexual Health:</i> Improving Attitudes, Intention, and Behavior Among American Indian and Alaska Native Youth

<p>Supplemental material, HPP761872_Supplemental_Table_A for <i>Texting 4 Sexual Health:</i> Improving Attitudes, Intention, and Behavior Among American Indian and Alaska Native Youth by Patricia Yao, Rongwei Fu, Stephanie Craig Rushing, David Stephens, Joan S. Ash and Karen B. Eden in Health Promotion Practice</p