Cutaneous sarcoidosis simulating porokeratosis of Mibelli

We report a skin localization of systemic sarcoidosis, which presented with lesions that resemble porokeratosis of Mibelli. Skin biopsy showed noncaseating sarcoidal granuloma. Whereas cutaneous sarcoidosis is present in up to one-third of cases and may present with a wide variety of lesions, our presentation is uncommon. Partial remission was obtained with  hydroxychloroquine and prednison

LES CANCERS CUTANES : EPIDEMIOLOGIE, ASPECTS CLINIQUES ET HISTOLOGIQUES

Skin cancers are most frequent of human cancers of the adult. Their incidence does not cease increasing because of lengthening of the lifespan and the modifications of the behavioural practices in particular of the repeated solar exposure. Among those, the epithelial tumours or carcinoma are most frequent in particular followed basocellular carcinoma, spinocellular carcinoma then come the melanoma, lymphoma, sarcoma… In this article, we discuss the.epidemiologic, clinical and histological profile of the cutaneous tumours in our contexte.Les cancers cutanés sont les plus fréquents des cancers humains de l’adulte. Leur incidence ne cesse d’augmenter du fait de l’allongement de la durée de vie et des modifications des habitudes comportementales en particulier de l’exposition solaire répétée. Parmi celles-ci, les tumeurs épithéliales ou carcinomes sont les plus fréquentes, en particulier les carcinomes baso-cellulaires suivis des carcinomes spino-cellulaires, puis viennent les mélanomes, les lymphomes, les sarcomes etc. Dans cet article, nous discutons le profil épidémiologique, clinique et histologique des tumeurs cutanées dans notre contexte

LESIONS PAPULO-PUSTULEUSES PRURIGINEUSES DU VISAGE ASSOCIEES A UNE CONJONCTIVITE CHRONIQUE

We report a case of face localization of demodecidosis wich presented as papulopustular lesion associated to ocular manifestations (chronic blepharitis, chelazian). Demodecidose is induced by Demodex folliculorum. This parasit can induced various clinical pictures as folliculitis; blepharitis, rosaciformes dermatosis. The diagnosis was made by the presence of the parasit on direct examination of skin prelevement. Cyclines seems to be an interesting alternative to acaricides in the treatment of demodecidosis.Notre patient présente une démodécidose du visage sous forme de lésions papulo-pustuleuses associées à une atteinte oculaire à type de blépharite chronique et de chalazion de l’oeil gauche. La démodécidose est due à Demodex folliculorum. Ce parasite peut être associé à différents tableaux cliniques dont les folliculites, les dermites rosacéiformes ou les blépharites. Le diagnostic est conformé par la présence de parasite à l’examen direct. L’emploi de cyclines semble être une alternative intéressante aux acaricides de contact dans la démodécidose

Frequency-modulated electromagnetic neural stimulation (FREMS) as a treatment for symptomatic diabetic neuropathy: results from a double-blind, randomised, multicentre, long-term, placebo-controlled clinical trial

AIMS/HYPOTHESIS: The aim was to evaluate the efficacy and safety of transcutaneous frequency-modulated electromagnetic neural stimulation (frequency rhythmic electrical modulation system, FREMS) as a treatment for symptomatic peripheral neuropathy in patients with diabetes mellitus. METHODS: This was a double-blind, randomised, multicentre, parallel-group study of three series, each of ten treatment sessions of FREMS or placebo administered within 3 weeks, 3 months apart, with an overall follow-up of about 51 weeks. The primary endpoint was the change in nerve conduction velocity (NCV) of deep peroneal, tibial and sural nerves. Secondary endpoints included the effects of treatment on pain, tactile, thermal and vibration sensations. Patients eligible to participate were aged 18-75 years with diabetes for ≥ 1 year, HbA(1c) <11.0% (97 mmol/mol), with symptomatic diabetic polyneuropathy at the lower extremities (i.e. abnormal amplitude, latency or NCV of either tibial, deep peroneal or sural nerve, but with an evocable potential and measurable NCV of the sural nerve), a Michigan Diabetes Neuropathy Score ≥ 7 and on a stable dose of medications for diabetic neuropathy in the month prior to enrolment. Data were collected in an outpatient setting. Participants were allocated to the FREMS or placebo arm (1:1 ratio) according to a sequence generated by a computer random number generator, without block or stratification factors. Investigators digitised patients' date of birth and site number into an interactive voice recording system to obtain the assigned treatment. Participants, investigators conducting the trial, or people assessing the outcomes were blinded to group assignment. RESULTS: Patients (n = 110) with symptomatic neuropathy were randomised to FREMS (n = 54) or placebo (n = 56). In the intention-to-treat population (50 FREMS, 51 placebo), changes in NCV of the three examined nerves were not different between FREMS and placebo (deep peroneal [means ± SE]: 0.74 ± 0.71 vs 0.06 ± 1.38 m/s; tibial: 2.08 ± 0.84 vs 0.61 ± 0.43 m/s; and sural: 0.80 ± 1.08 vs -0.91 ± 1.13 m/s; FREMS vs placebo, respectively). FREMS induced a significant reduction in day and night pain as measured by a visual analogue scale immediately after each treatment session, although this beneficial effect was no longer measurable 3 months after treatment. Compared with the placebo group, in the FREMS group the cold sensation threshold was significantly improved, while non-significant differences were observed in the vibration and warm sensation thresholds. No relevant side effects were recorded during the study. CONCLUSIONS/INTERPRETATION: FREMS proved to be a safe treatment for symptomatic diabetic neuropathy, with immediate, although transient, reduction in pain, and no effect on NCV. TRIAL REGISTRATION: ClinicalTrials.gov NCT01628627. FUNDING: The clinical trial was sponsored by Lorenz Biotech (Medolla, Italy), lately Lorenz Lifetech (Ozzano dell'Emilia, Italy)

Paronychia-like cutaneous leishmaniasis

Chronic paronychia is an inflammatory recalcitrant disorder affecting the nail folds. We report one patient with paronychia  revealing ungueal leishmaniasis.A 34-year-old man, resident in the north of Morocco, presented with a 6-month history of an inflamed proximal nail fold of  the left thumb, resistant to antibiotics and anti-fungal treatments.En bloc excision of the proximal nail fold was done. The histopathological exam showed epithelioid  granulomas  with giant  cells and the presence of  leshmania  amastigotes, leading to the diagnosis of ungueal leishmaniasis.Clinical aspects of cutaneous leishmaniasis can be very misleading. The paronychial form is rarely described. In endemic areas  it is necessary for the physician to be aware of atypical skin presentations of  leishmaniasis

Paronychia-like cutaneous leishmaniasis

Chronic paronychia is an inflammatory recalcitrant disorder affecting the nail folds. We report one patient with paronychia  revealing ungueal leishmaniasis.A 34-year-old man, resident in the north of Morocco, presented with a 6-month history of an inflamed proximal nail fold of  the left thumb, resistant to antibiotics and anti-fungal treatments.En bloc excision of the proximal nail fold was done. The histopathological exam showed epithelioid  granulomas  with giant  cells and the presence of  leshmania  amastigotes, leading to the diagnosis of ungueal leishmaniasis.Clinical aspects of cutaneous leishmaniasis can be very misleading. The paronychial form is rarely described. In endemic areas  it is necessary for the physician to be aware of atypical skin presentations of  leishmaniasis

Une nouvelle cause de périonyxis chronique : la rétronychie.

Retronychia is the phenomenon of ingrown nail resulting in inflammation of the proximal subungual fold and is a newly described entity. Herein, we report a new case revealed through chronic proximal perionyxis.Case ReportsEnglish AbstractJournal Articleinfo:eu-repo/semantics/publishe

Type 2 diabetes patients with peripheral neuropathy display an increased risk of hypertension

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