Normal postoperative appearances of lung cancer

International audienceThe major lung resections are the pneumonectomies and lobectomies. The sublobar resections are segmentectomies and wedge resections. These are performed either through open surgery through a thoracotomy or by video-assisted mini-invasive surgery for lobectomies and sublobar resections. Understanding the procedures involved allows the normal postoperative appearances to be interpreted and these normal anatomical changes to be distinguished from potential postoperative complications. Surgery results in a more or less extensive physiological adaptation of the chest cavity depending on the lung volume, which has been resected. This adaptation evolves during the initial months postoperatively. Chest radiography and computed tomography can show narrowing of the intercostal spaces, a rise of the diaphragm and shift of the mediastinum on the side concerned following major resections

Smoking-associated morbidities on computed tomography lung cancer screens in HIV-infected smokers

International audienc

The ASSET Architecture - Integrating Media Applications and Products through a Unified API

Applications and products currently available for the broadcasting market are vertically integrated or proprietary. They are based on components requiring specific and costly development to interoperate and do rely typically on a single manufacturer or system integrator. Hence they are not fully compliant with broadcasters' requirements. ASSET is a European funded project whose main goal is to overcome the limitations of custom specific implementations of a digital system for TV content creation. These limitations are generally due to the misfit of interfaces between software layers, proprietary APIs of equipment from different vendors and the lack of a generalised middleware for multimedia content management with openly defined interfaces. Besides presenting the ASSET proposed architecture and concepts, this paper describes the prototype under development to test and demonstrate the project proposals

Poor concordance between sequential transbronchial lung cryobiopsy and surgical lung biopsy in the diagnosis of diffuse interstitial lung diseases

Rationale: The diagnostic concordance between transbronchial lung cryobiopsy (TBLC)\u2014versus surgical lung biopsy (SLB) as the current gold standard\u2014in interstitial lung disease (ILD) cases requiring histology remains controversial. Objectives: To assess diagnostic concordance between TBLC and SLB sequentially performed in the same patients, the diagnostic yield of both techniques, and subsequent changes in multidisciplinary assessment (MDA) decisions. Methods: A two-center prospective study included patients with ILD with a nondefinite usual interstitial pneumonia pattern (on high-resolution computed tomography scan) confirmed at a first MDA. Patients underwent TBLC immediately followed by video-assisted thoracoscopy for SLB at the same anatomical locations. After open reading of both sample types by local pathologists and final diagnosis at a second MDA (MDA2), anonymized TBLC and SLB slides were blindly assessed by an external expert pathologist (T.V.C.). Kappa-concordance coefficients and percentage agreement were computed for: TBLC versus SLB, MDA2 versus TBLC, MDA2 versus SLB, and blinded pathology versus routine pathology. Measurements and Main Results: Twenty-one patients were included. The median TBLC biopsy size (longest axis) was 7 mm (interquartile range, 5\u20138 mm). SLB biopsy sizes averaged 46.1 6 13.8 mm. Concordance coefficients and percentage agreement were: TBLC versus SLB: k = 0.22 (95% confidence interval [CI], 0.01\u20130.44), percentage agreement = 38% (95% CI, 18\u201362%); MDA2 versus TBLC: k = 0.31 (95% CI, 0.06\u20130.56), percentage agreement = 48% (95% CI, 26\u201370)%; MDA2 versus SLB: k = 0.51 (95% CI, 0.27\u20130.75), percentage agreement = 62% (95% CI, 38\u201382%); two pneumothoraces (9.5%) were recorded during TBLC. TBLC would have led to a different treatment if SLB was not performed in 11 of 21 (52%) of cases. Conclusions: Pathological results from TBLC and SLB were poorly concordant in the assessment of ILD. SLBs were more frequently concordant with the final diagnosis retained at MDA