Does oral anticoagulant therapy (OAT) play a key role in triggering and maintaining calciphylaxis? A case report proposing a new etiological and nosological review

Calcific uremic arteriolopathy (CUA) is a rare but very serious morbid condition often observed during secondary hyperparathyroidism (HPTS). CUA affected patients by advanced chronic kidney disease (CKD). The Authors report a clinic case of a 63-year female diabetic patient on chronic hemodialysis that suddenly showed progressive necrotic cutaneous lesions similar to CUA. The status HPTS was in good control. This case led the authors to consider different etiological causes especially when vascular calcification. In the patient the main noxae could be the anticoagulant oral therapy (AOT) together smoking and inflammation induced by a severe malnutrition. Therapies proposals were sodium thiosulfate, based amino acids nutrition, an accurate and constant surgical medication of necrotic injuries. After the complete healing of skin lesions and good correction of nutritional status, the Authors asserted that OAT especially if associated with malnutrition smoking and diabetes can lead to necrotic lesions similar but not classifiable as calciphylaxis

Morbid obesity in a young woman affected by advanced chronic kidney disease: an exceptional case report. Does a high dose of essential amino acids play a key role in therapeutic success?

A 38-year-old woman, obese (219\u2009kg), diabetic, hypertensive, chronic kidney disease (CKD) stage 4, with low plasma albumin level (2.9\u2009g\u2009dl(-1)) and marked proteinuria (22\u2009g per day) was studied. Given the advanced-stage CKD with nephrotic proteinuria, we supplemented low-protein diet with high doses of a tailored essential amino acid mixture (AAs: 44\u2009g per day) to improve weight reduction in the patient. After 20 months of conservative therapy, the patient lost 43\u2009kg; despite two episodes of infection, albumin plasma levels increased up to 3.7\u2009g per day. After a further 20 months of dialysis, the patient maintained a diet of 1800 kcal supplemented with 32\u2009g of AAs and lost 47\u2009kg, whereas both albumin (3.89\ub10.12\u2009g\u2009dl(-1)) and C reactive protein returned to normal. During the follow-up period, anemia improved, erythropoietin was thus discontinued and insulin requirement decreased to 105 IU. This therapeutic option may be beneficial in advanced CKD patients with obesity and diabetes resulting from malnutrition

The medial septum is insulin resistant in the AD presymptomatic phase: rescue by nerve growth factor-driven IRS1 activation.

Basal forebrain cholinergic neurons (BFCN) are key modulators of learning and memory and are high energy-demanding neurons. Impaired neuronal metabolism and reduced insulin signaling, known as insulin resistance, has been reported in the early phase of Alzheimer's disease (AD), which has been suggested to be "Type 3 Diabetes." We hypothesized that BFCN may develop insulin resistance and their consequent failure represents one of the earliest event in AD. We found that a condition reminiscent of insulin resistance occurs in the medial septum of 3 months old 3 7Tg-AD mice, reported to develop typical AD histopathology and cognitive deficits in adulthood. Further, we obtained insulin resistant BFCN by culturing them with high insulin concentrations. By means of these paradigms, we observed that nerve growth factor (NGF) reduces insulin resistance in vitro and in vivo. NGF activates the insulin receptor substrate 1 (IRS1) and rescues c-Fos expression and glucose metabolism. This effect involves binding of activated IRS1 to the NGF receptor TrkA, and is lost in presence of the specific IRS inhibitor NT157. Overall, our findings indicate that, in a well-established animal model of AD, the medial septum develops insulin resistance several months before it is detectable in the neocortex and hippocampus. Remarkably, NGF counteracts molecular alterations downstream of insulin-resistant receptor and its nasal administration restores insulin signaling in 3 7Tg-AD mice by TrkA/IRS1 activation. The cross-talk between NGF and insulin pathways downstream the insulin receptor suggests novel potential therapeutic targets to slow cognitive decline in AD and diabetes-related brain insulin resistance

Micromechanical Properties of Injection-Molded Starch–Wood Particle Composites

The micromechanical properties of injection molded starch–wood particle composites were investigated as a function of particle content and humidity conditions. The composite materials were characterized by scanning electron microscopy and X-ray diffraction methods. The microhardness of the composites was shown to increase notably with the concentration of the wood particles. In addition,creep behavior under the indenter and temperature dependence were evaluated in terms of the independent contribution of the starch matrix and the wood microparticles to the hardness value. The influence of drying time on the density and weight uptake of the injection-molded composites was highlighted. The results revealed the role of the mechanism of water evaporation, showing that the dependence of water uptake and temperature was greater for the starch–wood composites than for the pure starch sample. Experiments performed during the drying process at 70°C indicated that the wood in the starch composites did not prevent water loss from the samples.Peer reviewe

Non una donna in politica, ma una donna politica: Women’s Political Language in an Italian Context

This chapter focuses on the metaphorical content of Italian women politicians’ speech to investigate if particularly ‘feminine’ language traits (see Jesperson 1922: 237–54) can be identified, or whether, as the driving hypothesis of this study posits, it is ministerial remit that conditions the use of a politician’s language more than any other single factor. This hypothesis is tested by examining a corpus of speeches, press interviews and press releases of five women ministers in the Prodi-led administration in Italy, covering the period June 2006 to May 2007

JADT 2010 INTERNATIONAL CONFERENCE ON STATISTICAL ANALYSIS OF TEXTUAL DATA

JADT is open to all scholars and researchers working in the field of textual data analysis, ranging from lexicography to the analysis of political discourse, from information retrieval to marketing research, from computational linguistics to sociolinguistics, from text mining to content analysis