In-field assessment of change-of-direction ability with a single wearable sensor.

The Agility T-test is a standardized method to measure the change-of-direction (COD) ability of athletes in the field. It is traditionally scored based on the total completion time, which does not provide information on the different CODs. Augmenting the T-test with wearable sensors provides the opportunity to explore new metrics. Towards this, data of 23 professional soccer players were recorded with a trunk-worn GNSS-IMU (Global Navigation Satellite System-Inertial Measurement Unit) device. A method for detecting the four CODs based on the wavelet-denoised antero-posterior acceleration signal was developed and validated using video data (60 Hz). Following this, completion time was estimated using GNSS ground speed and validated with the photocell data. The proposed method yields an error (mean ± standard deviation) of 0 ± 66 ms for the COD detection, - 0.16 ± 0.22 s for completion time, and a relative error for each COD duration and each sequential movement durations of less than 3.5 ± 16% and 7 ± 7%, respectively. The presented algorithm can highlight the asymmetric performance between the phases and CODs in the right and left direction. By providing a more comprehensive analysis in the field, this work can enable coaches to develop more personalized training and rehabilitation programs

The Effects of Humic Acid and Calcium on Morpho-Physiological Traits and Mineral Nutrient Uptake of Pistachio Seedling under Salinity Stress

Abstract The study was carried out to evaluate the effects of soil application of humic acid and calcium on morphophysiological traits and Na + , Mg 2+ , Ca 2+ uptake of Pistachio seedling (Akbari) grown under salt stress. A completely randomized design was used with four replications in greenhouse conditions. The experimental treatment consisted of four levels of humic acid (Bis humic) (0, 4, 8 and 12 gr kg -1 soil) and anti-salt as a source of Ca +2 (0, 1, 2 and 3 gr kg -1 soil). Results indicated that humic acid and anti-salt significantly increased vegetative growth, such as root fresh and dry weight, stem diameter, leaf number and leaf area, of pistachio seedling in comparison with the control group (p<0.05). However, no significant differences in fresh and dry weight of shoot of pistachio seedling were detected in all treatments except in humic acid 8 gr kg -1 soils. The results indicated that the application of humic acid and anti-salt decreased Na + absorption in pistachio seedling in all experimental treatments (p<0.05). No significant differences in Ca +2 and Mg +2 absorption were detected in all treatments. Results showed a significant reduction of the electrical conductivity (EC) and sodium adsorption ratio (SAR) in all levels of humic acid and anti-salt in soil. However, in these treatments, there were no statistically significant differences in the pH. The best concentration of humic acid and antisalt was 8 gr kg -1 soil and 3 gr kg -1 soil, respectively. This study revealed the relative importance and efficiency of humic acid and anti-salt to salinity stress tolerance in pistachio seedling

Walking Speed of Children and Adolescents With Cerebral Palsy: Laboratory Versus Daily Life.

The purpose of this pilot study was to compare walking speed, an important component of gait, in the laboratory and daily life, in young individuals with cerebral palsy (CP) and with typical development (TD), and to quantify to what extent gait observed in clinical settings compares to gait in real life. Fifteen children, adolescents and young adults with CP (6 GMFCS I, 2 GMFCS II, and 7 GMFCS III) and 14 with TD were included. They wore 4 synchronized inertial sensors on their shanks and thighs while walking at their spontaneous self-selected speed in the laboratory, and then during 2 week-days and 1 weekend day in their daily environment. Walking speed was computed from shank angular velocity signals using a validated algorithm. The median of the speed distributions in the laboratory and daily life were compared at the group and individual levels using Wilcoxon tests and Spearman's correlation coefficients. The corresponding percentile of daily life speed equivalent to the speed in the laboratory was computed and observed at the group level. Daily-life walking speed was significantly lower compared to the laboratory for the CP group (0.91 [0.58-1.23] m/s vs 1.07 [0.73-1.28] m/s, p = 0.015), but not for TD (1.29 [1.24-1.40] m/s vs 1.29 [1.20-1.40] m/s, p = 0.715). Median speeds correlated highly in CP (p < 0.001, rho = 0.89), but not in TD. In children with CP, 60% of the daily life walking activity was at a slower speed than in-laboratory (corresponding percentile = 60). On the contrary, almost 60% of the daily life activity of TD was at a faster speed than in-laboratory (corresponding percentile = 42.5). Nevertheless, highly heterogeneous behaviors were observed within both populations and within subgroups of GMFCS level. At the group level, children with CP tend to under-perform during natural walking as compared to walking in a clinical environment. The heterogeneous behaviors at the individual level indicate that real-life gait performance cannot be directly inferred from in-laboratory capacity. This emphasizes the importance of completing clinical gait analysis with data from daily life, to better understand the overall function of children with CP

The gait and balance of patients with diabetes can be improved: a randomised controlled trial

Aims/hypothesis: Gait characteristics and balance are altered in diabetic patients. Little is known about possible treatment strategies. This study evaluates the effect of a specific training programme on gait and balance of diabetic patients. Methods: This was a randomised controlled trial (n = 71) with an intervention (n = 35) and control group (n = 36). The intervention consisted of physiotherapeutic group training including gait and balance exercises with function-orientated strengthening (twice weekly over 12weeks). Controls received no treatment. Individuals were allocated to the groups in a central office. Gait, balance, fear of falls, muscle strength and joint mobility were measured at baseline, after intervention and at 6-month follow-up. Results: The trial is closed to recruitment and follow-up. After training, the intervention group increased habitual walking speed by 0.149m/s (p < 0.001) compared with the control group. Patients in the intervention group also significantly improved their balance (time to walk over a beam, balance index recorded on Biodex balance system), their performance-oriented mobility, their degree of concern about falling, their hip and ankle plantar flexor strength, and their hip flexion mobility compared with the control group. After 6months, all these variables remained significant except for the Biodex sway index and ankle plantar flexor strength. Two patients developed pain in their Achilles tendon: the progression for two related exercises was slowed down. Conclusions/interpretation: Specific training can improve gait speed, balance, muscle strength and joint mobility in diabetic patients. Further studies are needed to explore the influence of these improvements on the number of reported falls, patients' physical activity levels and quality of life. Trial registration:: ClinicalTrials.gov NCT00637546 Funding:: This work was supported by the Swiss National Foundation (SNF): PBSKP-123446/

Dual antiplatelet therapy for secondary prevention of coronary artery disease.

Dual antiplatelet therapy (DAPT) combining aspirin and a P2Y12 receptor inhibitor has been consistently shown to reduce recurrent major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) compared with aspirin monotherapy, but at the expense of an increased risk of major bleeding. Nevertheless, the optimal duration of DAPT for secondary prevention of CAD remains uncertain, owing to the conflicting results of several large randomised trials. Among patients with stable CAD undergoing PCI with drug-eluting stents (DES), shorter durations of DAPT (3-6 months) were shown non-inferior to 12 or 24 months duration with respect to MACE, but reduced the rates of major bleeding. Contrariwise, prolonged DAPT durations (18-48 months) reduced the incidence of myocardial infarction and stent thrombosis, but at a cost of an increased risk of major bleeding and all-cause mortality. Until more evidence becomes available, the choice of optimal DAPT regimen and duration for patients with CAD requires a tailored approach based on the patient clinical presentation, baseline risk profile and management strategy. Future studies are however needed to identify patients who may derive benefit from shortened or extended DAPT courses for secondary prevention of CAD based on their individual ischaemic and bleeding risk. Based on limited evidence, 12 months duration of DAPT is currently recommended in patients with ACS irrespective of their management strategy, but large ongoing randomised trials are currently assessing the efficacy and safety of a short-term DAPT strategy (3-6 months) for patients with ACS undergoing PCI with newer generation DES. Finally, several ongoing, large-scale, randomised trials are challenging the current concept of DAPT by investigating P2Y12 receptor inhibitors as single antiplatelet therapy and may potentially shift the paradigm of antiplatelet therapy after PCI in the near future. This article provides a contemporary state-of-the-art review of the current evidence on DAPT for secondary prevention of patients with CAD and its future perspectives

Studies on the host range of Septoria species on cereals and some wild grasses in Iran

In an attempt to determine the host range of Septoria species, 27 species/varieties of cereals and certain wild grasses were examined with inoculation experiments under controlled conditions. Most Septoria species were each pathogenic only on a particular host plant, and wild grasses played only a minor role as alternative hosts for these fungi. Septoria tritici isolates from Triticum aestivum infected T. aestivum, T. durum, T. dicoccum and T. compactum, species that may provide a primary inoculum source for S. tritici. Septoria isolates from Aegilops tauschii, Lolium loliaceum, Lophochloa phleoides, Phalaris paradoxa and Hordeum glaucum were pathogenic only on their original hosts. S. passerinii isolates from Hordeum vulgare and H. distichon were pathogenic on all Hordeum species/cultivars tested except H. glaucum. Thus various Hordeum species may play a role in the epidemiology of Septoria diseases on barley

COVID-19 Outbreak and Surgical Practice: Unexpected Fatality in Perioperative Period

: Little is known about surgical practice in the initial phase of coronavirus disease 2019 (COVID-19) global crisis. This is a retrospective case series of 4 surgical patients (cholecystectomy, hernia repair, gastric bypass, and hysterectomy) who developed perioperative complications in the first few weeks of COVID-19 outbreak in Tehran, Iran in the month of February 2020. COVID-19 can complicate the perioperative course with diagnostic challenge and a high potential fatality rate. In locations with widespread infections and limited resources, the risk of elective surgical procedures for index patient and community may outweigh the benefit

Metabolic Effects Of Duodenojejunal Bypass Surgery In A Rat Model Of Type 1 Diabetes

Background Metabolic surgery has beneficial metabolic effects, including remission of type 2 diabetes. We hypothesized that duodenojejunal bypass (DJB) surgery can protect against development of type 1 diabetes (T1D) by enhancing regulation of cellular and molecular pathways that control glucose homeostasis. Methods BBDP/Wor rats, which are prone to develop spontaneous autoimmune T1D, underwent loop DJB (n = 15) or sham (n = 15) surgery at a median age of 41 days, before development of diabetes. At T1D diagnosis, a subcutaneous insulin pellet was implanted, oral glucose tolerance test was performed 21 days later, and tissues were collected 25 days after onset of T1D. Pancreas and liver tissues were assessed by histology and RT-qPCR. Fecal microbiota composition was analyzed by 16S V4 sequencing. Results Postoperatively, DJB rats weighed less than sham rats (287.8 vs 329.9 g,P = 0.04). In both groups, 14 of 15 rats developed T1D, at similar age of onset (87 days in DJB vs 81 days in sham,P = 0.17). There was no difference in oral glucose tolerance, fasting and stimulated plasma insulin and c-peptide levels, and immunohistochemical analysis of insulin-positive cells in the pancreas. DJB rats needed 1.3 +/- 0.4 insulin implants vs 1.9 +/- 0.5 in sham rats (P = 0.002). Fasting and glucose stimulated glucagon-like peptide 1 (GLP-1) secretion was elevated after DJB surgery. DJB rats had reduced markers of metabolic stress in liver. After DJB, the fecal microbiome changed significantly, including increases inAkkermansiaandRuminococcus, while the changes were minimal in sham rats. Conclusion DJB does not protect against autoimmune T1D in BBDP/Wor rats, but reduces the need for exogenous insulin and facilitates other metabolic benefits including weight loss, increased GLP-1 secretion, reduced hepatic stress, and altered gut microbiome