Avrupa Birliği ve seçilmiş dünya ülkelerinde yatırım teşvikleri

In this study, investment incentive policies and investment promotion tools employed in the European Union and other selected world countries such as the USA, China, Japan, Russia and South Korea were examined. Firstly, place of the incentive policy recognized throughout the European Union within the Union's legislation is given. In addition, investment promotion tools of each EU member state have been tabulated in a collective manner. After explaining investment incentives employed in the European Union each country stated above were discussed upon one by one. Investment promotion policies and tools applied in these countries were given to underline importance given by those countries to investment

Uptake, accumulation and some biochemical responses in Raphanus sativus L. to zinc stress

The responses of radish (Raphanus sativus L.) to increasing concentrations of ZnCl2 (1, 5 and 10 mM) in Hoagland nutrient medium were studied. Under the conditions of these increasing zinc concentrations, the highest zinc accumulation was obtained in the roots of the plants treated with 10 mM applications. The zinc concentration in the vegetative parts, was highest in the root and was lowest in the cotyledons. The highest bioconcentration factor (BCF) value was detected in the roots in 5 mM zinc applications. When compared with the control, total zinc uptake was observed to increase in 1, 5 and 10 mM ZnCl2 treatments. The total accumulation rate (TAR) for zinc was highest in 10 mM ZnCl2 treatment, while the lowest TAR was observed in radish plants exposed to 1 mM ZnCl2. Plants treated with 5, 10 mM ZnCl2 showed significant decreases in chlorophyll (Chl a, Chl b, Chl a/b) and carotenoid content compared with the control. Peroxidase (POD) activity especially in radish roots increased significantly with increasing concentrations of ZnCl2 (5 and 10 mM) while the total protein amount decreased when compared with the control. The results of this study showed that, radish plants could tolerate the negative effects of zinc stress up to 1 mM ZnCl2 concentration and that in zinc concentrations of 5 mM and above toxic effects were existent.Key words: Radish, Raphanus sativus, zinc, metal toxicity, uptake, accumulation, peroxidase, pigment

Time-Kill Kinetics and In Vitro Antifungal Susceptibility of Non-fumigatus Aspergillus Species Isolated from Patients with Ocular Mycoses

Aspergillus species can cause ocular morbidity and blindness, and thus, appropriate antifungal therapy is needed. We investigated the in vitro activity of itraconazole, voriconazole, posaconazole, caspofungin, anidulafungin, and amphotericin B against 14 Aspergillus isolates obtained from patients with ocular mycoses, using the CLSI reference broth microdilution methodology. In addition, time-kill assays were performed, exposing each isolate separately to 1-, 4-, and 16-fold concentrations above the minimum inhibitory concentration (MIC) of each antifungal agent. A sigmoid maximum-effect (Emax) model was used to fit the time-kill curve data. The drug effect was further evaluated by measuring an increase/decrease in the killing rate of the tested isolates. The MICs of amphotericin B, itraconazole, voriconazole, and posaconazole were 0.5–1.0, 1.0, 0.5–1.0, and 0.25 µg/ml for A. brasiliensis, A. niger, and A. tubingensis isolates, respectively, and 2.0–4.0, 0.5, 1.0 for A. flavus, and 0.12–0.25 µg/ml for A. nomius isolates, respectively. A. calidoustus had the highest MIC range for the azoles (4.0–16.0 µg/ml) among all isolates tested. The minimum effective concentrations of caspofungin and anidulafungin were ≤0.03–0.5 µg/ml and ≤0.03 µg/ml for all isolates, respectively. Posaconazole demonstrated maximal killing rates (Emax = 0.63 h−1, r2 = 0.71) against 14 ocular Aspergillus isolates, followed by amphotericin B (Emax = 0.39 h−1, r2 = 0.87), voriconazole (Emax = 0.35 h−1, r2 = 0.098), and itraconazole (Emax = 0.01 h−1, r2 = 0.98). Overall, the antifungal susceptibility of the non-fumigatusAspergillus isolates tested was species and antifungal agent dependent. Analysis of the kinetic growth assays, along with consideration of the killing rates, revealed that posaconazole was the most effective antifungal against all of the isolates

The interplay between learner beliefs and foreign language anxiety: insights from the Turkish EFL context

Foreign language learning in classroom settings has long been found to be associated with anxiety (Horwitz, 1986). Though it is known that sources of foreign language anxiety are varied (Young, 1991), whether anxiety is related to learners’ inherent beliefs about language learning is understudied. To this end, the present study examines the possible relationship between learner beliefs and language anxiety in the under-researched Turkish EFL context. A population of university-level Turkish EFL learners (n=153) completed the Beliefs about Language Learning Inventory (BALLI) and the Foreign Language Classroom Anxiety scale (FLCAS). The underlying constructs in both instruments were explored using an Exploratory Factor Analysis (EFA). A series of Pearson Product-Moment Correlation Coefficient (PPMCC) tests were performed on the factor scores from both instruments. The findings revealed that fear of ambiguity was positively linked to classroom performance anxiety and negative feelings towards English. In addition, the more confident learners feel themselves using English, the more desire they seem to have to interact with native speakers. Overall, positive beliefs about language learning may be helpful in reducing anxiety and boosting confidence in language learning. These findings not only enhance our understanding of the complex psychology of language learning but also have important implications for instructed EFL/ESL settings

In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3

BackgroundNo treatment exists for the most common dominantly inherited ataxia Machado‐Joseph disease, or spinocerebellar ataxia type 3 (SCA3). Successful evaluation of candidate therapeutics will be facilitated by validated noninvasive biomarkers of disease pathology recapitulated by animal models.ObjectiveWe sought to identify shared in vivo neurochemical signatures in two mouse models of SCA3 that reflect the human disease pathology.MethodsCerebellar neurochemical concentrations in homozygous YACMJD84.2 (Q84/Q84) and hemizygous CMVMJD135 (Q135) mice were measured by in vivo magnetic resonance spectroscopy at 9.4 tesla. To validate the neurochemical biomarkers, levels of neurofilament medium (NFL; indicator of neuroaxonal integrity) and myelin basic protein (MBP; indicator of myelination) were measured in cerebellar lysates from a subset of mice and patients with SCA3. Finally, NFL and MBP levels were measured in the cerebellar extracts of Q84/Q84 mice upon silencing of the mutant ATXN3 gene.ResultsBoth Q84/Q84 and Q135 mice displayed lower N‐acetylaspartate than wild‐type littermates, indicating neuroaxonal loss/dysfunction, and lower myo‐inositol and total choline, indicating disturbances in phospholipid membrane metabolism and demyelination. Cerebellar NFL and MBP levels were accordingly lower in both models as well as in the cerebellar cortex of patients with SCA3 than controls. Importantly, N‐acetylaspartate and total choline correlated with NFL and MPB, respectively, in Q135 mice. Long‐term sustained RNA interference (RNAi)‐mediated reduction of ATXN3 levels increased NFL and MBP in Q84/Q84 cerebella.ConclusionsN‐acetylaspartate, myo‐inositol, and total choline levels in the cerebellum are candidate biomarkers of neuroaxonal and oligodendrocyte pathology in SCA3, aspects of pathology that are reversible by RNAi therapy. © 2020 International Parkinson and Movement Disorder SocietyPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163456/2/mds28140.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163456/1/mds28140_am.pd

Ion source and LEBT of KAHVELab proton beamline

The KAHVE Laboratory, at Bo\u{g}azi\c{c}i University, Istanbul, Turkey is home to an educational proton linac project. The proton beam will originate from a 20 keV H+ source and will be delivered to a two module Radio Frequency Quadrupole (RFQ) operating at 800 MHz via a low energy beam transport (LEBT) line. Currently, the design phase being over, commissioning and stability tests are ongoing for the proton beamline which is already produced and installed except the RFQ which is being manufactured. This work summarizes the design, production and test phases of the ion source and LEBT line components

Effect of heat treatment on the wear and corrosion behaviors of a gray cast iron coated with a COLMONOY 88 alloy deposited by high velocity oxygen fuel (HVOF) thermal spray

The present work has been conducted in order to determine the influence of heat treatment on the wear and corrosion behaviours of a gray cast iron substrate coated with a Ni base coating deposited by HVOF thermal spray. The wear resistance of the coatings was obtained using a reciprocating wear tester by rubbing a 10 mm diameter steel ball on the coatings at normal atmospheric conditions. Corrosion tests were performed using potentiodynamic polarization measurements in a 3,5 % NaCl solution. It was observed that the corrosion and wear resistance of the coatings increased along with the reduction of porosity and roughness by the heat treatment

O vrstama zmija u gorju Zapadni Taurus, Turska

A total of 85 specimens belonging to 14 snake species collected from the Western Taurus Mountain Range were examined in this study. Along with morphological information about the species, the study contains some topographical observations concerning the localities. The collection of material from a number of new localities helped efforts to complete missing information related to the distribution of species in this region. Moreover, the data obtained were compared with those contained in the relevant literature with the purpose of shedding light on the taxonomical status of the species.Obrađeno je ukupno 85 primjeraka odnosno 14 vrsta zmija prikupljenih u gorju Zapadni Taurus. Rad donosi morfološke osobitosti vrsta te neka topografska opažanja lokaliteta. Prikupljeni materijal pomogao je upotpuniti nedostatke u poznavanju rasprostranjenja vrsta koje žive u ovoj regiji. Prikupljeni podaci uspoređeni su s relevantnom literaturom u svrhu produbljivanja znanja o taksonomiji vrsta