Composite materials machining

Cílem této bakalářské práce je charakterizovat kompozitní materiály, popsat metody obrábění a používané nástrojové vybavení. První část bakalářské práce obsahuje základní pojmy, charakteristiku a rozdělení kompozitů. Druhá část se zabývá jednotlivými technologiemi obrábění kompozitních materiálů, používanými nástroji a problematikou obrábění těchto materiálů. K práci jsou přiloženy experimenty z praxe.Katedra technologie obráběníObhájenoThe aim of this Bachelor thesis is to describe composite materials, methods of machining and used tools. The first part of bachelor thesis includes basic concepts, characteristic and distribution of composites. The second part deals with various technologies machining of composite materials, used tools and problems of machining these materials. The practical experiments are attached to the Bachelor thesis

Machining and nitriding of inconel materials regulatory components of steam turbines

Diplomová práce se zabývá problematikou výroby regulačních vřeten pro regulaci páry ve ventilech parních turbín používaných na USC elektrárnách. Zabývá se charakteristikou inconelových materiálů a popisuje postup obrábění a používané nástrojové vybavení pro výrobu vřeten z žárupevné slitiny Nimonic 901. V druhé části práce je popisována aplikace iontové nitridace na povrch vřetena z Nimonicu 901 a zkoumání vlastností nitridované vrstvy. Věrohodnost výsledků je podložena množstvím experimentů, které jsou uvedeny v příloze diplomové práce.Katedra technologie obráběníObhájenoThe thesis deals with the production of regular spindles used for controling steam in a valve of steam turbines to USC power stations. Deals with characteristic of Inconel materials and describes the machining process and cutting tools for spindles production of high-temperature alloy Nimonic 901. The second part describes application ion nitriding on the surface the spindle from the Nimonic 901 and investigates the properties of nitride layer. The credibility of the results is supported by many experiments, which are indicated in Annex thesis

Měření střídavých proudů pomocí Rogowského cívky

Import 26/09/2007Prezenční454 - Katedra elektroniky a telekomunikační technik

"Příspěvek k reflexi pojetí člověka v behaviorismu, humanistické psychologii a psychoanalýze"

Katedra psychologieFilozofická fakult

Alpha-blockers for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: A systematic review and meta-analysis. A report from the Neuro-Urology Promotion Committee of the International Continence Society (ICS)

AIM We aimed to systematically assess the evidence on the efficacy and safety of alpha-blockers in patients with multiple sclerosis (MS) suffering from neurogenic lower urinary tract dysfunction (NLUTD). METHODS The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was used to perform this systematic review. An electronic search of Cochrane register, Embase, Medline, Scopus (last search 3 March 2018) and screening of reference lists as well as reviews were used to identify the studies. Articles were included if they reported on efficacy/safety of alpha-blockers for the treatment of NLUTD in patients with MS. RESULTS After screening of 7'015 abstracts, three studies enrolling a total of 50 patients were included: one randomized, placebo-controlled, single-blind trial and two prospective cohort studies. Alpha-blocker treatment was successful in 50% to 96% of the patients. Pooling data from the three included studies, the relative risk for successful alpha-blocker treatment was 3.89 (95% confidence interval 2.7-7.0). The general safety profile of alpha-blockers was favorable with 8% of the patients reporting adverse events. CONCLUSIONS Alpha-blockers may be effective and safe for treating NLUTD in female and male patients with MS but the studies were small and the overall quality of evidence was low. To make definitive conclusions, well designed randomized controlled trials are highly warranted

Toll-Like Receptor 3 Overexpression Induces Invasion of Prostate Cancer Cells, whereas Its Activation Triggers Apoptosis

Toll-like receptor 3 (TLR3) is an endosomal receptor expressed in several immune and epithelial cells. Recent studies have highlighted its expression also in solid tumors, including prostate cancer (PCa), and have described its role primarily in the proinflammatory response and induction of apoptosis. It is up-regulated in some castration-resistant prostate cancers. However, the role of TLR3 in prostate cancer progression remains largely unknown. The current study experimentally demonstrated that exogenous TLR3 activation in PCa cell lines leads to a significant induction of secretion of the cytokines IL-6, IL-8, and interferon-β, depending on the model and chemoresistance status. Transcriptomic analysis of TLR3-overexpressing cells revealed a functional program that is enriched for genes involved in the regulation of cell motility, migration, and tumor invasiveness. Increased motility, migration, and invasion in TLR3-overexpressing cell line were confirmed by several in vitro assays and using an orthotopic prostate xenograft model in vivo. Furthermore, TLR3-ligand induced apoptosis via cleavage of caspase-3/7 and poly (ADP-ribose) polymerase, predominantly in TLR3-overexpressing cells. These results indicate that TLR3 may be involved in prostate cancer progression and metastasis; however, it might also represent an Achilles heel of PCa, which can be exploited for targeted therapy