Enhanced reality live role playing

Live role-playing is a form of improvisational theatre played for the experience of the performers and without an audience. These games form a challenging application domain for ubiquitous technology. We discuss the design options for enhanced reality live role-playing and the role of technology in live role-playing games

WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

The WRAP53 protein regulates the formation and maintenance of Cajal bodies (nuclear sub-organelles), as well as directs the recruitment of nuclear factors to Cajal bodies

Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings

IS/IT-architectures & Precesses - What it takes from an IS/IT-architecture to support a process oriented organization

Organizations today have to deal with increasing competition and customer demands, and one effect that this has on an organization is that it has to be flexible, to be able to adapt to new situations quickly. One way to increase the speed and flexibility within a company is to work process oriented instead of having isolated functions. This structure, i.e. the process oriented, has to be supported by an equally flexible flow of information, and this in turn puts great pressure on the IS/IT-architecture, i.e. how to support the transfer and storage of information. It is this situation that is the subject for this thesis, i.e. what does it take from an IS/IT-architecture to support a process oriented organization? In order to answer this, there are lots of factors to consider. For example, what should the systems structure be like? how are roles and responsibilities affected? is there a need for standardization or centralization/decentralization? what about terminology? etc. To try to answer these questions, and to reach a conclusion, this thesis is an empirical study that builds upon real-life facts , opinions and experiences in combination with a number of established theories. Astra is our case study, and this is a company where this is a relevant issue, since the company is moving from a functional towards a process oriented structure. The answer to our research question suggests that all the above factors, plus some more, are absolutely critical in order to reach success. But, they also can cause serious problems if not managed properly. Consequently, this is an issue of great complexity, and it does indeed deserve thorough consideration within all companies that want to work process oriented and with the appropriate support from IS/IT

Värdering av IT-investeringar : en metodik för att underlätta bedömningen av IT-investeringar

IT-investeringar har under senare år blivit allt viktigare, och idag berör de i stort samtliga organisationer. För att bedöma mer traditionella investeringar finns det många olika metoder, och organisationer har betydande erfarenhet inom området. Vad det gäller IT-investeringar tillkommer dock flera problem, vilket försvårar möjligheten att genomföra en ekonomisk värdering. Framförallt är det mycket svårt att identifiera vilka effekter, positiva eller negativa, som investeringen för med sig. Vidare kan det vara ett problem att värdera dessa då många av dem kan vara av mjuk, och kvalitativ art. Trots att IT-investeringar har blivit allt viktigare för SMHI saknar organisationen, precis som många andra organisationer, en konsekvent metodik för att bedöma dessa investeringar. Utgångspunkten för det här arbetet är därför att ta fram en metodik, vilken SMHI kan använda som stöd för sina bedömningar av IT-investeringar

Värdering av IT-investeringar : en metodik för att underlätta bedömningen av IT-investeringar

IT-investeringar har under senare år blivit allt viktigare, och idag berör de i stort samtliga organisationer. För att bedöma mer traditionella investeringar finns det många olika metoder, och organisationer har betydande erfarenhet inom området. Vad det gäller IT-investeringar tillkommer dock flera problem, vilket försvårar möjligheten att genomföra en ekonomisk värdering. Framförallt är det mycket svårt att identifiera vilka effekter, positiva eller negativa, som investeringen för med sig. Vidare kan det vara ett problem att värdera dessa då många av dem kan vara av mjuk, och kvalitativ art. Trots att IT-investeringar har blivit allt viktigare för SMHI saknar organisationen, precis som många andra organisationer, en konsekvent metodik för att bedöma dessa investeringar. Utgångspunkten för det här arbetet är därför att ta fram en metodik, vilken SMHI kan använda som stöd för sina bedömningar av IT-investeringar

Experiences of a follow-up visit to an ICU

Godkänd; 2008; 20080904 (andbra