GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis

Multiple myeloma (MM) is an incurable disease characterized by the presence of malignant plasma cells in the bone marrow that secrete specific monoclonal immunoglobulins into the blood. Obesity has been associated with the risk of developing solid and hematological cancers, but its role as a risk factor for MM needs to be further explored. Here, we evaluated whether 32 genome-wide association study (GWAS)-identified variants for obesity were associated with the risk of MM in 4189 German subjects from the German Multiple Myeloma Group (GMMG) cohort (2121 MM cases and 2068 controls) and 1293 Spanish subjects (206 MM cases and 1087 controls). Results were then validated through meta-analysis with data from the UKBiobank (554 MM cases and 402,714 controls) and FinnGen cohorts (914 MM cases and 248,695 controls). Finally, we evaluated the correlation of these single nucleotide polymorphisms (SNPs) with cQTL data, serum inflammatory proteins, steroid hormones, and absolute numbers of blood-derived cell populations (n = 520). The meta-analysis of the four European cohorts showed no effect of obesity-related variants on the risk of developing MM. We only found a very modest association of the POC5rs2112347G and ADCY3rs11676272G alleles with MM risk that did not remain significant after correction for multiple testing (per-allele OR = 1.08, p = 0.0083 and per-allele OR = 1.06, p = 0.046). No correlation between these SNPs and functional data was found, which confirms that obesity-related variants do not influence MM risk.Instituto de Salud Carlos III (Madrid, Spain; PI17/02256 and PI20/01845)Consejería de Salud y Familia de la Junta de Andalucía (PY20/01282)Dietmar Hopp Foundation and the German Ministry of Education and Science (BMBF: CLIOMMICS (01ZX1309

Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers forMultipleMyeloma: AMeta-Analysis of Three Large Cohorts and Functional Characterization

European Union’s Horizon 2020 research and innovation program, N 856620Instituto de Salud Carlos III and FEDER (Madrid, SpainPI17/02256 and PI20/01845), Consejería de Transformación Económica, Industria, Conocimiento y UniversidadesDietmar Hopp Foundation and the German Ministry of Education and Science (BMBF: CLIOMMICS [01ZX1309]National Cancer Institute of the National Institutes of Health under award numbers: R01CA186646, U01CA249955 (EEB)Science and Technology (FCT)—project UIDB/50026/2020UIDP/50026/2020 and by the project NORTE-01-0145-FEDER-000055PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF

Entrepreneurship and employabiblity: the role of gender

A global concern about youth employment and the challenges to better connect companies’ needs and professional and labour profiles of graduates is shared by policy makers and higher education institutions. The recognition of entrepreneurship as an integral and sustainable part of the solution is a source of motivation for the incorporation of entrepreneurial competencies onto university curricula. The driving force of this study is to analyse how and to what extent the employability weighs on entrepreneurship. A Partial Least Squares Structural Equation Modeling (PLS-SEM) is applied using a survey that links Employability and Entrepreneurial Intention positively and highlights the moderating effect of gender. Our study contributes to research showing the interconnection between both and provides an insight from a gender approach. Women feel competences related to entreprising people are useful beyond business creation and they reinforce their self-confidence about their skills facing both entrepreneurial or employment objetives.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The role of gender and connections between entrepreneurship and employability in higher education

A global concern about youth employment and the challenges to better connect companies' needs and professional and labour profiles of graduates is shared by policy makers and higher education institutions. The recognition of entrepreneurship as an integral and sustainable part of the solution is a source of motivation for the incorporation of entrepreneurial competencies onto university curricula. The driving force of this study is to analyse how and to what extent the employability weighs on entrepreneurship. A Partial Least Squares Structural Equation Modeling (PLS-SEM) is applied using a survey that links Employability and Entrepreneurial Intention positively and highlights the moderating effect of gender. Our study contributes to research showing the interconnection between both and provides an insight from a gender approach. Women feel competences related to entreprising people are useful beyond business creation and they reinforce their self-confidence about their skills facing both entrepreneurial or employment objectives.This work was supported by the Programme PAIDI Andalucía under grant number PY20_00407 (Junta de Andalucía/Universidad de Málaga) and Funding for Open Access Charge: Universidad de Málaga/CBUA; Consejería de Conocimiento, Investigación y Universidad, Junta de Andalucía

Can a corporate well-being programme maintain the strengths of the healthy employee in times of COVID-19 and extensive remote working? An empirical case study.

The COVID-19 pandemic and the increase of working-from-home have drastically changed many aspects of work life, causing very negative effects on employees' physical and psycho-social well-being. Healthy organisations have healthy employees, who have at least five psycho-social strengths of engagement, self-efficacy, resilience, optimism and hope, which are reinforced by physical activity, relating to each other in a positive way and leading to numerous benefits for the company. These strengths are being weakened by the pandemic, and the aim of this empirical study is to analyse through a case study the effects of an updated corporate wellness programme in times of pandemic on these strengths of the healthy employee. The sample was of 251 employees, 91 women and 160 men. The instruments used were the International Physical Activity Questionnaire and the adaptation of the Healthy and Resilient Organization questionnaire. The results indicated that workers with high physical activity, higher seniority, well guided by supervisors, as well as a comprehensive (multi-component) well-being programme, not only physical but also psycho-social, and with the use of different digital tools (an App is not enough), can mitigate these negative effects. Whereas companies are grappling with reduced employee engagement among other harmful psychosocial and physical effects, this case study suggests that a good corporate well-being programme could help mitigate these detrimental consequences for their workforce and be helpful for the company to adapt to this rapidly changing workplace

Creative researchers conflicts management

La creatividad es una actitud, humana y dinámica, que promueve el cambio y el desarrollo, tanto a nivel individual como social. Aunque su procedimiento es individual, su trabajo toma la forma colectiva en un proceso discontinuo e instantáneo, sin dañar a los sujetos en la preocupación de evaluar su impacto. Su condición es el clima, el ambiente del equipo, presupone la capacitación, el aprendizaje de métodos, la generación continua de ideas, preguntas que, suponiendo un pensamiento divergente y lateral, inducen necesariamente la gestión de sus conflictos. En este sentido, intentamos encontrar, a través de un grupo de investigadores y coordinadores especializados, indicaciones de dicha gestión en los equipos que han orientado. Para hacer esto, utilizamos dos pruebas, una sobre creatividad y otra sobre conflictos, y el paquete estadístico para las ciencias sociales (versión SPSS-portugués), donde pudimos ver que la gestión de conflictos en investigadores creativos es una evidencia, debido a la búsqueda de mejoras en el rendimiento y en la productividad, por parte de sus miembros, y debido a la ausencia de conflictos en el objeto estudiado.Creativity is an attitude, human and dynamic, promoting change and development, both on an individual and social level. Although their procedure is individual, their work takes the collective form in a discontinued and instantaneous process, not harming the subjects in the concern of evaluating its impact. Their condition is the climate, the team environment, presupposes the training, the learning of methods, the continuous generation of ideas, questions that, assuming divergent and lateral thinking, necessarily induce the management of their conflicts. In this sense, we try to find, through a group of researchers and specialized coordinators, indications of such management in the teams they have oriented. In order to do this, we used two tests, one about creativity, and another about conflicts, and the statistical package for the social sciences (SPSS-Portuguese version), where we could see that conflict management in creative researchers is an evidence, due to the search for improvements in performance and in productivity, on the part of its members, and due to the absence of conflicts in the studied object .peerReviewe

Bibliometric Analysis of International Scientific Production on the Management of Happiness and Well-Being in Organizations

The interest of the scientific community and, consequently, the scientific production of topics on happiness and well-being at work, or the management of happiness in organizations, has been increasing over the years. The main objective of this bibliometric analysis is to determine the evolution of the concepts referred to in published scientific works. Bibliometric methods and techniques are used to analyze the themes and the most relevant trends, the number of papers and their citations, and the main institutions, and to highlight areas where the most research has been done on these issues. In addition to the review of the scientific literature, 312 studies are analyzed and net-mapped. The most outstanding results are the increase in the number of papers and citations during the health pandemic caused by COVID-19; the importance given to the transversality of wellbeing programs in corporations; and the greater frequency of research on the benefits of promoting the improvement of quality of life for work performance and its social impactThis work was supported by the Programme PAIDI Andalucía under grant number PY20_00407 (Junta de Andalucía/Universidad de Málaga) and Funding for Open Access Charge: Universidad de Málaga/CBUA

Territorial incidence of Andalusian Government budget. An exercise of provincial fiscal balance

El trabajo realiza una estimación de la balanza fiscal de la Junta de andalucía para el año 2001 con las provincias andaluzas. Para ello se ha desarrollado una metodología heredera de la ya dilatada tradición de cálculos de balanzas fiscales del Estado con las comunidades autónomas que incluye una pormenorizada descripción de las hipótesis de incidencia de ingresos y gastos que sigue las líneas generales usuales a este tipo de trabajos. En este trabajo se incluyen algunas novedades metodológicas como son la inclusión del análisis del sector público empresarial, un tratamiento novedoso de las transferencias recibidas por la administración Pública andaluza y un análisis de los resultados obtenidos en los cálculos.This paper performs an estimation of the “Junta de andalucía” fiscal flow with the andalusian provinces in 2001. In order to do that, we have developed a methodology that agrees with the fiscal flows’ usual estimations of the state with the autonomous communities. This methodology contains a detailed description of the incidence assumptions of receipts and expenditures that follows the habitual tradition. our paper also incorporates some methodological changes like the incorporation of the state-owned companies, a new treatment state grants to the “Junta de andalucía” and an analysis of the obtained outcome in the calculatio