Cert: un modelo matemático y tecnológico de evaluación

En este artículo, los autores, profesores del Área de Didáctica de las Matemáticas de la Facultad de Ciencias dela Educación de la Universidad de Sevilla, realizan un estudio de las componentes matemáticas del modelo de evaluación propuesto en el CERT (Coopertative Project of Evaluation Results Training). Este trabajo se basa fundamentalmente en modelos estadísticos básicos.In this article, the authors, teachers of the Area of Didactic of Mathematics of the Faculty of Science of Education of the University of Seville, accomplish a study of the mathematics components of the evaluation model porposed in the CERT (Cooperative Project of Evaluations Results Training). This work is based fundamentally on basic statistic models

Laboratorio virtual de matemáticas II

Los nuevos planes de estudios en la Diplomatura de Magisterio de la Facultad de Ciencias de la Educación nos ha llevado, en el proceso de continuación de los proyectos de Innovación desarrollados en los tres cursos anteriores, a la adaptación del proyecto actual a una nueva concepción metodológica de las asignaturas. Es por esto que en el actual curso hemos querido acercar a los futuros profesores a las nuevas tecnologías en el estudio y desarrollo de la Didáctica de las Matemáticas, como herramienta de trabajo en el proceso de aprendizaje, para luego ellos continuarlo en los futuros procesos de enseñanzaThe new curricula in the Diplomatura de Magisterio of the Faculty of Sciences of the Education have taken to us, in the process of continuation of the developed projects of Innovation in both previous courses, to the adaptation of the present project to the new methodologic conception of the subjets. It is by that in the present course we have wanted to approach the future professors to the new technologies in the study and development of the Didactics of the mathematics, like too! of work in the learning pr'ocess, soon they to continue it in the future processes of educatio

Flow y rendimiento en corredores de maratón

El flow es un estado subjetivo intensamente positivo y placentero que, por sus dimensiones y características (e.g., equilibrio entre las de- mandas percibidas de la tarea y las habilidades personales para la acción requerida, objetivos claros, máxima concentración, elevado control percibido sobre la ejecución, etc.), se asocia a un rendimiento superior en comparación con las actuaciones normales. La literatura señala que se puede experimentar en diferentes contextos y actividades, incluido el deporte. El objetivo de este estudio fue doble: Por un lado, quisimos comprobar si maratonianos de dis- tinto nivel de rendimiento experimentan flow y las características de este fenómeno en este colectivo de deportistas, así como conocer si las experiencias de flow eran diferentes en tres situaciones deportivas: Entrenamientos y carreras en general, la mejor carrera recordada y la última carrera; por otro lado, quisimos explorar la posible relación entre las experiencias de flow y las marcas esperadas y conseguidas por los corredores en las carreras mejor y última. Colaboraron voluntariamente en este estudio 170 maratonianos que corrieron el Maratón de Sevilla 2010, los cuales completaron la Escala Breve de Flow (Godoy-Izquierdo, Vélez, Rodríguez y Ramírez, 2009) antes y después de participar en dicha carrera. Los participantes refirieron experimentar estados de flow en las tres situaciones deportivas exploradas, aunque se encontraron diferencias interindividuales respecto a la frecuencia y profundidad de este estado, así como en la experimentación de las distintas dimensiones del fenómeno. Los participantes informaron experimentar episodios de flow más profundos, intensos y frecuentes en la mejor competición recordada y en el último maratón en comparación con los entrenamientos y las carreras en general. Además, los corredores con más experiencias de flow esperaron y obtuvieron mejores marcas. Como conclusión, el flow es un estado expe- rimentado con frecuencia, particularmente en las mejores carreras, por atletas de una especialidad tan exigente como el maratón. Saber qué condiciones personales y contextuales llevan al flow ayudaría a diseñar intervenciones psicológicas destinadas al incremento de las habilidades que permiten a los atletas alcanzar estados intensos de flow, lo que a su vez podría mejorar su ejecución y resultados.Flow is an intensely positive and pleasant subjective state that has been linked to superior performance compared to ordinal performance, due to its dimensions and features (e.g., a balance between perceived task challenges and one's own skills for the required action, clear goals, full concentration, elevated perceived control on performance, etc.). Research has shown that it occurs in different contexts and activities, including sports. In a two-fold aim, we sought to explore whether marathon runners with different levels of expertise experienced flow states, and the characteristics of this phenomenon in this athletic population; as well as to find out whether flow experiences were different in three sport conditions: practice sessions and competitions in general, the best race remembered by the athlete, and their last race. We further explored the possible relationship between flow states and the expected and achieved times in the last and the best races. A total of 170 males who were marathon runners participating in the Seville Marathon 2010 voluntarily collaborated in this study. Participants completed the Brief Flow Scale (EBF, Godoy-Izquierdo, Vélez, Rodríguez y Ramírez, 2009) before and after the marathon race. Participants reported experiencing flow states in the three athletic activities explored, but interindividual differences were found regarding the frequency and depth of such experiences. There were also differences between the runners regarding the dimensions of the phenomenon. Participants reported experiencing deeper, more intense and frequent episodes of flow in their best and last marathons in comparison to practice sessions and races in general. In addition, runners reporting deeper or more frequent flow episodes also expected and achieved better times. Concluding, flow is frequently experienced by marathon runners, particularly in their best performances, even when marathon running is a highly demanding sport modality. Establishing personal and contextual conditions leading to flow states will help us in designing psychological interventions aimed at increasing athletes' skills to achieve intense states of flow, which in turn might improve their performance and success.O flow é um estado subjetivo intensamente positivo e agradável, que, devido às suas dimensões e características (por exemplo, equilíbrio entre as demandas percebidas de as tarefas e as competências pessoais necessárias para a ação, objetivos claros, máxima concentração, elevada percepção de controle sobre a execução, etc.), tem sido associado com um desempenho superior em comparação com o desempenho normal. A literatura mostra que pode ser experimentado em diferentes contextos e atividades, incluindo esportes. O objetivo deste estudo foi duplo: Por um lado, queríamos ver se maratonistas com diferentes níveis de desempenho experimentam diferentes níveis de flow e as características desse fenômeno neste grupo de atletas, bem como saber se as experiências de flow foram diferentes em três situações desportivas: Os treinos e competições em geral, a melhor corrida lembrada pelo atleta, e sua última corrida; por outro lado, quisemos explorar a possível relação entre as experiências de flow e as marcas esperadas e obtidas por corredores em as corridas melhor e última. Voluntariamente colaboraram neste estudo 170 maratonistas que correram a Maratona de Sevilha 2010, quem responderam a Escala Breve de Flow (Godoy-Izquierdo, Vélez, Rodríguez e Ramírez, 2009) antes e depois de participar na corrida. Os participantes relataram experimentar estados de flow nas três situações atléticas exploradas, embora diferenças interindividuais foram encontradas em relação à frequência e profundidade de tais experiências, e também em várias dimensões do fenômeno. Os participantes relataram ter episódios de flow mais profundo, intenso e freqüente na melhor competição lembrada e na última maratona em comparação com o treinamento e corridas em geral. Além disso, os corredores com experiências de flow mais profundas ou mais frequentes esperaram e tem melhores marcas. Em conclusão, o flow é freqüentemente experimentado por atletas de uma especialidade tão exigente como maratona, principalmente em suas melhores corridas. Estabelecer as condições pessoais e contextuais que pode levar ao flow nos permite projetar intervenções psicológicas para aumentar as habilidades que ajudam os atletas a alcançar estados intensos de flow, que por sua vez poderiam melhorar o seu desempenho e resultados

Consumo de suplementos deportivos en corredores de montaña: diferencias en función del sexo y del nivel competitivo

Introduction: sports supplements (SS) are widely used by all types of athletes to improve their performance. These SS are classified according to the ABCD system of the Australian Institute of Sports (AIS) from higher to lower scientific evidence. In mountain runners, their use could be necessary due to the physiological demands required by this sport. However, the literature on the use of SS by mountain runners is scarce. Objective: to analyze the pattern of SS consumption in mountain runners by studying differences according to sex and competitive level (regional vs national). Methodology: this was a descriptive and cross-sectional study on the consumption and use of SS by mountain runners participating in the Alcoy Solidarity Trail. Data were collected through a validated questionnaire based on content, applicability, structure, and presentation. This questionnaire was completed online by the athletes, who could fill it out voluntarily and at their convenience, as well as anonymously. Results: the results showed that 87.5 % of participants reported consuming SS, with no significant differences observed with respect to competitive level, although differences were found with respect to sex (92.7 % in men vs 70.6 % in women; p = 0.029), with a higher consumption found in men compared to women. The most consumed SS were sports bars (81.9 %), sports drinks (75.0 %), caffeine (48.6 %), magnesium (38.9 %), and electrolytes (27.8 %). Conclusions: among mountain runners consumption of SS is high, and 4 of the 5 most habitually consumed SS belong in the category of greater scientific evidence.Introducción: los suplementos deportivos (SS) son muy utilizados por todo tipo de deportistas para mejorar su rendimiento. Estos SS se clasifican según el sistema ABCD del Australian Institute of Sports (AIS) de mayor a menor evidencia científica. En corredores de montaña, su uso podría ser necesario debido a las exigencias fisiológicas de este deporte. Sin embargo, la literatura sobre el uso de SS por corredores de montaña es escasa. Objetivo: analizar el patrón de consumo de SS en corredores de montaña, estudiando las diferencias según el sexo y el nivel competitivo (autonómico vs. nacional). Metodología: se trata de un estudio descriptivo y transversal sobre el consumo y uso de SS por parte de los corredores de montaña participantes en el Trail Solidario de Alcoy. Los datos fueron recolectados a través de un cuestionario validado en base al contenido, la aplicabilidad, la estructura y la presentación. El cuestionario fue completado de manera online por los atletas que pudieron rellenarlo voluntariamente y a conveniencia, y de manera anónima. Resultados: los resultados mostraron que el 87,5 % de los participantes reportaron consumir SS, no observándose diferencias significativas con respecto al nivel competitivo, aunque sí se encontraron diferencias con respecto al sexo (92,7 % en hombres y 70,6 % en mujeres; p = 0,029), donde los hombres tenían un mayor consumo en comparación con las mujeres. Los SS más consumidos fueron las barritas deportivas (81,9 %), las bebidas deportivas (75,0 %), la cafeína (48,6 %), el magnesio (38,9 %) y los electrólitos (27,8 %). Conclusiones: entre los corredores de montaña, el consumo de SS es alto y 4 de los 5 SS más consumidos pertenecen a la categoría de mayor evidencia científica

Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization

Background: Fertilization is a key physiological process for the preservation of the species. Consequently, different mechanisms affecting the sperm and the oocyte have been developed to ensure a successful fertilization. Thus, sperm acrosome reaction is necessary for the egg coat penetration and sperm-oolema fusion. Several molecules are able to induce the sperm acrosome reaction; however, this process should be produced coordinately in time and in the space to allow the success of fertilization between gametes. The goal of this study was to analyze the metabolites secreted by cumulus-oocyte-complex (COC) to find out new components that could contribute to the induction of the human sperm acrosome reaction and other physiological processes at the time of gamete interaction and fertilization. Methods: For the metabolomic analysis, eighteen aliquots of medium were used in each group, containing: a) only COC before insemination and after 3 h of incubation; b) COC and capacitated spermatozoa after insemination and incubated for 16–20 hours; c) only capacitated sperm after 16–20 h in culture and d) only fertilization medium as control. Six patients undergoing assisted reproduction whose male partners provided normozoospermic samples were included in the study. Seventy-two COC were inseminated. Results: The metabolites identified were monoacylglycerol (MAG), lysophosphatidylcholine (LPC) and phytosphingosine (PHS). Analysis by PCR and in silico of the gene expression strongly suggests that the cumulus cells contribute to the formation of the PHS and LPC. Conclusions: LPC and PHS are secreted by cumulus cells during in vitro fertilization and they could be involved in the induction of human acrosome reaction (AR). The identification of new molecules with a paracrine effect on oocytes, cumulus cells and spermatozoa will provide a better understanding of gamete interaction.This study was supported by grant GV/2009/097 from Department of Education, Generalitat Valenciana, Vicerrectorado de Investigación, University of Alicante, Alicante, Spain (Vigrob-137), the Spanish Ministerio de Economía y Competitividad AGL2012-40180-C03-02 and Fundación Seneca (04542/GERM/06)

DNA damage response-related alterations define the genetic background of patients with chronic lymphocytic leukemia and chromosomal gains

[EN]The presence of chromosomal gains other than trisomy 12 suggesting a hyperdiploid karyotype is extremely rare in chronic lymphocytic leukemia (CLL) and is associated with a dismal prognosis. However, the genetic mechanisms and mutational background of these patients have not been fully explored. To improve our understanding of the genetic underpinnings of this subgroup of CLL, seven CLL patients with several chromosomal gains were sequenced using a next-generation sequencing (NGS)-targeted approach. The mutational status of 54 genes was evaluated using a custom-designed gene panel including recurrent mutated genes observed in CLL and widely associated with CLL pathogenesis. A total of 21 mutations were detected; TP53 (42.8%), ATM (28.5%), SF3B1 (28.5%), and BRAF (28.5%) were the most recurrently mutated genes. Of these mutations, 61.9% were detected in genes previously associated with a poor prognosis in CLL. Interestingly, five of the seven patients exhibited alterations in TP53 or ATM (deletion and/or mutation), genes involved in the DNA damage response (DDR), which could be related to a high genetic instability in this subgroup of patients. In conclusion, CLL patients with several chromosomal gains exhibit high genetic instability, with mutations in CLL driver genes and high-risk genetic alterations involving ATM and/or TP53 genes

Impact of augmented renal clearance on the pharmacokinetics of linezolid: Advantages of continuous infusion from a pharmacokinetic/pharmacodynamic perspective

Objectives: The aim of this study was to assess the influence of renal function, in particular the presence of augmented renal clearance (ARC), on the pharmacokinetics of linezolid in critically ill patients. The effect of continuous infusion on the probability of therapeutic success from a pharmacokinetic/pharmacodynamic (PK/PD) perspective was also evaluated. Methods: Seventeen patients received linezolid (600 mg every 12 h) as a 30-min infusion and 26 as a continuous infusion (50 mg/h). The PK parameters were calculated and the probability of PK/PD target attainment (PTA) was estimated by Monte Carlo simulation (MCS) for different doses administered by intermittent (600 mg every 12 h or 600 mg every 8 h) or continuous infusion (50 mg/h or 75 mg/h). Results: In patients without ARC, the standard dose was adequate to attain the PK/PD target. However, linezolid clearance was significantly higher in ARC patients, leading to sub-therapeutic concentrations. Continuous infusion (50 mg/h) provided concentrations >= 2 mg/l in 70% of the ARC patients. MCS revealed that concentrations >= 2 mg/l would be reached in >90% of patients receiving 75 mg/h. Conclusions: ARC increases linezolid clearance and leads to a high risk of underexposure with the standard dose. Continuous infusion increases the PTA, but an infusion rate of 75 mg/h should be considered to ensure concentrations >= 2 mg/ml.This work was supported by the University of the Basque Country UPV/EHU (PPG17/65, GIU17/32), Spain

Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study

[EN] Background Levetiracetam pharmacokinetics is extensively altered in critically ill patients with augmented renal clearance (ARC). Consequently, the dosage regimens commonly used in clinical practice may not be sufficient to achieve target plasma concentrations. The aim of this study is to propose alternative dosage regimens able to achieve target concentrations in this population. Furthermore, the feasibility of the proposed dosing regimens will be discussed from a clinical point of view. Methods Different dosage regimens for levetiracetam were evaluated in critically ill patients with ARC. Monte Carlo simulations were conducted with extended or continuous infusions and/or high drug doses using a previously developed population pharmacokinetic model. To assess the clinical feasibility of the proposed dosages, we carried out a literature search to evaluate the information on toxicity and efficacy of continuous administration or high doses, as well as the post-dilution stability of levetiracetam. Results According to the simulations, target concentrations in patients with CrCl of 160 or 200 mL/min can be achieved with the 3000 mg daily dose by prolonging the infusion time of levetiracetam. For patients with CrCl of 240 mL/min, it would be necessary to administer doses higher than the maximum recommended. Available evidence suggests that levetiracetam administration in continuous infusion or at higher doses than those approved seems to be safe. It would be desirable to re-examinate the current recommendations about drug stability and to achieve a consensus in this issue. Conclusions Conventional dosage regimens of levetiracetam (500-1500 mg twice daily in a short infusion) do not allow obtaining drug plasma concentrations among the defined target in critically ill patients with ARC. Therefore, new dosing guidelines with specific recommendations for patients in this subpopulation are needed. This study proposes new dosages for levetiracetam, including extended (4 or 6 h) infusions, continuous infusions or the administration of doses higher than the recommended in the summary of product characteristics (> 3000 mg). These new dosage recommendations take into account biopharmaceutical and pharmacokinetic aspects and meet feasibility criteria, which allow them to be transferred to the clinical environment with safety and efficacy. Nevertheless, further clinical studies are needed to confirm these results.This research was funded by Department of Education of the Basque Government (PIBA 2019-57) and by the University of the Basque Country UPV/EHU (GIU20/048)

Flow and performance in marathon runners

El flow es un estado subjetivo intensamente positivo y placentero que, por sus dimensiones y características (e.g., equilibrio entre las de- mandas percibidas de la tarea y las habilidades personales para la acción requerida, objetivos claros, máxima concentración, elevado control percibido sobre la ejecución, etc.), se asocia a un rendimiento superior en comparación con las actuaciones normales. La literatura señala que se puede experimentar en diferentes contextos y actividades, incluido el deporte. El objetivo de este estudio fue doble: Por un lado, quisimos comprobar si maratonianos de dis- tinto nivel de rendimiento experimentan flow y las características de este fenómeno en este colectivo de deportistas, así como conocer si las experiencias de flow eran diferentes en tres situaciones deportivas: Entrenamientos y carreras en general, la mejor carrera recordada y la última carrera; por otro lado, quisimos explorar la posible relación entre las experiencias de flow y las marcas esperadas y conseguidas por los corredores en las carreras mejor y última. Colaboraron voluntariamente en este estudio 170 maratonianos que corrieron el Maratón de Sevilla 2010, los cuales completaron la Escala Breve de Flow (Godoy-Izquierdo, Vélez, Rodríguez y Ramírez, 2009) antes y después de participar en dicha carrera. Los participantes refirieron experimentar estados de flow en las tres situaciones deportivas exploradas, aunque se encontraron diferencias interindividuales respecto a la frecuencia y profundidad de este estado, así como en la experimentación de las distintas dimensiones del fenómeno. Los participantes informaron experimentar episodios de flow más profundos, intensos y frecuentes en la mejor competición recordada y en el último maratón en comparación con los entrenamientos y las carreras en general. Además, los corredores con más experiencias de flow esperaron y obtuvieron mejores marcas. Como conclusión, el flow es un estado expe- rimentado con frecuencia, particularmente en las mejores carreras, por atletas de una especialidad tan exigente como el maratón. Saber qué condiciones personales y contextuales llevan al flow ayudaría a diseñar intervenciones psicológicas destinadas al incremento de las habilidades que permiten a los atletas alcanzar estados intensos de flow, lo que a su vez podría mejorar su ejecución y resultados.Flow is an intensely positive and pleasant subjective state that has been linked to superior performance compared to ordinal performance, due to its dimensions and features (e.g., a balance between perceived task challenges and one’s own skills for the required action, clear goals, full concentration, elevated perceived control on performance, etc.). Research has shown that it occurs in different contexts and activities, including sports. In a two-fold aim, we sought to explore whether marathon runners with different levels of expertise experienced flow states, and the characteristics of this phenomenon in this athletic population; as well as to find out whether flow experiences were different in three sport conditions: practice sessions and competitions in general, the best race remembered by the athlete, and their last race. We further explored the possible relationship between flow states and the expected and achieved times in the last and the best races. A total of 170 males who were marathon runners participating in the Seville Marathon 2010 voluntarily collaborated in this study. Participants completed the Brief Flow Scale (EBF, Godoy-Izquierdo, Vélez, Rodríguez y Ramírez, 2009) before and after the marathon race. Participants reported experiencing flow states in the three athletic activities explored, but interindividual differences were found regarding the frequency and depth of such experiences. There were also differences between the runners regarding the dimensions of the phenomenon. Participants reported experiencing deeper, more intense and frequent episodes of flow in their best and last marathons in comparison to practice sessions and races in general. In addition, runners reporting deeper or more frequent flow episodes also expected and achieved better times. Concluding, flow is frequently experienced by marathon runners, particularly in their best performances, even when marathon running is a highly demanding sport modality. Establishing personal and contextual conditions leading to flow states will help us in designing psychological interventions aimed at increasing athletes’ skills to achieve intense states of flow, which in turn might improve their performance and success.Esta investigación ha sido parcialmente financiada con la ayuda económica concedida al Grupo de Investigación Psicología de la Salud y Medicina Conductual (CTS-0267) por la Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía (España)

Estímulo del trabajo autónomo en el aprendizaje práctico de la Histología: una experiencia transversal en Ciencias de la salud

El estudio microscópico de tejidos y órganos constituye un aspecto muy importante del aprendizaje de la histología, pero no siempre se dispone de suficientes colecciones de muestras, sobre todo humanas, para que el alumnado pueda disponer de ellas de forma presencial durante las prácticas. Por ello, el portal virtual digital slidebox (DSB) permite al profesorado generar una colección de preparaciones histológicas virtuales, de manera que los estudiantes tienen acceso "online" a estas muestras y pueden visualizarlas a la misma escala que ofrece la observación directa del microscopio óptico, e incluso mayor. Para la realización de cada práctica en sus horas presenciales el alumno dispone previamente de un guión con los objetivos que debe cumplir al realizar la observación de cada preparación histológica. Al final de cada práctica presencial los objetivos son explicados por el alumno, y evaluados por el profesor, realizando una puesta en común. Una vez realizada la práctica, y en horario no presencial, el alumnado tiene la posibilidad de completar este trabajo usando el portal virtual DSB. Con las imágenes digitales captadas el alumno realiza su portafolio de prácticas incorporando dichas imágenes y rotulándolas. Al final del curso se realiza un examen práctico global y la evaluación final del portafolio