PSA Response to Lenalidomide Therapy in a Pre-Treated Patient with Metastatic Prostate Cancer Refractory to Hormones and Chemotherapy: A Case Report

Hormone-resistant prostate cancer (HRPC) occurs when prostate cancer is no longer responsive to hormone therapy. Treatment options are limited, and there is a clear necessity for therapies that improve outcome. Preclinical and clinical evidence supports the role of the immunomodulatory agent lenalidomide in HRPC. In this paper, we report that lenalidomide showed antitumoral activity in a patient with HRPC and bone metastases pre-treated with chemotherapy, decreased the PSA level and improved the patient's health status for the first 5 months. It is important to emphasize that it was not associated with hematologic toxicity

Cartografía de zonas inundables y análisis de riesgo en Cataluña (Plan Inuncat)

Ponencia presentada en: V Congreso Internacional de la Asociación Española de Climatología celebrado en Zaragoza del 18 al 21 de septiembre de 2006.[ES]Se expone el contenido y la metodología empleada en la elaboración del Plan de Emergencias por inundaciones de Cataluña (INUNCAT). El Plan comprende el sistema de alerta, la organización y los procedimientos de actuación en el caso de inundaciones extraordinarias, de los servicios de la Generalitat de Catalunya, de las otras administraciones y de las entidades públicas. La asignación del nivel de riesgo requiere del análisis de la peligrosidad para diferentes períodos de retorno, del análisis de la vulnerabilidad de los elementos expuestos, así como de la zonificación del territorio y la localización de los puntos conflictivos.[EN]The special plan of floods emergencies of Catalonia (INUNCAT) must face as main objective the flood emergencies in the territorial Catalonia (DGESC). Thus, the warning system, the organization and the procedures of performance in case of flood are defined. All its previous quantification and location of the fundamental aspects for the risk analysis, between which they emphasize the hazard analysis and the establishment of the recurrence times, the vulnerability, the zonation and the location of conflicting points

Estudi sobre la percepció de la neutralitat dels esports pels nois i les noies de Barcelona

Sol·licitant de l’informe: Gerència de Recurso

Knowledge and attitudes of primary healthcare patients regarding population-based screening for colorectal cancer

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to assess the extent of knowledge of primary health care (PHC) patients about colorectal cancer (CRC), their attitudes toward population-based screening for this disease and gender differences in these respects.</p> <p>Methods</p> <p>A questionnaire-based survey of PHC patients in the Balearic Islands and some districts of the metropolitan area of Barcelona was conducted. Individuals between 50 and 69 years of age with no history of CRC were interviewed at their PHC centers.</p> <p>Results</p> <p>We analyzed the results of 625 questionnaires, 58% of which were completed by women. Most patients believed that cancer diagnosis before symptom onset improved the chance of survival. More women than men knew the main symptoms of CRC. A total of 88.8% of patients reported that they would perform the fecal occult blood test (FOBT) for CRC screening if so requested by PHC doctors or nurses. If the FOBT was positive and a colonoscopy was offered, 84.9% of participants indicated that they would undergo the procedure, and no significant difference by gender was apparent. Fear of having cancer was the main reason for performance of an FOBT, and also for not performing the FOBT, especially in women. Fear of pain was the main reason for not wishing to undergo colonoscopy. Factors associated with reluctance to perform the FOBT were: <b><it>(i) </it></b>the idea that that many forms of cancer can be prevented by exercise and, <b><it>(ii) </it></b>a reluctance to undergo colonoscopy if an FOBT was positive. Factors associated with reluctance to undergo colonoscopy were: <b><it>(i) </it></b>residence in Barcelona, <b><it>(ii) </it></b>ignorance of the fact that early diagnosis of CRC is associated with better prognosis, <b><it>(iii) </it></b>no previous history of colonoscopy, and <b><it>(iv) </it></b>no intention to perform the FOBT for CRC screening.</p> <p>Conclusion</p> <p>We identified gaps in knowledge about CRC and prevention thereof in PHC patients from the Balearic Islands and the Barcelona region of Spain. If fears about CRC screening, and CRC per se, are addressed, and if it is emphasized that CRC is preventable, participation in CRC screening programs may improve.</p

Assessing associations between the AURKAHMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers

While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood appr

Supplementary Figure S1 from Biomarkers of Efficacy and Safety of the Academic BCMA-CART ARI0002h for the Treatment of Refractory Multiple Myeloma [Dataset]

B-cell maturation antigen (BCMA)-chimeric antigen receptor T-cells (CART) improve results obtained with conventional therapy in the treatment of relapsed/refractory multiple myeloma. However, the high demand and expensive costs associated with CART therapy might prove unsustainable for health systems. Academic CARTs could potentially overcome these issues. Moreover, response biomarkers and resistance mechanisms need to be identified and addressed to improve efficacy and patient selection. Here, we present clinical and ancillary results of the 60 patients treated with the academic BCMA-CART, ARI0002h, in the CARTBCMA-HCB-01 trial. We collected apheresis, final product, peripheral blood and bone marrow samples before and after infusion. We assessed BCMA, T-cell subsets, CART kinetics and antibodies, B-cell aplasia, cytokines, and measurable residual disease by next-generation flow cytometry, and correlated these to clinical outcomes. At cut-off date March 17, 2023, with a median follow-up of 23.1 months (95% CI, 9.2–37.1), overall response rate in the first 3 months was 95% [95% confidence interval (CI), 89.5–100]; cytokine release syndrome (CRS) was observed in 90% of patients (5% grades ≥3) and grade 1 immune effector cell-associated neurotoxicity syndrome was reported in 2 patients (3%). Median progression-free survival was 15.8 months (95% CI, 11.5–22.4). Surface BCMA was not predictive of response or survival, but soluble BCMA correlated with worse clinical outcomes and CRS severity. Activation marker HLA-DR in the apheresis was associated with longer progression-free survival and increased exhaustion markers correlated with poorer outcomes. ARI0002h kinetics and loss of B-cell aplasia were not predictive of relapse. Despite deep and sustained responses achieved with ARI0002h, we identified several biomarkers that correlate with poor outcomes.Instituto de Salud Carlos III (ISCIII) 'la Caixa' Foundation ('la Caixa') Fundación Científica Asociación Española Contra el Cáncer (AECC)Peer reviewe

The management of religious pluralism in Catalan municipalities

Aquest article se centra en els mecanismes utilitzats pels ajuntaments catalans a l&rsquo;hora de fer una gesti&oacute; del pluralisme religi&oacute;s a partir de les dades de la Fundaci&oacute; Carles Pi i Sunyer. Durant la d&egrave;cada passada, l&rsquo;exist&egrave;ncia i visibilitzaci&oacute; de la diversitat de cultes professats a Catalunya va cr&eacute;ixer, en part, gr&agrave;cies a les altes taxes immigrat&ograve;ries. D&rsquo;acord amb les capacitats que la legislaci&oacute; atorga als ajuntaments, en aquest article parem atenci&oacute; als &agrave;mbits de la pol&iacute;tica, la normativitzaci&oacute; i l&rsquo;administraci&oacute; per tal de fer una explicaci&oacute; estructural sobre les diferents maneres d&rsquo;afrontar la gesti&oacute; dels afers municipals en aquesta tem&agrave;tica. La recerca per a aquest treball s&rsquo;ha dut a terme mitjan&ccedil;ant un disseny multiestrat&egrave;gic gr&agrave;cies al qual diferenciem tres models de gesti&oacute; i hi aprofundim depenent dels mecanismes emprats i que anomenem no gesti&oacute;, gesti&oacute; politiconormativa i gesti&oacute; administrativa. Com a rerefons principal de distinci&oacute; tenen, a m&eacute;s de les diferents estrat&egrave;gies de gesti&oacute;, l&rsquo;exist&egrave;ncia de problem&agrave;tiques pr&egrave;vies, una diversificaci&oacute; de la poblaci&oacute; quant al lloc de proced&egrave;ncia i una diferenciaci&oacute; en les capacitats de gesti&oacute;. Un aspecte al qual tamb&eacute; prestarem atenci&oacute; &eacute;s la no incid&egrave;ncia del color pol&iacute;tic de l&rsquo;alcalde en la pertinen&ccedil;a a un model de gesti&oacute; o un altre.Paraules clau: religi&oacute;, conflictes socials, gesti&oacute; administrativa, institucions regionals.By analysing data from the Carles Pi i Sunyer Foundation, this article focuses on the mechanisms used by Catalan city councils to address the management of religious pluralism. Over the last decade, the existence and visibility of religious diversity in Catalonia has grown, largely due to high rates of immigration. Considering to the competences that legislation assigns local government, the article analyses political, regulatory and administrative areas so as to perform a structural explanation of the different ways of addressing the management of municipal affairs in this sphere. The research was carried out using a multi-strategic design that permitted the identification of three management models depending on the mechanisms used. We label these three mechanisms non-management, political regulation management and administrative management. In addition to various management strategies, the examples share a background of previous problems, the diversification of the population in terms of origin and the differentiation of management capabilities. Another issue we will focus on is the non-impact of the Mayor&rsquo;s political persuasion on the development of one or other management model.Keywords: religion, social conflicts, administrative management, regional institutions

Consumo de tabaco de los adolescentes en Barcelona y tendencias a lo largo de 20 años

Objetivos: El tabaquismo es causa de muerte prematura y prevenible, que se inicia en la adolescencia. Se describe el consumo de tabaco en escolares durante 2008 y la tendencia en los últimos 20 años en Barcelona. Material y métodos: Estudio de análisis de la tendencia del consumo. Se comparan datos de ocho encuestas realizadas entre 1987 y 2008 en 2° y 4° cursos de Educación Secundaria Obligatoria (ESO) y 2° de Bachillerato o Ciclos Formativos de Grado Medio. Se utilizó el cuestionario FRESC. Se presentan datos del consumo regular y diario de tabaco en 2008 y sus factores asociados, y se comparan con los de estudios precedentes. Se calculan los porcentajes de cambio anual mediante regresión joinpoint y se estratifica por sexo y curso académico. Resultados: En 2008 fumaban regularmente en ESO el 6,1% de los chicos y el 4,5% de las chicas de 2° curso, y el 15,8% y el 20,4% de 4° curso; en 2° curso de Bachillerato y Ciclos los porcentajes eran, respectivamente, el 26,1% y el 33,1%. Entre los factores asociados al consumo regular, en los tres cursos se observó una fuerte asociación entre consumo de tabaco y cannabis, así como tener amigos fumadores y un bajo rendimiento escolar. A los 15-16 años de edad, la disminución media anual desde 1996 hasta 2008 era del 6,8% en las chicas y del 6,1% en los chicos. Conclusiones: El consumo de tabaco en los adolescentes está disminuyendo desde hace algunos años en Barcelona. Hay una asociación muy intensa entre el consumo de tabaco y el de cannabis