The 2010<i>M</i>_w8.8 Maule, Chile earthquake: Nucleation and rupture propagation controlled by a subducted topographic high

Knowledge of seismic properties in an earthquake rupture zone is essential for understanding the factors controlling rupture dynamics. We use data from aftershocks following the Maule earthquake to derive a three-dimensional seismic velocity model of the central Chile forearc. At 36°S, we find a highvp (&gt;7.0 km/s) and high vp/vs(?1.89) anomaly lying along the megathrust at 25 km depth, which coincides with a strong forearc Bouguer gravity signal. We interpret this as a subducted topographic high, possibly a former seamount on the Nazca slab. The Maule earthquake nucleated at the anomaly's updip boundary; yet high co-seismic slip occurred where the megathrust is overlain by lower seismic velocities. Sparse aftershock seismicity occurs within this structure, suggesting that it disrupts normal interface seismogenesis. These findings imply that subducted structures can be conducive to the nucleation of large megathrust earthquakes, even if they subsequently hinder co-seismic slip and aftershock activity

Constraints on Lorentz invariance violation from gamma-ray burst GRB090510

We obtain modified dispersion relations by requiring the vanishing of determinant of inverse of modified photon propagators in Lorentz invariance violation (LIV) theory. Inspired by these dispersion relations, we give a more general dispersion relation with less assumption and apply it to the recent observed gamma-ray burst GRB090510 to extract various constraints on LIV parameters. We find that the constraint on quantum gravity mass is slightly larger than the Planck mass but is consistent with the other recent observations, so the corresponding LIV coefficient $\xi_1$ has reached the natural order ($o(1)$) as one expects. From our analysis, the linear LIV corrections to photon group velocity might be not excluded yet.Comment: 10 latex pages, no figures, version accepted for publication in PR

Quantum Electrodynamics and the Origins of the Exchange, Dipole-Dipole, and Dzyaloshinsky-Moriya Interactions in Itinerant Fermion Systems

It is shown how the exchange interaction, the dipole-dipole interaction, and the Dzyaloshinsky-Moriya interaction between electronic spin-density fluctuations emerge naturally from a field-theoretic framework that couples electrons to the fluctuating electromagnetic potential. Semi-quantitative estimates are given to determine when the dipole-dipole interaction, which is often neglected, needs to be considered, and various applications are discussed, with an emphasis on weak ferromagnets and on helimagnets.Comment: 12pp, 3 fig

Energetic nuclear transients in luminous and ultraluminous infrared galaxies

Energetic nuclear outbursts have been discovered in luminous and ultraluminous infrared galaxies (U/LIRGs) at unexpectedly high rates. To investigate this population of transients, we performed a search in mid-IR data from the Wide-field Infrared Survey Explorer (WISE) satellite and its NEOWISE survey to detect and characterise luminous and smoothly evolving transients in a sample of 215 U/LIRGs. We report three new transients, all with ΔL >  1043 erg s−1, in addition to two previously known cases. Their host galaxies are all part of major galaxy mergers, and through radiative transfer model fitting we find that all have a significant contribution from an active galactic nucleus (AGN). We characterised the transients through measurements of their luminosities and resulting energetics, all of which are between 1050.9 erg and 1052.2 erg. The IR emission of the five transients was found to be consistent with re-radiation by the hot dust of emission at shorter wavelengths, presumably originating from an accretion event, onto the supermassive black hole. The corresponding transient rate of (1.6–4.6) × 10−3 yr−1 galaxy−1 is over an order of magnitude higher than the rate of large amplitude flares shown by AGN in the optical. We suggest that the observed transients are part of a dust-obscured population of tidal disruption events (TDEs) that have remained out of the reach of optical surveys due to the obscuring dust. In one case, this is supported by our radio observations. We also discuss other plausible explanations. The observed rate of events is significantly higher than optical TDE rates, which can be expected in U/LIRG hosts undergoing a major galaxy merger with increased stellar densities in the nuclear regions. Continued searches for such transients and their multi-wavelength follow-up is required to constrain their rate and nature. </p

Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks

The role of chromosome rearrangements in driving evolution has been a long-standing question of evolutionary biology. Here we focused on ruminants as a model to assess how rearrangements may have contributed to the evolution of gene regulation. Using reconstructed ancestral karyotypes of Cetartiodactyls, Ruminants, Pecorans, and Bovids, we traced patterns of gross chromosome changes. We found that the lineage leading to the ruminant ancestor after the split from other cetartiodactyls was characterized by mostly intrachromosomal changes, whereas the lineage leading to the pecoran ancestor (including all livestock ruminants) included multiple interchromosomal changes. We observed that the liver cell putative enhancers in the ruminant evolutionary breakpoint regions are highly enriched for DNA sequences under selective constraint acting on lineage-specific transposable elements (TEs) and a set of 25 specific transcription factor (TF) binding motifs associated with recently active TEs. Coupled with gene expression data, we found that genes near ruminant breakpoint regions exhibit more divergent expression profiles among species, particularly in cattle, which is consistent with the phylogenetic origin of these breakpoint regions. This divergence was significantly greater in genes with enhancers that contain at least one of the 25 specific TF binding motifs and located near bovidae-to-cattle lineage breakpoint regions. Taken together, by combining ancestral karyotype reconstructions with analysis of cis regulatory element and gene expression evolution, our work demonstrated that lineage-specific regulatory elements colocalized with gross chromosome rearrangements may have provided valuable functional modifications that helped to shape ruminant evolution

Variable short duration treatment versus standard treatment, with and without adjunctive ribavirin, for chronic hepatitis C: the STOP-HCV-1 non-inferiority, factorial RCT

Background: High cure rates with licensed durations of therapy for chronic hepatitis C virus suggest that many patients are overtreated. New strategies in individuals who find it challenging to adhere to standard treatment courses could significantly contribute to the elimination agenda. Objectives: To compare cure rates using variable ultrashort first-line treatment stratified by baseline viral load followed by retreatment, with a fixed 8-week first-line treatment with retreatment with or without adjunctive ribavirin. Design: An open-label, multicentre, factorial randomised controlled trial. Randomisation: Randomisation was computer generated, with patients allocated in a 1 : 1 ratio using a factorial design to each of biomarker-stratified variable ultrashort strategy or fixed duration and adjunctive ribavirin (or not), using a minimisation algorithm with a probabilistic element. Setting: NHS. Participants: A total of 202 adults (aged ≥ 18 years) infected with chronic hepatitis C virus genotype 1a/1b or 4 for ≥ 6 months, with a detectable plasma hepatitis C viral load and no significant fibrosis [FibroScan® (Echosens, Paris, France) score F0–F1 or biopsy-proven minimal fibrosis], a hepatitis C virus viral load  24 weeks on anti-human immunodeficiency virus drugs. Interventions: Fixed-duration 8-week first-line therapy compared with variable ultrashort first-line therapy, initially for 4–6 weeks (continuous scale) stratified by screening viral load (variable ultrashort strategy 1, mean 32 days of treatment) and then, subsequently, for 4–7 weeks (variable ultrashort strategy 2 mean 39 days of duration), predominantly with ombitasvir, paritaprevir, ritonavir (Viekirax®; AbbVie, Chicago, IL, USA), and dasabuvir (Exviera®; AbbVie, Chicago, IL, USA) or ritonavir. All patients in whom first-line treatment was unsuccessful were immediately retreated with 12 weeks’ sofosbuvir, ledipasvir (Harvoni®, Gilead Sciences, Inc., Foster City, CA, USA) and ribavirin. Main outcome measure: The primary outcome was overall sustained virological response (persistently undetectable) 12 weeks after the end of therapy (SVR12). Results: A total of 202 patients were analysed. All patients in whom the primary outcome was evaluable achieved SVR12 overall [100% (197/197), 95% confidence interval 86% to 100%], demonstrating non-inferiority between fixed- and variable-duration strategies (difference 0%, 95% confidence interval –3.8% to 3.7%, prespecified non-inferiority margin 4%). A SVR12 following first-line treatment was achieved in 91% (92/101; 95% confidence interval 86% to 97%) of participants randomised to the fixed-duration strategy and by 48% (47/98; 95% confidence interval 39% to 57%) allocated to the variable-duration strategy. However, the proportion achieving SVR12 was significantly higher among those allocated to variable ultrashort strategy 2 [72% (23/32), 95% confidence interval 56% to 87%] than among those allocated to variable ultrashort strategy 1 [36% (24/66), 95% confidence interval 25% to 48%]. Overall, a SVR12 following first-line treatment was achieved by 72% (70/101) (95% confidence interval 65% to 78%) of patients treated with ribavirin and by 68% (69/98) (95% confidence interval 61% to 76%) of those not treated with ribavirin. A SVR12 with variable ultrashort strategies 1 and 2 was 52% (25/48) (95% confidence interval 38% to 65%) with ribavirin, compared with 44% (22/50) (95% confidence interval 31% to 56) without. However, at treatment failure, the emergence of viral resistance was lower with ribavirin [12% (3/26), 95% confidence interval 2% to 30%] than without [38% (11/29), 95% confidence interval 21% to 58%; p = 0.01]. All 10 individuals who became undetectable at day 3 of treatment achieved first-line SVR12 regardless of treatment duration. Five participants in the variable-duration arm and five in the fixed-duration arm experienced serious adverse events (p = 0.69), as did five participants receiving ribavirin and five participants receiving no ribavirin. Conclusions: SVR12 rates were significantly higher when ultrashort treatment varied between 4 and 7 weeks, rather than between 4 and 6 weeks. We found no evidence of ribavirin significantly affecting first-line SVR12, with unsuccessful first-line short-course therapy also not compromising subsequent retreatment with sofosbuvir, ledipasvir and ribavirin

Star formation and AGN activity in a sample of local luminous infrared galaxies through multiwavelength characterization

Nuclear starbursts and active galactic nucleus (AGN) activity are the main heating processes in luminous infrared galaxies (LIRGs) and their relationship is fundamental to understand galaxy evolution. In this paper, we study the star formation and AGN activity of a sample of 11 local LIRGs imaged with subarcsecond angular resolution at radio (8.4 GHz) and near-infrared (2.2 mu m) wavelengths. This allows us to characterize the central kpc of these galaxies with a spatial resolution of similar or equal to 100 pc. In general, we find a good spatial correlation between the radio and the near-IR emission, although radio emission tends to be more concentrated in the nuclear regions. Additionally, we use an Markov Chain Monte Carlo code to model their multiwavelength spectral energy distribution (SED) using template libraries of starburst, AGN and spheroidal/cirrus models, determining the luminosity contribution of each component, and finding that all sources in our sample are starburst-dominated, except for NGC 6926 with an AGN contribution of similar or equal to 64 per cent. Our sources show high star formation rates (40-167 M(circle dot)yr(-1)), supernova rates (0.4-2.0 SN yr(-1)) and similar starburst ages (13-29 Myr), except for the young starburst (9 Myr) in NGC 6926. A comparison of our derived star-forming parameters with estimates obtained from different IR and radio tracers shows an overall consistency among the different star formation tracers. AGN tracers based on mid-IR, high-ionization line ratios also show an overall agreement with our SED model fit estimates for the AGN. Finally, we use our wide-band Very Large Array observations to determine pixel-by-pixel radio spectral indices for all galaxies in our sample, finding a typical median value (alpha similar or equal to -0.8) for synchrotron-powered LIRGs

The Pseudomonas aeruginosa PSL Polysaccharide Is a Social but Noncheatable Trait in Biofilms

Extracellular polysaccharides are compounds secreted by microorganisms into the surrounding environment, and they are important for surface attachment and maintaining structural integrity within biofilms. The social nature of many extracellular polysaccharides remains unclear, and it has been suggested that they could function as either cooperative public goods or as traits that provide a competitive advantage. Here, we empirically tested the cooperative nature of the PSL polysaccharide, which is crucial for the formation of biofilms in Pseudomonas aeruginosa. We show that (i) PSL is not metabolically costly to produce; (ii) PSL provides population-level benefits in biofilms, for both growth and antibiotic tolerance; (iii) the benefits of PSL production are social and are shared with other cells; (iv) the benefits of PSL production appear to be preferentially directed toward cells which produce PSL; (v) cells which do not produce PSL are unable to successfully exploit cells which produce PSL. Taken together, this suggests that PSL is a social but relatively nonexploitable trait and that growth within biofilms selects for PSL-producing strains, even when multiple strains are on a patch (low relatedness at the patch level). IMPORTANCE: Many studies have shown that bacterial traits, such as siderophores and quorum sensing, are social in nature. This has led to an impression that secreted traits act as public goods, which are costly to produce but benefit both the producing cell and its surrounding neighbors. Theories and subsequent experiments have shown that such traits are exploitable by asocial cheats, but we show here that this does not always hold true. We demonstrate that the Pseudomonas aeruginosa exopolysaccharide PSL provides social benefits to populations but that it is nonexploitable, because most of the fitness benefits accrue to PSL-producing cells. Our work builds on an increasing body of work showing that secreted traits can have both private and public benefits to cells

The nature of supernovae 2010O and 2010P in Arp 299-II. Radio emission

We report radio observations of two stripped-envelope supernovae (SNe), 2010O and 2010P, which exploded within a few days of each other in the luminous infrared galaxy Arp 299. Whilst SN 2010O remains undetected at radio frequencies, SN 2010P was detected (with an astrometric accuracy better than 1 milli arcsec in position) in its optically thin phase in epochs ranging from similar to 1 to similar to 3 yr after its explosion date, indicating a very slow radio evolution and a strong interaction of the SN ejecta with the circumstellar medium. Our late-time radio observations towards SN 2010P probe the dense circumstellar envelope of this SN, and imply M [M-circle dot yr(-1)]/upsilon(wind) [10 km s(-1)] = (3.0 - 5.1) x 10(-5), with a 5 GHz peak luminosity of similar to 1.2 x 10(27) erg s(- 1) Hz(- 1) on day similar to 464 after explosion. This is consistent with a Type IIb classification for SN 2010P, making it the most distant and most slowly evolving Type IIb radio SN detected to date.</p