Venous drainage of the middle lobe of the right lung in man

The shape of the middle lobe of the right lung may vary greatly because of the varying extent of its surfaces in different specimens and the profuse branching of the two segmental bronchi, arteries and veins. The architecture of the middle lobe is therefore especially difficult to understand. For these reasons, attention must be paid to the arrangements of the veins which separate its segments. Thus, the aim of this study was to investigate the ways in which venous drainage of the middle lobe segments may take place. The studies were performed on 40 organs taken from adult human cadavers of both sexes. The pulmonary vessels and bronchi were filled with Plastogen G, after which corrosion casts were made and skeletonised. The lateral segment (SIV) and the medial segment (SV) of the middle lobe were drained in 55% of specimens by one vein and in 35% of specimens by two separately terminated veins. Considerably less frequently there were 3 veins (7.5% of specimens) and only in 2.5% of specimens - 4 veins. In specimens where the middle lobe was drained by one vein (55%) it was formed by joining the lateral (V4) and the medial (V5) segmental veins. In 32.5% of specimens these two segmental veins were formed by a junction of their typical sub-segmental tributaries, where the posterior sub-segmental vein V4a and the superior sub-segmental vein V5a were intra-segmental veins, whereas the anterior sub-segmental vein V4b and the inferior sub-segmental vein V5b were inter-segmental veins. In the remaining 22.5% of specimens with one vein of the middle lobe we noticed modifications in the course of the bronchi, arteries and veins. In the middle lobes drained by two separate veins (35% of specimens) there were independently running segmental veins, V4 and V5. These were formed by their typical tributaries (15%), whereas in the remaining 20% of specimens there were unusual patterns. Three individual veins of the middle lobe (7.5% of specimens) accompanied the lateral-medial type of bronchial arrangement in 5% of specimens, while in 2.5% of specimens the bronchial pattern was of the superior-inferior type. These veins run so as to form more often two superior and one inferior vein. The venous pattern of the middle lobe was consistent with the bronchial and arterial patterns in 35% of specimens. However, this conformation was present in those organs (32.5% of specimens) where the middle lobe was drained by one vein and only in 2.5% of specimens if there were two veins. If 3 or 4 individually emptied veins were present, we could not find any organ in which the bronchial, arterial and venous pattern would be fully compatible. Thus, the research revealed that convenient conditions for the separation of the segments of the middle lobe of the right lung were present in approximately 1/3 of the middle lobes

Chemical studies of the passivation of GaAs surface recombination using sulfides and thiols

Steady-state photoluminescence, time-resolved photoluminescence, and x-ray photoelectron spectroscopy have been used to study the electrical and chemical properties of GaAs surfaces exposed to inorganic and organic sulfur donors. Despite a wide variation in S2–(aq) concentration, variation of the pH of aqueous HS–solutions had a small effect on the steady-state n-type GaAs photoluminescence intensity, with surfaces exposed to pH=8, 0.1-M HS–(aq) solutions displaying comparable luminescence intensity relative to those treated with pH=14, 1.0-M Na2S·9H2O(aq). Organic thiols (R-SH, where R=–CH2CH2SH or –C6H4Cl) dissolved in nonaqueous solvents were found to effect increases in steady-state luminescence yields and in time-resolved luminescence decay lifetimes of (100)-oriented GaAs. X-ray photoelectron spectroscopy showed that exposure of GaAs surfaces to these organic systems yielded thiols bound to the GaAs surface, but such exposure did not remove excess elemental As and did not form a detectable As2S3 overlayer on the GaAs. These results imply that complete removal of As0 or formation of monolayers of As2S3 is not necessary to effect a reduction in the recombination rate at etched GaAs surfaces. Other compounds that do not contain sulfur but that are strong Lewis bases, such as methoxide ion, also improved the GaAs steady-state photoluminescence intensity. These results demonstrate that a general class of electron-donating reagents can be used to reduce nonradiative recombination at GaAs surfaces, and also imply that prior models focusing on the formation of monolayer coverages of As2S3 and Ga2S3 are not adequate to describe the passivating behavior of this class of reagents. The time-resolved, high level injection experiments clearly demonstrate that a shift in the equilibrium surface Fermi-level energy is not sufficient to explain the luminescence intensity changes, and confirm that HS– and thiol-based reagents induce substantial reductions in the surface recombination velocity through a change in the GaAs surface state recombination rate

Using Mussel Isotope Ratios to Assess Anthropogenic Nitrogen Inputs to Freshwater Ecosystems

Stable nitrogen isotope ratios (δ15N) of freshwater mussels from a series of lakes and ponds were related to watershed land use characteristics to assess their utility in determining the source of nitrogen inputs to inland water bodies. Nitrogen isotope ratios measured in freshwater mussels from 19 lakes and ponds in Rhode Island, U.S.A., ranged from 4.9–12.6% and were found to significantly correlate with the fraction of residential development in 100 and 200 m buffer zones around the ponds. Mussel δ15N values in 12 of the 19 ponds also showed significant correlation with average dissolved nitrate concentrations, which ranged from 23–327 μg L-1. These observations, in light of previous studies which link elevated δ15N values of nitrogen derived from septic wastewater with those seen in biota, suggest that mussel isotope ratios may reflect nitrogen source in freshwater ecosystems. We followed an iterative approach using multiple regression analysis to assess the relationship between mussel δ15N and the land use categories fraction residential development, fraction feedlot agriculture, fraction row-crop agriculture, and fraction natural vegetation in 100 and 200 m buffer zones and pond watersheds. From this we developed a simple regression model to predict mussel δ15N from the fraction of residential development in the 200 m buffer zone around the pond. Subsequent testing with data from 16 additional sites in the same ecoregion led us to refine the model by incorporating the fraction of natural vegetation. The overall average absolute difference between measured and predicted δ15N values using the two-parameter model was 1.6%. Potential sources of error in the model include differences in the scale and categorization of land-use data used to generate and test the model, differences in physical characteristics, such as retention time and range of residential development, and exclusion of sources of enriched nitrogen such as runoff from feedlot operations or increased nitrogen loading from inefficient or failed septic systems

High salt recruits aversive taste pathways

In the tongue, distinct classes of taste receptor cells detect the five basic tastes; sweet, sour, bitter, sodium salt and umami. Among these qualities, bitter and sour stimuli are innately aversive, whereas sweet and umami are appetitive and generally attractive to animals. By contrast, salty taste is unique in that increasing salt concentration fundamentally transforms an innately appetitive stimulus into a powerfully aversive one. This appetitive–aversive balance helps to maintain appropriate salt consumption, and represents an important part of fluid and electrolyte homeostasis. We have shown previously that the appetitive responses to NaCl are mediated by taste receptor cells expressing the epithelial sodium channel, ENaC, but the cellular substrate for salt aversion was unknown. Here we examine the cellular and molecular basis for the rejection of high concentrations of salts. We show that high salt recruits the two primary aversive taste pathways by activating the sour- and bitter-taste-sensing cells. We also demonstrate that genetic silencing of these pathways abolishes behavioural aversion to concentrated salt, without impairing salt attraction. Notably, mice devoid of salt-aversion pathways show unimpeded, continuous attraction even to very high concentrations of NaCl. We propose that the ‘co-opting’ of sour and bitter neural pathways evolved as a means to ensure that high levels of salt reliably trigger robust behavioural rejection, thus preventing its potentially detrimental effects on health

The Taste of Carbonation

Carbonated beverages are commonly available and immensely popular, but little is known about the cellular and molecular mechanisms underlying the perception of carbonation in the mouth. In mammals, carbonation elicits both somatosensory and chemosensory responses, including activation of taste neurons. We have identified the cellular and molecular substrates for the taste of carbonation. By targeted genetic ablation and the silencing of synapses in defined populations of taste receptor cells, we demonstrated that the sour-sensing cells act as the taste sensors for carbonation, and showed that carbonic anhydrase 4, a glycosylphosphatidylinositol-anchored enzyme, functions as the principal CO_2 taste sensor. Together, these studies reveal the basis of the taste of carbonation as well as the contribution of taste cells in the orosensory response to CO_2

Optical and EPR spectroscopy of Er3+ in lithium yttrium borate, Li6Y(BO3)3:Er single crystals

The energy levels of Er3+ ions have been determined in lithium yttrium borate (Li6Y(BO3)3) single crystals in a wide spectral range between 6000 and 40000 cm-1 together with an analysis of the ground state, using optical and EPR spectroscopy. The crystal field splittings of the 4I15/2 ground state and those of nearly all excited states up to the 4D7/2 manifold have been obtained at low temperature from luminescence (T = 5 K) and absorption (T = 9 K) measurements, respectively. The numbers of experimentally observed Stark sublevels agree well with those expected theoretically for Er3+ ions occupying a single low symmetry (C1) site. A full set of g- and 167Er hyperfine tensor parameters are presented for the ground state characterized by EPR; the measured Orbach-type spin-relaxation rates viz. the involved activation energies correspond to the optically derived lowest excited sublevels

T2Rs Function as Bitter Taste Receptors

AbstractBitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying paper, we report the characterization of a large family of putative mammalian taste receptors (T2Rs). Here we use a heterologous expression system to show that specific T2Rs function as bitter taste receptors. A mouse T2R (mT2R-5) responds to the bitter tastant cycloheximide, and a human and a mouse receptor (hT2R-4 and mT2R-8) responded to denatonium and 6-n-propyl-2-thiouracil. Mice strains deficient in their ability to detect cycloheximide have amino acid substitutions in the mT2R-5 gene; these changes render the receptor significantly less responsive to cycloheximide. We also expressed mT2R-5 in insect cells and demonstrate specific tastant-dependent activation of gustducin, a G protein implicated in bitter signaling. Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds

‘School, family and then hockey!’ Coaches’ views on dual career in ice hockey

Despite the extensive research into coaches’ roles in supporting athletic development and motivation for sport, few studies have examined coaches’ attitudes and practices towards athletes’ dual careers. The present study extends European research into athletes’ dual careers by examining Finnish ice hockey coaches’ attitudes and practices surrounding players’ education. Ten male coaches aged 27–52 participated in semi-structured interviews. The data were analysed with an existential-narrative theoretical framework and with thematic and structural narrative analysis. Three composite vignettes were created entitled ‘supporting athletic development and players in reaching their own goals’, ‘enjoyment and physically active lifestyle’ and ‘developing good persons’. The analysis revealed that although all coaches embraced the official rhetoric where school is a priority over ice hockey, most of them had few practical examples of how this view had informed their coaching practice. It is concluded that young players may be easily lured into dreams of professionalism, whereas coaches’ dominant narrative of education as a back-up may be ineffective to spark athletes’ interest and engagement with education. © 2017, © The Author(s) 2017

The High Time Resolution Universe Survey II: Discovery of 5 Millisecond Pulsars

We present the discovery of 5 millisecond pulsars found in the mid-Galactic latitude portion of the High Time Resolution Universe (HTRU) Survey. The pulsars have rotational periods from ~2.3 to ~7.5 ms, and all are in binary systems with orbital periods ranging from ~0.3 to ~150 d. In four of these systems, the most likely companion is a white dwarf, with minimum masses of ~0.2 Solar Masses. The other pulsar, J1731-1847, has a very low mass companion and exhibits eclipses, and is thus a member of the "black widow" class of pulsar binaries. These eclipses have been observed in bands centred near frequencies of 700, 1400 and 3000 MHz, from which measurements have been made of the electron density in the eclipse region. These measurements have been used to examine some possible eclipse mechanisms. The eclipse and other properties of this source are used to perform a comparison with the other known eclipsing and "black widow" pulsars. These new discoveries occupy a short-period and high-dispersion measure (DM) region of parameter space, which we demonstrate is a direct consequence of the high time and frequency resolution of the HTRU survey. The large implied distances to our new discoveries makes observation of their companions unlikely with both current optical telescopes and the Fermi Gamma-ray Space Telescope. The extremely circular orbits make any advance of periastron measurements highly unlikely. No relativistic Shapiro delays are obvious in any of the systems, although the low flux densities would make their detection difficult unless the orbits were fortuitously edge-on.Comment: 11 pages, 5 figures, 4 tables, for publication in MNRA

The ultra-cool white dwarf companion of PSR J0751+1807

We present optical and near-infrared observations with Keck of the binary millisecond pulsar PSR J0751+1807. We detect a faint, red object - with R=25.08+-0.07, B-R=2.5+-0.3, and R-I=0.90+-0.10 - at the celestial position of the pulsar and argue that it is the white dwarf companion of the pulsar. The colours are the reddest among all known white dwarfs, and indicate a very low temperature, Teff~4000 K. This implies that the white dwarf cannot have the relatively thick hydrogen envelope that is expected on evolutionary grounds. Our observations pose two puzzles. First, while the atmosphere was expected to be pure hydrogen, the colours are inconsistent with this composition. Second, given the low temperature, irradiation by the pulsar should be important, but we see no evidence for it. We discuss possible solutions to these puzzles.Comment: 9 pages, 3 figures, accepted for publication in A&