sk_p: a neural program corrector for MOOCs

We present a novel technique for automatic program correction in MOOCs, capable of fixing both syntactic and semantic errors without manual, problem specific correction strategies. Given an incorrect student program, it generates candidate programs from a distribution of likely corrections, and checks each candidate for correctness against a test suite. The key observation is that in MOOCs many programs share similar code fragments, and the seq2seq neural network model, used in the natural-language processing task of machine translation, can be modified and trained to recover these fragments. Experiment shows our scheme can correct 29% of all incorrect submissions and out-performs state of the art approach which requires manual, problem specific correction strategies

A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses

Using pHluorin-tagged synaptic vesicle proteins we have examined the partitioning of these probes into recycling and nonrecycling pools at hippocampal nerve terminals in cell culture. Our studies show that for three of the major synaptic vesicle components, vGlut-1, VAMP-2, and Synaptotagmin I, approximately 50-60% of the tagged protein appears in a recycling pool that responds readily to sustained action potential stimulation by mobilizing and fusing with the plasma membrane, while the remainder is targeted to a nonrecycling, acidic compartment. The fraction of recycling and nonrecycling (or resting) pools varied significantly across boutons within an individual axon, from 100% resting (silent) to 100% recycling. Single-bouton bleaching studies show that recycling and resting pools are dynamic and exchange between synaptic boutons. The quantitative parameters that can be extracted with the approaches outlined here should help elucidate the potential functional role of the resting vesicle pool

A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses

Using pHluorin-tagged synaptic vesicle proteins we have examined the partitioning of these probes into recycling and nonrecycling pools at hippocampal nerve terminals in cell culture. Our studies show that for three of the major synaptic vesicle components, vGlut-1, VAMP-2, and Synaptotagmin I, approximately 50-60% of the tagged protein appears in a recycling pool that responds readily to sustained action potential stimulation by mobilizing and fusing with the plasma membrane, while the remainder is targeted to a nonrecycling, acidic compartment. The fraction of recycling and nonrecycling (or resting) pools varied significantly across boutons within an individual axon, from 100% resting (silent) to 100% recycling. Single-bouton bleaching studies show that recycling and resting pools are dynamic and exchange between synaptic boutons. The quantitative parameters that can be extracted with the approaches outlined here should help elucidate the potential functional role of the resting vesicle pool

Asynchronous Assistance: a Social Network Analysis of Influencing Peer Interactions in PeerWise

This mixed methods, investigative case study explored student patterns of use within the online PeerWise platform to identify the most influencing activities and to build a model capable of predicting performance based on these influencing activities. Peerwise is designed to facilitate student peer-to-peer engagement through creating, answering and ranking multiple choice questions; this study sought to understand the relationship between student engagement in Peerwise and learning performance. To address the research question, various usage metrics were explored, visualized and modelled, using social network analysis with Gephi, Tableau and Python. These findings were subsequently analyzed in light of the qualitative survey data gathered. The most significant activity metrics were evaluated leading to rich data visualisations and identified the activities that influenced academic performance in this study. The alignment of the key qualitative and quantitative findings converged on answering questions as having the greatest positive impact on learner performance. Furthermore, from a quantitative perspective the Average Comment Length and Average Explanation Length correlated positively with superior academic performance. Qualitatively, the motivating nature of PeerWise community also engaged learners. The key limitation of the size of the data set within the investigative case study suggests further research, with additional student cohorts as part of an action research paradigm, to broaden these findings

Efficiency of 2D Photonic Crystal Emitters in Thermophotovoltaic Systems

Thermophotovoltaic (TPV) systems have the potential to convert energy in a very efficient way by using 2D photonic crystal (PhC) emitters. Recent advancements in TPV technology have developed many methods for effectively generating power. These recent advancements propose that emitters can suppress low energy photon emissions while increasing higher energy photon emissions. This can be achieved by utilising new 2D photonic crystal (PhC) structures on the surface of the emitter with varying diameter and shape.In this meta study we consider the multiple design fabrications of photonic crystal emitters and compare the efficiencies, power densities, and their potential use for converting different wavelengths into heat and power. This is done by analysing the thermodynamic factors present in the system that could potentially reduce the efficiency, and therefore power generation, of the thermophotovoltaic cell. This study found that certain shapes and materials can impact on the PhC structure and its ability to emit energy.

The Plethora of Science Afforded by a Lunar Swirl : A White Paper to the Planetary Science Decadal Survey Committee

Whitepaper #166 submitted to the Planetary Science and Astrobiology Decadal Survey 2023-2032. Topics: surface/geological evolution; Mercury and/or the Moon; other science themes: Physics, Heliophysics, Magnetohydrodynamics, Volcanology, ISRU, PhotometryLunar swirls should be the top priority target of the next lunar mission. The swirls are a fascinating lunar feature, as well as a laboratory to study the solar wind, space weathering, plasma weathering, and plasma kinetics. In this white paper we present examples of broad scientific interest in lunar swirls as well as some example mission types

Engram cells retain memory under retrograde amnesia

Memory consolidation is the process by which a newly formed and unstable memory transforms into a stable long-term memory. It is unknown whether the process of memory consolidation occurs exclusively through the stabilization of memory engrams. By using learning-dependent cell labeling, we identified an increase of synaptic strength and dendritic spine density specifically in consolidated memory engram cells. Although these properties are lacking in engram cells under protein synthesis inhibitor–induced amnesia, direct optogenetic activation of these cells results in memory retrieval, and this correlates with retained engram cell–specific connectivity. We propose that a specific pattern of connectivity of engram cells may be crucial for memory information storage and that strengthened synapses in these cells critically contribute to the memory retrieval process.RIKEN Brain Science InstituteHoward Hughes Medical InstituteJPB Foundatio

Characterization of nuclear mitochondrial insertions in the whole genomes of primates

Altres ajuts: CERCA Programme/Generalitat de Catalunya i Obra Social "La Caixa"The transfer and integration of whole and partial mitochondrial genomes into the nuclear genomes of eukaryotes is an ongoing process that has facilitated the transfer of genes and contributed to the evolution of various cellular pathways. Many previous studies have explored the impact of these insertions, referred to as NumtS, but have focused primarily on older events that have become fixed and are therefore present in all individual genomes for a given species. We previously developed an approach to identify novel Numt polymorphisms from next-generation sequence data and applied it to thousands of human genomes. Here, we extend this analysis to 79 individuals of other great ape species including chimpanzee, bonobo, gorilla, orang-utan and also an old world monkey, macaque. We show that recent Numt insertions are prevalent in each species though at different apparent rates, with chimpanzees exhibiting a significant increase in both polymorphic and fixed Numt sequences as compared to other great apes. We further assessed positional effects in each species in terms of evolutionary time and rate of insertion and identified putative hotspots on chromosome 5 for Numt integration, providing insight into both recent polymorphic and older fixed reference NumtS in great apes in comparison to human events

COVID-19 and immune checkpoint inhibitors: initial considerations.

COVID-19 infections are characterized by inflammation of the lungs and other organs that ranges from mild and asymptomatic to fulminant and fatal. Patients who are immunocompromised and those with cardiopulmonary comorbidities appear to be particularly afflicted by this illness. During pandemic conditions, many aspects of cancer care have been impacted. One important clinical question is how to manage patients who need anticancer therapy, including immune checkpoint inhibitors (ICIs) during these conditions. Herein, we consider diagnostic and therapeutic implications of using ICI during this unprecedented period of COVID-19 infections. In particular, we consider the impact of ICI on COVID-19 severity, decisions surrounding continuing or interrupting therapy, diagnostic measures in patients with symptoms or manifestations potentially consistent with either COVID-19 or ICI toxicity, and resumption of therapy in infected patients. While more robust data are needed to guide clinicians on management of patients with cancer who may be affected by COVID-19, we hope this commentary provides useful insights for the clinical community

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive memory decline and subsequent loss of broader cognitive functions. Memory decline in the early stages of AD is mostly limited to episodic memory, for which the hippocampus has a crucial role. However, it has been uncertain whether the observed amnesia in the early stages of AD is due to disrupted encoding and consolidation of episodic information, or an impairment in the retrieval of stored memory information. Here we show that in transgenic mouse models of early AD, direct optogenetic activation of hippocampal memory engram cells results in memory retrieval despite the fact that these mice are amnesic in long-term memory tests when natural recall cues are used, revealing a retrieval, rather than a storage impairment. Before amyloid plaque deposition, the amnesia in these mice is age-dependent, which correlates with a progressive reduction in spine density of hippocampal dentate gyrus engram cells. We show that optogenetic induction of long-term potentiation at perforant path synapses of dentate gyrus engram cells restores both spine density and long-term memory. We also demonstrate that an ablation of dentate gyrus engram cells containing restored spine density prevents the rescue of long-term memory. Thus, selective rescue of spine density in engram cells may lead to an effective strategy for treating memory loss in the early stages of AD.RIKEN Brain Science InstituteHoward Hughes Medical InstituteJPB Foundatio